SDC 4 [paper title: Arginase1 and 2 variation associates with asthma, asthma severity and β2-agonist and steroid response]
Table E6: Asthmatic probands: pharmacogenetic effect of ARG1 and ARG2 and inhaled corticosteroids (ICS) on the annual FEV1 change. Only
dominant models (i.e. heterozygotes and homozygotes for the minor allele together are compared to the wildtypes (homozygous for the major
allele)
SNP
Alleles*
Before ICS†
During ICS†
estimate (95% CI)
estimate (95% CI)
Difference during vs
before ICS†
estimate (95% CI)
ARG1
rs2781667
rs2781668
rs17599586
C/T
C/T
C/T
-7.3 (-32.6;18.0)
2.0 (-26.6;30.6)
13.7 (-17.8;45.3)
19.9 (4.8;35.0)
9.9 (-8.5;28.2)
8.0 (-12.3;28.4)
27.2 (-1.7;56.2)
7.9 (-25.8;41.5)
-5.7 (-42.4;31.1)
ARG2
rs2145467
rs2295643
rs17249437
rs17249444
rs12896052
rs7140310
rs3742879
rs10483801
T/A
A/T
T/C
G/C
G/A
T/G
A/G
C/A
-8.0 (-34.3;18.2)
9.2 (-17.0;35.4)
5.9 (-19.0;30.9)
-9.6 (-40.8;21.5)
-2.0 (-41.5;37.4)
21.4 (-8.7;51.4)
2.0 (-26.1;30.1)
13.4 (-15.4;42.2)
0.5 (-15.9;16.9)
-1.2 (-17.3;14.9)
-9.6 (-25.1;5.9)
-5.8 (-24.8;13.2)
-10.9 (-36.1;14.2)
-9.2 (-26.7;8.3)
5.9 (-10.6;22.4)
-7.6 (-24.7;9.6)
8.6 (-21.7;38.9)
-10.4 (-40.6;19.8)
-15.5 (-44.1;13.1)
3.9 (-31.6;39.4)
-8.8 (-55.2;37.5)
-30.6 (-64.6;3.4)
3.9 (-27.9;35.8)
-20.9 (-53.7;11.8)
*
†
major allele first
Before ICS: estimated difference in FEV1 change before the start of ICS between the heterozygotes and homozygotes for the minor
allele together compared to the wildtypes (i.e. dominant model)
During ICS: estimated difference in FEV1 change during the use of ICS between the heterozygotes and homozygote for the minor
allele together compared to the wildtypes (i.e. dominant model)
Difference during vs before ICS: estimated difference in the effect of ICS of the FEV1 change between the heterozygotes and
homozygotes for the minor allele together compared to the wildtypes (i.e. dominant model)