Lecture Notes for Med. Tech. Class
Transplantation and Rejection
Oct. 2000
C.K.Shieh
Transplantation Immunology
• Study of tissue transplantation lead to the discovery of MHC molecules and the
subsequent discovery of T cell receptor.
• Organ transplantation is now an important clinical practice.
Saintly Transplantation
by Sts. Cosmas and Damian
the 3rd Century
Genetic Barrier of Transplantation
Clinical Transplantation
• Brain cells
• Gene modified
cells
Histocompatability Inheritance
H-2 as MHC
Codominant Inheritance of MHC
• MHC class I molecules are expressed on most cells in the body, while MHC class
II are usually expressed only on antigen presenting cells.
Transplant Rejection I: Host vs. Graft
Transplant Rejection II: Graft vs. Host
Tolerance Induction in Transplantation
• Thymic negative selection mediated by dendritic cells
Primary and Secondary Rejection
Role of T Cells in Rejection
Types of Rejection
Hyperacute Rejection
Acute Rejection
Chronic Rejection
Prevention of Rejection
• Tissue matching
• Immunosuppression with anti-mitotic drugs
• Specific immunosuppression (enhancement)
Blood transfusion for kidney transplant patients
Tissue Typing (I): Serotyping
Tissue Typing (II): MLR
Immunological Enhancement: Peripheral Tolerization