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Web Activity: Your mission is to create a pedigree by interviewing and questioning a family.
The case of solving Nicotine Addiction is in your hands MCP Biology students!
INSTRUCTIONS
1. Make sure to answer all questions and follow the steps in this handout. Going anywhere
except to the site found on the wiki will be 1-2 demerits.
2. Go to mcpbiology.wikispaces.com. Click on
3. Once you have entered the PI office, select the “play” button
and then select “next”
from the instruction box.
Pedigree Analysis Information.
Step 1: Go to the pedigree Analysis Information and click the tab “What is it?
Go through the 6 slides to answer the following questions.
Question 1: What do researchers use pedigrees for?
Question 2: Predict how large families give more information about a trait’s inheritance pattern.
Question 3: What are most common diseases influenced by?
Question 4: Give a prediction on how risk factors may influence a disease.
Question 5: Give the definition of a risk factor and list the risk factors for nicotine addiction.
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Step 2: Click on “DONE”
Click on “What Do The Symbols Mean?” Use it to fill the
table below. When you are done filling the table click “done”
Step 3: Click on “Why do it?”
Then answer the following questions.
Question 6: What conclusion can you make about a trait that has a genetic component?
Question 7: How can you predict if a disease has a genetic component?
Question 8: Why should scientists collect DNA samples from family members if a trait is heritable?
Question 9: Why can’t scientists just create a pedigree by looking at phenotypes? Explain the importance
of having genotype information.
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Step 4: Click on
Listen to the interviews given by the Marshall family to fill in the
pedigree on the next page with the appropriate symbols. Place the symbols for the individual
above his or her name. You may have to use the notes from the previous section to answer
questions. Click on
at the top left. Then watch the video on Wally
Step 5: After watching the video click on
and click on the symbol that most accurately
describes Wally. Then place his symbol on the pedigree above. Then watch him talk about his
wife Trudy. After watching select the symbol that best represents Trudy.
Question 10: Explain why Trudy is best represented by the symbol you chose. Give examples Wally used
in the video to help support your choice.
Step 6: Enlarge the Certificate of Death to learn more about Ken Marshall.
Question 11: What conclusion can you make about Kenneth Marshall? What led you to this conclusion?
Step 7: Keep clicking
and using the information your assistant gathered to find the
symbols for Elizabeth and Allison. Then watch the video on Todd and Alex
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Question 12: Explain how Ken may have affected his Todd’s and Alex’s behavior to smoke. List any other
risk factors the twins may have.
Step 8: Watch the video on Jennifer and determine her symbol.
Question 12: Explain why Jennifer has a smaller probability of nicotine addiction than some of her
siblings.
Step 9: Watch what Jennifer has to say about her sister Joy. Answer the question below before
selecting her symbol.
Question 13: Explain what risk factors may be affecting Joy.
Step 10: Watch the video on Vanessa and determine her symbol.
Question 14: Make a hypothesis on how your environment may affect individual’s need to smoke.
Step 11: Watch what Vanessa has to say about Michael and Tina. Determine their symbols.
Question 15: Use a punnet square to explain how it would be possible for two affected individuals to have
a normal child.
Step 12: Watch the video on Victor. Use the information given to determine Viktor and Lilly’s
symbols. Then use the surveys to determine the symbols for Brian and Peter. Watch the video on
James. Read the survey on Linda. Determine their symbols. Then watch the video on their
daughter Tess and answer the question below.
Question 16:Predict how James may have genetically and environmentally affected Tess.
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Question 17: In your own words and using examples from your pedigree explain the clues that point to a
genetic component for nicotine addiction.
Analysis Questions
1.
Explain why Nicotine addiction could not be a sex-linked trait.
2.
Looking at the pedigree you notice there are no carriers. You also have affected
individuals having both normal and affected children. Using the table below explain whether
this is an autsomal dominant or recessive trait.
3.
Suppose you have collected DNA samples from some individuals in the
Marshall family. Use your pedigree and table to determine the genotypes and phenotypes for
all the family members. Also correctly show carriers on your pedigree.
Name
Wally
Trudy
Ken
Elizabeth
Todd
Alex
Jennifer
Joy
Jason
Michael
Tina
Viktor
Lily
Brian
Peter
James
Linda
Tess
Genotype
Phenotype
Nn
Affected
NN
Affected
nn
Normal
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4.
Draw a punnet square to show how Ken and Elizabeth can have both normal
and affected children.
5.
Draw a punnet square and determine what percent of Viktor and Lily’s children
would be affected by nicotine addiction.
6.
Suppose Brian marries a women and they have a son who is affected by
nicotine addiction. What must be the genotype of Brian’s Wife. Draw a punnett square
showing their crossing.
7.
Make a hypothesis for why Todd and Alex must have the same genotype for
every trait. Predict how it would be possible for Todd and Alex to have different risk factors.
8.
Create your own made up pedigree with 3 generations for color blindness.
Include 2 individuals in Generation I, at least two couples in Generation II and at least 4
children in Generation III. Include genotypes and make it sex linked.