Xiaochun Chen, Ph.D.
Research associate
xiachen@som.umaryland.edu
Education:
Research
Interests
Publications
PhD Biomedical Engineering. Zhejiang University, P.R.China 2001
M.S. Pharmacology, China Pharmaceutical University, P.R.China 1998
Using chemical, biological and genetic tools to identify and manipulate
molecular mechanisms of HSC proliferation, cell fate determination, and
differentiation and to discover new drugs for clinics as well. Ongoing
projects includes screening compounds a) affecting micro RNA function,
b) affecting HSC cell type commitment and c) inhibiting leukemia stem
cell proliferation. Collaborative project with other groups in Johns
Hopkins includes the discovery of novel anti-proliferation agents for
leukemia using both in vitro cell culture and our recently developed in
vivo mice model.
1. Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin
and fumarranol interact with P. falciparum methionine
aminopeptidase 2 and inhibit malaria parasite growth in vitro and in
vivo. Chem Biol. 2009; 16(2):193-202.
2. Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro
TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Oral
Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively
and Powerfully Cytotoxic to Cancer Cells. J Med Chem. 2009; 52
(4), 1198–1203.
3. Hu X.V., Chen X, Han K.C., Mildvan A.S., Liu J.O. Kinetic and
Mutational Studies of the Number of Interacting Divalent Cations
Required by Bacterial and Human Methionine Aminopeptidases.
Biochemistry. 2007; 46(44): 12833-12843.
4. Chen X, Chong C. R., Shi L., Yoshimoto T., Sullivan D. J. Jr., Liu
J.O. From the Cover: Inhibitors of Plasmodium falciparum
Methionine Aminopeptidase 1b Possess Antimalarial Activity. Proc
Natl Acad Sci U S A.2006; 103(39): 14548-14553.
5. Chong C. R., Chen X, Shi L., Liu J.O. Sullivan D. J. Jr., A clinical
drug library screen identifies astemizole as an antimalarial agent. Nat
Chem Biol. 2006; 2(8): 415-416.
6. Maldve RE, Chen X, Zhang TA, Morrisett RA. Ethanol selectively
inhibits enhanced vesicular release at excitatory synapses: real-time
visualization in intact hippocampal slices. Alcohol Clin Exp Res.
2004; 28(1): 143-152.
7. Xu Q, Chen X. CD4 T lymphocytes cause hepatocyte apoptosis by
releasing Th1 cytokines in cellular immunological liver injury.
Inflammation Res. 2002; 51(9): 444-450.
8. Chen X, Sheng C, Zheng X. Direct nitric oxide imaging in cultured
hippocampal neurons with diaminoanthraquinone and confocal
microscopy. Cell Biology International. 2001; 25(7): 593-598.
9. Chen X, Sheng C, Zheng XX. Inhibitive Effect of N-nitro-L-arginine
on Hippocampal Neurons Excitation. Acta Biochimica et Biophysica
Sinica. 2001; 33(4): 437-442.
10. Chen X, Sheng C, Zheng XX. Inhibitive Effect of Nitric Oxide on
Hippocampal Neurons Excitation. Acta Biophysica Sinica 2001;
17(3): 469-476.
11. Chen X, Cao J and Xu Q. Endotoxin exacerbates the immunological
liver injury in the cooperation of interferon-. Inflammation Res
2000; 49: 571-577.
12. Cao J, Lu J, Wu F, Cheng X, Xu Q. Effects of several drugs on the
liver injury induced by delayed-type hypersensitivity to picryl
chloride by regulating suppressor or helper T cells. Pharmacol Res.
1999; 39(2): 97-102.
13. Xu Q, Wu F, Jiang J, Lu J, Chen X and Zhang B. Role of CD4+ and
CD8+ T cells in regulating the chronic development of liver injury
induced by delayed-type hypersensitivity to picryl chloride. Int Arch
Allergy Immunol 1998; 116: 154-164.
14. Xu Q, Lu J, Wang R, Wu F, Cao J, and Chen X. Liver injury model
induced in mice by a cellular immunologic mechanism – study for
use in immunopharmacological evaluations. Pharmacol Res, 1997;
35: 273-276.