Theme: Crossing boundaries: Inflammation, Infection, Immunity
iCubed retreat
The Carlton Hotel
88 Madison Avenue (at 28th St)
May 12, 2010
8-9 AM Continental Breakfast Country Main Dining Room
9:00 AM Seville Room
Introduction and Overview: goals of iCubed
Roth, Littman, Dustin
Plenary Session I Seville Room
9:15-12:00
(Plenary sessions will focus on large, cross-disciplinary problems
Each topic gets 30’ only, with 15’ discussion
1. Microbiome, pathogen sequences, and host responses to microbiome
9:15-10:00 (including 15’ discussion)
Zhiheng Pei, Moderator
9:15-9:16: Introduction. Zhiheng Pei
9:17-9:26: A Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis. Steve
Abramson
9:27-9:29: Discussion
9:30-9:39: Relationships between inflammation, tumorigenesis, and microbiome. Daniel
Rifkin
9:40-9:42: Discussion
9:43-9:52: Subtherapeutic antibiotics alter the colonic microbiome and early life
adiposity in mice. Ilseung Cho
9:53-10:00 Discussion
10:00-10:30 COFFEE BREAK (30 minutes) Seville Foyer
2. Inflammation
10:30-11:15 (including 15’ discussion)
Dan Littman, Moderator
Dafna Bar-Sagi
Kathryn Moore
Ed Fisher
3. Host-pathogen interactions
11:15-12:00 (including 15’ discussion)
Joel Ernst, Moderator
11:15-11:20: Introduction to host-pathogen interactions (Joel Ernst)
11:20-11:22: Discussion
11:23-11:28: Functional Genomics of the Host: Defining Susceptibility to Mycobacterial
Infection (Jennifer Philips)
11:28-11:30: Discussion
11:31-11:36: Bacterial Gasoprotectors (Evgeny Nudler)
11:38-11:40: Discussion
11:41-11:46: Inflammation and autoimmunity in malaria (Ana Rodriguez)
11:46-11:48: Discussion
11:49-11:54: Evasion of antiviral host restriction factors by HIV (Ned Landau)
11:55-11:57: Discussion
11:57-12:00: Closing discussion
12:00-1:00 LUNCH Country Main Dining Room
Plenary Session II Seville Room
4. Human Immunology
1:15-2:00
Derya Unutmaz, Moderator
Derya Unutmaz Immunobiology of Human Regulatory T cells
Nina Bhardwaj Modulating immunity with dendritic cell vaccines
Mike Dustin Reversal of regulatory T cell defects in Rheumatoid Arthritis
5. Lung inflammation
2:00-2:45
Michael Weiden, Moderator
Joan Reibman
2:00-2:15pm: Dr. Reibman 15 min From the clinic to the genetics of asthma
2:15-2:30pm: Dr Weiden 15 min From bedside to bench and back: Causal Identification
in polygenic traits
2:30-2:45pm: Discussion time
2:45- 3:15 COFFEE BREAK (30’)
III. Focused sessions
3:30-5:00pm
3:30-4:15pm
45 minutes:
1. Biomedical informatics, high throughput sequencing, imaging
Jane Carlton: 7 mins max + 3 mins questions/discussion
Overview of genomics technologies at NYULMC Genome Technology Center & support
for investigators
Alex Statnikov: 7 mins max + 3 mins questions/discussion
Overview of NYULMC Center of Health Informatics & Bioinformatics Best Practices
Integrative Consulting service’s support for investigators.
Bright idea: Systematic benchmarking of informatics methods and knowledge sources
can vastly improve quality of research
Rich Bonneau: 7 mins max + 3 mins questions/discussion
Genomics & systems biology at NYU Biology/Center for Genomics & Systems Biology
Bright idea: consolidated, curated database for publically available microarray data of
human & model organisms
as a means to consolidate NYU genomics & bioinformatics efforts
Michael Dustin: 7 mins max + 3 mins questions/discussion
Overview of Nanomedicine Center? Microscopy (core?)/imaging at NYULMC.
Bright idea:
5 mins discussion/wrap-up
4:15-5:00pm
45 minutes:
2. Human and translational immunology: designing a human immunology core
David Levy and Derya Unutmaz, Moderators
David Levy 10 minutes
Shared resources as a platform for human immunology
Bruce Cronstein 10 minutes
CTSI Cores
Derya Unutmaz 10 minutes
CfAR and the Human Immunology Initiative
Discussion 15 min
Synthesis session and discussion
5:00-5:15
David Roth, moderator
Priority list of next steps and general discussion
Cocktail reception Mezzanine level
5:15-6:15 pm