D – Donate Priority 1 content Donate Thank you for considering making a donation. The money raised for Stand Up To Cancer will go directly to leading UK clinical cancer research projects, helping them get new treatments to patients faster. Channel 4 and Cancer Research UK are bringing Stand Up To Cancer to the UK for the first time. The goal is to boost funds for collaborative cancer studies and trials and, therefore, accelerate new cancer treatments to UK patients. Online donations are a quick, easy and safe way to donate. Donate online >> Priority 2 content Want to pay in your fundraising money? Did you Dare to Stand Up To Cancer? Thank you. You’ve done the hard bit, now’s the easy (and satisfying) bit. Pay in your fundraising money >> Priority 3 content Let’s Stand Up To Cancer Scientists are getting closer and closer to finding cures for all cancers. Your donations really can help turn those dreams into reality. Priority 4 content E – TV Priority 1 content Stand Up To Cancer Channel 4: October 19 It’s time that we all Stood Up To Cancer. And, thanks to a groundbreaking new collaboration between Cancer Research UK and Channel 4, that’s exactly what’s about to happen. On 19 October 2012 Alan Carr and Davina McCall will host Stand Up To Cancer, a live Friday-night entertainment extravaganza [link to channel4.com/standup], featuring a star-studded line-up of A-list celebrities. It will be a night of fun. A night of fundraising. And the money raised will go towards getting new cancer treatments to UK patients faster. In the build up to the big night, Channel 4 will show five days of related programming designed to inspire everyone at home. Now’s the time to make a change. So please, do your bit. Get involved. Get fundraising. Get involved >> F – About cancer Priority 1 content About cancer Cancer is a complex disease – with more than 200 types and thousands of subtypes. Right now, 1 in 3 of us will develop cancer in our lifetime. But there is hope. We have the technology and the knowledge to conquer cancer – we just need the funds to make it happen. Research is our biggest weapon. And we’ve made amazing progress in the past few decades. Thanks to new treatments, screening and prevention – more people are surviving the disease than ever before. Stand Up To Cancer is our chance to make history. Donate now >> Priority 2 content Translational research Your donations will rapidly turn breakthroughs in the lab into breakthroughs in our hospitals. Find out more >> Priority 3 content (to be supplied) F1 – About cancer – translational research Priority 1 content We’ve made amazing breakthroughs against cancer in the past few decades and, thanks to advances in technology, are on the brink of making many more. New treatments, screening and prevention mean more people are surviving the disease than ever before. Stand Up To Cancer funds translational cancer research. In other words, your money will translate discoveries in the lab into benefits for the patient. The money raised by this year’s Stand Up To Cancer campaign will fund new clinical trials running at hospitals and universities across the UK. Priority 2 content About translational research At Stand Up to Cancer we believe there is sufficient knowledge of the basic science of cancer, and the technology available, to make rapid advances in treatment and prevention. The money we raise will fund more clinical trials of the most exciting new treatments and cancer tests. Find out more about clinical trials >> Priority 3 content Prevention and early diagnosis Early detection of cancer can be lifesaver. So it’s important to get to know your body, and learn about any signs and symptoms of cancer [link to health checker]. There are also lifestyle changes you can make to minimise your chances of developing cancer. Find out more about prevention and early diagnosis >> Priority 4 content Get support We’re here to answer any questions you might have about cancer – from early diagnosis and prevention, to trials and treatments. Get support >> F1i – Trials info & case studies Priority 1 content About clinical trials None of the amazing progress against cancer could have happened without clinical trials. From life-saving drugs, to advances in surgery and radiotherapy - every new treatment, test, and screening programme needs a trial to make it happen. Trials are the only reliable way to find whether new treatments are safe, what their side effects are and whether they are better than the current approach. We’re on the brink of many new breakthroughs. By getting everyone to Stand Up To Cancer and fund more of these trials, we can make these breakthroughs happen - fast. Priority 2 content How does a trial work? Most trials involve patients – in fact 1 in 5 cancer patients in the UK now take part in trials - but screening and prevention trials often recruit healthy volunteers too. Trials happen in 3 stages: • Phase 1 trials check that the treatment is safe and find the best dose to use. The treatment is usually tested in small doses on a very small number of people • Phase 2 trials test how well a test or treatment works. These trials typically involve a larger number of people, up to a few hundred • Phase 3 trials compare the new treatment with the current treatment. Treatments only move into a Phase 3 trial if Phases 1 and 2 have been successful and they often involve many more patients, up to several thousands Once a drug has been through all 3 stages of testing, which can take over 10 years, it can be considered for licensing. If a medicine is granted a licence by the Medicines and Healthcare products Regulatory Agency (MHRA) it can then be sold in the UK. [Insert story from someone going through a trial – with ‘share this’ CTA] Find out more about clinical trials >> F2 – Prevention and early diagnosis Did you know, up to 10,000 cancer deaths could be avoided each year through earlier detection? But, by spotting the signs of cancer, and getting an early diagnosis, the chances of successful treatment are higher. You’re already twice as likely to survive cancer today, as you would have been 40 years ago. So stand up to cancer and do your bit to help yourself, and others, get the message. Early detection really makes a difference between life and death. Know the signs? Know your body! Start by getting to know your body. If you know what's normal for you, it's easier to notice when something's different. If you do notice any unexplained or persistent change, it's important to get it checked out by your doctor. Cancer signs and symptoms Find out about the possible warning signs and symptoms of cancer [link to http://info.cancerresearchuk.org/spotcancerearly/cancersignandsymptoms/]. If you notice any of these, it's most likely to be something much less serious than cancer, but it's worth getting checked out by your doctor. Find out what more you could be doing >> [Link to our spot cancer early website] Many people believe that getting cancer is purely down to genes, fate or bad luck. But research has shown that our risk actually depends on a combination of our genes, our environment and aspects of our lives, many of which we can control. Experts estimate that more than four in 10 cancer cases could be prevented by lifestyle changes. Find out more about reducing the risk of cancer >> [Link to health checker app (download free at the iTunes store: http://itunes.apple.com/gb/app/cancer-signs-andsymptoms/id429676749?mt=8) ]