Charles E. Keller * 3978 Lochview DR * Socastee, SC 29588 *
(843) 750-0200 (home)
* ckeller@coastal.edu
PROFESSIONAL PROFILE
Creative, growth oriented thinker with ability to transform ideas into reality. I intuitively see how individual parts come together to arrive at a final
product. After weighing alternatives and being open and flexible to outside input, focus on and work toward achievement of corporate goals. This is
accomplished through effective communication and either taking or delegating responsibility.
I begin every task by analyzing, evaluating, researching, and troubleshooting the situation. In response perceive an idea, conceptualized and finally
develop an action plan. If necessary invent solutions, especially utilizing mechanical skills to solve problems. Able to quickly establish procedures and
policies to address situations that arise. Finally, coordinating, instructing, training and/or supervising in a hands-on environment will result in cost
savings to the employer.
I was regularly selected to work on critical projects that would affect the bottom line. Often given projects because my employers knew I could get
results more rapidly than most of my colleagues.
PROFESSIONAL EXPERIENCE
Teaching Associate, Carolina Coastal University, Conway, SC (temporary position)
03/22/10 to present

Began teaching career mid-Spring Semester General Chemistry classes – eight Sections (138 students).

Prepare lectures, write/grade exams, hold extended office hours and help sessions to meet the needs of students.

Contribute to continuous improvement of the teaching program in Chemistry being involved in Chem. Lab committee meetings.
Technician, SuperPower Inc., Schenectady, NY (Select Staffing Temp Agency employee)
2008-2009

Worked as a 2nd shift “Temp” operating silver sputter step in the production of superconducting tapes (2G-HTS wire).

Ran numerous optimization studies to improve throughput continuously monitoring temperature, and vacuum.

Used several analytical tools to measure product changes such as Dektak stylus, and XRF thickness measuring instruments.

Worked with other groups as needed to solve chemistry related problems with their processes.
Senior Analytical Chemist, Evident Technologies Inc., Troy, NY
2007-2008

Assist Manufacturing Group with analytical instrumentation and methods to support production activities.

Method Development for AA, FTIR, UV-Vis, SEC-HPLC, and other instrumentation for Quantum Dot Materials.

Technical consultant with regard to taking processes from R&D labs to production scale.

Successfully designed, built, and tech transferred a batch manufacturing process for nanoparticles to a semi-continuous one.
Senior Process Chemist, Mallinckrodt-Baker Inc., Phillipsburg, NJ
2004-2007

Assist with plant support and product development groups in specialty chemical products.

Working on process improvement of an acid distillation unit for a product in the electronics industry.

Coordinating the process development for an inorganic salt for the pharmaceutical industry.

Tech transferring a cGMP process into Pilot Plant, writing SOP, BPR, Validation Protocol, and other needed documentation.

Working on cost reductions and process optimization for Silane based products, currently have improved throughput 1.6X.

Successfully achieved a 15-fold improvement in a new process saving over $50,000 per year in costs, more expected.
Senior Chemist, Organichem, Rensselaer, NY
2000-2003

Successfully coordinated the first technology transfer of a process developed by Albany Molecular Research 2000 gal. scale.

Completed a ten-step cGMP process for a Phase 3 High Potency pharmaceutical (API) in 50 and 100 L kilo lab equipment.

Shepherded many other projects from lab development to manufacturing production.

Lab development: wrote batch records, selected equipment, and supervised the production work.

Successfully completed a six-step process in production resulting in more than $1.2 million in sales. The product was on-spec and delivered to the
customer on time.
Senior Chemist, Chemfirst Fine Chemicals (CFC), Dayton, OH
1993-2000
Research Scientist/Liaison to First Chemical Corp. (FCC) at Mississippi State University (MSU) until September 1999.

Work focused mainly in the area of organic synthesis of photoinitiators for the UV cure industry as well as other specialty chemicals.

Made numerous contributions for several process development projects.

Worked at the Pascagoula site for ten months, performing process development and scale-up full time at CFC after the FCC/MSU program ended in
1999.

Developed a process for a 2000 gallon cGMP product and two cGMP 50L reactions in the kilolab.

Successfully completed a large-scale anaerobic/anhydrous polymerization product that was being tested for new flexible LCD.

Supervised graduate students and one post-doc doing R&D lab work at FCC.
Doctoral Fellowship, Wichita State University, Wichita, KS
1986-1993
Acted as NMR Manager until May 1989.

Early research activities included organic synthesis of α lactams and ring expansions of α lactams to other heterocyclic compounds.

Later research focused on numerous NMR studies (300 MHz.) of pharmaceutical compounds and correlating molecular modeling results to
experiment using MOPAC and SYBYL.
Senior Chemist, Koch Industries Inc., Wichita, KS

Developed new processed, supported plant, and was NMR liaison.

Regularly performed syntheses including alkylation, free radical chlorination, esterification, hydrosilylation, and oxidation.

Performed some formulation of silane-based concrete water proofing agents for low VOC applications.

Completed process development of several commercial fragrances.
1989-1991
Chemist, Catalytica Associates, Mountain View, CA

Represented Koch Industries in a joint venture to commercialize an alternative catalyst system for fuel synthesis.

Significantly contributed to the development of regeneration methods for a supported solid catalyst.
1990-1991
EDUCATION
Ph.D., Chemistry, Wichita State University, Wichita, KS
Dissertation: Conformational Studies of Selected Antipsychotic Drugs
B.S., Biology, minor in Chemistry, Pittsburg State University, Pittsburg, KS
SELECTED ACHIEVEMENTS
Problem Solving / Mechanical Skill
Problem solving and mechanical skills were key to my task of finding a commercially feasible means to regenerate spent catalyst. This
required solving complex problems to make the theoretical concept commercially practical. Application of mechanical skills to put
together the equipment to do small scale testing of spent catalyst. Several approaches were tested and analyzed from calcining catalyst
and monitoring weight loss and /or directing the off-gas to a mass spectrometer.
Results: Catalytica piloted the project.
Management / Training
Manage the kilolab production campaign. This required designing and purchasing the equipment to supervising the assembly for each
step. The first several steps were done in 50 and 100 L glass reactors, the last few (high potency) were done in 10 – 20 L glassware inside
a glove box. Coordinating many departments’ activities in QA/QC, Warehouse, Pilot Plant Operators, and Management was an important
aspect as well.
Results: Produced a kilogram lot of high potency API, under cGMP for clinical trails.
Troubleshooting
Trouble shot a first time production campaign (2000 gal) involving enzymatic resolution of an isomer several problems were encountered
associated with scale-up of this reaction. Several minor adjustments to this system were implemented as it progressed. Coordination
between many departments including QC/QA and plant operation was successfully done.
Results: A successful campaign of three runs was completed and product yielding $1.2 million in sales was shipped to customer on time
and on spec.
Planned / Instruct
Directed five students to produce samples of more than 100 new chemicals. I structured the system such that appropriate chemicals and
equipment were made available when needed. Guidance involved not only fact based knowledge, but teaching them “tricks” and
techniques as well as providing motivation. Samples were submitted to our employer for testing as a photoinitiator for UV curing of
acrylates.
Results: Two promising candidates were found, one was to be commercialized.
Analyzed / Established Procedures
An exciting project I successfully scaled up was an anaerobic / anhydrous polymerization product that was being tested for ne w flexible
LCD display screen. This project was a “tolling” operation where the customer came in and used our facility to produce a large-scale
quantity of a new polymer product. Spent two days observing this reaction being performed then the work-up that followed in order to
familiarize myself with their procedures. I translated their lab approaches into our plant equipment and purchased additional equipment
as needed.
Results: The customer’s campaigns were done successfully and the product (APPEAR™) was the best they had ever seen made.
Multitasking
My graduate stipend was based on work as NMR manager at WSU while working toward my PhD. The work consisted of maintaining the
instrument, running samples for students and faculty, and training users who wanted to run their own samples. In addition to this I ran
samples for some faculty that would lead to publications that I would co-author. After leaving WSU, I was a liaison between instruments
located at other sites from where I was employed. Companies for which I did this kind of work include Koch, First Chemical, and
Organichem. Samples could be run for the chemists on a timely basis on instruments not available to their direct access.
Results: I have experience with numerous instruments/operating systems including Varian, GE, Perkin-Elmer, and Bruker.
SIGNIFICANT INSTRUMENTATION
NMR  Capillary GC  HPLC  TGA/DSC  FT-IR  UV/VIS  AA  Mettler RC-1
PUBLICATIONS
Published 29 refereed journal articles, below are three highlighted citations
(1) Carper, W.R., Keller, C.E., and Piersma, B.J., “27Al NMR Studies of Ethylaluminum Dichloride Melts,” 9th International Symposium on Molten Salts, C. Hussey, Y. Ito,
G. Mamantov, D. Newman, D. Shores, eds, Electromechanical Society, New York, May 1993.
(2) Keller, C.E. and Carper, W.R., 13C and 27Al NMR Relaxation Studies of Ethylaluminum Dichloride,” Journal of Magnetic Resonance Series A, 110.125-129 (1994).
(3) Keller, C.E., Carper, W.R., “13C NMR Relaxation and Dual Spin Probe Studies of Molten Salts Containing Ethylaluminum Dichloride,” Journal of Physical Chemistry,
98(27), 6865-6869.
PRESENTATIONS (Full list reverse chronological order)
1) Talaty, E.R.; Zandler M.E.; and Keller, C.E., "A Theoretical Study of Isomers of Aziridinone, Cyclopropanone, and Their Methyl
Derivatives'', Presented at the 196th National ACS Meeting in Los Angeles, Sept. 25 - 30, 1988 (presented by Keller).
2) Shaw, P.A.; Carper, W.R.; Keller, C.E.; and Wilkes, J.S., "NMR Relaxation Studies of Microdynamics in Chloroaluminate Melts'', 11th Int.
Soc. Mag. Reson. Meeting, Vancouver, B.C. Canada, July 23, 1992.
3) Huang, H.; Epp, J.B.; Brubaker, M.J.; Keller, C.E.; McClenahan, J.J.; and Groutas, W.C., "Inhibitition of Human Leukocyte elastase by
Substituted Dihydrouricils'', presented at 27th ACS Midwest Regional Meeting, Lawrence, KS, Nov. 5 1992.
4) Chong, L.S.; Epp, J.B.; Venkataraman, R.; Brubaker, M.J.; Stanga, M.A.; Kim, E.; and Keller, C.E.; McClenahan, J.J.; and Groutas, W.C.,
"Inhibition of Human Leukocyte Elastase and Cathepsin G by Isoxazoline Derivatives'', presented at 27th ACS Midwest Regional Meeting,
Lawrence, KS, Nov. 5 1992.
5) Carper, W.R.; Keller, C.E.; and Piersma, B.J., "27Al NMR Studies of Ethylaluminum Dichloride Melts'', International Symposium on Molten
Salt Chemistry & Technology Physical Electrochemistry/High Temperature Materials, to be presented May 16, 1993, Honolulu, Hawaii.
6) Carper, W.R.; Keller, C.E.; Shaw, P.A.; Parrish, M.; and Wilkes, J.S., "Dual Spin Probe Relaxation Studies of Microdynamics in
Chloroaluminate Melts'', Eighth International Symposium on Molten Salts, May 20, 1992. St. Louis, MO.
PUBLICATIONS (Full list reverse chronological order)
1) Fejfar S.; Talaty, E.R.; and Keller, C.E., "Synthesis of Heterocyclic Compounds Starting with Aziridinones'', Proc. S. Dakota Acad. of
Science, 67 150(1989)
2) Keller, C.E.; Karr, P.A.; Zandler M.E.; and Carper, W.R., "Conformational Studies of Haloperidol'', Structural Chemistry, 3(3), 195-201
3) Keller, C.E.; and Carper, W.R., "NMR 1H Relaxation and NOESY Studies of Spiperone Conformational Features in Solution'', Magnetic
Resonance in Chemistry 31(in press).
4) Carper, W.R.; Keller, C.E.; Shaw, P.A.; Parrish, M.; and Wilkes, J.S., "Dual Spin Probe Relaxation Studies of Microdynamics in
Chloroaluminate Melts'', Proceedings Eighth International Symposium on Molten Salts, R.J. Gale, ed., The Electrochemical Society, Inc.,
Pennington, NJ, 92-16 335-44, 1992.
5) Shaw, P.A.; Carper, W.R.; Keller, C.E.; and Wilkes, J.S., "NMR Relaxation Studies of Microdynamics in Chloroaluminate Melts'', Bulletin of
Magnetic Resonance, 14(1-4), 92-95, Oct. 1992.
6) Groutas, W.C.; Brubaker, M.J.; Chong, L.S.; Epp, J.B.; Huang, H.; Keller, C.E.; McClenahan, J.J.; Givens, R.S.; Singh, R.; Zandler, M.E.;
Karr, P.A.; and Tagusagawa, F, "Inhibition of Human Leukocyte Elastase by 3-Benzyl-N-Hydroxy-Succinimide Derivatives: Probing the Effect
of Structure on Inhibitory Activity'', Journal of Medicinal Chemistry, (Submitted)
7) Groutas, W.C.; Chong, L.S.; Epp, J.B.; Venkataraman, R.; Brubaker, M.J.; Stanga, M.A.; Kim, E.; and Keller, C.E., "Inhibition of Human
Leukocyte Elastase and Cathepsin G by Isoxazoline Derivatives'', Bioorganic & Medicinal Chemistry Letters, 2(12), 1571-74, Dec. 1992.
8) Groutas, W.C.; Huang, H.; Epp, J.B.; Brubaker, M.J.; Keller, C.E.; and McClenahan, J.J., "A General Approach Toward the Design of
Inhibitors of Serine Proteinases: Inhibition of Human Leukocyte Elastase by Substituted Dihydrouracils'', Bioorganic & Medicinal Chemistry
Letters, 2(12), 1565-70, Dec. 1992.
9) Groutas, W.C.; Brubaker, M.J.; Chong, L.S.; Epp, J.B.; Huang, H.; Keller, C.E.; McClenahan, J.J.; Givens, R.S.; Singh, R.; Zandler, M.E.;
Karr, P.A.; and Tagusagawa, F, "Derivatives of 3-Alkyl-N-Hydroxy-Succinimide: Probing the Effect of Structure on the Bio Activity Toward
Human Leukocyte Elastase '', Drug Des. Discovery, 11(2), 149-57, 1994.
10) Keller, C.E.; Carper, W.R.; and Piersma, B.J., "Characterization of Species in Ethylaluminum Dichloride Melts'', Inorganica Chimica Acta,
209, 239, 1993
11) Keller, C.E.; and Carper, W.R., "27Al NMR Relaxation Studies of Ethylaluminum Dichloride Molten Salts'', Inorganica Chimica Acta, 210,
203 (1993)
12) Carper, W.R.; Keller, C.E.; and Piersma, B.J., "27Al NMR Studies of Ethylaluminum Dichloride Melts'', 9th International Symposium on
Molten Salts, C. Hussey, Y. Ito, G. Mamantov, D. Newman, D. Shores, eds., Electrochemical Society, New York, May, 1993
13) Keller, C.E.; and Carper, W.R., "13C and 27Al NMR Relaxation Studies of Ethylaluminum Dichloride'', Journal of Magnetic Resonance
Series A, 110, 125-129 (1994)
14) Keller, C.E.; Carper, W.R.; and Wilkes, J.S., "13C NMR Relaxation Studies of Ionic Structure in Ethylaluminum Dichloride Molten Salts'',
Journal of Physical Chemistry (status unknown)
15) Carper, W.R.; Wilkes, J.S.; Keller, C.E., "Low Temperature 1H NMR Relaxation studies of Molten Salts Containing Ethylaluminum
Dichloride'', Journal of Physical Chemistry (status unknown)
16) Keller, C.E.; Piersma, B.J.; Mains, G.J.; Carper, W.R., "13C NMR Relaxation Studies of 1:2 LiCl—Ethylaluminum Dichloride Solutions'',
Inorganica Chimica Acta, 230, 185-188 (1995)
17) Keller, C.E.; Carper, W.R., "A Method for the Determination of Nuclear Quadrupole Coupling Constants in Highly Viscous Solutions'',
Inorganic Chemistry, (status unknown)
18) Keller, C.E.; Piersma, B.J.; Mains, G.J.; Carper, W.R., "Determination of Nuclear Quadrupole Coupling Constants in 1:2 LiCl—
Ethylaluminum Dichloride Solutions'', Inorganic Chemistry, 33, 5601-5603
19) Keller, C.E.; Carper, W.R., "1H NMR Relaxation Studies of Molten Salts Containing Ethylaluminum Dichloride'', Inorganica Chimica Acta,
99(1995) 1-6
20) Keller, C.E.; Carper, W.R., "13C NMR Relaxation and Dual Spin Probe Studies of Molten Salts Containing Ethylaluminum Dichloride'',
Journal of Physical Chemistry 98(27), 6865-6869
21) Keller, C.E.; Carper, W.R.; Evangelos, N.A.; Zandler, M.E., "13C NMR Relaxation Studies of an Acidic Chloroaluminate Melt'', Main Group
Chemistry (status unknown)
22) Keller, C.E.; Piersma, B.J.; Carper, W.R., "NMR Relaxation Studies of Lithium-Aluminum Interaction in 1:2 LiCl—Ethylaluminum
Dichloride Melts'', Journal of Physical Chemistry 99 12998-13001 (1995)
23) Carper, W.R.; Keller, C.E., ``Direct Determination of NMR Correlation Times from Spin-Lattice and Spin-Spin Relaxation Times'', Journal
of Physical Chemistry 101 3246-3250 (1997)
24) Talaty, E.R.; Yusoff, M.M.; Ismail, I.; Gomez, J.A.; Keller, C.E. and Younger, J.M., ``Preparation of Substituted Imidazolidinones and
Hydantoins by Ring-Expansion of Aziridinones,'' Synlett 683-684 (1997)
25) Liu, Y.; Keller, C.; Pittman, C. U., ``Cationic 1,2-Addition Polymerization of Cyclic Ketene Acetals Initiated by Conventional Acids'', J.
Polym. Sci. Part A. Polym. Chem., 35 3707-3716 (1997)
26) Bowers, J.S.; Nagarajan, R.; Williams, E.; Pittman, C.U.; Keller, C.E.; Wu, Z.; Cao, L., ``An Unusual Difference in the Efficiency of ITX
Isomers'' Radtech Asia 97, Japan.
27) Larive, C.K.; Lin, M.; Kinnear, B.S.; Piersma, B.J.; Keller, C.E.; Carper, W.R., ``13C and 27Al NMR Relaxation, Viscosity, and 1H Diffusion
Studies of an Ethylaluminum Dichloride Melt'', Journal of Physical Chemistry B 102 1717-1723 (1998)
28) Bowers, J.S.; Nagarajan, R,; Cui, H.; Muller, A.J. Eubanks, J.R.I.; Wu, Z.; Geiger, C.C.; Pittman, C.U.; Keller, C.E.; Roman, P.J. and Feng,
Y. ``A Novel Initiator for Curing Pigmented Coatings'', Proceedings of Radcure Coatings and Inks: Curing and Performance, Harrowgate,
England, June 22-23, 1998.
29) Nagarajan, R.; Bowers, J.S.; Cui, H.; Eubanks, J.R.I.; Wu, Z.; Geiger, C.C.; Pittman, C.U.; Keller, C.E.; Roman, P.J.; Feng, Y., “A Novel
Initiator for Curing Pigmented Coatings'', Journal of the Oil & Colour Chemist’s Association, 83 (4) 181-184 (2000)