The influence of anti-endothelial cell antibodies on leukocyte-endothelial cell
interactions
Antibodies capable of reacting with the EC surface membranes are commonly
detected in serum of patients with vascular inflammatory diseases (eg allograft
rejection, SLE, scleroderma, vasculitis), and may have a role in atherogenesis 1-3.
Whether or not anti-endothelial cell antibodies have pathophysiological effects is still
unclear. Recent papers have suggested that interaction between leukocyte FcRIII
(CD16) and immobilised IgG can substitute for selectins in causing primary leukocyte
capture under flow 4, 5. We have found that anti-endothelial cell antibodies derived
from patients with inflammatory rheumatic diseases can amplify leukocyte adhesion
to endothelium in a parallel plate flow chamber via interactions with Fcg receptors
and are currently dissecting the molecular mechanisms in more detail.
Reference List
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