Cyclic AMP(-)-Adenosine 3’,5’-cyclic monophosphate
100mg
5
NONE LISTEDPossible irritant. (Toxicological effects not yet fully investigated)
INTENDED USE**
NONE LISTEDMay cause skin/eye irritationMay cause irritation on ingestionMay cause irritation on inhalation
Hazardous Substances Policy - Assessment
CHEMICAL HAZARD AND RISK ASSESSMENT
School of Biosciences
Name of
supervisor
M. Callow
Assessor
R. Holland
Assessment Number*
2063
Date of Assessment
09/08/02
Signature
Signature
Notes
A School COSHH form in Word is available on the School Server.
Available from the Health and Safety Unit.
Guidance on making an assessment is given in Making a Chemical Hazard and Risk Assessment.
Guidance is also available from Guidance on Completing the Chemical Hazard and Risk Assessment Form.
Use a continuation sheet to expand any section of this form in hard copy version.
1
LOCATION OF THE WORK ACTIVITY
2
PERSONS WHO MAY BE AT RISK
List names where possible
N114
M. Stanley, J. Finlay, R.Perry, K Marshall, A. Humphrey, R. Holland, M.Callow and any
other future research group members and project students working in N114.
3
ACTIVITY ASSESSED
4
MATERIALS INVOLVED
NAME
Cyclic AMP
(-)-Adenosine 3’,5’-cyclic
monophosphate
Investigation of effects of cAMP on unicellular algae and algal spores
AMOUNT
Max/stored
Attach copies of data sheet(s)
HAZARD
HAZDAT NO***
BIOSCIENCESNO***
100mg
NONE
LISTED
Possible
irritant.
(Toxicological
effects not yet
fully
investigated)
5
RISK PHRASES
NONE LISTED
May cause skin/eye
irritation
May cause irritation on
ingestion
May cause irritation on
inhalation
INTENDED USE**
Give brief details and attach protocol/instructions
Small quantities (1-2 mg/L) used in sea water to examine effects on settlement and behaviour of unicellular algae
and algal spores.
6
RISKS to HEALTH and SAFETY from INTENDED USE
From personal exposure or hazardous reactions. Refer to OELs, flash points, etc., as appropriate. Are pregnant women, breast-feeding
mothers especially at risk?
No risks listed, however as toxicological properties of cAMP have not been fully investigated, potential eye, skin,
digestive and respiratory tract irritation may be minor risks when handling. As small quantities will be used, these
potential risks are further minimalised.
7
CONCLUSIONS ABOUT RISKS
Is level of risk acceptable? Can risk be prevented or reduced by change of substance/procedure? Are control measures necessary?
As long as good chemical practice is used the potential risk should be minimal. As the amounts used are small,
the hazards are reduced. Protective clothing such as goggles, gloves and lab. coats should be worn when
handling Cyclic AMP in order to reduce potential risks.
8
CONTROL MEASURES
Additional to Good Chemical Practice
Handle the stock bottles with care to prevent accidental spillage on a large scale. Wash after handling. Store in a
sealed, refrigerated container below 4ºC. Use with adequate ventilation.
9
INSTRUCTION/TRAINING
Specify course(s) and/or special arrangements.
None
10
MONITORING
Performance of control measures,
None
Personal exposure
11
Health Surveillance
WASTE DISPOSAL PROCEDURE
See School Server for Approved Procedure Document on specific Chemical Waste Disposal.
Dispose solutions down fume cupboard sink with copious amounts of water.
12
REVIEW
Enter the date or circumstances for review of assessment (maximum review interval 5 years)
5 years or if quantities or porcedures change significantly
13
EMERGENCY ACTION
TO CONTROL HAZARDS To stabilize situation eg spread absorbant on liquid spill; eliminate sources of ignition, etc.
Wear appropriate protective clothing, such as lab. Coat, gloves and goggles when handling. In case of spillage of
solution, wash site of spillage with copious amounts of water. In case of spillage of powder. In case of spillage of
powder, sweep up and place in a suitable container for disposal. Avoid generating dusty conditions.
TO PROTECT PERSONNEL Evacuation, protection for personnel involved in clean-up, Special First Aid
Eyes: Irrigate thoroughly with water for at least 15 minutes. Obtain medical attention.
Skin: Wash skin with soap and water for at least 15 minutes. Obtain medical attention.
Ingestion: If conscious and alert, rinse mouth and drink 2-4 cups full of milk or water. DO NOT INDUCE
VOMITING. Obtain medical attention.
Inhalation: Remove from exposure to fresh air immediately. Obtain medical attention.
Clean-up/decontamination
TO RENDER SITE OF EMERGENCY SAFE
In case of spillage of solution, wash site of spillage with copious amounts of water. In case of spillage of powder.
In case of spillage of powder, sweep up and place in a suitable container for disposal. Avoid generating dusty
conditions.
CONTACT
PHONE
10.10.00
*
**
***
Prefix T is used for Teaching Assessment Number.
Please include amount of chemicals used and how.
Hazdat No is the UNICOSHH datasheet report number.
Biosciences No is the Biosciences data sheet number.
UNICOSHH IS A CHEMICAL DATABASE ON THE HEALTH AND SAFETY UNIT SERVER.
BIOSCIENCES DATA SHEETS ARE AVAILABLE IN THE SCHOOL SAFETY OFFICE.