OPIOID ANALGESICS 1
Dr Diana Pendicheva (2012)
Faculty of Medicine, Medical University – Pleven
1. All of the following opioid receptors are correctly matched with their physiological effects,
except: A)  – analgesia and respiratory depression; B) k – analgesia and dysphoria; C)  –
miosis and physical dependence; D)  - euphoria and reduced GIT motility.
2. Which of the following analgesics are strong opioid receptor agonists? A) Morphine; B)
Pethidine; C) Buprenorphine; D) Fentanyl.
3. Which of the following statements about morphine is correct? A) It causes tremor, tachycardia
and dry mouth; B) It is most effective by oral route of administration; C) It is contraindicated in
patients with head injury; D) It is clinically useful to treat emesis.
4. The  opioid receptor is responsible for the following actions, except: A) Analgesia; B)
Sedation; C) Diarrhea; D) Respiratory depression.
5. Fentanyl is: A) A strong opioid receptor agonist; B) A phenylpiperidine derivative, 80-100 times
more potent than morphine; C) An opioid analgesic with long duration of action; D) Avaliable in
transdermal patches for use in chronic malignant pain.
6. Opioid analgesics are either contraindicated or must be used with extreme caution in all of
following clinical situations, except: A) Bronchial asthma; B) Undiagnosed acute abdominal
pain; C) Chronic pain in terminally ill patients with cancer; D) Head injury.
7. Choose the pathognomonic sign in acute opioid poisoning: A) Tremor; B) Miosis; C) Diarrhea;
D) Involuntary urination.
8. Which of the following are pure opioid antagonists? A) Nalorphine; B) Naloxone; C) Tramadol;
D) Naltrexone.
9. All of the following are mixed opioid agonist-antagonists, except: A) Buprenorphine; B) Codeine;
C) Nalorphine; D) Pentazocine.
10. Which is true regarding naltrexone: A) It is an opioid antagonist; B) It is an opioid agonist; C)
Used to treat opioid dependence; D) Used to treat acute opioid intoxication.
11. Opioids may provoke all of the following side effects, except: A) Nausea and vomiting; B) Dry
mouth; C) Constipation; C) Miosis.
12. In chronic opioid treatment, tolerance develops to which of the following effects? A) Analgesia;
B) Respiratory depression; C) Miosis; D) Constipation.
13. Drug of choice in the treatment of acute opioid poisoning is: A) Pethidine; B) Pentazocine; C)
Naloxone; D) Loperamide.
14. You are on your way to take an examination and you suddenly get an attack of diarrhea. If you
stop at a pharmacy for an over-the-counter opioid with anthidiarrheal action, you will be asking
for: A) Codeine; B) Loperamide); C) Tramadol); D) Dextromethorphan.
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Answers: 1C; 2A, B, D; 3C; 4C; 5A, B, D; 6C; 7B; 8B, D; 9B; 10A, C; 11B; 12A, B; 13C; 14B.