Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
RFA Synopsis:
Title: RFA: CCNE-T_P2ACP. Solicitation for Alliance Challenge Project Proposals
Release date: December 12, 2011
Application due date: January 20, 2012 (submission window: 1/2/2012-1/20/2012)
Amount of Funding: Up to $73,408 total costs for the Stanford portion for 18 months
Number of Projects to be Funded: Two projects
Project Performance Period: 05/11/2012 – 11/10/2013 (tentative)
Contact: Dr. Demir Akin (demir.akin@stanford.edu), T: 650-721-2016
Center Website: http://mips.stanford.edu/grants/ccne-t
1. Purpose: The Center for Cancer Nanotechnology Excellence and Translation (CCNE-T, PI: Sanjiv Sam Gambhir,
MD, PhD, co-PI: Shan X. Wang, PhD) is soliciting new trans Alliance Challenge Projects (ACP) from investigators
who are participants in the NCI Nanotechnology in Cancer Alliance programs. These ACP proposals will need to
be between two or more of the Alliance Programs (http://nano.cancer.gov) such as the CCNEs, CNPPS and
CNTCs and must have at least one member from CCNE-T as an investigator and/or PI/co-PI. The ACP proposals
are expected to have distinct but complementary research goals to the original grant. The intended goal of
these seed projects is to develop new intra-Alliance collaborations between the CCNE-T members and the other
NCI Alliance funded program investigators to speed-up the development of nano-based or nano-enabled
solutions in the area of Cancer and potentially attract larger funding to facilitate clinical translation of these
endeavors.
The vision of CCNE-T (http://mips.stanford.edu/grants/ccne-t) is to bring together researchers from various
disciplines to form synergistic teams that will make significant advances in developing and validating
nanotechnology that will impact cancer diagnosis, therapy and management. Thus, the proposed projects will
mainly include those that have a high potential for linking nanotechnology to early detection, therapy response
monitoring, diagnostics and pre-clinical imaging models for the improvement of cancer patient
management. Potential proposals solely focused on drugs or experimental treatments are strongly discouraged
but the proposals with diagnostic or imaging technologies that have therapy components (theranostics) are
highly encouraged. If you would like to discuss the suitability of your project for this program funding, please
contact Dr. Demir Akin, Deputy Director of the CCNE-T, at 650-721-2016 or demir.akin@stanford.edu before or
after the Winter Closure time period.
2. Eligibility: Established investigators (Stanford faculty with UTL, MCL or NTLR appointments or CCNE-T
consortium members with PI authorizations). Preference will be given to those investigators who are already
involved in the CCNE-T programs or who have strong complementary research areas to the CCNE-T goals and
who can synergistically work with the CCNE-T members to form new bridges with the other NCI Alliance funded
programs. All applications will undergo the same level of scrutiny before being identified as an appropriate
Project.
3. Deadline: January 20, 2012 (see "Submitting an Application" below).
4. Amount of Funding/Budget Information:
Applicants may request up to $73,408.00 in total (direct+indirect) costs for 18-month duration of the
supplemental Alliance Challenge Projects under this program. Up to two applicants will be selected for
funding. Each Alliance Challenge Project will be an 18-month duration project and continuation of a project
beyond its first year will be contingent upon the success of the previous year. Once all required documents are
received, the selected candidates will have a tentative funding period from 05/11/2012 – 11/10/2013. The
exact start and end dates of the research performance periods and the exact amount of the funding will be
1
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
released by NCI in early 2012. Awards pursuant to this funding opportunity are contingent upon the availability
of funds, the receipt of a sufficient number of meritorious applications and the approval of the NCI Program
officer of the selected proposals.
The selected projects will be required to send all required documents and protocols prior to the initiation of the
funding. The due dates will be provided upon selection of the applicants. Attendances to several CCNE
meetings are required to show progress of the project. An interim and yearly progress report in NIH format will
also be required. In addition, a presentation of progress is required for the annual NCI site visit, which will be
held on April 26, 2012 and again in late spring of 2013.
5. Submitting an Application
A complete application package consists of the following with the listed page requirements:
a. Face page (1 page)
b. Project description (3-4 pages including milestones and timetable)
c. Budget (1 page) and its justification ( 1/2 page)
d. NIH Biographical Sketch of the proposed PI (not to exceed 4 pages)
All applications must include a Milestones and Timetable section; these milestones should be descriptive,
quantitative and reasonable. This section should clearly provide a timeline and a logical pathway for the
development of the proposed technology. The following will be the main evaluation criteria for the proposals.
1. Scientific Value of the Idea(s) and their Relevance to CCNE-T Missions
2. Relevance to Cancer and/or Nanotechnology field
3. Novelty and Clinical Translation Potential
4. Inter Alliance Team and Milestones Proposed
5. Ability to Lead to Extramural Funding after 18 moths
6. Methodology
7. The strength of any preliminary data if exists.
8. Budget—if adequate to accomplish work
Applicants should send their individual project proposals as a single e-mail attachment in PDF format to
brobles@stanford.edu by Friday, January 20, 2012. Please note that due to the Stanford Winter Closure, the
proposal submission period is between January 2 and 20, 2012. Any proposals submitted during the winter
closure will not be acknowledged until after 1/3/2012.
5a. FACE PAGE (1 page)
Please feel- in the requested information. This information will enable CCNE-T to determine which proposals to
fund, which copies of research compliance approvals (human, animal, etc.) will be needed from each awardee
before funds can be released.
Your department chair and RPM or (for other school faculty-OSR) signatures are not needed for this RFA only.
We will collect the full SU-42 forms from only selected projects.
Please list the Project Leaders’ and other key personnel (from both CCNE-T and the other Alliance partner)
names, titles, departments, and complete contact information.
5b. PROJECT DESCRIPTION (maximum 4 pages)
Describe the proposed research, including the following:
 Research plan.
2
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/



Description of research subjects involved (human or animal).
Description of interdisciplinary and trans-Alliance characteristics of this project as to how it utilizes the
CCNE-T Resources and the entire range of the NCI's Cancer Nanotechnology Alliance.
Explanation of how the proposed research fits into existing CCNE-T (note: illustrations and references
are not included in the 6-page limit).
5c. BUDGET (1 PAGE) AND ITS JUSTIFICATION ( 1/2 PAGE)
The total allocated funds for Alliance Challenge Projects is $94,600 (direct costs) and each project will be funded
for up to 18 months. Please provide a detailed prorated budget up to $47,300 for 18 months in total direct costs
at applicable rates. Please note that the CCNE-T Executive Council is likely to choose to fund more than one
project therefore, it is highly advised that the budgeted research is appropriate for the funding level.
Please provide a ½ page Budget Justification in NIH format.
5d. Biosketch (NIH format) for the Project Leader and Co-Investigators
- Other Support (NIH format). Please include both active and pending support
SELECTION PROCESS:
All applications will be reviewed by the Center Executive Council for their suitability for the goals of CCNE-T and
the Alliance. Preference will be given to those investigators who are already involved in the CCNE-T program or
who have strong complementary research areas to the CCNE-T goals. All applications will undergo the same
level of scrutiny before being identified as an appropriate Project. Example evaluation factors are given below.
INQUIRIES/CONTACT PERSON:
Applicants are welcome to discuss their plans in response to this solicitation. Please direct all initial inquiries to
Dr. Demir Akin at demir.akin@stanford.edu or by phone at 650-721-2016.
Please note that the release of funds will be contingent upon verification by CCNE-T of the recipient's human
subject, SCRO, and animal subject approvals and compliance with other administrative issues.
3
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
5a. FACE PAGE
LEAVE BLANK—FOR CCNE USE ONLY.
Type: ACP
Number:
Date Initiated
Stanford University
Center for Cancer Nanotechnology Excellence and Translation
Alliance Challenge Project
Grant Application
1. TITLE OF PROJECT
2. STANFORD PRINCIPAL INVESTIGATOR
NAME (Last, first, middle)
POSITION TITLE
MAILING ADDRESS (Street, city, state, zip code)
DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT
MAJOR SUBDIVISION
TELEPHONE AND FAX (Area code, number and extension)
TEL:
E-MAIL ADDRESS:
FAX:
3. HUMAN SUBJECTS 3b.
RESEARCH
No
Yes
3a. Exempt Research
No
Yes
5. Human Stem Cells
No
Yes
8. Recombinant DNA
No
Yes
Human Subjects Assurance No.
4. VERTEBRATE ANIMALS
3d. NIH-defined Phase III
Clinical Trial
No
Yes
3c. Clinical Trial
No
Yes
No
Yes
4a.
If “Yes,” IACUC
approval
Date
4b. Animal welfare assurance no.
6. Radiological Hazards
No
Yes
7. Human Blood or Body Fluids
No
Yes
If “Yes,” Exemption No.
If Yes, approval number of the Stem Cell Research
Oversight Panel :
10. All participating researchers, including postdocs, students and
scholars, signed Stanford's Patent & Copyright form (SU-18/18A)
9. Infectious/Biohazardous Agents
No
Yes
11. DATES OF PROPOSED PERIOD OF
SUPPORT (month, day, year—MM/DD/YY)
From
Through
5/10/2012
11/09/2013
No
12. COSTS REQUESTED FOR
BUDGET PERIOD
12a.Direct Costs ($)
Yes
$
KEY PERSONNEL. List all other key personnel in alphabetical order, last name first. Please list the intra-Alliance
Collaborators here.
Name and Primary Title
Degree(s Organization
)
4
Role on Project
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
5b. PROJECT DESCRIPTION (maximum 4 pages)








State the application’s broad impact, long-term objectives and specific aims.
Description of interdisciplinary and trans-Alliance characteristics of this project as to how it utilizes the
CCNE-T resources and the entire range of the NCI's Cancer Nanotechnology Alliance.
Explanation of how the proposed research fits into existing CCNE-T goals
Describe concisely the research design and methods for achieving these goals.
Description of research subjects involved (human or animal or in vitro cultured cells).
Describe the rationale and techniques you will use to pursue these goals.
Describe the path and brief timeline to extramural funding.
Note: illustrations and references are not included in the-page limits but should be kept to reasonable
minimum.
Milestones and Timetable
Milestones
2012
1 2 3 4
2013
1 2 3 4
5
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
5c. BUDGET (1 Page) and BUDGET JUSTIFICATION (1/2 Page)
5c1. Budget :
Principal Investigator (Last, First, Middle):
DETAILED BUDGET FOR INITIAL BUDGET PERIOD
DIRECT COSTS ONLY
PERSONNEL (Applicant organization only)
ROLE ON
PROJECT
Principal
Investigator
NAME
Acad.
Mnths
Sum.
Mnths
THROUGH
5/10/2012
12/31/2012
DOLLAR AMOUNT REQUESTED (omit cents)
Months Devoted to Project
Cal.
Mnths
FROM
INST.BASE
SALARY
SALARY
REQUESTED
FRINGE
BENEFITS
TOTAL
SUBTOTALS
CONSULTANT COSTS
EQUIPMENT (Itemize)
SUPPLIES (Itemize by category)
TRAVEL
PATIENT CARE COSTS
INPATIENT
OUTPATIENT
ALTERATIONS AND RENOVATIONS (Itemize by category)
OTHER EXPENSES (Itemize by category)
CONSORTIUM/CONTRACTUAL COSTS
DIRECT COSTS
TOTAL DIRECT COSTS
$
6
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
5c2. Budget Justification:
7
Center for Cancer Nanotechnology Excellence
and Translation
Department of Radiology, School of Medicine
Stanford University
http://mips.stanford.edu/grants/ccne-t/
5d: NIH BIOSKETCH of the PI.
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
eRA COMMONS USER NAME (credential, e.g., agency login)
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral
training and residency training if applicable.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
MM/YY
FIELD OF STUDY
NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions below.
A.
Personal Statement
Briefly describe why your experience and qualifications make you particularly well-suited for your role (e.g.,
PD/PI, mentor, participating faculty) in the project that is the subject of the application.
B.
Positions and Honors
List in chronological order previous positions, concluding with the present position. List any honors. Include
present membership on any Federal Government public advisory committee.
C.
Selected Peer-reviewed Publications
D.
Research Support
List both selected ongoing and completed research projects for the past three years (Federal or non-Federallysupported). Begin with the projects that are most relevant to the research proposed in the application. Briefly
indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical
Sketch. Do not include number of person months or direct costs.
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