Genetics Course Outline - Spring 2015
Lectures: Mondays, Thursdays 10:00-11:40
Literature Discussions: Tuesdays 12:55-15:40 (Zhiyuan Room 516)
TEXT:
Introduction to Genetic Analysis, 10th Edition by Griffiths, Wessler, Carroll and Doebley (2012), W. H Freeman and Company.
ISBN 1-4292-2943-8.
Topics
March 2-March 12
Single gene inheritance
Allele types and gene interactions
Independent assortment of genes
Genetic control of Development
Forward vs reverse genetics
Human pedigree analysis
Lecturer/Reading materials
Xin Sun
2: 29-54.
6:211-236.
3:82-110.
13:449-483.
1:17; 2:46-50; 10:369-377, 14:516-518.
2:54-65.
Primary literature discussions:
March 3
March 10
WormBook.org. 2006, Jun 14:1-19.
Nature 287:795-801; Nusslein-Volhard Nobel lecture 1995.
Quiz 1:
March 12, last 25 minutes of class.
March 16-March 26
DNA: structure and replication
RNA: transcription and processing
Protein: translation
Fang Wu
1:1-8; 7:251-279.
1:9-10; 8:283-306.
1:10-11; 9:309-334.
March 30-April 9
Jade Wang
Genetic transmission in bacteria and phage
From physics to classical bacteria genetics
Recombination and mutagenesis in bacteria
Bacterial genetic and genomic methods
Reg of gene exp in bacteria and viruses
(April 6 morning lecture shifted to evening)
Primary literature discussions:
March 31
April 7
5:169-203.
Special Topic.
Special Topic.
Special Topic.
11:381-409.
Crick et al., (1961) Nature 192: 1227-1232,
Barrangou et al., (2007), Science, 315:1709-1712.
Quiz 2:
April 9, last 25 minutes of class.
April 13-April 23
Transposable elements
Mutation, repair, recombination and cancer
Large chromosome changes
Jing Zhang
15:523-551.
16: 553-584.
17:589-625.
Primary literature discussions:
April 14
April 21
Nature 436, 272-276 (2005).
Nature 297, 474–478 (1982).
Quiz 3:
April 23, last 25 minutes of class.
April 27-May 7
Mapping eukaryote chromosome by recombination
Regulation of gene expression in eukaryotes
Gene isolation and manipulation
Zheng Yuan
4:121-156.
12:415-447.
1:18-21, 10:341-378.
May 11-May 21
Population Genetics
Inheritance of complex traits
Evolution of genes and traits
Qiang Chang
18:637-680.
19:683-723.
1:14-17; 20:727-756.
Primary literature discussions:
May 12
May 19
Science, 329:75-78.
Cell 152:691-702.
Quiz 4:
May 21, last 25 minutes of class.
May 25-June 4
Paper discussion
Zheng Yuan and Fang Wu
June 8-18
Genomes and genomics
Epigenetics and genome imprinting.
Genetic modifiers.
Advanced genetic mapping and positional cloning.
Modeling diseases in mice.
Akihiro Ikeda
14:487-520.
Special Topic.
Special Topic.
Special Topic.
Special Topic.
Primary literature discussions:
June 9
June 16
Science 345: p455-459.
Nature Genetics 45: p1013-1020.
Quiz 5:
June 18, last 25 minutes of class.
Final Exam: Date to be determined.
Grading:
Grades will be determined based on your performance in 5 quizzes (each 10%) and the final exam (50%).