Supplementary Figure 1 Haplotype block structure of the chromosome 5 target region. (a)
Haplotype block structure of the region (38-39.5 Mb) covering the LIFR gene and OSMR
gene in 4 different HapMap populations (CEU, YRI, JPT, CHB) and our study subjects
(Controls+ Patients, PCA patients and controls; controls; PCA patients; PCA patients with the
OSMR mutation p.P694L). (b) Haplotype block structure of the region (54.5-56 Mb) covering
the IL31RA gene and IL6ST gene in 4 different HapMap populations (CEU, YRI, JPT, CHB)
and our study subjects.
Supplementary Figure 2 Alignment of NP_620586 among mammals at codon 521 region.
Sequences were aligned with the ClustalW2 multiple sequence alignment program
(http://www.ebi.ac.uk/Tools/clustalw2/).
The location of p.S521F is shown in red, the
number at the end of depicted sequenced indicated the amino acid number, star below the
sequences indicated identical amino acids across species.
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