CURRICULUM VITAE
Name: Cheng, Yuan-Bin
Working Address: Kaplan Lab 8645, Discovery way, La
Jolla, CA, 92037.
Home Address: No.93, 2F, Jing-An St. Taipei county, 235,
Taiwan, Republic of China.
E-mail: jmb0709@hotmail.com
Phone: 886-02-2245-6352
Mobile phone: 858-345-0879
Date of Birth: July 9, 1979
Nationality: Taiwan
Marital Status: Single
Employment:
Post-Doctoral Fellow in Center for Marine Biotechnology and Biomedicine,
Center for Marine Science, University of North Carolina Wilmington
(September 2011 – August 2012)
Post-Doctoral Fellow in Center for Marine Biotechnology and Biomedicine,
Scripps Institution of Oceanography, University of California San Diego
(August 2010 – August 2011)
Post-Doctoral Fellow in School of Pharmacy, College of Medicine, National
Taiwan University (June 2008 – July 2010)
Academic Qualifications:
(1) Ph. D in Marine Biotechnology and Resources, College of Marine Sciences,
Sun Yat-sen University, Taiwan (2002-2007)
(2) M. Sc in Marine Biotechnology and Resources, College of Marine Sciences,
Sun Yat-sen University, Taiwan (2001-2002)
(3) B. Sc in Chemistry, College of Life Science, Kaohsiung medicinal
University, Taiwan (1997-2001)
Research Interest:
I am interested in the isolation and characterization of natural products from
both terrestrial and marine organisms in particular diterpenoids, lignans,
triterpenoids, steroids, alkaloids, etc. In addition, I am also interested in
modifying bioactive lead compounds and studying the Structure-Activity
Relationship.
Topics of Research:
Phytochemistry – Isolation, purification and structural elucidation of
secondary metabolites from traditional Chinese medicines (Kadsura,
Schisandra, Illicium) and potential anti-cancer plants (Taxus, Casearia,
Hypercium).
Marine Invertebrates Natural Product Chemistry – research of secondary
metabolites from marine invertebrates, such as soft corals (Clavularia, Xenia,
Cespitularia, Sarcophyton) and sponges (Xestospongia).
Marine Microorganisms – actinomycine and dinoflagellate
Working techniques
1. Spectrometers of LC-Mass, IR, UV, CD, optical rotation
2. Bruker and Varian NMR operation and application to structural elucidation
(served as a NMR supervisor in the Institute of Marine Biotechnology and
Resources)
3. HPLC operation (Hitachi, Shimadzu, HP, Waters)
4. Computer skills including MS-Word, MS-PowerPoint, Xwin-NMR,
ChemDraw, MestReNova
Summary of Research:
Title of Ph. D Thesis: Studies on the Natural Products from the Taiwanese
Soft Corals Clavularia viridis, Xenia florida, Cespitularia taeniata, Cespitularia
hypotentaculata, and Sarcophyton stolidotum
 Isolation of eight new and seven known prostanoids from Clavularia viridis.
 Isolation of three new and seven known xenicane-type diterpenes from
Xenia florida.
 Isolation of ten new and four known verticillane-type diterpenes from
Cespitularia taeniata.
 Isolation of three new and seven known verticillane-type diterpenes from
Cespitularia hypotentaculata.
 Isolation of seven new and two known cembrane-type diterpenes from
Cespitularia hypotentaculata.
Other researches (2004-2011)
 Isolation of twenty new and nineteen known lignans from kadsura
philippinensis.
 Isolation of five new and fifteen known lignans from Schisandra arisanensis
Hayata.
 Isolation of two new compounds from Hypercium geminiflorum.
 Isolation of three new clerodane-type diterpenes from Casearia
membranacea.
 Isolation of thirty known compounds from several species of sponge.
 Isolation of new Napyradiomycins from actinomycine.
* Characterization of these compounds used IR, UV, Mass, 1D and 2D-NMR
techniques, such as COSY, HMQC, HMBC, NOESY.
* All compounds showed biological activities.
Conferences Attended:
1. Participated in “The 52nd annual meeting of the American Society of
Pharmacognosy” from July 30 to August 3. 2011. San Diego.
2. Participated in “The 50th annual meeting of the American Society of
Pharmacognosy” from June 27 to July 1. 2009. Hawaii.
3. Participated in “2nd Taiwan-France Workshop on Herbal Medicine” April
16. 2009. Taipei
4. Participated in “2004 annual meeting of the Chinese Pharmacy Society”
December 18. 2004. Taipei.
5. Participated in “International Biotech Conference & Exhibition” from
October 31 to November 25-27. 2004. Kaohsiung.
6. Participated in “18th International Symposium on Natural Product
Chemistry” from October 31 to November 2. 2003. Kaohsiung.
List of Publications (since 2004, total 32 papers published):
1. Yuan-Bin Cheng, Yu-Chi Lin, Ashraf Taha Khalil, Shorong-Shii Liou,
Guo-Chi Lee, Yao-Haur Kuo and Ya-Ching Shen, ” Seven New Lignan
Esters from Kadsura philippinensis “,Helv. Chim. Acta, 2011, 94, 148-158.
2. Yuan-Bin Cheng, Tzu-Ching Liao, Yi-Wen Lo, Yu-Chen Chen, Yuh-Chi
Kuo, Shun-Ying Chen, Ching-Te Chien, Tsong-Long Hwang, and Ya-Ching
Shen; “Nortriterpene Lactones from the Fruits of Schisandra arisanensis” J.
Nat. Prod., 2010, 73, 1228-1233.
3. Yuan-Bin Cheng, Tzu-Ching Liao, Yi-Wen Lo, Yu-Chen Chen, Yuh-Chi
Kuo, Shun-Ying Chen, Ching-Te Chien, and Ya-Ching Shen;
“Arisandilactone A, a New Triterpenoid from the Fruits of Schisandra
arisanensis”, Org. Lett, 2010, 12, 1016-1019.
4. Chin-Cheng Liu, Mohamed H. Abd El-Razek, Chia-Ching Liaw, Yuan-Bin
Cheng, Chien-Kuang Chen, Ching-Te Chien, Yao-Haur Kuo, Shorong-Shii
Liou, and Ya-Ching Shen “Arisanschinins A-E, Lignans from Schisandra
arisanensis Hay”, Planta ,medica, 2010, 76, 1-6.
5. Jiun-Yang Chang, Mohamed H. Abd El-Razek, Yu-Hui Chen, Yuan-Bin
Cheng, Shun-Ying Chen, Ching-Te Chien, Yao-Haur Kuo and Ya-Ching
Shen; “Phytoquinoids and Secoprezizaane-Type Sesquiterpenes from
Illicium arborescens”, Helv. Chim. Acta, 2010, 93, 123-132.
6. Yuan-Bin Cheng, Meng-Ting Chang, Yi-Wen Lo, Ching-Jen Ho, Yuh-Chi
Kuo, Ching-Te Chien, Shun-Ying Chen, Shorong-Shii Liou, Yao-Haur Kuo,
and Ya-Ching Shen; “Oxygenated Lignans from the Fruits of Schisandra
arisanensis”, J. Nat. Prod., 2009, 72, 1663-1668.
7. Yuan-Bin Cheng, Ching-Yeu Chen, Ya-Ching Shen; “New Nitrogencontaining Sesqiterpenoids from the Taiwanese Soft Coral Cespitularia
taeniata May”, Chemistry & Biodiversity, 2009, 6, 1266-1272.
8. Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Michael Y. Chiang,
Shorong-Shii Liou, Ashraf Taha Khalil; “Dibenzocyclooctadiene lignans
from kadsura philippinensis” Phytochemistry, 2009, 70, 114-120.
9. Yuan-Bin Cheng, Ya-Ching Shen, Yao-Haur Kuo, and Ashraf Taha Khalil;
“Cembrane Diterpenoids from the Taiwanese Soft Coral Sarcophyton
stolidotum”, J. Nat. Prod., 2008, 71, 1141-1145.
10. Yuan-Bin Cheng, Kuang-Liang Lo, Ching-Yeu Chen, Ashraf Taha Khalil,
and Ya-Ching Shen; “New Verticillane-type Diterpenoids from the
Taiwanese Soft Coral Cespitularia hypotentaculata”, Helv. Chim. Acta,
2008, 91, 2308-2315.
11. Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Chia-Ju Chang, Ting-Wei
Lan, Shorong-Shii Liou, Ching-Te Chien, Chia-Ching Liaw, and Ashraf
Taha Khalil; “New Oxygenated Lignans from Kadsura philippinensis”, Helv.
Chim. Acta, 2008, 91, 483-494.
12. Ching-Yu Chen, Yuan-Bin Cheng, Shun-Ying Chenc, Ching-Te Chienc,
Yao-Haur Kuod, Jih-Hwa Guh, Ashraf Taha Khalile, and Ya-Ching Shen;
“New Bioactive Clerodane Diterpenoids from the Roots of Casearia
membranacea”, Chemistry & Biodiversity, 2008, 5, 162-167.
13. Yun-Sheng Lin, Ashraf Taha Khalil, Shih-Hwa Chiou, Yuh-Chi Kuo,
Yuan-Bin Cheng, Chia-Ching Liaw, and Ya-Ching Shen; “Bioactive Marine
Prostanoids from Octocoral Clavularia viridis”, Chemistry & Biodiversity,
2008, 5, 784-792.
14. Ya-Ching Shen, Yu-Hui Chen, Yuan-Bin Cheng, Yao Haur Kuo, Ashraf
Taha Khalil; “Two new xeniolides from a Taiwanese Xenia soft coral”, Nat.
Prod. Res., 2007, 13, 1171-1177.
15. Ya-Ching Shen, Yuan-Bin Cheng, Jun’ichi Kobayashi, T akaaki Kubota,
Yohei Takahashi, Yuzuru Mikami, Junji Ito and Yun-Sheng Lin;
“Nitrogen-Containing Verticillene Diterpenoids from the Taiwanese Soft
Coral Cespitularia taeniata”, J. Nat. Prod., 2007, 70, 1961-1965.
16. Ya-Ching Shen, Yuan-Bin Cheng, Ting-Wei Lan, Chia-Ching Liaw,
Shorong-Shii Liou, Yaoil; “Kadsuphilols
A-H, Oxygenated Lignans from Kadsura philippinensis”, J. Nat. Prod., 2007,
70, 1139-1145.
17. Ya-Ching Shen, Yu-Chi Lin, Atallah F. Ahmed, Yuan-Bin Cheng,
Chia-Ching Liaw, and Yao-Haur Kuo; “Four New Nonaoxygenated C18
Dibenzocyclooctadiene Lignans from Kadsura philippinensis”, Chem.
Pharm. Bull., 2007, 55, 280-283.
18. Ya-Ching Shen, Chia-Ching Liaw, Yuan-Bin Cheng, Atallah F. Ahmed,
Mei-Chou Lai, Shorong-Shii Liou, Tian-Shung Wu, Yao-Haur Kuo, and
Yu-Chi Lin; “C18 Dibenzocyclooctadiene Lignans from Kadsura
philippinensis”, J. Nat. Prod., 2006, 69, 963-966.
19. Yuan-Bin Cheng, Jiun-Yang Jang, Ashraf Taha Khalil, Yao-Haur Kuo, and
Ya-Ching Shen; “Xenicane-Type Diterpenes with Cytotoxicity from Xenia
florida”, J. Nat. Prod., 2006, 69, 675-678.
20. Ya-Ching Shen, Yun-Sheng Lin, Yao-Haur Kuo, and Yuan-Bin Cheng;
“Cespitulactams A, B, and C, three new nitrogen-containing diterpenes
from Cespitularia taeniata May”, Tetrahedron Lett, 2005, 46, 7893-7897.
21. Ya-Ching Shen, Shaw-Man Hsu, Yun-Sheng Lin, Kuen-Ching Cheng,
Ching-Te Chien. Chang-Hung Chou, and Yuan-Bin Cheng; “New Bicyclic
Taxane Diterpenoids from Taxus sumatrana”, Chem. Pharm. Bull., 2005, 53,
808-810.
22. Ya-Ching Shen, Yun-Sheng Lin, Yuan-Bin Cheng, Kuen-Ching Cheng,
Ashraf Taha Khalil, Yao-Haur Kuo, Ching-Te Chien and Yu-Chi Lin; “Novel
taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester”,
Tetrahedron, 2005, 61, 1345-1352.
23. Ya-Ching Shen, Yuan-Bin Cheng, Atallah F. Ahmed, Cheng Lin Lee,
Shun-Ying Chen, Ching-Te Chien, Yao-Haur Kuo, and Guo-Lin Tzeng;
“Cytotoxic Clerodane Diterpenoids from Casearia membranacea”, J. Nat.
Prod., 2005, 68, 1665-1668.
24. Ya-Ching Shen, Kuen-Ching Cheng, Yu-Chi Lin, Yuan-Bin Cheng, Ashraf
Taha Khalil, Jih-Hwa Guh, Ching-Te Chien, Che-Ming Teng, and Yao-To
Chang; “Three New Taxane Diterpenoids from Taxus sumatrana”, J. Nat.
Prod., 2005, 68, 90-93.
25. Ya-Ching Shen, Cheng Lin Lee, Ashraf Taha Khalil, and Yuan-Bin Cheng;
“New Clerodane Diterpenes from Casearia membranacea”, Helv. Chim.
Acta, 2005, 88, 68-77.
26. Ya-Ching Shen, Yuan-Bin Cheng, Yu-Hui Chen, Ashraf Taha Khalil, and
Chin-Lien Ko; “Three New Clerodane Diterpene Derivatives from Casearia
membranacea”, J. Chin. Chem. Soc., 2005, 52, 1263-1268.
27. Ya-Ching Shen, Yu-Chi Lin, Yuan-Bin Cheng, Yao-Haur Kuo, and
Chia-Ching Liao; “Taiwankadsurins A, B, and C, Three New C19
Homolignans from Kadsura philippensis”, Org. Lett, 2005, 7, 5297-5300.
28. Ya-Ching Shen, Yu-Chi Lin, Michael Y. Chiang, Sheau Farn Yeh, Yuan-Bin
Cheng, and Chia-Ching Liao; “Kadsuphilactones A and B, Two New
Triterpene Dilactones from Kadsura philippensis”, Org. Lett, 2005, 7,
3307-3310.
29. Ya-Ching Shen, Chih-Hsin Wang, Yuan-Bin Cheng, Li-Yung Wang,
Jih-Hwa Guh, Ching-Te Chien, and Ashraf Taha Khalil; “New Cytotoxic
Clerodane Diterpenoids from the Leaves and Twigs of Casearia
membranacea”, J. Nat. Prod., 2004, 67, 316-321.
30. Ya-Ching Shen, Yuan-Bin Cheng, A. T. Khalil, Meng-Hsien Chen and
Yu-Chi Lin; “Clavulazols A and B, Two New Pyrazine Derivatives from
Clavularia viridis”, J. Chin. Chem. Soc., 2004, 51, 1421-1424.
31. Ya-Ching Shen, Chin-Lien Ko, Yuan-bin Cheng, Michael Y. Chiang, and
Ashraf Taha Khalil; “New Regio- and Stereoselective O-Deacetylated and
Epoxy Products of Taxanes Isolated from Taxus mairei”, J. Nat. Prod., 2004,
67, 2136-2140.
32. Ya-Ching Shen, Yuan-Bin Cheng, Yu-Chi Lin, Jih-Hwa Guh, Che-Ming
Teng, and Chin-Lien Ko; “New Prostanoids with Cytotoxic Activity from
Taiwanese Octocoral Clavularia viridis”, J. Nat. Prod., 2004, 67, 542-546.
References:
1. Prof. Ya-Ching Shen
School of Pharmacy, College of Medicine, National Taiwan University
Phone: 886-2-233937083
E-mail: ycshen@ntu.edu.tw
2. Prof. Yao-Haur Kuo
National Research Institute of Chinese Medicine
Phone: 886-2-8201999
E-mail: kuoyh@nricm.edu.tw
3. Prof. Hong-Nong Chou
Institute of Fisheries Science, National Taiwan University
Phone: 886-2- 33662879
E-mail: unijohn@ntu.edu.tw
4. Prof. Jyh-horng Sheu
Department of Marine Biotechnology and Resources, College of Marine
Sciences, Sun Yat-sen University
Phone: 886-7-5252000-5030
E-mail: sheu@mail.nsysu.edu.tw
5. Dr. Oliver McConnell
Project Scientist, Center for Marine Biotechnology and Biomedicine Scripps
Institution of Oceanography University of California, San Diego
Phone: 484-844-3499
E-mail: omcconnell@ucsd.edu