Service Offering from Macro Innovations, Cambridge
Macro is offering the contract production of monoclonal antibodies and Fc fusion
proteins. The service offer is for the growth in appropriate systems, harvest of the
culture using centrifugation and filtration followed by TFF concentration (eg 50Kda).
A standard single step purification using Protein A or G will be used to isolate and
purify your antibody. The final step will be a buffer exchange into PBS with a
terminal sterilisation for storage at volumes required. Typical storage will be at 2-8oC.
Macro aims to provide a collaborative personal and interactive approach with our
clients in order to provide a flexible response to project needs that develop.
A flexible pricing structure based on the antibody or protein quantity desired, with the
purification method, and any special requirements.
A standard costing structure for processing upto 1L of culture medium is highlighted
below.
Antibody
Quantity (mg)
25
50
100
Guide Costing £
700
950
1400
If your requirements differ from our proposed standard conditions we will provide a
quotation for your specific project work.
Included in the cost structure is a set of basic QC checks outlined below:Quantification of the purified antibody using A280nm using an extinction coefficient of
1.4 for IgG.
A purity profile using SDS PAGE analysis
Confirmation of product using a Western Blot with the clients reagents.
If required at additional services can also be requested:Small cell bank prepared (5 ampoules)
Antibody isotyping
Arrangement of Mycoplasma testing
Mycoplasma eradication protocol
£75
£60
£125 (includes external test fee)
£775
Payment of 50% total on order the remainder on project completion once material has
been received.
Project Requirement Information Form
Please complete the following form and either email it to rsmith@macroinnovations.co.uk
By Post:
Macro Innovations Ltd,
Unit 6,
Edinburgh House,
Innovation Park,
Cowley Road,
Cambridge,
CB4 0DS
Tel 01223-424283
Contact Name
Company/Institution
Address
Contact details
Email:
Telephone:
Cell Line designation
Product designation
Growth medium currently used
including any additional additives
Typical culture period
Typical morphology of cultures
(suspension, adherent, semi adherent)
Typical cell density achieved
(cells/mL)
Estimated Productivity (mg/mL)
Project Requirements
Amount of product required
Mycoplasma free certificate
attached
□
50mg □
100mg □
Yes □
25mg
£700
£950
£1400
No □
Mycoplasma test required
Yes
No
Cell bank required
Yes
No
Antibody Isotyping Required
Yes
No
□
□
□
□
□
□
£125
£75
£60