September 2015
Curriculum Vitae
KENNETH J. OESTREICH, Ph.D.
Contact Information
Address:
Virginia Tech Carilion Research Institute
and School of Medicine
2 Riverside Circle
Roanoke, VA 24016
E-mail:
oestrk@vtc.vt.edu
Telephone:
(540) 526-2208
Fax:
(540) 985-3373
Appointments
2013-Present
2013-Present
2014-Present
2014-Present
Assistant Professor
Virginia Tech Carilion Research Institute (VTCRI),
Roanoke, VA
Assistant Professor
Department of Biomedical Sciences and Pathobiology,
Virginia-Maryland Regional College of Veterinary Medicine
(VMRCVM)
Virginia Tech, Blacksburg, VA
Assistant Professor
Virginia Tech Carilion School of Medicine (VTCSOM),
Roanoke, VA
Assistant Professor
Faculty of Health Sciences,
Virginia Tech, Blacksburg, VA
Education and Training
2008-2013
Senior Postdoctoral Fellow
University of Washington, Seattle, WA
Mentor: Dr. Amy S. Weinmann
2006-2008
Postdoctoral Fellow
Emory University, Atlanta, GA
Mentor: Dr. Jeremy M. Boss
2006
Ph.D. - Microbiology and Immunology
Vanderbilt University, Nashville, TN
Advisor: Dr. Eugene M. Oltz
2000
Bachelor of Science, Chemistry
College of Arts and Sciences
Tennessee Tech University, Cookeville, TN
Publications
Peer-reviewed Publications
1. Oestreich, K.J.*, K.A. Read, S.E. Gilbertson, K.P. Hough, P.W. McDonald, V. Krishnamoorthy, and
A.S. Weinmann*. Bcl-6 directly represses the glycolysis pathway gene program. Nat. Immunol. 15:
957-964, 2014. PMCID: In process.
*Co-Corresponding authorship
Featured in “News and Views”: Man, K. and Kallies, A. Bcl-6 gets T cells off the sugar. Nat.
Immunol. 15: 904-905, 2014.
Featured in “Nature Reviews Immunology”: Leavy, O. BCL-6 curbs glycolysis. Nat. Rev.
Immunol. 14: 650-651, 2014.
2. Oestreich, K.J., S.E. Mohn, and A.S. Weinmann. Molecular mechanisms that control the
expression and activity of Bcl-6 in Th1 cells to regulate flexibility with a Tfh-like gene profile. Nat.
Immunol. 13: 405-11, 2012. PMCID: PMC3561768.
3. Youngblood, B*, K.J. Oestreich*, S.J. Ha, J. Duraiswamy, R.S. Akondy, E.E. West, Z. Wei, P. Lu,
J.W. Austin, J.L. Riley, J.M. Boss, and R. Ahmed. Chronic virus infection enforces demethylation of
the locus that encodes PD-1 in antigen-specific CD8+ T cells. Immunity. 35: 400-12, 2011. PMCID:
PMC3183460.
*These authors contributed equally to this manuscript.
4. Oestreich, K.J., A.C. Huang, and A.S. Weinmann. The lineage-defining factors T-bet and Bcl-6
collaborate to regulate Th1 gene expression patterns. J. Exp. Med. 208: 1001-13, 2011. PMCID:
3092354.
5. Kao, C., K.J. Oestreich, M.A. Paley, A. Crawford, J.M. Angelosanto, M.A.A. Ali, A.M. Intlekofer,
J.M. Boss, S.L. Reiner, A.S. Weinmann, E.J. Wherry. T-bet represses expression of PD-1 and
sustains virus-specific CD8 T cell responses during chronic infection. Nat. Immunol. 12: 663-671,
2011. PMCID: 3306165.
6. Clauson, C.L., K.J. Oestreich, J.W. Austin, and P.W. Doetsch. Abasic sites and strand breaks in
DNA cause transcriptional mutagenesis in Escherichia coli. Proc. Natl. Acad. Sci. 107: 3657-62,
2010. PMCID: PMC2840506.
7. Oestreich, K.J., H. Yoon, R. Ahmed, and J.M. Boss. Regulation of programmed death-1 by NFATc1
upon T cell activation. J. Immunol. 181: 4832-9, 2008. PMCID: PMC2645436.
8. Osipovich, O., R. Cobb, K.J. Oestreich, S. Pierce, P. Ferrier, J. Chen, and E. Oltz. Essential function
for SWI/SNF chromatin-remodeling complexes in the promoter-directed assembly of TCRb genes.
Nat. Immunol. 8: 809-16, 2007.
9. Oestreich, K.J.*, R. Cobb*, S. Pierce, J. Chen, P. Ferrier, and E. Oltz. Regulation of TCRb gene
assembly by a promoter/enhancer holocomplex. Immunity 24: 381-91, 2006.
*These authors contributed equally to this manuscript.
Invited Reviews
1. Oestreich, K.J. and A.S. Weinmann. Master regulators or
lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat. Rev. Immunol. 12:
799-804, 2012. PMCID: PMC3584691.
2. Oestreich, K.J. and A.S. Weinmann. Transcriptional mechanisms that regulate T helper 1 cell
differentiation. Curr. Opin. Immunol. 24: 191-5, 2012. PMCID: PMC3319510.
3. Oestreich, K.J. and A.S. Weinmann. T-bet employs diverse regulatory mechanisms to repress
transcription. Trends Immunol. 33: 78-83, 2012. PMCID: PMC3273642.
4. Oestreich, K.J. and A.S. Weinmann. Encoding stability versus flexibility: Lessons learned from
examining epigenetics in T helper cell differentiation. Curr. Top. Microbiol. Immunol. 356: 145-164,
2012.
5. Oestreich, K.J. and A.S. Weinmann. Ikaros changes the face of NuRD remodeling. Nat. Immunol. 13:
16-18, 2012.
6. Cobb, R.*, K.J. Oestreich*, O. Osipovich*, and E. Oltz. Accessibility control of V(D)J
recombination. Advances in Immunology 91: 91:45-109, 2006.
*These authors contributed equally to this manuscript.
Research Conference Presentations
Read, K.A., McDonald, P.W., Baker, C., Cooley, I., and K.J. Oestreich. Identification of molecular
mechanisms that regulate T helper 1 cell plasticity. American Association of Immunologists,
Annual Meeting, Pittsburgh, PA, 2014.
Read, K.A., McDonald, P.W., and K.J. Oestreich. How do lineage-defining transcription factors
regulate immune cell development and function? Southwest Virginia Life Sciences Forum,
Roanoke, VA, 2014.
Oestreich, K.J., S.E. Mohn, and A.S. Weinmann. The lineage-defining factors T-bet and Bcl-6
collaborate to regulate Th1 gene expression patterns. Gene Expression and Signaling in the
Immune System, FASEB Meeting, Aspen, CO, 2011.
Oestreich, K.J., R. Ahmed, J.M. Boss. Regulation of programmed death-1 by a novel NFAT-binding
regulatory element. Gene Expression and Signaling in the Immune System, Cold Spring Harbor,
NY, 2008.
Oestreich, K.J., R. Ahmed, J.M. Boss. Transcriptional regulation of programmed death-1, Mechanisms
of Eukaryotic Transcription, Cold Spring Harbor, NY, 2007.
Oestreich, K.J., S. Pierce, E. Oltz. Promoter-directed remodeling of local chromatin regulates V(D)J
recombination. International FOCIS meeting, Montreal, Canada, 2004.
Academic and Professional Honors
2015
AAI Pfizer-Showell Award Recipient
2015
Invited speaker, Roanoke College
2014
Invited speaker, Virginia-Maryland Regional College of Veterinary Medicine
2014
Invited speaker, Modeling Mucosal Immunity Symposium, Virginia
Bioinformatics Institute
2013-Present
Member, The American Association of Immunologists (AAI)
2012
2012
2011
2011
2008-2009
2006-2008
2006
Invited speaker, Earl Stadtman Immunology Symposium, National Institutes
of Health
Article of the Month designation for: Oestreich, K.J., S.E. Mohn, and A.S.
Weinmann. Molecular mechanisms that control the expression and activity of
Bcl-6 in Th1 cells to regulate flexibility with a Tfh-like gene profile. Nat.
Immunol. 13: 405-11, 2012.
“Faculty of 1000” designation for: Oestreich, K.J., A.C. Huang, and A.S.
Weinmann. The lineage-defining factors T-bet and Bcl-6 collaborate to
regulate Th1 gene expression patterns. J. Exp. Med. 208: 1001-13, 2011.
“Faculty of 1000” designation for: Youngblood, B*, K.J. Oestreich*, S.J. Ha, J.
Duraiswamy, R.S. Akondy, E.E. West, Z. Wei, P. Lu, J.W. Austin, J.L. Riley,
J.M. Boss, and R. Ahmed. Chronic virus infection enforces demethylation of
the locus that encodes PD-1 in antigen-specific CD8+ T cells. Immunity. 35:
400-12, 2011.
Developmental Immunology institutional training grant recipient
Ruth Kirschstein institutional postdoctoral training grant recipient
“Faculty of 1000” designation for: Oestreich, K.J.*, R. Cobb*, S. Pierce, J. Chen, P.
Ferrier, and E. Oltz. Regulation of TCRb gene assembly by a promoter/enhancer
holocomplex. Immunity 24: 381-91, 2006.