COST CM06-02
Inhibitors of Angiogenesis: design, synthesis and
biological exploitation (ANGIOKEM)
Final Conference
Smolenice Castle, Slovakia, 11.-14. June 2011
Organizing Committee
Prof. Daniele Passarella
Prof. Marta Sališová
Prof. Andrej Boháč
June 11th 2011 Arrival, Social Dinner (Smolenice Castle at 19h)
June 12th 2011
Permanent poster session 12. – 13. June 2011 (within the castle interior)
12/06/2011
Title / Lecturer
Session chair: D. Passarella
Sunday
8:30-8:40
Opening Remarks
8:40-9:20
Chemical Genetic Control of Type III Intermediate
Filaments using Withaferin A
9:20-9:45
Antiangiogenesis in cancer and beyond
9:45-10:10
An overview on Met discoveries within the
Passarella, Sališová, Boháč
Royce Mohan
(invited speaker)
Ana Rodriguez Quesada
Flavio Maina
AngioKem network
10:10-10:25
Coffee Break
Coffee Break
Session chair: R. Sanyal
10:25-10:50
Optimization of the antitumor activity of tyrosine
Maurizio Botta
kinases inhibitors
10:50-11:15
Mapping Chemical Space for Drug Discovery
Jean-Louis Reymond
11:15-11:40
Resistance mechanisms to anti-angiogenic therapies
11:40-13.00
Lunch break
13:00-13:40
Activity of anti-VEGFs small molecules in different
Sandro de Falco
pathological contexts
(invited speaker)
13:40-14:05
Antioxidant genes regulate microRNA transcriptome
Alicja Jozkowicz
14:05-14:30
Natural Products as Building Blocks and Modelling
Daniele Passarella
James Lorens
Session chair: G. Hanquet
Studies as Guidance toward the Synthesis of new
Anticancer and Antiangiogenesis Compounds
14:30 - 14:45
Coffee Break
14:45-15:10
Inhibitory cross-talk between HGF/c-Met and EGFR
Session chair: H. Stepien
Jurgen Borlak
signalling in liver cancer – Implications for the
development of new agents targeting tumour
angiogenesis
15:10-15:35
Oxygenated PUFAs as potential modulators of
angiogenesis: Initial results
Social program:
16:00-19:00
Visiting of Carst Cave Driny (45-60min walk distance)
19:00-22:00
Picnic – Castle Smolenice Garden
Trond Vidar Hansen
June 13th 2011
13/06/2011
Title / Lecturer
Session chair: A.R. Quesada
Monday
9:00-9:40
9:40-10:05
Structural and functional analysis of VEGF receptor
2; how a detailed knowledge of receptor structure
and intracellular trafficking may lead the way to the
development of specific inhibitors of VEGF
signaling
Synthesis of novel heterocyclic compounds and their
Kurt Ballmer-Hofer
(invited speaker)
Serkos Haroutounian
anti-angiogenetic activities assays
10:05-10:30
Synthesis of DNJ derivatives with potential as anti-
Stephen Barron
angiogenesis agents
10:30-10:45
Coffee Break
10:45-11:10
Antiangiogenic activity of 1,4-benzoxazine- and 1,4-
Session chair: J. Bosch
Danijel Kikelj, Sandra Liekens
benzodioxine based dual antithrombotic compounds
11:10-11:35
Virtual screening guided discovery of new kinase
Lars Ruddigkeit
inhibitors
11:35-12:00
Synthesis of the antineoplastic calmodulin antagonist
John Snaith
pseudodistomin F
12:00-13:10
Lunch break
13:10-13:50
How to make complex molecules from simple
starting material: the Palladium, a fantastic tool
13:50-14:15
An integrated, systems biology approach to the study
Session chair: T.V. Hansen
Suffert Jean
(invited speaker)
Miguel Angel Medina Torres
of angiogenesis- inflammation-metastasis in cancer
14:15-14:30
Coffee Break
14:30-14:55
Application of computational chemistry in medicinal
Milan Remko
chemistry and drug design
14:55-15:20
Radiolabeled inhibitors of tyrosine kinase - a tool for
Kniess Torsten
monitoring the angiogenic process
Social program:
16:00
Departure for a dinner and sightseeing-excursion in
Bratislava
19:00-22:00
G. Verdi: Nabuco, Opera - Historical Building,
alternative program to
Bratislava City
sightseeing-excursion
June 14th 2011
14/06/2011
Title / Lecturer
Tuesday
08:30-10:00
MC and EVALUATION MEETING
MC members + evaluators
09:30-10:30
Surprise lecture + Closing Remarks
Marta Sališová
Danielle Passarella
parallel session
11:00
Lunch
12:00
DEPARTURE to Bratislava (60 - 70 min)
Poster session 12.-13. June 2011 (own pins required):
1.
Charles Lambert (WG1, BE)
2.
Ana Apostolou (WG2, S. Haroutounian group, GR)
3.
Michael Christodoulou (WG2, D. Passarella group, IT)
4.
Stella Borrelli (WG2, D. Passarella group, IT)
5.
Matthew Sadler (WG2, J. Snaith group, UK)
6.
Danka Valková (WG2, A. Boháč group, SK)
7.
Melissa García Caballero (WG2, A. Quesada group, SP)
8.
Javier Alejandro García-Vilas García (WG2, A. Quesada group, SP)
9.
Joanna Soin (WG2, PLN)
10. Joanna Soin (WG2, PLN)
11. Pavol Ježko, M. Remko (WG3, M. Remko group, SK)
12. Alessandra Mascarello (WG3, B. Botta group, SK)
13. Cinzia Ingallina (WG3, B. Botta group, SK)
14. M. Zeman, R. Moravčík (WG4, M. Zeman group, SK):
15. Miloš Ilijič (WG4, D. Kikelj group, SL)
16. Marco Radi (WG4, M. Botta group, IT)
The best way to come to Bratislava is to take a plane to Bratislava or Vienna Airport
Schwechat (Wien in German, Viedeň in Slovak) and from the Vienna Airport take a bus directly to
Bratislava (performing each hour, 60 min trip duration). There are two companies Slovak Lines (name
of their station in Bratislava: “Bratislava, AS” or also “Mlynské Nivy”) and Blagus (name of the station:
“Nový Most”). You may find their timetables here:
http://www.slovaklines.sk/fileadmin/user_upload/cestovne_poriadky/mal/102806a.pdf
(connection Vienna-Bratislava is on the 2nd page there!)
http://www.blaguss.sk/media/PDF/bratislava_vieden_blaguss.pdf
Bratislava Smolenice: 53-77 km (depends on a rout) a bus connection from Bratislava to Smolenice
will be organized.
Schwechat – Bratislava: 55-69km direct bus connection (Slovak Lines and Blagus).
Vienna – Bratislava 66-79 km bus (Slovak Lines, Blagus) or train connections (name of
the train station in Bratislava is “Petržalka” or “Hlavná stanica – Main Station”).