6.
PUBLICATIONS
Book Chapters & Reviews - In Print
P. Read NW & Brown NJ (1991) The eighties: A decade of the ileal brake. Gastrointestinal Transit:
1.
Pathophysiology and Pharmacology. Eds., Kamm, M.W. & Lennard Jones, J.E. Wrightson Biomedical U.K.
J. Read NW, Sepple CP & Brown NJ (1989) The ileal brake: is it relevant to the action of viscous
2.
polysaccharides? Ed: D. Kritchevsky: Dietary Fibre, Chapter 16, pp 219-225. Plenum Press, New York and
London.
P. Read NW & Brown NJ (1988). Methods for assessing gastrointestinal transit. In: Drug Delivery and the
3.
Gastrointestinal Tract. Ed. C. Wilson & S.S. Davis.
J. Read NW, Mangnall YF, Tomlin J & Brown NJ (1988) Non-invasive methods for measuring gastrointestinal
4.
transit. Chapter 1, 9-25. In: Drug Delivery to the Gastrointestinal Tract. Eds. Hardy, J.G., Davis, S.S. &
Wilson, C.G. Ellis Horwood Ltd, Division of J Wiley & Sons, London.
5.
P. Brown NJ (1988).The regulation of gastrointestinal transit in the rat. Ph.D. University of Sheffield.
6.
J.
Staton C, Brown NJ, Lewis CE. (2003) Effects of fibrinogen and associated peptide fragments on the
activation of endothelial cells by VEGF. In : VEGF and Cancer. Edited by J Harmey.
7.
J.
Staton CA, Brown NJ, Lewis CE. (2003) The role of fibrinogen and related fragments in tumour
angiogenesis and metastasis. Expert Opinion on Biological Therapy 3: 1105-1120.
8.
J. Scriven P, Wyld L, Brown NJ, Pockley AG. (2007) The unfolded protein response and cancer: a brighter
future unfolding? Journal of Molecular Medicine. 85(4):331-41.
9.
J. Staton CA, Kumar I, Reed MWR, Brown NJ. (2007) Neuropilins in physiological & pathological angiogenesis.
Journal of Pathology, 212(3):237-48.
10.
Staton CA, Brown NJ, Reed MWR. Current status and future prospects for anti-angiogenic therapies in cancer.
Expert Opinion on Drug Discovery In Press 2009
Papers In Press
11.
Murdoch C, Reeves KJ, Hearnden V, Colley H, Massignani M, Canton I, Madsen J, Blanazs A, Armes SP,
Lewis AL, MacNeil S, Brown NJ, Thornhill MH, Battaglia G. (2010) Internalization and biodistribution of
polymersomes into oral squamous cell cancer cells in vitro and in vivo. Nanomedicine In press.
12.
Young R, Brown NJ, Reed MWR, Woll P. (2010) Vascular targeting of angiosarcoma. Lancet Oncol In
press.
13.
McGown, Brown NJ, Hellewell PG, Reilly CS, Brookes ZLS (2010). Beneficial vascular effects of pravastatin
during sepsis involve nitric oxide synthase III. British Journal of Anaesthesia 104:183-190
14.
Michailidou M, Evans CA, Coleman RE, Holen I, Brown NJ. (2010) Microvascular endothelial cell responses
in vitro and in vivo : modulation by zoledronic acid and paclitaxel? Journal of Vascular Research 47:481493.
15.
Mansart A, Ruff LJ, Ariaans MP, Ross JJ, Reilly CS, Brown NJ, Kaufman S, Brookes ZLS. Constriction of
rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Br J Pharmacol 2010 In Press
16.
Scicluna J, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZL (2009). Lipopolysaccharide alters
vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: time dependent effects European
Journal of Pharmacology. Eur J Pharmacol 621;1-3: 67-70
17.
Kumar I, Staton CA, Cross SS, Reed MWR, Brown NJ (2009). Angiogenesis, vascular endothelial growth
factor and its receptors in human surgical wounds. British Journal of Surgery 96: 1484-1491
18.
Bluff JE, Menakuru, SR, Cross SS, Higham SE, Balasubramanian SP, Brown NJ, Reed MW, Staton CA.
(2009) In human breast cancer the angiogeniic switch occurs at the onset of dysplasia in the breast. British
Journal of Cancer 18: 666-672
19.
Reid P, Brown NJ, Holen I. Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial
cells through direct cell contact. Molecular Cancer 2009 Jul 15;8(1):49.
20.
Brookes ZLS, Mansart A, McGown CC, Ross JJ, Reilly CS, Brown NJ (2009). Macromolecular leak from extrasplenic lymphatics during endotoxemia. Lymphat Res Biology 7;3: 131-7
21.
Staton CA, Reed MWR, Brown NJ. (2009) A critical analysis of current in vitro and in vivo angiogenesis
assays. International Journal of Experimental Pathology 90: 195-221
22.
Reeves KJ, Reed MWR, Brown NJ. (2009) Is Nitric Oxide important in Photodynamic Therapy? Journal of
Photochemistry and Photobiology B: Biology 95 (3): 141-147.
23.
Menakuru SR, Brown NJ, Staton CA, Reed MWR. (2008) Angiogenesis in premalignant conditions. British
Journal of Cancer 99(12): 1961-66.
24.
Mansart A, Ross, J, Reilly CS, Brown NJ, Brookes ZLS. (2008) Lipopolysaccharide abolishes extrasplenic
vasoconstriction to atrial natriuretic peptide: the role of nitric oxide and endothelin1. Shock 29(6):675-80.
25.
Muthana M, Scott SD, Farrow N, Morrow F, Murdoch, Grubb S, Brown NJ, Dobson J, Lewis CE. (2008) A
Novel Magnetic Approach to Enhance the Efficacy of Cell-Based Gene Therapies. Gene Therapy 15(12): 902910.
26.
Scicluna JK, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. (2008) Reduced vascular response to
phenylephrine during exposure to lipopolysaccharide in vitro involves nitric oxide and endothelin1. Shock. 29
(3):417-421.
27.
Bluff JE, Brown NJ, Reed MWR, Staton CA (2008). Tissue factor, angiogenesis and tumour progression.
Breast Cancer Research 10(2): 204.
28.
Darby S, Cross SS, Brown NJ, Hamdy FC, Robson CN. (2008) BMP-6 over-expression in prostate cancer is
associated with increased Id-1 protein and a more invasive phenotype. Journal of Pathology. 214(3):394-404.
29.
Staton CA, Chetwood AS, Cameron IC, Cross SS, Brown NJ, Reed MW. (2007) The angiogenic switch occurs
at the adenoma stage of the adenomacarcinoma sequence in colorectal cancer. Gut 56(10): 1426-1432
30.
Balasubramanian SP, Cross SS, Globe J, Cox A, Brown NJ, Reed MWR. (2007) Endostatin gene variation and
protein levels in breast cancer susceptibility and severity. BMC Cancer, 7:107.
31.
Balasubramanian SP, Cox A, Cross SS, Higham SE, Brown NJ, Reed MWR. (2007) Influence of VEGF – A
gene variation and protein levels in breast cancer susceptibility and severity. International Journal of Cancer,
121(5):1009-16.
32.
P. Staton CA, Stribbling, Carlos, Tazzyman S, Lewis CE, Brown NJ. (2007) Identification of key residues
involved in mediating the in vivo anti-tumour/anti-endothelial activity of Alphastatin. Journal of Thrombosis
and Haemostasis 5(4): 846-854.
33.
J. Balasubramanian SP, Azmy IAF, Wilson AG, Cross SS, Cox A, Brown NJ, Reed MWR. (2006) Interleukin
gene polymorphisms and breast cancer: a case control study and systematic review. BMC Cancer 2006,
6:188
34.
J. Brookes ZLS, Reilly CS, Lawton BK, Brown NJ. (2006) Intravenous anesthesia inhibits leukocyteendothelial interactions and expression of CD11b after hemorrhage. Shock 2006 25: 492-9.
35.
J. Cross SS, Yang Z, Brown NJ, Balasubramanian SP Evans CA, Woodward JK, Lippitt, Reed MWR,
Coleman RE, Holen I. (2006) Osteoprotogerin (OPG) – a potential new role in the regulation of endothelial
cell phenotype and tumour angiogenesis. International Journal of Cancer 118(8): 1901-1908
36.
J. Globe J, Smythe A, Kelty CJ, Reed MWR, Brown NJ, Ackroyd R. (2006) The effect of photodynamic
therapy (PDT) on oesophageal motility and acid clearance in patients with Barretts oesophagus. Journal of
Photochemistry and Photobiology 85(1): 17-22.
37.
J. Bingle, CE Lewis, KP Corke, MWR Reed and NJ Brown (2006) Macrophages promote angiogenesis in
human breast tumour spheroids in vivo. British Journal of Cancer 94(1): 101 – 107
38.
J. MacRae EJ, Giannoudis A, Ryan R, Brown NJ, Hamdy FC, Maitland N, Lewis CE. (2006) Gene therapy
for prostate cancer: current strategies and new-cell based approaches. Prostate 66(5): 470-94
39.
J. Langton KP, McKie N, Brown NJ, Smith BM, Barker MD. (2005) Sorsbys Fundus Dystrophy mutations
impair turnover of TIMP-3 by retinal pigment epithelial cells. Human Molecular Genetics 14(23): 3579-3586
40.
P. Kalia N, Wood RFM, Pockley AG, Brown NJ (2005) Ketotifen abrogates local and systemic
consequences of rat intestinal ischaemia-reperfusion injury. Journal of Gastroenterology and Hepatology
20(7): 1032-1038
41.
J. West CC, Brown NJ, Mangham DC, Grimer RJ, Reed MWR. (2005) Microvessel density does not predict
outcome in high grade soft tissue sarcoma. European Journal of Surgical Oncology 31(10): 1198-1205
42.
J. Sahota PS, Burn JL, Brown NJ, Mac Neil S. (2004) Approaches to improve angiogenesis in tissue
engineered skin. Wound Repair and Regeneration 12(16): 635-642.
43.
J. Kelty CJ, Ackroyd R, Brown NJ, Brown SB, Stoddard CJ, Reed MWR (2004) Comparison of high versus
low 5ALA for Photodynamic therapy of Barretts oesophagus. Surgical Endoscopy 18(3): 452-458
44.
J. Kelty CJ, Ackroyd R, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MWR (2004). Endoscopic ablation
of Barretts esophagus: a randomised controlled trial of Photodynamic therapy (PDT) versus argon plasma
coagulation. Alimentary Pharmacology and Therapeutics 20(11-12): 1289-1296.
45.
J. Balasubramanian SP, Cox A, Brown NJ, Reed MWR. (2004) Candidate gene polymorphisms in solid
cancers. European Journal of Surgical Oncology 30(6):593-601
46.
P. Brookes ZLS, Reilly CS, Brown NJ (2004) Differential effects of propofol, ketamine and thiopental
anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo. British
Journal of Anaesthesia 93(2): 249-256
47.
J. Staton CA, Stribbling SM, Tazzyman S, Hughes R, Brown NJ, Lewis CE (2004) Current methods for
assaying angiogenesis in vitro and in vivo. International Journal of Experimental Pathology 85(5): 233-248
48.
J. Ali S, Ahmad M, Lynam J, Rees RC, Brown NJ (2004) Trafficking of tumour peptide specific cytotoxic
T-lymphocytes into tumour microcirculation. International Journal of Cancer 110(2): 239-44
49.
J. Pearce HR, Kalia N, Bardhan KD, Atherton JC, Brown NJ (2004) Effects of helicobacter pylori on
endothelial cell proliferation and chemotaxis. Digestion 69(4):201-210
50.
J. Azmy IAF, Balasubramanian SP, Wilson AG, Stephenson TJ, Cox A, Brown NJ, Reed MWR (2004) Role
of tumour necrosis factor gene polymorphism (-308 and –238) in breast cancer susceptibility and severity.
Breast Cancer Research 6(4): R395-R400
51.
J. Gillard J, Reed MWR, Buttle DJ, Cross SS, Brown NJ (2004) Matrix metalloproteinase activity and
immunohistochemical profile of MMP-2, -9, and TIMP-1 during human dermal wound healing. Wound
Repair and Regeneration 12(3): 295-304
52.
J. Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCE, Lewis CE (2004)
Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated
endothelial cells in vitro and in vivo. Blood 103(2): 601-6
53.
J. Ackroyd R, Kelty CJ, Brown NJ, Stephenson TJ, Stoddard CJ, Reed MWR (2003) Eradication of
dysplastic Barrett’s Oesophagus using photodynamic therapy: long-term follow-up. Endoscopy 35(6): 496501
54.
J. Pearce HR, Kalia N, Bardhan KD, Brown NJ (2003) Effects of aspirin and indomethacin on endothelial
cell proliferation in vitro. Journal of Gastroenterology and Hepatology 18(10): 1180-87
55.
J. Sahota PS, Burn JL, Heaton M, Freedlander E, Survana SK, Brown NJ, MacNeil S (2003) Development
of a reconstructed human skin model of angiogenesis. Wound Repair and Regeneration 11(4): 275-84
56.
P. Brookes ZLS, Reilly CS, Brown NJ (2003) The dose dependent effects of fentanyl on rat skeletal muscle
microcirculation in vivo. Anaesthesia Analgesia 96(2): 456-62
57.
J. Kalia N, Hopkinson K, Fairburn, Wood RFM, Brown NJ, Pockley AG (2003) Effects of intestinal
ischaemia-reperfusion injury on rat peripheral blood neutrophil activation. Digestive Diseases and Sciences
48(9): 1677-1684
58.
P. Kalia N, Wood RFM, Pockley AG, Brown NJ (2003) Mucosal villous microcirculatory disturbances
associated with rat intestinal ischaemia-reperfusion injury are not prevented by tacrolimus. Digestion
67(3): 154-60
59.
P. Kalia N, Bardhan KD, Atherton J, Brown NJ (2002) Toxigenic Helicobacter pylori induces changes in the
gastric mucosal microcirculation in rats. Gut 51(5): 641-47
60.
P. Baker EA, Stephenson TJ, Reed MWR, Brown NJ (2002) Expression of proteinases and inhibitors in
human breast cancer progression and survival. Molecular Pathology 55(5): 300-304
61.
J. Brookes ZLS, Brown NJ, Reilly CS (2002) Response of the rat cremaster microcirculation to
hemorrhage in vivo: differential effects of intravenous anesthetic agents. Shock 18(6): 542-48
62.
J. Balasubramanian S, Brown NJ, Reed MWR (2002) Role of genetic polymorphisms in tumour
angiogenesis. British Journal of Cancer 87(10): 1057-65
63.
P. Brown NJ, Smyth EAE, Cross SS, Reed MWR (2002) Angiogenesis induction and regression in human
surgical wounds. Wound Repair and Regeneration 10(4): 245-51
64.
P. Wyld L, Reed MWR, Brown NJ (2002) Aminolaevulinic acid-induced photodynamic therapy: cellular
responses to glucose starvation. British Journal of Cancer 86(8): 1343-47
65.
P. Kalia N, Pockley AG, Wood RFM, Brown NJ (2002) Effects of hypothermia and rewarming on the
mucosal villus microcirculation and survival after rat intestinal ischaemia-reperfusion injury. Annals of
Surgery 236(1): 67-74
66.
J. Kalia N, Brown NJ, Hopkinson K, Stephenson TJ, Wood RFM, Pockley AG (2002) FK409 inhibits both
local and remote organ damage after intestinal ischaemia. Journal of Pathology 197(5): 595-602
67.
J. Brown NJ, Staton C, Rodgers G, Corke KP, Lewis CE (2002) Fibrinogen E fragment selectively disrupts
the vasculature and inhibits the growth of tumours in a syngeneic murine model. British Journal of Cancer
86(11): 1813-16
68.
J. Bingle L, Brown NJ, Lewis CE (2002) The role of tumour–associated macrophages in tumour
progression: implications for new anticancer therapies. Journal of Pathology 196(3): 254-65
69.
J. Brookes ZLS, Brown NJ, Reilly CS (2002) Differential effects of intravenous anaesthetic agents on the
response of rat mesenteric microcirculation in vivo after haemorrhage British Journal of Anaesthesia 88(2):
255-63
70.
J. Kelty CJ, Ackroyd R, Brown NJ, Reed MWR (2002) The use of 5-aminolaevulinic acid as a
photosensitiser in photodynamic therapy and photodiagnosis. Photochemical and Photobiological Sciences
1(3): 158-68
71.
J. Crowther M, Brown NJ, Bishop ET, Lewis CE (2001) Microenvironmental influence on macrophage
regulation of angiogenesis in wounds and malignant tumors. Journal of Leucocyte Biology 70(4): 478-90
72.
P. Kalia N, Pockley AG, Wood RFM, Brown NJ (2001) Effects of FK409 on intestinal ischaemia-reperfusion
injury and ischaemia-induced changes in the rat mucosal villus microcirculation. Transplantation 72(12):
1875-80
73.
J. Donovan D, Brown NJ, Bishop, ET, Lewis, CE (2001) Comparison of three in vitro human ‘angiogenesis’
assays with capillaries formed in vivo. Angiogenesis 4(2): 113-21
74.
J. Ackroyd R, Kelty C, Brown NJ, Reed MWR (2001) The history of photodynamic therapy and
photodetection. Photochemical &Photobiological 74(5): 656-69
75.
J. Wyld L, Reed MWR, Brown NJ (2001) Differential cell death response to photodynamic therapy is
dependent on dose and cell type. British Journal of Cancer 84(10): 1384-86
76.
P. Kalia N, Bardhan KD, Reed MWR, Atherton JC, Brown NJ (2001) Effects of genotypically different
strains of Helicobacter pylori on human microvascular endothelial cells in vitro. Digestive Diseases and
Sciences 46(1): 54-61
77.
P. Garbett EA, Reed MWR, Stephenson T, Brown NJ (2000) Proteolysis in Human Breast Cancer.
Molecular Pathology 53(2): 99-106
78.
J. Brookes ZLS, Brown NJ, Reilly CS (2000) Intravenous anaesthesia and the rat microcirculation: the
dorsal microcirculatory chamber. British Journal of Anaesthesia 85(6): 901-903
79.
P Ali SA, Rees RC, Anderson DQ, Reed MWR, Brown NJ (2000) Trafficking of “Immune” CD4+/CD8+ TLymphocytes into the RENCA Tumour Microcirculation In Vivo in Mice. British Journal of Cancer 83(8):
1061-1068
80.
J. Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Marcus SL, Stoddard CJ, Reed MWR (2000)
Photodynamic therapy (PDT) for dysplastic Barretts oesophagus: a prospective double-blind placebocontrolled trial. Gut 47(5): 612-617
81.
J. Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Stoddard CJ, Reed MWR (2000) Aminolaevulinic acidinduced photodynamic therapy: safe and effective ablation of Barretts oesophagus. Diseases of the
Esophagus 13(1): 18-22
82.
P. Kalia N, Bardhan KD, Reed MWR, Jacob S, Brown NJ (2000) L-arginine protects and exacerbates
ethanol induced rat gastric mucosal injury. Journal of Gastroenterology and Hepatology 15(8): 915-924
83.
P. Kalia N, Bardhan KD, Reed MWR, Jacob S, Brown NJ (2000) Effects of chronic administration of H.
pylori extracts on rat gastric mucosal microcirculation in vivo. Digestive Diseases and Sciences 45(7): 13431351
84.
P. Kalia N, Bardhan KD, Reed MWR, Jacob S, Brown NJ (2000) Mast cell stabilisation prevents ethanolinduced rat gastric mucosal injury - mechanism of protection. Journal of Gastroenterology & Hepatology
15(2): 133–141
85.
P. Kalia N, Bardhan KD, Reed MWR, Jacob S, Brown NJ (2000) Mechanisms of Helicobacter pylori-induced
rat gastric mucosal microcirculatory disturbances in vivo. Digestive Diseases and Sciences 45(4): 763-772
86.
P. Garbett EA, Reed MWR, Brown NJ (1999) Proteolysis in Human Breast and Colorectal Cancer. British
Journal of Cancer 81(2): 287-293
87.
J. Ackroyd R, Brown NJ, Vernon DI, Roberts DJH, Stephenson TJ, Marcus SL, Stoddard CJ, Reed MWR
(1999) 5-Aminolevulinic Acid Photosensitization of Dysplastic Barretts Esophagus: A Pharmacokinetic
Study. Photochemistry Photobiology 70: 656-662
88.
J. Ackroyd, R, Brown NJ, Davis MF, Stephenson TJ, Stoddard CJ, Reed, MWR (1999) Aminolaevulinic
acid-induced
photodynamic
therapy
in
the
treatment
of
dysplastic
Barretts
oesophagus
and
adenocarcinoma. Lasers in Medical Science 14: 278-285
89.
P. Garbett EA, Reed MWR, Brown NJ (1999) Proteolysis in colorectal cancer. Molecular Pathology 52(3):
140-145.
90.
J. J.Ackroyd R, Brown, NJ, Stephenson TJ, Stoddard CJ, Reed, MWR (1999) Ablation treatment for
Barrett oesophagus: what depth of tissue destruction is needed? Journal of Clinical Pathology 52(7): 509512.
91.
J. P Wyld L, Smith O, Lawry J, Reed MWR, Brown NJ (1998) Cell cycle phase influences tumour cell
sensitivity to ALA-induced photodynamic therapy in vitro. British Journal of Cancer 78(1): 50 - 55.
92.
J. Mayhew JEW, Hu D, Zheng Y, Askew S, Hou Y, Berwick J, Coffey P, Brown NJ (1998) An evaluation of
linear model analysis techniques for processing images of microcirculation activity. Neuroimage 7(1): 4971.
93.
P. Wyld L, Reed MWR, Brown NJ (1998) The influence of hypoxia and pH on ALA-induced PDT in bladder
cancer cells in vitro. British Journal of Cancer 77(10): 1621 - 1627.
94.
J. Ackroyd R, Davis MF, Stephenson TJ, Brown NJ, Stoddard CJ, Reed MWR (1998) Ablation of dysplastic
Barrett’s oesophagus by photodynamic therapy. Nante, France, July, 1998.
95.
P. Brown NJ, Ali SA, Reed MWR, Wiltrout RW, Rees RC (1997) Trafficking of activated lymphocytes into
the RENCA tumour microcirculation in vivo in mice. British Journal of Cancer 76(12): 1572-1578.
96.
J. Kalia N, Brown NJ, Jacob S, Reed MWR, Bardhan KD (1997) Studies on gastric mucosal
microcirculation. 2. Helicobacter Pylori water soluble extracts induce platelet aggregation in the gastric
mucosal microcirculation in vivo. Gut 41(6): 748-752.
97.
P. Wyld L, Burn JL, Reed MWR, Brown NJ (1997) Factors affecting aminolaevulinic acid-induced
generation of protoporpyhrin IX. British Journal of Cancer 76(6): 705-712.
98.
P. Brown NJ, Reed MWR (1997) Leucocyte interactions with the mouse cremaster muscle microcirculation
in vivo in response to tumour conditioned medium. British Journal of Cancer 75(7): 993-999.
99.
J. Kalia N, Brown NJ, Jacob S, Reed MWR, Bardhan KD (1997) Studies on the gastric mucosal
microcirculation. 1. The nature of regional variations induced by ethanol injury. Gut 40(1): 31-35.
100.
J. Leveckis J, Brown NJ, Reed MWR (1995) The effect of aminolaevulinic acid-induced protoporphyrin IXmediated photodynamic therapy on the cremaster muscle microcirculation in vivo. British Journal of Cancer
72(5): 1113-1119.
101.
J. Leveckis J, Burn JL, Brown NJ, Reed MWR (1994) Kinetics of endogenous protoporphyrin IX induction
by aminolaevulinic acid: preliminary studies in the bladder. Journal of Urology 152(2 pt 1): 550-553.
102.
P. Brown NJ, Pollock KJ, Bayjoo P, Reed, MWR (1994) The effects of cryotherapy on the cremaster
muscle microcirculation in vivo. British Journal of Cancer 69(4): 706-710.
103.
J. Brown NJ, Rumsey RDE, Read NW (1994) Gastrointestinal adaptation to enhanced small intestinal lipid
exposure. Gut 35(10): 1409-1412.
104.
J. Brown NJ, Greenborough A, Tomlin J (1994) The effects of pectin and wheat bran on the distribution
of a meal in the gastrointestinal tract of the rat. British Journal of Nutrition 72(2): 289-297
105.
P. Brown NJ, Rumsey RDE, Read NW (1994) The influence of nutrient infusions into rat small intestinal
Thiry-Vella loops on stomach to caecum transit of a meal. Neurogastroenterology & Motility 6: 49-54
106.
J. Rochester JR, Brown NJ, Reed MWR (1994) Characterisation of an experimental model of chronic
lower limb ischaemia in the anaesthetised rat. International Journal of Microcirculation: Clinical &
Experimental 14(1-2): 27-33.
107.
P. Brown NJ, Rumsey RDE, Read NW (1993) The effect of the CCK antagonist Devazepide (L364718) on
the ileal brake mechanism in the rat. Journal of Pharmacy and Pharmacology 45(12): 1033-1036.
108.
J. Tomlin J, Brown NJ, Ellis A, Carlsson A, Bogentoft C, Read NW (1993) The effect of liquid fibre on
gastric emptying in rat and humans and the distribution of small intestinal contents in the rat. Gut 34(9):
1177-1181.
109.
P. Brown NJ, Bayjoo P, Reed MWR (1993) Effects of cryosurgery on liver and blood flow. British Journal
of Cancer 68(1): 10- 12
110.
J. Majeed AW, Allison K, Brown NJ, Reed MWR (1993) Photodynamic ablation of the gallbladder mucosa.
In: Photodynamic therapy and biomedical lasers. Eds. Spinelli, P., Dal Fante, M., Marchesine, R. Experta
Medica International Congress Series 1011, pp 297-299. Elsevier Science Publishers B.V. Amsterdam.
111.
J. Brown NJ, Rumsey RDE, Bogentoft C, Read NW (1993) The effect of an opiate receptor antagonist on
the ileal brake mechanism in the rat. Pharmacology 47(4): 230-236.
112.
P. Brown NJ, Horton A, Rumsey RDE, Read NW (1993) Granisetron and Ondansetron: effects on the ileal
brake mechanism in the rat. Journal of Pharmacy & Pharmacology 45(6): 521-524.
113.
P. Brown NJ, Rumsey RDE, Bogentoft C, Read NW (1992) The effect of adrenoceptor antagonists on the
ileal brake mechanism in the rat. British Journal of Pharmacology 105(3): 751-755.
114.
P. Brown NJ, French SJ, Rumsey RDE, Read NW (1991) The effect of 5HT 3 antagonist on the ileal brake
mechanism in the rat. Journal of Pharmacy and Pharmacology 43(7): 517-519.
115.
J. Richardson A, Delbridge AT, Brown NJ, Rumsey RDE, Read NW (1991) Short chain fatty acids in the
terminal ileum accelerate stomach to caecum transit time in the rat. Gut 32(3): 266-269.
116.
P. Brown NJ, Read NW, Richardson A, Rumsey RDE, Bogentoft C (1990) Characteristics of lipid
substances activating the ileal brake in the rat. Gut 31(10): 1126-1129.
117.
J. Akkerman, LMA, Houghton LA, Brown NJ (1989) Neural and hormonal control of pyloric sphincter
function. Scandinavian Journal of Gastroenterology 24 (Suppl 171): 27-31.
118.
P. Brown NJ, Coupar I, Rumsey RDE (1988) The effect of acute and chronic administration of morphine
and morphine withdrawal on intestinal transit time in the rat. Journal of Pharmacy and Pharmacology
40(12): 844-848.
119.
P. Brown NJ, Worlding J, Rumsey RDE, Read NW (1988) The effect of guar gum on the distribution of a
radiolabelled meal in the gastrointestinal tract of the rat. British Journal of Nutrition 59(2): 223-231.
120.
P. Brown NJ, Rumsey RDE, Read NW (1987) Adaptation of hydrogen analysis to measure stomach to
caecum transit time in the rat. Gut 28(7): 849-854.
121.
J. Brookes ZLS, Brown NJ, Reilly CS (2000) Effects of intravenous anaesthesia on leukocyte rolling and
adhesion. Proceedings of Twelfth World Congress of Anesthesiologists Montreal, Canada, 295.
122.
J. Brookes ZLS, Brown NJ, Reilly CS (2000) Effects of hemorrhage on the mesenteric microcirculation
during propofol anaesthesia. Proceedings of Twelfth World Congress of Anesthesiologists, Montreal,
Canada, 251.
123.
P. Brown NJ, Murray BE (1989) A non-invasive technique for measuring the gastric emptying of nutrients
in the mini-pig. Proceedings of the IVth International Seminar of Digestive Physiology in the Pig, pp 81-87.
124.
P. Moss S, Wyld L, Reed MWR, Brown, NJ (1998) Endothelin is not increased in response to 5aminolaevulinic acid-induced phototoxicity in vitro. Proceedings of the 7th Biennial Congress. International
Photodynamic Association 65 (1-4).
125.
P. Wyld L, Reed MWR, Brown NJ (1998) Photodynamic therapy-induced apoptosis is dose and cell type
dependent. Proceedings of the 7th Biennial Congress. International Photodynamic Association RC1-5.
126.
P. Wyld L, Reed MWR, Brown NJ (1998) Influence of the tumour microenvironment on aminolaevulinic
acid (ALA)-induced photodynamic therapy. Proceedings of the 7th Biennial Congress. International
Photodynamic Association RC 102-6.
127.
P. Wyld L, Reed MWR, Brown NJ (1998) Cell cycle phase variation in aminolaevulinic acid (ALA)-induced
photodynamic therapy. Proceedings of the 7th Biennial Congress. International Photodynamic Association
RC 106-11.
128.
J. Ackroyd R, Davis MF, Brown NJ, Stoddard CJ, Reed MWR (1998) Light delivery device for
photodynamic therapy of Barretts oesophagus. Proceedings of the 7th Biennial Congress. International
Photodynamic Association RC172 (1-5).
129.
J. Ackroyd R, Davis MF, Brown NJ, Stoddard CJ, Reed MWR (1998) Photodynamic therapy for Barretts
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Papers Submitted
1. Muthana M, Giannoudis A, Simon D, Morrow FJ,
2. McGown C, Brown NJ, Hellewell PG, Brookes ZLS. ROCK induced inflammation of the microcirculation
during endotoxemia mediated by nitric oxide synthase. AJP 2010
3. Hankin SL, Reed MWR, Pockley AG, Brown NJ. The mode of cell death induced by photofrin-PDT. British
Journal Cancer 2008.
4. Reeves KJ, Reed MWR, Brown NJ. The role of Nitric Oxide in tumours treated with Aminolaevulinic acidPhotodynamic therapy in vivo. Cancer Research 2008
5. Reeves KJ, Reed MWR, Brown NJ.
The role of Nitric Oxide in tumours treated with Photodynamic
therapy. Journal of Photochemistry Photobiology Review
Abstracts In Print
Over 450 refereed abstracts.