Sabet W. Hashim, M.D.
CURRICULUM VITAE
Date of Revision:
July 16th 2015
Name:
Sabet W. Hashim, M.D, FACS.
Education:
B.S.
M.D.
Baccalauréat in Mathematics: Lycée Français of Beirut (High
Honors) 1968
St. Joseph’s University School of Medicine, Beirut (Honors) 1975
Ranked 1st in medical school admission exam
Specialized Training:
1983:
Mitral Valve Repair, Broussais University Hospital, Paris, France
1984:
Heart Transplantation, Stanford University, Palo Alto, CA, University of
Pittsburgh, Pittsburgh, PA and Columbia University/New York Presbyterian
Hospital, New York, NY
2008:
Robotic Cardiac Surgery, St. Joseph’s Hospital, Atlanta, GA and Good Samaritan
Hospital, Cincinnati, OH
2009:
Minimally Invasive Mitral Valve Repair through Right Thoracotomy, OLV Clinic,
Aalst, Belgium and Lankenau Hospital, Wynnewood, PA
2012:
Trans-femoral Aortic Valve Replacement (TAVR), Edwards Sapien Course,
Vancouver, Canada
Career/Academic Appointments:
1975-76
Internship, General Surgery, St. Luke’s Hospital Medical Center, New York, NY
1976-77
First Year Resident, General Surgery, St. Luke’s Hospital Medical Center, New
York, NY
1977-78
Third Year Resident, General Surgery, St. Luke’s Hospital Medical Center, New
York, NY (promoted by bypassing Second Year Residency)
1978-79
Chief Resident, General Surgery, St. Luke’s Hospital Medical Center, New
York, NY
Instructor in Surgery, Columbia University School of Medicine
1979-81
Resident, Cardiothoracic Surgery, Yale New Haven Hospital
1981-83
Attending Surgeon, VA Hospital, West Haven, CT
1981-present Attending Surgeon, Yale New Haven Hospital
1981-86
Assistant Professor of Surgery, Yale University School of Medicine
2007-present Associate Professor of Surgery, Yale University School of Medicine
Administrative Positions:
2006-present Director of Cardiac Valve Surgery, Yale New Haven Hospital
2010-11
Surgical Director, Heart and Vascular Center, Yale New Haven Hospital
2010-11
Clinical Chief, Section of Cardiac Surgery, Yale University School of Medicine
1981-86
Co-Director of Cardiac Transplantation, Yale New Haven Hospital
Board Certification:
Sabet W. Hashim, M.D.
American Board of Surgery, 1980
American Board of Thoracic Surgery, 1982
American Board of Thoracic Surgery, Recertification, 1992, 2001, 2012
Professional Honors & Recognition:
2014:
Nominated for the Thoracic Surgery Residents Association Socrates Award
2010-present Best Doctors in New York, New York Magazine
2010-present NY Metro Area’s Top Doctors, Castle Connolly Medical Ltd.
2010-present America’s Top Doctors, Castle Connolly Medical Ltd.
2010-present Patients' Choice Award, Vitals
2010-present Most Compassionate Doctor, Vitals
Professional Organizations:
American College of Surgeons, Fellow
Society of Thoracic Surgeons, Member
American Medical Association, Member
Yale Surgical Society, Member
Lebanese American University School of Medicine, Founding Faculty
American-Lebanese Medical Association, Board Member
New Haven Medical Association, Member
Connecticut Medical Association, Member
Active Clinical Trials:
Agency: Edwards LifeSciences, Inc.
Title:
“Commence” Trial comparing valve preparations: Glutaraldehyde versus dry
preparation
P.I.:
Sabet Hashim, M.D.
Role on Project: Yale Site P.I.
Project period: 2015-2020
Cost: $550,000
Agency: Abbott, Inc.
I.D. #
NCT01626079
Title:
“Clinical Outcomes Assessment of the MitraClip Therapy Percutaneous Therapy for
High Surgical Risk Patients (COAPT)”
P.I.:
Sabet Hashim, M.D.
Role on Project: Yale Site P.I.
Project period: 2013-2018
Agency: Medtronic, Inc.
I.D.#
NCT01586910
Title:
“Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of
Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic
Valve Replacement (SURTAVI)”
P.I.:
Sabet Hashim, M.D.
Role on Project: Yale Site P.I.
Sabet W. Hashim, M.D.
Project period: 2013-2018
Agency: Medtronic, Inc.
I.D.#
IDE G100012
Title:
“CoreValve Pivotal Clinical trial to evaluate the safety and efficacy of the Medtronic
CoreValve® System in the treatment of symptomatic severe aortic stenosis in subjects
necessitating aortic valve replacement, with predicted operative mortality or serious,
irreversible morbidity risk of ≥ 50% at 30 days”
P.I.:
Craig Thompson
Role on Project: Sub-investigator
Project period: 2012-2017
Agency: Medtronic, Inc.
I.D.#
IDE G100012
Title:
“CoreValve Continued Access clinical trial to evaluate the safety and efficacy of the
Medtronic CoreValve® System in the treatment of symptomatic severe aortic stenosis
in subjects necessitating aortic valve replacement, with predicted operative mortality
or serious, irreversible morbidity risk of ≥15% and <50% (High Risk) or ≥ 50%
(Extreme Risk) at 30 days”
P.I
Craig Thompson
Role on Project: Sub-investigator
Project period: 2012-2017
Agency: Medtronic, Inc.
I.D.#
IDE G100012
Title:
“CoreValve Expanded Use clinical trial to evaluate the safety and efficacy of the
Medtronic CoreValve® System in the treatment of symptomatic sever aortic stenosis
in subjects with significant comorbidities in whom the risk of surgical aortic valve
replacement has a predicted operative mortality or serious, irreversible morbidity
risk of ≥ 15% and <50% (high risk) or ≥ 50% (extreme risk) at 30 days”
P.I.:
Craig Thompson
Role on Project: Sub-investigator
Project period: 2012-2017
Past Clinical Trials
Agency: Abbott, Inc.
Title:
“Indicators of Acute Kidney Injury in Patients Undergoing Cardiac Surgery”
P.I.:
Chirag Parikh, M.D.
Role on Project: Collaborator
Project period: 2007-2011
Sabet W. Hashim, M.D.
Invited Speaking Engagements, Presentations, Symposia & Workshops Not Affiliated With
Yale:
International/National
2015: AATS 2015 Mitral Conclave, New York City, NY. Session XV, “Repair Techniques:
When to do resection”
2014: American University of Beirut Symposium, Beirut, Lebanon. “The role of surgery in
ischemic mitral regurgitation”
2013: Edwards LifeSciences Fellow Program, Irvine, CA. “Mitral valve surgery: Helpful
techniques to enhance your repair rate”
2009: American Lebanese Medical Association, Beirut, Lebanon. “The future of mitral
valve repair”
2008: Symposium Mitral, Medellin, Columbia. “New Techniques of mitral valve
reconstruction”
2008: American Association of Thoracic Surgery, San Diego, CA. “Evolving techniques of
mitral valve repair”
Regional:
2013: Cardiology Conference Bridgeport Hospital, Bridgeport, CT. “Surgery for ischemic
mitral regurgitation”
2013: Homestead Inn, Greenwich, CT. “The role of surgery in ischemic mitral
regurgitation”
2009: Seventeenth Annual Bradley Memorial Cardiovascular Symposium, Southington, CT.
“Mitral valve repair: The third decade”
2004: American Heart Association, Middletown, CT. “Atrial fibrillation roundtable”
2002: Greenwich Hospital, Greenwich, CT. “Trends in cardiac surgery”
2002: Norwalk Hospital, Norwalk, CT. “Mitral valve repair”
2001: Annual Meeting of Physicians Assistants, Ledyard, CT. “Progress or gimmick in
cardiac surgery”
Peer-Reviewed Presentations & Symposia:
International/National
2014: 28th EACTS Annual Meeting, Milan, Italy. “Radial artery versus right internal
thoracic artery as the best second conduit in multi arterial CABG: A multi
institutional study.”
2012: Annual American Heart Association Scientific Sessions Meeting, Los Angeles, CA.
“The free right internal thoracic artery: A versatile and durable conduit.”
2011: American Association for Thoracic Surgeons Mitral Valve Conclave Meeting, New
York, NY. “Identification of pseudo-prolapse of the anterior leaflet in a subgroup of
patients with chronic ischemic mitral regurgitation and correction with neochordae
improves late mid-term outcomes of mitral valve repair.”
2011: Annual American Heart Association Scientific Sessions Meeting, Orlando, FL.
“Modulation of transforming growth factor-P signaling and extracellular matrix in
myxomatous mitral valve degeneration by angiotensin II receptor blocker losartan.”
Sabet W. Hashim, M.D.
2011: 6th International Congress on Cardiovascular Diseases, New Delhi, India. “Towards
adopting right-sided pacemaker implantation: A safer surgical practice.” (Awarded
“Best paper in clinical cardiology”)
2011: 21st World Congress, World Society of Cardio-Thoracic Surgeons, Berlin, Germany.
“Durable mitral valve repair in chronic ischemic mitral regurgitation requires
identification and correction of pseudo-prolapse of anterior leaflet, when present.”
2010: 90th Annual Meeting of the American Association for Thoracic Surgeons, Toronto,
Canada. “Transforming growth factor-B induces the expression of extracellular
matrix molecules in myxomatous mitral valves.”
2007: Valves in the Heart of the Big Apple Symposium, New York, NY. “Improved results
of tricuspid valve repair using undersized annuloplasty rings.”
1984: New England Surgical Society, NH. “Non-cardiology pulmonary edema following
cardiopulmonary bypass: An anaphylactic reaction to fresh frozen plasma.”
1984: American Cardiology of Surgeons, Surgical Forum, San Francisco, CA. “A safer
method of cardioplegia delivery in aortic valve surgery.”
Professional Service:
Journal Service:
2010-present Guest Reviewer, Cardiology
2010-present Guest Reviewer, Cardioexchange, An NEJM Practice Community
Professional Service for Professional Organizations:
Abbott Laboratories
2012-2014 Acute Kidney Injury Advisory Board
Edwards LifeSciences LLC
2009-present Consultant
Yale University Service:
Hospital Boards & Committees
2013-present Patient safety and quality subcommittee, Yale Heart and Vascular Center
2010-present Council on cardiothoracic surgery
2009-10
Heart and Vascular service task force
2004-06
Operating room committee
1985:
Task force on coronary bypass surgery
Sabet W. Hashim, M.D.
Hospital Programs Initiated
2012:
Trans-femoral and trans-apical aortic valve replacement (TAVR) using the
Edwards LifeSciences sapien valve, in collaboration with Drs. Cleman,
Thompson, Geirsson and Forrest
2005:
Minimally-invasive techniques of mitral valve repair: Mini-sternotomy, submammary incision and the right mini-thoracotmy approach
2005:
Aortic valve replacement using mini-upper sternotomy incision
2001:
Atrial fibrillation surgery
1984:
Co-directed the heart transplant program and performed the first heart
transplant in Connecticut.
1984:
Mitral valve repair program
Bibliography:
Peer-Reviewed Original Research:
1. Kay H, Barash P, Geha A, Kopf G, Hashim SW and Kopriva C: A Placebo-Controlled
Randomized Blind Study of Parenteral Nitroglycerin During Open Heart Operations. Surg
Forum 33:251-253, 1982.
2. Barash PG, Seinfeld F, Kay H, Condos SG, Hashim SW, Tinker J and Geha AS: RPP:
May it R.I.P. Anesthesiol 57:A22, 1982.
3. Stavens B, Hashim SW, Hammond GL, Stansel HC, Gatehouse J, Kopf GS and Geha
AS: Optimal Methods of Repair of Descending Thoracic Aortic Disruptions and
Aneurysm. Am J Surg 145(4):508-513, 1983.
4. Hashim SW, Hammond GL, Condos S, Kopf GS and Geha AS: A Safer Method of
Cardioplegia Delivery in Aortic Valve Surgery. Surg Forum 35: 286-287, 1984.
5. Hashim SW, Kay HR, Hammond GL, Kopf GS and Gela AS: Noncardiogenic Pulmonary
Edema following Cardiopulmonary Bypass: An Anaphylactic Reaction to Fresh Frozen
Plasma. Am J Surg 147(4):560-564, 1984. Chosen for the Year Book of Surgery, 1985
6. Geha AS, Hashim SW, Kopf GS and Hammond GL: Early and Late Results of Combined
Valve Replacement and Myocardial Revascularization: The Problem of Severe Ischemic
Mitral Regurgitation. Chest 86:292, 1984.
7. Breisblatt WM, Berger RB, Cabin HS, Cleman MW, Cerqueira MD, Neumann RD,
Ezekowitz MD, Hashim SW and Berger HJ: Unsuspected Left Ventricular
Pseudoaneurysm in a Patient with Coronary Artery Disease. Am J Roent 142:680-682,
1984.
8. Geha AS, Francis CK, and Hammond GL, Laks H, Kopf GS and Hashim SW: Combined
Valve Replacement and Myocardial Revascularization. J Vasc Surg 1:27-35, 1984.
Sabet W. Hashim, M.D.
9. Zahler R, Breisblatt W, Hashim SW, Kleinman C, Langou R: Isolated Right Atrial
Tamponade by Serous Fluid Simulating Tricuspid Stenosis. Am J Med 79:531-534, 1985.
10. Kopf GS, Hume AL, Durkin MA, Hammond GL, Hashim SW and Geha AS:
Measurement of Central Somatosensory Conduction Time in Patients Undergoing
Cardiopulmonary Bypass: An Index of Neurological Function. Am J Surg 149:445-448,
1985.
11. Gertler J, Elefteriades JA, Kopf GS, Hammond GL, Hashim SW, and Geha AS: Predictors
of Outcome following Early and Delayed Revascularization for Acute Myocard Am J
Surg 149:441-444, 1985.
12. Hashim SW: Safe Technique for Aortic Anastomosis in Orthopedic Canine Cardiac
Transplantation. Ann Thorac Surg 39:389-390, 1985.
13. Morse SS, Strauss ED, Hashim SW, Greenwood CH, Denny DF and Sniderman KW:
Percutaneous Retrieval of an Unusually Large Nonopaque Intravascular Foreign Body. Am J
Radiol 146:863-864, 1986.
14. Kopf GS, Hammond GL, Geha AS, Elefteriades JE and Hashim SW: Long Term
Performance of St. Jude Medical Valve: Low Incidence of Thromboembolism and
Hemorrhagic Complications with Modest Doses of Warfarin. Circulation 76 (3 Pt 2): III
132-136, 1987.
15. Hammond GL, Geha AS, Kopf GS, and Hashim SW: Biological Versus Mechanical
Valves: Analysis of 1,116 valves inserted in 1,012 adult patients with a 4,818 patient-year
and a 5,327 valve year follow up. J Thorac Cardiovas Surg 93:182-198, 1987.
16. Passik CS, Hashim SW: Right Ventricular Failure. Ann Thorac Surg 62: 630,1996.
17. Jovin A, Hashim SW, Jovin IS, Clancy JF, Klovekorn WP and Muller-Berghaus G: Atrial
Fibrillation at Discharge from the Hospital in Patients Undergoing Mitral Valve Repair. J
Thorac Cardiovasc Surg 53: 41-45, 2005.
18. Oprea D, Memet R, Jovin A, Duggal M, Collazo S, Jovin IS, Hashim SW, Clancy JF:
Anticoagulation at Discharge after Mitral Valve Repair and Long-Term Mortality.
Circulation 114 (Suppl.): II-734, 2006.
19. Kurup V, Perrino A, Barash P, Hashim SW: Echo Rounds: Infundibular Pulmonary
Stenosis. Anesthes Analges 104, 507-508, 2007.
20. Hashim SW, Rousou AJ, Geirsson A, Sigurdur R: Solving the Puzzle of Chronic Ischemic
Mitral Regurgitation. Yale J Bio Med 81; 167-173, 2008.
21. Jovin A, Oprea D, Jovin IS, Hashim SW, Clancy JF: Atrial Fibrillation and Mitral Valve
Repair. Pacing and Clinical Electrophysiology 31;1057-62, 2008.
Sabet W. Hashim, M.D.
22. Hashim SW, Youssef SJ, Ayyash B, Ragnarsson S, Collazo S, Geirsson A: PseudoProlapse of the Anterior Leaflet in Chronic Ischemic Mitral Regurgitation: Identification
and Repair. J Thorac Cardiovasc Surg 143 (4 suppl): S33-7, 2012.
23. Coca S, Jammalamadaka, D, Sint K, Thiessen Philbrook H, Shlipak M, Zappitelli M,
Devarajan P, Hashim SW, Garg A, MD, Parikh C: Preoperative Proteinuria Predicts
Acute Kidney Injury in Patients Undergoing Cardiac Surgery. J Thorac Cardiovasc Surg
143 (2): 497-502, 2012.
24. Dodson J, Wang Y, Desai MM, Filho J, Sugeng L, Hashim SW, Krumholz HM: Outcomes
for Mitral Valve Surgery among Medicare Fee-for Service Beneficiaries, 1999- 2008. Circ
Cardiovasc Qual Outcomes 5(3); 298-307, 2012.
25. Geirsson A, Singh M, Ali R, Abbas H, Li W, Sanchez J, Hashim SW, Tellides G.
Modulation of TGF-B signaling and Extracellular Matrix Production in Myxomatous
Mitral Valves by Angiotensin II Receptor Blockers. Circulation 126: S189-S197, 2012.
26. Hashim PW, Hashim SW:Aortic Cannulation with a Single Purse-String Suture. J Thorac
Cardiovasc Surg 147(4):1430-31, 2014.
27. Hashim PW, Hashim SW: Liver Laceration from a Diaphragmatic Suture in
Minithoracotomy Mitral Valve Repair. J Card Surg 29(4):476-7, 2014.
28. Khan UA, Coca SG, Hong K, Koyner JL, Garg AX, Passik CS, Swaminathan M, Garwood
S, Patel UD, Hashim SW, Quantz MA, Parikh CR. Blood Transfusions Are Associated
with Urinary Biomarkers of Kidney Injury in Cardiac Surgery. J Thorac Cardiovasc
Surg 148(2):726-32, 2014.
29. Hashim PW, Assi R, Hashim SW. The Imbrication Technique: An Alternative to the
Sliding Leaflet Technique. Ann Thorac Surg 98:1124-26, 2014.
30. Assi R, Youssef SJ, Almarzooq Z, Al-Raweshidy Y, Hashim PW, Geirsson A, Hashim
SW: The “Free” Right Internal Thoracic Artery: A Versatile and Durable Conduit. J Card
Surg 29(5):609-15, 2014.
31. Schwann TA, Hashim SW, Badour S, Obeid M, Engoren M, Tranbaugh RF, Bonnell MR,
Habib RH. Equipoise between Radial Artery and Right Internal Thoracic Artery as the
Second Arterial Conduit in LITA based CABG: A Multi Institutional Study. Eur J
Cardiothoracic Surg. Epub ahead of print. March 2015.
32. Dodson JA, Wang Y, Murugiah K, Dharmarajan K, Cooper Z, Hashim S, Nuti SV, Spatz
E, Desai N, Krumholz HM. Trends in Hospital Readmission Rates among Medicare Feefor-Service Survivors of Mitral Valve Surgery, 1999-2010. PLoS One 10(7):e0132470,
2015.
Sabet W. Hashim, M.D.
Chapters, Books, and Reviews
33. Hashim SW, Baue AE and Geha AS: The Role of Mediastinoscopy and Mediastinotomy in
Lung Cancer. Clin Chest Med 3:353-359, 1982.
34. Rafferty TD, Hasel R, Tousignant G, Woodruff A, Braxton JH, Hashim SW:
Transesophageal echocardiographic diagnosis of excessive motion of the mitral valve
leaflets. Video J. Echocardiogr. 1995; 5: 59-77 (110 mins).
35. Rafferty TD, Hasel R, Tousignant G, Woodruff A, Braxton JH, Hashim SW:
Transesophageal echocardiographic evaluation of the result of mitral valve repair. Video J.
Echocardiogr. 1996; 6: 33-60 (62 mins).
Invited Editorial and Commentaries
36. Adams D, Hashim SW, Sarano ME, Elefteriades JA: Mitral Valve Surgery and Mitral
Prolapse. Medical Roundtable-CV Edition 1(2) 79-85, 2010.
37. Hashim SW, Hashim PW: Minimally Invasive Repair with Gore-Tex for Barlow’s Disease:
Will it Fly? Cardiology 128:95-96, 2014.