Principal Investigator: Protocol # (if available): Date: SECTION M: EXEMPTIONS FROM ANIMAL WELFARE STANDARDS* * This section should be used to request exemptions from UMD Policies or the Guide for the Care and Use of Laboratory Animals (2011) for scientific reasons. All exemptions are reviewed annually and additional information may be required to sustain an exemption over the life of a protocol. M1. EXEMPTIONS (indicate response with “X” in applicable box(es)): Housing Density Exemption [Complete M2] Cage Change/ Water Change Frequency Exemption Radios/Sound/Noise Exemption [Complete M3] [Complete M4] Exemption from Enrichment [Complete M5] Exemption from Social Housing [Complete M6] Environmental Conditions/Housing and Husbandry Exemption Restricted food/fluid Prolonged restraint [Complete M7] [Complete M8] [Complete M9] Non-pharmacological grade compounds [Complete M10] Other (describe below): [Complete M11] M2. HOUSING DENSITY EXEMPTION Identify group, number of animals & maximum housing density requiring this exemption Group # Animals/group Max Housing Density Describe the management plan that will be used to avoid exceeding max density indicated above. Include any plan to return animals to standard housing density when specific conditions are met: Justification for housing these animals at a density that exceeds established guidelines: 1 M3. CAGE CHANGE / WATER CHANGE FREQUENCY EXEMPTION Specify maximum time that will elapse between changing the bedding or water or animal housing: Identify group & number of animals for each animal or study group requiring this exemption Group # Animals/group Justification for extending the schedule of cleaning beyond established guidelines: M4. RADIO / SOUND / NOISE EXEMPTION Specify the type of sound to which animals will be exposed (e.g. radio, controlled sounds, random noise) and describe its nature (e.g soft music, natural calls, buzzer): Describe sound stimulus: Volume/Decibel Duration of exposure Frequency of Exposure Identify group & number of animals for each animal or study group requiring this exemption: Group # Animals/group Justification for exposing animals to generated sounds or noise. If the sound is a component of the experimental design or the plan for environmental enrichment, please describe its purpose. M5. ENVIRONMENTAL ENRICHMENT EXEMPTION (includes food items) Describe the specific environmental enrichment for which you request an exemption: For each animal or study group requiring this exemption, identify the specific group and indicate the number of animals involved: Group # Animals/group Please describe the experimental or other scientific reason why animals should be exempted from standard species-specific environmental enrichment: 2 M6. SOCIAL HOUSING EXEMPTION Note: Animals that are not considered social do not require an exemption to be singly housed (e.g., animals that will fight if housed with conspecifics/conspecifics of same sex). Describe the housing arrangement that is requested under this exemption (e.g. single housing, restrictive housing, isolated housing): For each animal or study group requiring this exemption, identify the specific group and indicate the number of animals involved: Group # Animals/group Please describe the experimental or other scientific reason why animals should be exempted from standard species-specific housing conditions: M7. ENVIRONMENTAL CONDITIONS/HOUSING AND HUSBANDRY EXEMPTION Describe the environmental conditions for which you are requesting an exemption: Identify group & number of animals for each animal or study group requiring this exemption: Group # Animals/group Please describe the experimental or other scientific reason why animals should be exempted from standard species-specific environmental conditions: M8. RESTRICTED FOOD/FLUID Please provide justification for restriction: Duration of restriction Frequency of restriction Describe procedures for monitoring criteria for removing from study: 3 M9. PROLONGED RESTRAINT Please provide justification for restraint (e.g. animal acclimatization; training; observation; behavioral study): M10. NON-PHARMACOLOGICAL GRADE COMPOUNDS EXEMPTION Identify the compounds for which you are requesting under the “Non-pharmaceutical grade compounds” category: For each compound, explain why pharmaceutical grade equivalents will not be used: M11. OTHER EXEMPTION Describe the exemption that you are requesting under the “Other” category: Identify group & number of animals for each animal or study group requiring this exemption: Group # Animals/group Please describe the experimental or other scientific reason why animals should have this exemption: 4