Research Institute for Science
& Technology in Medicine
MSc Cell & Tissue Engineering / Biomedical
Engineering Seminar Programme
Dr Paul De Sousa
Senior Research Fellow
Scottish Centre for Regenerative Medicine
University of Edinburgh
Presenting:
“Plurioptent stem cell translation: basic and applied
science supporting human embryonic stem cells in
regenerative medicine”
Wednesday 9th November, 1.00 p.m.
Seminar Room, Guy Hilton Research Centre
Thornburrow Drive, Hartshill
ALL WELCOME
ABSTRACT
Plurioptent stem cell translation: basic and applied science supporting
human embryonic stem cells in regenerative medicine
Thirty years from the isolation of pluripotent mouse embryonic stem cells and over 13 years
from the same accomplishment in humans, translational applications of this science are now
underway. This includes the use of animal and human pluripotent stem cells in drug
screening, to model disease and in humans cellular therapies. However, the transformation
of these practices into robust manufacturing and clinical processes still requires a better
understanding of the intrinsic and extrinsic determinants of pluripotent stem cell viability,
renewal and lineage specification. Our laboratory has sought to define the intra and extra
cellular determinants of human embryonic stem cell identity and develop methods by which
these can be modulated using chemically defined bio-similarly active molecules. Our aim is
to develop improved systems for the safe and efficacious culture of pluripotent stem cells in
support of cellular therapies.
Dr Paul De Sousa
-Hildegarde Wright
MSc Course Administrator
Keele University School of Medicine - Postgraduate
Clinical Education Centre (SF18)
University Hospital of North Staffordshire
Newcastle Road, Stoke-on-Trent,
Staffordshire ST4 6QB
Tel: +44(0)1782 672691
Fax: +44(0)1782 672699
e-mail: h.wright@pmed.keele.ac.uk