Supplemental Table 2: Top biological processes mediated by KLF11 and mutants compared to empty vector.
KLF11
EAPP
486
A347S
cellular lipid metabolic process
2-oxoglutarate metabolic process
nitric oxide transport
olfactory bulb interneuron
differentiation
cellular lipid metabolic process
positive regulation of protein
binding
cellular lipid metabolic process
G2/M transition DNA damage
checkpoint
triglyceride biosynthetic process
thymine catabolic process
triglyceride biosynthetic process
response to estrogen stimulus
response to insulin stimulus
cellular amino acid biosynthetic
process
negative regulation of glycolysis
proton transport
glycoside catabolic process
steroid catabolic process
response to hypoxia
glycoside catabolic process
ketone body catabolic process
vesicle-mediated transport
glycosylceramide catabolic process
positive regulation of protein tyrosine
kinase activity
glycosylceramide catabolic process
outer ear morphogenesis
UDP-N-acetylglucosamine
biosynthetic process
cellular ketone body metabolic
process
positive regulation of cell growth
cellular nitrogen compound
metabolic process
response to DNA damage stimulus
2-oxoglutarate metabolic process
regulation of protein heterodimerization
activity
tricarboxylic acid cycle
triglyceride biosynthetic process
glucose metabolic process
negative regulation of telomere
maintenance
ketone body biosynthetic process
erythrocyte development
ER to Golgi vesicle-mediated
transport
fatty acid beta-oxidation
response to nutrient
tricarboxylic acid cycle
response to cholesterol
response to heat
negative regulation of IGFR signaling
pathway
response to ethanol
glycerol-3-phosphate metabolic
process
embryonic digit morphogenesis
response to ionizing radiation
response to estrogen stimulus
positive regulation of protein binding
cellular response to stimulus
mesenchymal to epithelial transition
polyamine metabolic process
positive regulation of DNA repair
biosynthetic process
valine metabolic process
regulation of neural precursor cell
proliferation
oxidation-reduction process
forelimb morphogenesis
post-embryonic development
hindlimb morphogenesis
fructose 6-phosphate metabolic
process
glycoside catabolic process
proton transport
induction of apoptosis by intracellular
signals
regulation of transcription, DNAdependent
regulation of protein homodimerization
activity
glycosylceramide catabolic process
response to folic acid
oxygen transport
myeloid leukocyte differentiation
oxidation-reduction process
positive regulation of cell growth
cellular nitrogen compound metabolic
process
isocitrate metabolic process
regulation of protein
heterodimerization activity
L-methionine salvage from
methylthioadenosine
chromatin remodeling