Supporting Information
A Facile and Efficient Synthesis of (15R)-Latanoprost from Chiral
Precursor Corey Lactone Diol
K VIJENDHARa,b, B SRINIVASb and SATHYANARAYANA BOODIDA*,a
a
Department of Chemistry, JNTUH College of Engineering Jagtial, Karimnagar 505 501, India
b
R&D Division, Aspen Bio Pharma Labs Pvt. Ltd, Genome Vally, Turkapally, Hyderabad 500
078, India
e-mail: bs14@jntuh.ac.in
Table of Contents:
1. Figure S1: 1H-NMR Spectrum of compound 5
2. Figure S2 : 1H-NMR Spectrum of compound 6
3. Figure S3: 1H-NMR Spectrum of compound 8
4. Figure S4: 1H-NMR Spectrum of compound 9
5. Figure S5: 1H-NMR Spectrum of compound 11
6. Figure S6: IH-NMR Spectrum of compound 13
7. Figure S7 : 1H-NMR Spectrum of compound 03
8. Figure S8 : 13C-NMR Spectrum of compound 05
9. Figure S9 : 13C-NMR Spectrum of compound 06
10. Figure S10 : 13C-NMR Spectrum of compound 08
11. Figure S11 : 13C-NMR Spectrum of compound 09
12. Figure S12 : 13C-NMR Spectrum of compound 03
13. Figure S13 : IR Spectrum of compound 03
14. Figure S14: HPLC spectrum of compound 03
15. Figure S15 : Mass spectrum of compound 03
1
16. Table S1: SOR Spectrum of compound 3
2
O
Br
Figure S1: 1H-NMR Spectrum of compound 5
O
O
P
OMe
OMe
Figure S2 : 1H-NMR Spectrum of compound 6
3
O
O
OSi(Et)3
OSi(Et)3
Figure S3: 1H-NMR Spectrum of compound 8
O
O
OSi(Et)3
O
Figure S4: 1H-NMR Spectrum of compound 9
4
O
O
OSi(Et)3
OSi(Et)3
Figure S5: 1H-NMR Spectrum of compound 11
(Et)3SiO
COOiPr
OSi(Et)3
OSi(Et)3
Figure S6: 1H-NMR Spectrum of compound 13
5
HO
COOiPr
OH
OH
Figure S7 : 1H-NMR Spectrum of compound 03
O
Br
Figure S8 : 13C-NMR Spectrum of compound 05
6
O
O
P
OMe
OMe
Figure S9 : 13C-NMR Spectrum of compound 06
7
O
O
OSi(Et)3
OSi(Et)3
Figure S10 : 13C-NMR Spectrum of compound 08
O
O
OSi(Et)3
O
Figure S11 : 13C-NMR Spectrum of compound 09
8
HO
COOiPr
OH
OH
Figure S12 : 13C-NMR Spectrum of compound 03
HO
COOiPr
OH
OH
Figure S13: IR Spectrum of compound 03
9
HO
COOiPr
OH
Figure S14: HPLC spectrum of compound 03
HO
COOiPr
OH
OH
Figure S15 : Mass spectrum of compound 03
10
OH
Table S1: SOR Spectrum of compound 3
11