吳益群教授
(Yi-Chun Wu, Professor)
電話 02-33662483 ; 傳真 02-33665248;
E-mail：yichun@ntu.edu.tw
學歷
民國 76 年，清華大學化學系學士
民國 78 年，台灣大學生物化學所碩士
民國 80 年，美國哥倫比亞大學生物學系碩士
民國 86 年，美國麻省理工學院博士
經歷
民國 87 至 91 年，台灣大學動物系/所助理教授
民國 91 至 92 年，台灣大學動物系/所副教授
民國 92 至 94 年，台灣大學分子與細胞生物學研究所副教授
民國 94 年迄今，台灣大學分子與細胞生物學研究所教授
民國 99 年迄今，中央研究院原子與分子科學所合聘研究員
研究興趣
＊ 細胞凋亡、細胞辨識、細胞遷移; ＊ 奈米物質在生物醫學的應用; ＊ 分子遺傳發育學
REFEREED PAPERS:
(1) Wu, Y.C. and Horvitz, H. R. C. elegans phagocytosis and cell-migration protein CED-5 is
similar to human DOCK180. Nature 392, 501-504 (1998).
(2) Wu, Y.C. and Horvitz, H. R. The C. elegans cell corpse engulfment gene ced-7 encodes a
protein similar to ABC transporters. Cell 93, 951-960 (1998).
(3) Wu, Y.C., Stanfield, G. M. and Horvitz, H. R. NUC-1, a Caenorhabditis elegans DNase II
homolog, functions in an intermediate step of DNA degradation during apoptosis. Genes & Dev.,
14, 536-548 (2000).
(4) Ledwich, D., Wu, Y.C., Driscoll, M. and Xue, D., Analysis of programmed cell death in the
nematode Caenorhabditis elegans. Methods in Enzymology, 322, 76-88 (2000).
(5) Wu, Y.C.*, Tsai, M.C., Cheng L.C., Chou, C.C. and Weng N.Y., C. elegans CED-12 acts in the
conserved CrkII/DOCK180/Rac pathway to control cell migration and cell-corpse engulfment. Dev.
Cell, 1, 491-502 (2001). *corresponding author
(6) Lin, C.C. * , Yeh, Y.C., Yang, C.Y., Chen, C.L., Chen, G.F., Chen, C.C. * , Wu, Y.C.*,
Selective binding of mannose encapsulated gold nanoparticles to type 1 pili in Escherichia coli. J.
Am. Chem. Soc. , 124, 3508-3509 (2002).* corresponding author
(7) Wu, Y.C.*, Cheng, T.W., Lee, M.C. and Weng, N.Y. Distinct Rac activation pathways control
C. elegans cell migration and axon outgrowth. Dev. Biol. , 250, 145-155 (2002). * corresponding
author
(8) Lin, C.C., Yeh, Y.C., Chen, G., Yang, C., Chen, Y., Wu, Y.C. and Chen, C.C.Quantitative
Analysis of Multivalent Interactions of Carbohydrate Encapsulated Gold Nanoparticles with
Concanavalin Chem. Com. 23, 2920-2921 (2003).
(9) Wang, X. # , Wu, Y.C.*#, Fadok, V., Lee, M., Gengyo-Ando, K., Cheng, L. Ledwich, D., Hsu,
P., Chen, J., Chou, B., Henson, P., Mitani, S. and Xue, D. * Cell Corpse Engulfment Mediated by C.
elegans Phosphatidylserine Receptor Through CED-5 and CED-12. Science 302,1563-1566 (2003)
#These authors contributed equally to this work. * corresponding author
(10) deBakker, C. D., Haney, L. B., Kinchen, J. M., Grimsley, C., Lu,M., Klingele,D., Hsu, P.K.,
Chou, B.K., Cheng, L.C., Blangy, A., Sondek, J., Hengartner, M. O., Wu, Y.C. and Ravichandran,
K.S. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO─MIG-2/RhoG signaling
module and Armadillo repeats of CED-12/ELMO. Curr. Biol. 14,2208-2216(2004)
(11) Chen, C. C., * Liu, Y.C., Wu, C.H., Yeh, C.C., Su, M.T. and Wu, Y.C.* Preparation of
Fluorescent Silica Nanotubes and their Application in Gene Delivery. Adv. Mater.
17,404-407(2005) *corresponding author
(12) Liu, W.H., Lin, Y.L., Wang, J.P., Liou,W., Hou, R.F., Wu, Y.C.* and Liao, C.L.* Restriction
of Vaccinia Virus Replication by a ced-3 and ced-4 -Dependent Pathway in C. elegans . Proc. Natl.
Acad. Sci. U S A. 103, 4174-4179 (2006). *corresponding author
(13) Chen,C.C., * Lin,I.P., Tzeng, S.C., Wang, J.W., Wu, C.H., Chen, Y.C., Chen, J.P., Chen, K.H.,
Su, M.T. and Wu, Y.C.* DNA-Gold Nanorod Conjugates for Remote Control of Localized Gene
Expression by Near Infrared Irradiation. J. Am. Chem. Soc. 128, 3709-3715 (2006).
*corresponding author
(14) Chen K.Y., Pan H., Lin M.J., Li Y.Y., Wang L.C., Wu, Y.C. , Hsiao K.M. Length-dependent
toxicity of untranslated CUG repeats on Caenorhabditis elegans. Biochem. Biophys. Res.
Commun. 352 , 774-9 (2007) .
(15) Wang L.C., Hung W.T., Pan H., Chen K.Y., Wu, Y.C., Liu Y.F., Hsiao K.M.,
Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans. Biochem. Biophys.
Res. Commun. 366,705-9(2008)
(16) Lin, Y.M., Chen, Y.R., Lin, J.R., Wang, W.J., Inoko, A., Inagaki, M., Wu, Y.C., Chen, R.H.,
eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing
inclusions. J. Cell Sci. 121:2382-93 (2008).
(17) Tong A., Lynn G., Ngo Vy, Wong D., Moseley S.L., Ewbank J.J., Goncharov A., Wu, Y.C.,
Pujol N., and Chisholm A.D., Negative regulation of Caenorhabditis elegans epidermal damage
responses by death-associated protein kinase. Proc. Natl. Acad. Sci. U S A. 106:1457-61(2009)
(18) Hsu, T. and Wu, Y.C.*, Engulfment of apoptotic cells in C. elegans is mediated by integrin,
Curr. Biol. 20:477-486 (2010) * corresponding author
(19) Mohan, N., Chen, C.S., Hsieh, H.H., Wu, Y.C.* and Chang, H.C. * In vivo imaging and
toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans. Nano Lett.
10:3692-3699 (2010) * corresponding author