Supplementary Table 2. Unadjusted and adjusted estimates of associations for comparisons of PHEU, PHIV
without encephalopathy, and PHIV with encephalopathy for the CCTT test, the BRIEF-SR, and the BRIEF-PR.
Test
Outcome
Level
Estimate
Unadjusted
Adjusted
Results
Results
(95% CI)
P-
Estimate
(95% CI)
value
CCTT
Pvalue
Interference Index Categories
PHEU
<=5%, between 6 and 16%,
PHIV/No Enc
1.10
(0.71, 1.71)
0.669
0.93
(0.54, 1.62)
0.803
PHIV/With
0.64
(0.23, 1.77)
0.389
0.35
(0.09, 1.30)
0.115
>16%1
Enc
CCTT-1
Sequence error percentile
PHEU
range score <=16%2
PHIV/No Enc
0.96
(0.53, 1.74)
0.898
1.28
(0.63, 2.62)
0.495
PHIV/With
0.56
(0.20, 1.52)
0.253
0.88
(0.25, 3.14)
0.848
PHIV/No Enc
-0.24
(-2.13, 1.64)
0.801
0.30
(-1.35, 1.95)
0.722
PHIV/With
-11.06
(-15.54, -6.57)
<0.001
-10.36
(-15.07, -5.65)
<0.001
Enc
Time T-score3
PHEU
Enc
CCTT-2
Color sequence error
PHEU
percentile range score
PHIV/No Enc
1.17
(0.69, 1.97)
0.555
1.11
(0.56, 2.21)
0.769
PHIV/With
2.53
(0.60, 10.68)
0.206
1.68
(0.35, 8.14)
0.518
<=16%2
Enc
Sequence error percentile
PHEU
range score <=16%2
PHIV/No Enc
0.65
(0.24, 1.71)
0.381
0.75
(0.23, 2.46)
0.641
PHIV/With
0.34
(0.08, 1.44)
0.144
0.29
(0.05, 1.67)
0.166
PHIV/No Enc
-1.95
(-3.66, -0.23)
0.026
-0.61
(-2.56, 1.34)
0.538
PHIV/With
-12.04
(-15.66, -8.42)
<0.001
-9.06
(-13.70, -4.42)
<0.001
PHIV/No Enc
-1.46
(-4.71, 1.79)
0.379
-3.26
(-5.89, -0.64)
0.015
PHIV/With
-1.98
(-7.18, 3.21)
0.454
-1.55
(-5.59, 2.49)
0.451
PHIV/No Enc
-3.76
(-7.34, -0.19)
0.039
-5.11
(-7.46, -2.75)
<0.001
PHIV/With
-4.85
(-9.38, -0.32)
0.036
-3.66
(-6.74, -0.57)
0.02
Enc
Time T-score3
PHEU
Enc
BRIEF-PR
GEC T-score3
PHEU
Enc
BRI T-score3
PHEU
Enc
MI T-score3
PHEU
PHIV/No Enc
0.04
(-2.78, 2.85)
0.98
-1.89
(-4.58, 0.80)
0.169
PHIV/With
-0.04
(-5.64, 5.57)
0.99
-0.17
(-4.63, 4.28)
0.94
PHIV/No Enc
0.79
(-3.94, 5.52)
0.744
-0.65
(-4.91, 3.61)
0.765
PHIV/With
4.99
(-0.28, 10.27)
0.064
4.30
(-1.37, 9.97)
0.137
PHIV/No Enc
0.11
(-4.17, 4.40)
0.958
-1.40
(-5.49, 2.69)
0.502
PHIV/With
1.25
(-3.70, 6.20)
0.621
0.26
(-4.73, 5.24)
0.92
PHIV/No Enc
1.09
(-3.47, 5.65)
0.64
-0.14
(-4.13, 3.85)
0.947
PHIV/With
7.35
(2.22, 12.47)
0.005
7.06
(0.98, 13.14)
0.023
Enc
BRIEF-SR
GEC T-score3
PHEU
Enc
BRI T-score3
PHEU
Enc
MI T-score3
PHEU
Enc
Parameter estimates are adjusted odds ratios from an ordinal logistic regression model1, a logistic regression model2, and adjusted mean differences from a linear
regression model3. Adjusted models include adjustment for for age, gender, race, Hispanic ethnicity, caregiver relationship to the youth, caregiver education, English use in
the home, caregiver reported internalizing problems in the child, and site region. Perinatally HIV-exposed uninfected, PHEU; Perinatally HIV-infected, PHIV; No encephalopathy,
No Enc; Children’s Color Trails Test, CCTT; Behavior Rating Inventory of Executive Functions-Parent Report, BRIEF-PR; Behavior Rating Inventory of Executive Functions-Self
Report, BRIEF-SR; Global Executive Composite, GEC; Behavioral Regulation Index, BRI; Metacognition Index, MI. For the CCTT, higher percentiles and T-scores reflect better
performance; for the BRIEF, higher T-scores reflect report of more problems.