Analytical
Methods
CRITICAL REVIEW
Sequential injection lab-on-valve platform as a
miniaturisation tool for solid phase extraction
Cite this: Anal. Methods, 2013, 5, 585
Susana S. M. P. Vidigal,a Ildikó V. Tóthb and António O. S. S. Rangel*a
Received 20th September 2012
Accepted 21st November 2012
DOI: 10.1039/c2ay26322j
www.rsc.org/methods
There is a growing interest in the possibility to perform pre-concentration of analyte and its derivatization
with the aim of eliminating interferences, to increase the sensitivity and selectivity of analytical
methodologies. The manipulation of the solid phase in conventional analysis may involve the use of
relatively large amounts of solid phase. This limitation can be minimized by manipulation in flow
systems through the bead injection approach. In this scenario, sequential injection lab-on-valve (SI-LOV)
platform has proved to be a powerful tool in the automation of solid phase extraction, and is reviewed
in
this
paper.
Susana S.M.P. Vidigal is a PostDoc Researcher at Center for
Biotechnology and Fine Chemistry (CBQF) at Universidade
Católica Portuguesa, Escola
Superior de Biotecnologia (ESBUCP). She obtained a PhD in
Biotechnology with specialization in Chemistry at ESB-UCP,
a er
graduating
in
Microbiology
from the same institution. Her
research interests focus on
automation and miniaturization
of new analytical methodologies for wine monitoring using owbased systems. The developed methodologies use separation
procedures including solid phase spectrometry and low pressure
chromatography.
This journal is ª The Royal Society of Chemistry 2013
Ildikó V. Tóth is an assistant
researcher at the Requimte,
Faculty of Pharmacy at the
University of Porto. She received
a BSc in Food Engineering from
the Kertészeti és Élelmiszeripari
Egyetem (Budapest), and a PhD
in Biotechnology, specialty in
Chemistry, from the Universidade Católica Portuguesa,
Escola Superior
de
Biotecnologia (Porto). She is coauthor of 35 papers in international peer reviewed journals. Her current research interests
include chemical sensors for emerging environmental contaminants and laboratory automation.
Anal. Methods, 2013, 5, 585–597 | 585
Analytical Methods
ntónio O. S. S. Rangel is Associate Professor at the Universidade Católica Portuguesa,
Escola Superior de Biotecnologia
(ESB-UCP), Porto; he is a member
of the direction board of the
Center of Biotechnology and Fine
Chemistry. He obtained a degree
in Chemistry from the University
of Porto and a PhD in Biotechnology (specialisation in Chemistry) from ESB-UCP. He has coauthored more than 120 papers
in international journals and supervised 16 PhD theses. His
research interests are mainly focused on the development of ow
methods for the automation and miniaturization of (bio)chemical
assays, with applications in the food and environmental sectors.
586 | Anal. Methods, 2013, 5, 585–597
Critical Review
cell monitor the absorbance of the eluted phase post-column.
This journal is ª The Royal Society of Chemistry 2013
Critical Review
Analytical Methods
1
This journal is ª The Royal Society of Chemistry 2013
Anal. Methods, 2013, 5, 585–597 | 587