SECTION-A
No- 1 .Are the standard and recommended actions consistent with PCORI mission and vision?
Comment; Being transparent in developing policies to encourage public registration of all PCORI studies
and the sharing of study, protocols, statistical code, and data, there is nothing than a person of any race
that honors more than getting to know that he or she is dealing with people who are transparent and
much devoted in their work the way PCORI is with their staff in running their work in all ways and
means. In fact Neemeka herbal clinic and research centre honors nothing than being transparence in all
that it does on patients and in research study, so that patients gets the really high quality herbal
medicine findings needed especially on these chronic and multiple chronic diseases that can serve
patients on large scale population worldwide.
Forming a standing committee within PCORI to recommend appropriate methods for data sharing and
to ensure that proper scientific credit is given to those sharing protocols, code data, this shows PCORI’s
profile(layout)on how the organization operates is committed with their work by ensuring that proper
scientific credit is given to those sharing protocols, code and data.
Speeding up implementation of standards in funding announcements, peer, review and other internal
process, PCORI staff developed templates for the preparation and review of proposals that incorporate
the key elements of the standards; this makes the process of working to become very easy to operate or
to run in all channels of work, to be keenly monitored, since some standards apply only to certain types
of studies, a portfolio of templates applicable to various study designs should be developed.
Support development and use of software for adaptive trials that can stimulate complex designs,
broaden experience with adaptive trials for PCORI, perhaps through funding of a cohort of adaptive
trials on priority topic areas. Mentor investigators and develop a ‘how to’ guide and a forum to share
experiences with adaptive trials, develop a course work and training opportunities for statisticians and
other methodologists interested in developing expertise in adaptive trials. Sponsor an institute of
medicine committee to develop standards for research on medical tests.
NO-2. What methodological caps should be addressed in future report?
-Create an infrastructure to support research on patient engagement.
-Develop a sample patient engagement plan to demonstrate the key elements required for patient
engagement in the research process.
-The sample plan should illustrate engagement of both patient informants and study participants.
-Systematically collect information about patient engagement methods from PCORI sponsored studies.
-Evaluate the effectiveness of patient informant engagement.
-Synthesizes results across studies.
-Disseminate findings to improve patient engagement in PCOR.
-Support training in patient engagement methods for investigators and patient informants.
-Improve the patient-reported outcomes( PRO) evidence base by supporting research on methods for
assessing measurements properties ( based on qualitative and quantitative evaluations),score
interpretability,meangfulness of score changes and strategies for minimizing and interpreting missing
PRO data in PCOR.
-Evaluate patient dissemination activities and require incorporation in future research of relevant
learning from this evaluation.
3. Can this report be used to inform PCORI policy regarding grant reviews and submission?
Comments. Should ensure that a sufficient number and range of topics are considered, before topics for
research findings are selected. Engagement of multiple stakeholders, especially patients, involving
patients and other stakeholders in developing questions for systematic review, researchers can compare
what people want and need to know with what is and is not known. As a result, systematic reviews can
identify gaps in knowledge that underlie un certainty among patients and clinicians. Sometimes
systematic reviews can generate new questions. For example, a pooled analysis of several studies can
reveal an important finding that was not evident in the individual studies.
Value of information analysis may be used to identify questions that have the greatest potential to
improve population health by considering uncertainty in the health benefits and risks associated with
alternative treatment choices, the ability of research findings to alter uncertainty, and the resulting care
decisions. Reviews process identifies those proposals most likely to fulfill PCORI’s objective and agenda.
4. Do have any ideas about what the PCORI might distribute the final report to increase awareness and
application of the standards?
PCORI should develop and implement dissemination assessment to achieve broad awareness. P CORI
research proposals must include an assessment that describes how the project and composition of the
research team to support dissemination and the anticipated facilitators, barriers and potential
strategies for dissemination to key stakeholder groups, including patients and individuals at risk of
acodition,clinicians and other health care system staff, and policy leaders.
Effective dissemination should include the reports of results in a manner that is understandable to each
target audience, information regarding the relevance of the results for decision-making (recognizing that
research findings from a single study alone should not necessary affect decision-making or practice.) a
long with attention to how the results can be incorporated into health decision-making, if applicable,
the plan must specify how the dissemination strategy is expected to affect the identified health
decisions and how dissemination engages the study participants or the population of interest ,that
requires research dissemination, as well as engagement of patients and other stakeholders at this stage
of research to represent a cultural shift for institutions and researchers.
5- Enter any additional comments or concerns here.
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Neemeka herbal clinic and research centre the personnel investigator would like to upload full
findings that are in the letter of support of Kenya Medical Research Institute (Centre for
Traditional Medicine and Drug Research, P.O.BOX 54840-00200 NAIROBI, Kenya) Kemri and also
a letter of support Kenyatta University office of the chairman Department of Health Sciences,
Centre for Complementary Medicine and Biotechnology P.O Box 43844 Nairobi Kenya. Neemeka
herbal clinic and research centre plus entire staff is in atonally research of herbs that are
medicine for these chronic diseases. The centre is working round the clock in ensuring that they
in research high quality findings required for these chronic diseases. In the letter of Kenya
Medical Research Institute (Kemri) page2, second paragraph states that search of available
literature revealed no published report on the toxicity of s.longepedunculata in humans despite
the wide-spread use of the plant in various herbal remedies. Considering the potential toxicity of
s.longepedunculata, herbal practitioners should be educated on this especially when they
recommend this plant as part of complex regimen in the long term management of chronic
illness.
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Neemeka herbal clinic and research centre would like to appreciate and thank the entire staff of
PCORI about the good work they are doing for patients especially those with chronic and
multiple chronic diseases worldwide, working hand in hand in all means and ways in doing more
research and being honest in submitting the really high quality findings needed for these chronic
diseases that gathers large population worldwide. Neemeka herbal clinic and research centre
also reflects thanks giving to anybody whose main objective is putting patients first by funding
researchers in all means and ways as per research study is concerned, so that high quality
findings is achieved for these chronic diseases.
Neemeka herbal clinic and research centre is doing more research on Diseases like;
-Heart diseases
-Diseases of liver
-Kidney problems
-A.I.D.S Virus
-Diabetes
-Lungs problems
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