CURRCULUM VITAE
Yu-Chih Lo
Assistant Professor
Institute of Bioinformatics and Biosignal Transduction, National Cheng Kung University
No.1 University Road, Tainan
06-2757575 ext. 31208
Email: gracelo@mail.ncku.edu.tw
EDUCATION:
Ph.D. in Life Sciences, April 2004
Graduate Institute of Life Sciences
National Defense Medical Center, Taipei, Taiwan
Thesis: Studies of the crystal structures and substrate specificities of Escherichia
coli Thioesterase I/Protease I /Lysophospholipase L1
Advisor: Dr. Yen-Chyaw Liaw
Expertise: Structural Biology, Crystallography & Biochemistry
M.Sc. in Biotechnology, June 1997
Institute of Biotechnology
National Taiwan Ocean University, Keelung, Taiwan
Thesis: Expression and
characterization of recombinant
lipase 4 in Escherichia coli
Advisor: Dr. Shye -Jye Tang
Expertise: Molecular biology & Biotechnology
EXPERIENCE:
Research Assistant, July 1997 – July 1998
Institute of Biomedical Sciences
Academia Sinica, Taipei, Taiwan
Prof. Steve Roffler’s Lab
Candida
rugosa
POSTGRADUATE:
Postdoctoral Associate, Jan. 2005 - Jan. 2011
Department of Biochemistry
Weill Medical College of Cornell University, NY, USA
Dr. Hao Wu’s Lab
Postdoctoral fellow, April 2004 - Jan. 2005
Institute of Molecular Biology
Academia Sinica, Taipei, Taiwan
Dr. Yen-Chywan Liaw’s Lab
HONOR:
American Heart Association Postdoctoral Fellowship
U.S.A. July 2009 - Feb. 2011
Cancer Research Institute Postdoctoral Fellowship
NY, U.S.A. July 2005 - 2008
Associate Faculty Member of F1000 Biology
June 2008 - present
Publications:
1. Guozhou Xu, Yu-Chih Lo (Co-First Author), Qiubai Li, Gennaro Napolitano, Xuefeng
Wu, Xuliang Jiang, Michel Dreano, Michael Karin & Hao Wu. Crystal Structure of
Inhibitor of kB kinase β. (2011) Nature. Apr. 472: 325-332.
2. Su-Chang Lin, Yu-Chih Lo, and Hao Wu. Helical Assembly in the MyD88-IRAK4IRAK2 complex in TLR/IL-1R signaling. (2010) Nature. Jun 465: 885- 890.
3. Yu-Chih Lo, Su-Chang Lin, Carla C. Rospigliosi, Dietrich B. Conze, Chuan-Jin Wu,
Jonathan D. Ashwell, David Eliezer and Hao Wu. Structural Basis for Recognition of
Diubiquitin by NEMO. (2009) Mol. Cell. Mar 13;33(5):602-15.
4. Qian Yin, Su-Chang Lin, Yu-Chih Lo, Steven M. Damo, and Hao Wu. Tumor
Necrosis Factor Receptor-Associated Factors in Immune Receptor Signal Transduction.
(2009) Handbook of Cell Signaling 2nd edition. Oxford: Academic Press, Chapter 49.
339-345.
5. Hao Wu and Yu-Chih Lo. Structures, Domains and Functions in Cell Death (DD,
DED, CARD, PYD). (December 2009) Encyclopedia of Life Sciences (ELS). John Wiley
& Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0021579.
6. Qian Yin, Su-Chang Lin, Betty Lamothe, Miao Lu, Yu-Chih Lo, Gregory Hura, Lixin
Zheng, Rebecca L Rich, Alejandro D Campos, David G Myszka, Michael J Lenardo,
Bryant G Darnay and Hao Wu. E2 Interaction and Dimerization in the Crystal Structure
of TRAF6. (2009) Nature Structural & Molecular Biology 16, 658 – 666.
7. Hao Wu and Yu-Chih Lo and Su-Chang Lin. Recent Advances in Polyubiquitin Chain
Recognition. (2010) F1000 biology reports, 2:20.
8. Yu-Chih Lo, Maddineni U, Chung JY, Rich R, Myszka D and Hao Wu. High Affinity
Interaction Between IKKβ and NEMO. (2008) Biochemistry. Mar 11;47(10), 3109-16.
9. Su-Chang Lin, Jee Y. Chung, Betty Lamothe, Kanagalaghatta Rajashankar, Miao Lu,
Yu-Chih Lo, Amy Y. Lam, Bryant G. Darnay and Hao Wu. Molecular Basis for the
Unique Deubiquitinating Activity of the NF-kB Inhibitor A20. (2008) J. Mol. Biol. 376 ,
526-540.
10. Su-Chang Lin, Yihua Huang, Yu-Chih Lo, Maio Lu, Hao Wu. Crystal structure of the
Bir1 domain of XIAP in two crystal forms. (2007) J. Mol. Biol. 372,847-850.
11. Miao Lu, Su-Chang Lin, Yihua Huang, Young Jun Kang, Rebecca Rich, Yu-Chih Lo,
David Myszka, Jiahuai Han and Hao Wu. XIAP induces NF-kappaB activation via the
BIR1/TAB1 interaction and BIR1 dimerization. (2007) Mol. Cell 26: 689- 702.
12. Hyun Ho Park, Yu-Chih Lo, Su-Chang Lin, Liwei Wang, Jin Kuk Yang, Hao Wu.
The death domain superfamily in intracellular signaling of apoptosis and inflammation.
(2007) Annu. Rev. Immunol. 25: 561-586.
13. Qian Yin, Hyun Ho Park, Jee Y Chung, Su-Chang Lin, Yu-Chih Lo, S. da Graca 3
Li, Xuejun Jiang, and Hao Wu. Caspase-9 Holoenzyme is a specific and optimal
procaspase-3 processing machine. (2006) Mol. Cell, 22, 259-268.
14. Yu-Chih Lo, Su-Chang Lin, Jei-Fu Shaw and Yen-Chywan Liaw. Switch loop
governed substrate specificities of Escherichia coli Thioesterase I/Protease I
/Lysophospholipase L1 are governed by its switch loop movement. (2005) Biochemistry
44, 1971-9.
15. Su-Chang Lin, Yu-Chih Lo, Jung-Yiaw Lin and Yen-Chywan Liaw. Crystal
structures and electron micrographs of fungal volvatoxin A2. (2004) J. Mol. Biol. 343,
477-491.
16. Yu-Chih Lo, Su-Chang Lin, Jei-Fu Shaw and Yen-Chywan Liaw. Crystal structure of
Escherichia coli Thioesterase I/Protease I /Lysophospholipase L1: Consensus sequence
blocks constitute the catalytic center of SGNH-hydrolases through a conserved hydrogen
bond network. (2003) J. Mol. Biol. 330, 539-551.
17. Sergiy I. Tyukhtenko, Alexandra V. Litvinchuk, Chi-Fon Chang, Yu-Chih Lo, ShinJye Lee, Jei-Fu Shaw, Yen-Chywan Liaw, and Tai-Huang Huang. Sequential Structural
Changes of Escherichia coli Thioesterase/Protease I in the Serial Formation of Michaelis
and Tetrahedral Complexes with Diethyl p-Nitrophenyl Phosphate. (2003) Biochemistry
42, 8289 -8297.
18. Shye-Jye Tang, Jei-Fu Shaw, Kuang-Hui Sun, Guang-Huan Sun, Terng-Yuan Chang,
Ching-Kai Lin, Yuh-Chih Lo, and Guang-Chiun Lee. Recombinant Expression and
Characterization of the Candida rugosa lip4 Lipase in Pichia pastoris: Comparison of
Glycosylation, Activity, and Stability. (2001) Arch. Biochem. Biophys. 389, 93-98.
19. Kuang-Wen Liao, Wan-Chih Chou, Yu-Chih Lo, Steve R. Roffler. Design of
transgenes for efficient expression of active chimeric proteins on mammalian cells.
(2001) Biotechnolo. Bioeng. 73, Issue 4, 313-323.
20. Yu-Chih Lo, Ya-Lin Lee, Jei-Fu Shaw and Yen-Chywan Liaw. Crystallization and
preliminary X-ray crystallographic analysis of thioesterase I from Escherichia coli.
(2000) Acta Crystallogr. D 56, 756-757.
21. Kuang-Wen Liao, Yu-Chih Lo, Steve R. Roffler. Activation of lymphocytes by 4
anti-CD3 single -chain antibody dimers expressed on the plasma membrane of
tumorcells.(2000)Gene Therapy 7,339–347.
22. Wan-Chih Chou, Kuang-Wen Liao, Yu-Chih Lo, Shu Yaun Jiang, Ming Yang Yeh,
Steve R. Roffler. Expression of chimeric monomer and dimer proteins on the plasma
membrane of mammalian cells. (1999) Biotechnolo. Bioeng. 65, 339-347.