Virology Test #1 – Spring, 2014
NAME:____________________________________________________________
Instructions: This test has two parts. In Part I, answer 5 of the 6 questions clearly
indicating which questions you want me to grade (15 points each). Part II has one
essay worth 25 points. All students must answer that question.
Part 1: Answer 5 of the following 6 questions
Question 1: Write the number of the descriptor in Column B in the space next to its
matching term in Column A.
Column A
_______
Column B
gD
1. Required for replication of viral
DNA
2. Needed for maintenance of
Herpes latency
__________
VP16
__________
IE genes
__________
__________
Vector
polymerase processivity
factor
3. Needed for expression of late
genes
4. Transmits virus from one host
to another
5. Required for binding to host
cell
6. Required for packaging of viral
genome into capsid
7. Needed for expression of
immediate early genes
Question 2: How do common source epidemics differ from host to host epidemics?
State how each starts and describe (or draw) the typical disease outbreak pattern
that you would expect to see in each case.
Question 3: Briefly describe one biological, one social and one environmental factor
that can increase the occurrence or severity of disease outbreaks (and how it does
so).
Question 4: In order to replicate in permissive cells, viruses must be able to 1)
attach and enter the cell, to 2) replicate their nucleic acids and 3) express their
proteins before finally emerging from the host cell once again. List three specific
characteristics/components that our cells must have (one for each of the three
critical stages listed above; naming molecules, as appropriate) that make them
permissive to herpesvirus infections.
Question 5: Virus nucleic acids can be very different from ours. Tell what the
defining characteristics of Baltimore type III virus are, clearly defining the difference
between (+) and (-) nucleic acid strands.
Part Two Essay: List the steps in a typical epidemiological investigation of a disease
outbreak and then describe how you and your classmates have (or have not - yet)
dealt with each of those steps in our class “Outbreak San Diego!” scenario. Be
complete, making sure to describe the work of other teams, in addition to your own.
Given your answer, what do you think the class should prioritize (describe two
things) as it moves forward into the next phase of this outbreak investigation. (25
points).