DH206: Pharmacology
Chapter 4 Practice
1. Sympathetic activation produces all of the following effects EXCEPT which one?
a. Relaxation of urinary bladder
b. Increased heart rate
c. Pupillary dilation
d. Bronchoconstriction
2. The sympathetic postganglionic nerve ending releases
a. Epi
b. Norepi
c. ACH
d. Dopamine
3. The NT released at both sympathetic and parasympathetic ganglion is
a. ACH
b. Dopamine
c. Epi
d. Norepi
4. Somatic nerves send nerve impulses to:
a. Smooth muscle
b. Skeletal muscle
c. Cardiac muscle
d. Visceral organs
5. During the fight or flight reaction, the adrenal medulla predominately releases:
a. ACH
b. Norepi
c. Epi
d. Dopamine
6. Which of the following belong in the CNS?
a. Spinal cord
b. Cranial nerves
c. Spinal nerves
d. Brain
7. Which of the following belong in the PNS?
a. Spinal cord
b. Cranial nerves
c. Spinal nerves
d. Brain
8. Which of the following NT work on the cholinergic nerves?
a. Norepi
b. Epi
c. Catecholamine
d. ACH
9. The neurotransmitter released from the post ganglionic ending of a SANS fiber.
a. Epinephrine
b. Norepinephrine
c. ACH
10. What happens when the parasympathetic nervous system is activated?
a. All nerves are activated
b. Specific nerves are stimulated
c. The whole body is stimulated
d. No nerves are activated
11. Match the following effects of nervous system activation with the correct division
a. Parasympathetic
b. Sympathetic
1) Increase GI motility
2) Urinary bladder relaxation
3) Increased heart rate
4) Pupil constriction
5) Urinary sphincter relaxation
6) ACH released
7) Vasoconstriction
8) Increased heart contractility
12. Parasympathetic receptors located on the membranes of the internal organs are classified as:
a. Alpha-1
b. Nicotinic-neural
c. Nicotinic-muscle
d. Muscarinic
13. Select the pharmacologic effect produced by cholinergic drugs.
a. Increased heart rate
b. Increased GI motility
c. Decreased urination
d. Pupillary dilation
14. Pilocarpine is classified as a(an):
a. Direct-acting cholinergic drug
b. Reversible anticholinesterase inhibitor
c. Irreversible anticholinesterase inhibitor
d. Anticholinergic drug
15. Physostigmine (Eserine) is classified as a(an):
a. Direct-acting cholinergic drug
b. Reversible anticholinesterase inhibitor
c. Irreversible anticholinesterase inhibitor
d. Anticholinergic drug
16. Symptoms of cholinergic drug over-dosage include
a. Slow pulse rate
b. Increased urination
c. Diarrhea
d. All of the following
17. Treatment of cholinergic drug over-dosage is accomplished with
a. Atropine
b. Pilocarpine
c. Physostigimine
d. Bethanechol
18. Anticholinergic actions include all of the following EXCEPT
a. Bronchodilation
b. Increased heart rate
c. Increased GI activity
d. Decreased respiratory secretions
19. The antidote for atropine poisoning is
a. Scopolamine
b. Bethanechol
c. Neostigmine
d. Physostigmine
20. Tolterodine (Detrol) is indicated for treatment of
a. Motion sickness
b. Relief of urinary incontinence
c. Ophthalmic exams
d. Glaucoma
21. Which of the following are used for the treatment of myasthenia gravis?
a. Tensilon
b. Mytelase
c. Prostigmin
d. Mestinon
22. Select the conditions produced by anticholinergic drugs. SELECT ALL THAT APPLY.
a. Mydriasis
b. Relax smooth muscle
KNOW THIS!
c. Decrease salivation
d. Sedation
23. Which of the following are NOT cholinergic receptors?
a. Muscarinic
b. Nicotinic-neural
c. Nicotinic-muscle
d. Sympathomimetic
24. Pick the correct pharmacological effects of direct-acting cholinergic drugs.
a. Respiratory paralysis
b. Urinary retention
c. Increased heart rate
d. Bronchodilation
25. Which of the following would be a preferred treatment for overactive bladder?
a. Cognex
b. Detrol
c. Pilocar
d. Bentyl
26. The main pharmacologic effect of norepi on alpha-1 receptors is:
a. Increase heart rate
b. Bronchodilation
KNOW THIS!
c. Vasoconstriction
d. Contraction of urinary bladder
27. Epi stimulates
a. Alpha receptors
b. Beta-1 receptors
KNOW THIS!
c. Beta-2 receptors
d. All of the above
28. At therapeutic doses, albuterol stimulates
a. Alpha receptors
b. Beta-1 receptors
c. Beta-2 receptors
d. All of the above
29. Which of the following agents is used in the treatment of glaucoma? SELECT ALL THAT APPLY.
a. Cholinergic
b. Anticholinergic
KNOW THIS!
c. Sympathomimetic
d. Sympatholytic
30. Propranolol is classified as a(an)
a. Alpha blocker
KNOW THIS!
b. Nonselective beta-blocker
c. Selective beta-1 blocker
d. Adrenergic neuronal blocker
31. The drug of choice to treat acute allergic reactions is
a. Norepi
b. Phenylephrine
c. Pseudoepherdrine
d. Epi
32. Select all the processes that occur with stimulation of a beta receptor
a. Decreases artery constriction
b. Increases heart rate
KNOW THIS!
c. Relaxes smooth muscle
d. Dilation of pupils
33. Which receptor is responsible for vasodilation & constriction?
a. Alpha-1
b. Alpha-2
KNOW THIS!
c. Beta-1
d. Beta-2
34. Which of the following are actions of beta-adrenergic blocking drugs?
a. Decreasing heart activity
b. Preventing NE from working
c. Interfere with lipid metabolism
d. Lowering blood pressure
e. Vasodilation
35. Select the effects of epi on the body
a. Bronchodilation
b. Vasoconstriction
c. Relaxation of uterus
d. Increased heart conduction
Match the definitions or descriptions in the left column with the appropriate terms in the right column
36. Drug that blocks or decreases sympathetic nervous
system activity
37. Drug that acts at the neuronal endings to reduce the
formation or release of NE
38. Receptor that mediates smooth muscle contraction
39. Adrenergic receptor located on either the heart or
smooth muscle
40. Drug that blocks both beta-1 and beta-2 effects of epi
41. Drug that blocks alpha effects of Norepi and epi
42. Chemical classification of norepi and epi
43. Adrenergic drug or effect that increases sympathetic
nervous system activity
44. Hormone released from the adrenal medulla that
stimulates the sympathetic nervous system
a. Adrenergic neuronal blocker
b. Alpha-blocker
c. Alpha-receptor
d. Beta receptor
e. Catecholamine
f. Epi
g. Nonselective beta blocker
h. Sympatholytic
i. Sympathomimetic
45. In the ANS, the target organ is innervated by the __________ neuron.
a. Preganglionic afferent
b. Preganglionic efferent
KNOW THIS!
c. Postganglionic afferent
d. Postganglionic efferent
46. The neurotransmitter released from a preganglionic neuron in the sympathetic division of the
ANS is:
a. Epinephrine
b. Norepinephrine
c. Dopamine
d. Acetylcholine
47. Which of the following substances will block the action of acetylcholine at the postganglionic
endings in the PANS?
a. Atropine
b. Pilocarpine
c. Hexamethonium
d. Acetic acid
48. Which of the following statements is true concerning direct- and indirect-acting cholinergic
agents?
a. A direct agent causes release of neurotransmitter and an indirect agent acts on the
receptor.
b. The indirect-acting agents include the choline derivatives and pilocarpine.
c. The indirect-acting cholinesterase inhibitors act by stimulating release of acetylcholine.
d. Inhibiting the enzyme that normally destroys acetylcholine results in stimulation of the
PANS.
49. The direct effect of acetylcholine on the heart is:
a. Negative chronotropic and negative inotropic
b. Positive chronotropic and positive inotropic
c. Negative chronotropic and positive inotropic
d. Positive chronotropic and negative inotropic
e. None of the above
50. Which of the following choices is true concerning the pharmacologic effects associated with
cholinergic agents?
a. Decrease urinary incontinence
b. Stasis of intestinal motility
c. Miosis
d. An increase in intraocular pressure
51. The acronym SLUD denotes adverse reactions associated with administration of __________
agents.
a. Cholinergic
KNOW THIS!
b. Anticholinergic
c. Adrenergic
d. Antiadrenergic
52. Which of the following conditions is not a relative contraindication or caution with the use of
cholinergic agents?
a. Bronchial asthma
b. Hypothyroidism
c. Myasthenia gravis treated with neostigmine
d. Peptic ulcer
53. Muscarinic receptors are associated with:
a. PANS
KNOW THIS!
b. SANS
54. Anticholinergics:
a. Accelerate gastric emptying
b. Decrease gastric motility
c. Cause miosis
d. Do not have an effect on heart rate
55. Which of the following categories of ANS agents can cause an acute rise in intraocular pressure
in patient with narrow-angle glaucoma?
a. Cholinergic
b. Anticholinergic
56. Stimulation of β2-receptors results in:
a. Vasoconstriction of skin and skeletal muscle
KNOW THIS!
b. Increase in heart rate and force of contraction
c. Smooth-muscle relaxation
d. Bronchoconstriction
57. Sympathomimetic agents will stimulate salivary flow from which of the following salivary
glands? (1) parotid, (2) submandibular, (3) sublingual
a. 1, 2, 3
b. 1, 2
c. 1, 3
d. 2, 3
58. Sympathomimetic agents should be used with caution in patients with (1) angina, (2)
hypertension, (3) hypothyroidism.
a. 1, 2, 3
b. 1, 2
c. 1, 3
d. 2, 3
59. Patients pretreated with __________ are prone to epinephrine reversal.
a. Cholinergic agents
b. Anticholinergic agents
c. α-Adrenergic agents
d. α-Adrenergic blocking agents
60. All of the ANS drug classes can be used safely in patients with glaucoma EXCEPT which one?
a. Cholinergic agents
b. Anticholinergic agents
c. Sympatholytic
d. Sympathomimetic
61. Which agent would you use for nasal congestion?
a. Cholinergic agents
b. Anticholinergic agents
c. Sympatholytic
d. Sympathomimetic
62. Which of the following classes of drug has no clinical use?
a. Alpha-1 blocker
b. Alpha-2 blocker
c. Beta-1 blocker
d. Beta-2 blocker
63. Which of the following drug classes can be used in the treatment of Raynaud’s?
a. Cholinergic agents
b. Anticholinergic agents
c. Sympatholytic
d. Sympathomimetic
64. The stimulation of which receptor can result in vasodilation.
a. Alpha-1
b. Alpha-2
c. Beta-1
d. Beta-2
65. The stimulation of which receptor can result in vasoconstriction.
a. Alpha-1
b. Alpha-2
c. Beta-1
d. Beta-2
66. Which of the following drug classes can cause vasodilation? SELECT ALL THAT APPLY.
a. Sympathomimetic alpha-1
b. Sympathomimetic alpha-2
c. Sympathomimetic beta-1
d. Sympathomimetic beta-2
e. Sympatholytic alpha-1
f. Sympatholytic alpha-2
g. Sympatholytic beta-1
h. Sympatholytic beta-2
67. If a patient was in heart failure, they could be taking a sympathomimetic beta-1 selective drug.
However, if the patient had hypertension, they could be taking a sympatholytic beta-1 or
sympathomimetic alpha-2 drug.
a. Both statements are true
b. Both statements are false
c. The first statement is true, the second is false
d. The first statement is false, the second is true
68. List all the conditions a patient could be taking a nonselective beta-blocker for.
ANSWERS
1.D
2.B
3.A
4.B
5.C
6.A,D
7.B,C
8.D
9.B
10.B
11.
A,B,B,A,A,A,B,B
12. D
13. B
14. A
15. B
16. D
17.A
18. C
19. D
20.B
21. C,D
22. A,B,C,D
23. D
24. B
25. B
26. C
27. D
28. C
29. A,D
30. B
39. D
40. G
41.B
42.E
43.I
44.F
45.D
46.D
47.A
48.D
49.A
31.D
32.B,C
33.A
34.A,B,C,D
35.A,B,D
36.H
37.A
38.C
50.C
51.A
52.B
53.A
54.B
55.B
56.C
57.D
58.B
59.D
60. B
61. D
62. D
63. C
64. D
65. A
66. D,E
67. A