Dr. Vajihe Akbari
PhD of Pharmaceutical Biotechnology
Corresponding address:
Department of pharmaceutical biotechnology, Faculty of pharmacy and pharmaceutical
sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Phone: 0098 3117922571
Email : v_akbari@pharm.mui.ac.ir
Educational Background:
Pharm .D
Faculty of pharmacy, Kerman, Iran, 2002-2008
Titles of Pharm.D 's thesis:
Preparation, characterization and cytotoxicity evaluation of ciprofloxacin loaded niosomes
PhD
Faculty of pharmacy, Isfahan, Iran, 2009-2014
Title of PhD 's thesis
Construction, expression and biological activity evaluation of a single-chain Fv antibody fragment
specific for domain II of HER2 receptor in Escherichia coli
Experience:
Scientific referee in 15th Iranian Seminar of Pharmacy Students (ISPS) (2010).
Editorial assistants of Research in Pharmaceutical Sciences journal. A biannually publication
of school of pharmacy and pharmaceutical sciences, Isfahan university of medical sciences,
Isfahan, Iran.
Editorial board of Drug Information Journal. A monthly publication of student research
committee of school of pharmacy and pharmaceutical sciences, Kerman, Iran.
Poster Presented at Conferences:
Feizizadeh Sahar, Abbas Jafarian Dehkordi, Daryoush Abedi, and Vajihe Akbari. "Evaluation
of antibacterial activity of Lactobacillus delbrueckii susp bulgaricuis against Escherichia
coli" ECB15, 15th European Congress on Biotechnology, Istanbul, Turkey, 23-26 Sep. 2012.
The abstract was indexed by New Biotechnology 29 (2012): S126-S127.
Akbari Vajihe, Daryoush Abedi, Hamid Mir Mohammad Sadeghi, Abbas Jafrian-Dehkordi,
and Perry Chou. "Cloning, expression and purification of a single chain variable fragment
antibody against Her2 in Escherichia coli." ECB15, 15th European Congress on
Biotechnology, Istanbul, Turkey, 23-26 Sep. 2012. The abstract was indexed by New
Biotechnology 29 (2012): S117.
V. Akbari, H. Sadeghi, D. Abedi, A. Pardakhty, S. Shafizadegan, Antimicrobial properties of
non-ionic surafactant vesicles containing ciprofloxacin, The 12th Iranian Pharmaceutical
sciences conference. The abstract was indexed by Research in Pharmaceutical Sciences,
2012; 2012;7(5) S15.
A. Jafarian Dehkordi, D. Abedi, V. Akbari, S. Feizizadeh, Evaluation of anti-bacterial and
anti-adherence properties of Lactobacillus delbrueckii susp bulgaricuis on Escherichia coli,
The 12th Iranian Pharmaceutical sciences conference. The abstract was indexed by Research
in Pharmaceutical Sciences, 2012; 2012;7(5) S411.
Akbari.V, Sadeghi. H, Abedi. D, Pardakhty.A (2011). In-vitro antimicrobial activity of
niosomal ciprofloxacin in comparison with free ciprofloxacin . The 1th Internarional and 12th
Iranian congress of microbiology (international).
Akbari.V, Pardakhty.A, Moshafi.M.H (2010). Preparation, characterization and cytotoxicity
evaluation of ciprofloxacin loaded niosomes . The 12th Iranian Pharmaceutical sciences
conference (international).
Akbari.V, Pardakhty.A, Moshafi.M.H (2008). Intracellular delivery of niosomal
ciprofloxacin in J774 cell line. The 11th Iranian Pharmaceutical sciences conference
(international).
Akbari.V, Pardakhty.A, Moshafi.M.H (2006). Formulation of non ionic surfactant vesicles
(niosom) containing ciprofloxacin. The 12th Seminar of Iranian Pharmacy Students.
Akbari.V, Mehrabani.M, Moshafi.M.H (2005). Evaluation of antibacterial effect of Maclura
pomifera extract by cylinder plate method. The 11th Seminar of Iranian Pharmacy Students.
Electronic poster Presented at Conferences:
Akbari.V, Mofid MR. (2011). Binding mode of microtubule stabilizing agents to yeast tubulin.
The 12th Iranian Congress of Biochemistry & 4th International Congress of Biochemistry and
Molecular Biology. (international) The abstract was indexed by Clinical Biochemistry, Volume
44, Issue 13, Supplement, September 2011, Page S101
Oral Presented at Conferences:
Akbari.V, Pardakhty.A, Moshafi.M.H (2007). Enhancement of encapsulation efficacy of
ciprofloxacin in noiosomal vesicles by remote loading method. The 13th Seminar of Iranian
Pharmacy Students
Awards and Honors:
Rewarded for been second in 16th generation of graduated students of Pharmacy of Kerman
university of medical science.
Rewarded for been third in pharmaceutics science of the 12th Seminar of Iranian Pharmacy
Students.
Rewarded for been fifth in 22th exam of pharmaceutical basic science of Iranian pharmacy
students.
Training workshop:
Attended and successfully completed the theoretical and practical training workshop entitled
How to present an academic paper on April 10, 2011.
Attended and successfully completed the theoretical and practical training workshop entitled
Systematic Review on January 23-24, 2011.
Attended and successfully completed the theoretical and practical training workshop entitled
Ultera Performance Liquid Chromatography (UPLC) on January 18, 2011.
Attended and successfully completed the theoretical and practical training workshop entitled
EndNote on September 4-5, 2010.
Attended and successfully completed the theoretical and practical training workshop entitled
SPSS on July 4-7, 2010.
Attended and successfully completed training workshop entitled effective relationship on
June 20-21, 2010.
Attended and successfully completed the theoretical and practical training workshop entitled
Real Time PCR on August 19, 2008.
Attended and successfully completed the training workshop entitled Life Skills on January
23, 2006.
Basic research skills:
-Familiar with Windows, Microsoft office abilities.
-Familiar with search methodology in the scientific data bases such as Medline.
-Familiar with Endnote software in managing research reports/manuscript/papers.
Professional skills:
Experiences on molecular modeling and docking small molecules in proteins using softwares
such as PyMol, Auto Dock.
Experiences on molecule manipulation and analysis, sequence analysis, and synthetic gene
design using softwares such VectorNTi, Gene Designer.
Familiar with search (DNA/RNA , protein molecules, enzymes, single nucleotide
polymorphism and BLAST search) in the data bases such as PDB, Expasy and Pubmed.
Evaluation of cytotoxic activity of compounds against cancer/ normal cell lines (in vitro:
cell culture assays).
Some experiences on Intracellular infection models to evaluate efficacy of drug carriers for
intracellular delivery of antimicrobial agents. (in-vitro).
Research and Projects:
No
Title
1
Antimicrobial evaluation of
ciprofloxacin loaded niosomes
against intracellular
Staphylococcus aureus infection
in mouse J774 macrophages
2
Director/cooleague
Second director
Construction, expression and
Second director
biological activity evaluation of
a single-chain Fv antibody
fragment specific for domain II
of HER2 receptor in Escherichia
coli
Date
2010
Grant
University of
Medical
Sciences
(Isfahan, Iran)
2011
University of
Medical
Sciences
(Isfahan, Iran)
Patent
Single chain antibody specific for HER2
Iran patent patent number:80466
Publications:
a ) Books
'The vaccines and their application in prevent and treatment of disease', in
Persian.
‘Biological product Vaccines’ , in Persian
‘Blood biologiacal products’ , in persian
b.) Articles published in ISI Journals:
1. Comparison of epothilone and taxol binding in yeast tubulin using molecular modeling.
Vajihe Akbari, Sharareh Moghim and Mohammad Reza Mofid, Avicenna Journal of Medical
Biotechnology. 2011;3(4):167-76.
2. Optimization of the Expression of Genes Encoding Poly (3-hydroxyalkanoate) Synthase
from Pseudomonas aeruginosa PTCC 1310 in Escherichia coli. Daryoush Abedi, Maryam
Beheshti, Ali Jahanian Najafabadi, Hamid Mir Mohammad Sadeghi, and Vajihe Akbari,
Avicenna Journal of Medical Biotechnology. 2012;4(1):47-51.
3. Comparison of five methods for extraction of genomic DNA from a marine Archaea,
Pyrococcus furiosus. Hamid Mirmohammadsadeghi, Daryoush Abedi, Hamid Reza
Mohmoudpour and Vajihe Akbari, Pakistan Journal of Medical Sciences.
2013;29(1)Suppl:390-394.
4. Ciprofloxacin nano-niosomes for targeting intracellular infections: an in vitro evaluation.
Vajihe Akbari, Daryoush Abedi, Abbas Pardakhty and Hojjat Sadeghi-Aliabadi, Journal of
Nanoparticle Research. 2013; 15(4):1-14.
5. In vitro anti-bacterial and anti-adherence effects of Lactobacillus delbrueckii subsp
bulgaricus on Escherichia coli. Daryoush Abedi, Sahar Feizizadeh, Vajihe Akbari and
Abbas Jafarian-Dehkordi. Research in Pharmaceutical Sciences. 2013;8(4):261-8.
6. Akbari Vajihe, Mir Mohammad Sadeghi Hamid, Jafrian-Dehkordi Abbas, Abedi
Daryoush, Chou CPerry. Functional expression of a single-chain antibody fragment against
human epidermal growth factor receptor 2 (HER2) in Escherichia coli. J Ind Microbiol
Biotechnol. 2014;41(6):947-56.
7. Feizizadeh Sahar, Salehi-Abargouei Amin, Akbari Vajihe. Efficacy and Safety of
Saccharomyces boulardii for Acute Diarrhea. Pediatrics. 2014:peds. 2013-3950.
8. Akbari Vajihe, Mir Mohammad Sadeghi Hamid, Jafarian-Dehkordi Abbas, Chou C Perry,
Abedi Daryoush. Optimization of a single-chain antibody fragment overexpression in
Escherichia coli using response surface methodology. Research in Pharmaceutical Sciences.
2014;10(1):65-73.