8:00am Registration
8:50am Opening ceremony
9:00am Plenary lecture
Multiscale modeling of skeletal strength: achievements and open challenges
Viceconti, Marco
9:45am MUSCULOSKELETAL MODELING
Hybrid neuromusculoskeletal modeling of the human lower extremity
Sartori, Massimo; Lloyd, David G.; Farina, Dario
IMAGING / TRANSPORT
Multiscale modelling of the human hepatic perfusion
Debbaut, Charlotte; Monbaliu, Diethard; Cornillie, Pieter;
Casteleyn, Christophe; Dierick, Manuel; Segers, Patrick
Subject-specific versus scaled-generic musculoskeletal modeling: a case study using the
NMSBuilder software
Valente, Giordano; Pitto, Lorenzo; Bisi, Maria Cristina;
Stagni, Rita; Cristofolini, Luca; Taddei, Fulvia
Variation in estimated contact and muscle forces
Wesseling, Mariska; Derikx, Loes; Meyer, Christophe; de
Groote, Friedl; Desloovere, Kaat; Verdonschot, Nico;
Jonkers, Ilse
A clinical web app for patient-specific multiscale simulations to plan vascular access surgery
Manini, Simone; Antiga, Luca; Huberts, Wouter; Remuzzi,
Andrea
Intrinsic signal quantification of bioluminescent light emitted from 3D cell culture systems
Lambrechts, Dennis; Roeffaers, Maarten; Kerckhofs,
Greet; Vande Velde, Greetje; Van de Putte, Tom;
Schrooten, Jan; Van Oosterwyck, Hans
Computational evaluation of the ANN approach for the prediction of proximal femoral loads
Garijo, Noelia; García-Aznar, José Manuel; Pérez, Mª
Ángeles
Spatial variability in cytosolic calcium transients in urothelial cells following wounding
Appleby, Peter; Walker, Dawn; Shabir, Saqib; Southgate,
Jennifer
10:45am Coffee
11:15am Plenary lecture
Predictive and mechanistic models of signalling networks from (phospho)proteomic data and prior knowledge
Saez-Rodriguez, Julio
12:00pm BONE MECHANICS I
Case specific finite element analysis of the strains experienced by osteocytes
Varga, Peter; Pacureanu, Alexandra; Langer, Max; Hesse,
Bernhard; Peyrin, Françoise; Raum, Kay
COMPUTATIONAL BIOLOGY (MOLECULAR SIGNALING)
DNA-methylation profiles in hyperplastic tissues
Przybilla, Jens; Binder, Hans; Loeffler, Markus; Galle,
Joerg
The role of local bone mineralization for mechanical strain amplification
Schneider, Philipp; Ruffoni, Davide; Sommer, Remo;
Chiapparini, Ilaria; Müller, Ralph
Mathematical modeling of endochondral ossification through mutual inhibition and bistability
Germain, Morgan; Kerkhofs, Johan; Geris, Liesbet
A new method to implement anisotropy in clinical continuum-FE analyses of the proximal femur
Hazrati Marangalou, Javad; Ito, Keita; Taddei, Fulvia; van
Rietbergen, Bert
Modeling signaling pathways in chondrocytes
Melas, Ioannis N; Chairakaki, Aikaterini D; Mitsos,
Alexander; Dailiana, Zoe; Provatidis, Christopher;
Alexopoulos, Leonidas G
Estimation of femoral FE strength for the fracture prediction in retrospective and prospective studies
Falcinelli, Cristina; Schileo, Enrico; Sigurdsson, Sigurdur;
Gudnason, Vilmundur; Taddei, Fulvia
Construction of an in silico model of hyaline cartilage and use for in silico experiments
Scholma, Jetse; Kerkhofs, Johan; Schivo, Stefano; Van de Pol, Jaco; Langerak, Rom; Van der Vet, Paul;
Karperien, Marcel; Geris, Liesbet; Post, Janine
1:00pm Lunch
2:30pm Plenary lecture
Multiscale models of tumor angiogenesis and therapeutic applications

3:15pm
Popel, Aleksander
ORTHOPAEDIC BIOMECHANICS
Screw insertion has a negative impact on periimplant bone quality
Steiner, Juri A.; Ferguson, Stephen J.; van Lenthe, G.
Harry
Multisite measure of micromotions around a cementless femoral stem in compression and torsion
Malfroy Camine, Valérie; Bauduin, Pierrick; Rüdiger,
Hannes; Pioletti, Dominique; Terrier, Alexandre
COMPUTATIONAL BIOLOGY (MULTI-SCALE)
Uncovering new mechanisms of individual stalk cell movement in angiogenesis: an in silico/in vivo approach
Bentley, Katie; Gerhardt, Holger
To heal or not to heal: modeling the influence of oxygen during fracture healing
Carlier, Aurélie; Geris, Liesbet; Van Oosterwyck, Hans
The influence of unilateral total hip arthroplasty on contact mechanics of non-operated limbs
Li, Junyan; Stewart, Todd; Jin, Zhongmin; Fisher, John;
Wilcox, Ruth
How tip cells contribute to Angiogenesis: Exploring specialized cell behavior in a cell-based model
Palm, Margriet M.; van Dijk, Erik; Merks, Roeland M.H.
A phenomenological model for the immunity response
Vermolen, Fred; Mul, Mathias; Gefen, Amit
A clustering model for the musculoskeletal disorders with fused data from multiple sources
Hoang, Tuan Nha; Dao, Tien Tuan; Denoeux, Thierry; Ho
Ba Tho, Marie Christine
4:15pm Poster session
7:00pm Reception

9:00am Plenary lecture
In-silico organogenesis: multiscale modeling of limb development driven by quantitative imaging
9:45am BONE REMODELING I
On Wolff's Law in human bone
Christen, Patrik; Ito, Keita; Ellouz, Rafaa; Boutroy,
Stephanie; Sornay-Rendu, Elisabeth; Chapurlat, Roland; van Rietbergen, Bert
COMPUTATIONAL BIOLOGY (TISSUE ORGANIZATION)
A gene regulatory network model to assess the stability of the cartilage phenotype
Kerkhofs, Johan; Van Oosterwyck, Hans; Geris, Liesbet
Time-lapsed in vivo monitoring of peri-implant bone remodeling in a mouse model
Li, Zihui; Kuhn, Gisela; von Salis-Soglio, Marcella; Cooke,
Stephen John; Schirmer, Michael; Zimmermann,
Hanngörg; van Lenthe, G. Harry; Müller, Ralph; Ruffoni,
Davide
Cell-based modelling of phenotypic plasticity in healthy and cancerous tissues
Szabó, András; Merks, Roeland M.H.
Bone remodelling analysis of the scapula after a total shoulder arthroplasty
A cell-regulatory mechanism between wound contraction and tissue formation
Valero, Clara; Javierre, Etelvina; García-Aznar, José
Manuel; Gómez-Benito, María José
Quental, Carlos; Folgado, Joao; Fernandes, Paulo;
Monteiro, Jacinto
A self-organizing model of intestinal crypt morphology
Buske, Peter; Przybilla, Jens; Loeffler, Markus; Galle,
Joerg
Mechanobiological model for the simulation of
BMDD - Long-term effects of osteoporosis treatment
Santos, Luís; Fernandes, Paulo Rui; Rodrigues, Hélder;
Fonseca, João Eurico
10:45am Coffee
11:15am Plenary lecture
In-silico mechanobiology of bone
Müller, Ralph
12:00pm BONE REMODELING II
Long-term in silico bone adaptation in highresolution human bones
Badilatti, Sandro Domenico; Levchuk, Alina; Webster,
Duncan James; Müller, Ralph
CARTILAGE / CARDIOVASCULAR MECHANICS
Deciphering mechanoregulation of chondrogenic differentiation of human mesenchymal stem cells in fibrin-polyurethane composite scaffolds
Zahedmanesh, Houman; Stoddart, Martin; Lezuo, Patrick;
Alini, Mauro; Van Oosterwyck, Hans
Analytical and µFE-based modeling approaches for multiscale bone remodeling simulation studies A damage model for articular cartilage
Colloca, Michele; Ito, Keita; Van Rietbergen, Bert van Donkelaar, Corrinus C; Hosseini, Sayyed M; Wilson,
Wouter; Ito, Keita
A computational model for mechanostat regulation in bone based on biochemical osteocyte feedback
Pivonka, Peter; Buenzli, Pascal; Scheiner, Stefan;
Hellmich, Christian; Dunstan, Collin; Johnson, Mark;
Bonewald, Lynda
The improved elasticity-palpography technique: in vivo detection of vulnerable atherosclerotic plaques
Ohayon, Jacques; Deleaval, Flavien; Bouvier, Adeline; Le
Floc'h, Simon; Finet, Gérard; Cloutier, Guy; Pettigrew,
Roderic I.
Towards the creation of patient-specific bone remodeling models
Garijo, Noelia; Walscharts, Steven; Pérez, Mª Ángeles;
Vigneron, Lara; Vander Sloten, Jos; van Lenthe, Harry;
García-Aznar, José Manuel
Noninvasive constitutive model parameter identification method for arterial tissue
Smoljkic, Marija; Vander Sloten, Jos; Famaey, Nele
1:00pm Lunch
2:30pm Plenary lecture
Patient-specific image-based neurovascular modeling and interventional planning
Frangi, Alejandro
3:15pm CARDIOVASCULAR MECHANICS I
2D intracardiac flow estimation by combining speckle tracking with navier-stokes based
SPINE
Early degenerated lumbar motion segment: are they truly unstable?

regularization: a validation study
Gao, Hang; Bijnens, Nathalie; Coisne, Damien; Lugiez,
Mathieu; Kremer, Florence; Choi, Hon Fai; Rutten, Marcel;
D'hooge, Jan van Rijsbergen, Marc; Barthelemy, Véronique; Vrancken,
Anne; Crijns, Sjoerd; Wilke, Hans-Joachim; Ito, Keita
Factors influencing finite element models of functional spinal units and facet joint interactions
Multiphysics modeling to support the development of vascular ultrasound imaging
Tarsuslugil, Sami Metin; Hall, Richard M; Wilcox, Ruth K
Swillens, Abigail Emily; Lovstakken, Lasse; Degroote,
Joris; Vierendeels, Jan; Segers, Patrick
Investigating the effect of vertebroplasty on complex vertebral fractures
Koh, Ilsoo; Marini, Giacomo; Vogt, Patrick J; Ferguson,
Stephen J Computational modelling of aneurysm risk in giant cell arteritis (GCA)
Manhas, Varun; Piper, Jennifer E; Singh, Surjeet;
Ventikos, Yiannis; Luqmani, Raashid A
Simulating collagen phenotype and lamellae stiffness distribution in the intervertebral disc
Marini, Giacomo; Ferguson, Stephen J
Impact of pericardial effusion on cardiac mechanics in patients with dilated cardiomyopathy
Pasta, Salvatore; Scardulla, Francesco; Scardulla, Cesare
4:15pm Coffee
4:45pm MULTISCALE / SOFT TISSUE BIOMECHANICS
Elastic properties of the mineralized turkey leg tendon: experiment and model
Tiburtius, Sara; Schrof, Susanne; Varga, Peter; Raum,
Kay; Grimal, Quentin; Gerisch, Alf
COMPUTATIONAL BIOLOGY (CELL-MATRIX
INTERACTION)
Endothelial cell-fibrin interactions during blood vessel growth
Boas, Sonja E.M.; Weijers, Ester M.; Koolwijk, Pieter;
Merks, Roeland M.H.
A quantitative multiscale approach to the fibrillar structure and elasticity of collagen
Morin, Claire; Hellmich, Christian; Henits, Peter
A numerical model of tissue adaptation by cell traction and collagen remodeling
Heck, Tommy AM; Wilson, Wouter; Foolen, Jasper; Ito,
Keita; van Donkelaar, Corrinus C
Development and validation of a patient-specific finite element head model
Tse, Kwong Ming; Tan, Long Bin; Lim, Siak Piang; Lee,
Heow Pueh
Matrix geometry determines optimal cancer migration strategy and modulates response to intervensions
Tozluoglu, Melda; Tournier, Alexander L.; Jenkins, Robert
P.; Manning, Cerys S.; Bates, Paul A.; Sahai, Erik
Dynamic finite element modeling of transcrestal sinus membrane elevation for maxillary bone augmentation
Pommer, Bernhard; Unger, Ewald; Hof, Markus; Leuridan,
Steven; Famaey, Nele
Initial cell spreading investigated by a new deformable cell model
Odenthal, Tim; Smeets, Bart; Van Liedekerke, Paul;
Tijskens, Engelbert; Ramon, Herman; Van Oosterwyck,
Hans
8:00pm Conference Dinner

9:00am Plenary lecture
Biomechanics as a tool to functionalize biomaterials
Pioletti, Dominique
9:45am CARDIOVASCULAR MECHANICS II
Finite element modelling of coated biocorrodible stents
Debusschere, Nic; De Beule, Matthieu; Segers, Patrick;
Dubruel, Peter; Verhegghe, Benedict
Coupling of plaque formation and treatment of atherosclerosis with stent heating
Filipovic, Nenad; Nikolic, Dalibor; Milosevic, Zarko;
Saveljic, Igor; Exarchos, Themis; Parodi, Oberdan
Shape optimization of a cardiovascular stent
Ribeiro, Nelson da Silva; Folgado, João; Rodrigues,
Hélder
TISSUE ENGINEERING
Congenital pseudarthrosis of the tibia: a mathematical approach
Van Schepdael, An; Carlier, Aurélie; Ashbourn, Joanna
M.A.; Nica, Ioana; Kerkhofs, Johan; Geris, Lies
Individual-based modelling of the mechanical microenvironment in microbead cell expansion
Smeets, Bart; Odenthal, Tim; Tijskens, Engelbert; Ramon,
Herman; Van Oosterwyck, Hans
A model for cell/matrix growth on 3D surfaces: a coupling of level set method and brinkman equation
Guyot, Yann; Papantoniou, Ioannis; Chai, Yoke Chin;
Schrooten, Jan; Geris, Liesbet
The potential of sub-cycling to speed up fluidstructure interaction simulations
Taelman, Liesbeth; Degroote, Joris; Vierendeels, Jan;
Segers, Patrick
Pore width regulates human bone marrow cell invasion rate and actin organisation
Sengers, Bram Gijsbert; Bouropoulos, Nikolaos; Catt,
Chris J; Please, Colin P; Knychala, Jonathan
10:45am Coffee
11:15am Plenary lecture
Multiscale modeling and simulation of cytoskeletal actin filaments
Adachi, Taiji
12:00pm BONE MECHANICS II
Sclerostin is locally regulated in an in vivo model for load-induced trabecular bone adaptation
Trüssel, Andreas J; Webster, Duncan J; von Salis-Soglio,
Marcella; Kuhn, Gisela A; Müller, Ralph
CELL MECHANICS
Lipid Droplet Contents Determines the Cellular
Stiffness in Maturing Adipocytes
Katzengold, Rona; Shoham, Naama; Girshovitz, Pinhas;
Shaked, Natan; Benayahu, Dafna; Gefen, Amit
Computational models for predicting canine long bone mechanical behavior up to fracture
Laurent, Cédric P; Böhme, Beatrice; D'otreppe, Vinciane;
Balligand, Marc; Ponthot, Jean-Philippe
Morphological determinants of hip instability
Vogt, Patrick J.; Leunig, Michael; Zaltz, Ira; Ferguson,
Stephen J.
Simulation model for 3D Traction Force Microscopy experiments of cells lying on an elastic hydrogel
Jorge-
Peñas, Alvaro; Muñoz-Barrutia, Arrate; de-Juan-
Pardo, Elena M.; Ortiz-de-Solorzano, Carlos
Solving microscopic flow problems using stokes equations in SPH
Van Liedekerke, Paul; Odenthal, Tim; Smeets, Bart;
Tijskens, Engelbert; Ramon, Herman
A musculoskeletal numerical model of total knee replacement with the focus on the patella modelling
Latypova, Adeliya; Levrero Florencio, Francesc; Pioletti,
Dominique; Jolles, Brigitte; Terrier, Alexandre
1:00pm Closing ceremony
Modeling flow-induced deformation of osteocyte process in canaliculus
Kameo, Yoshitaka; Yamamoto, Ryuta; Ootao, Yoshihiro;
Ishihara, Masayuki; Kamioka, Hiroshi; Adachi, Taiji

,
A multiscale immune system simulator for the onset of type 2 diabetes
Castiglione, Filippo
Understanding and simulation of the cell decisions leading to bone formation and remodeling
Assar, Rodrigo; Montecino, Martin A
Towards a stochastic model of the human femur
Wille, Hagen; Rank, Ernst; Yosibash, Zohar
Three dimensional flow modelling inside a differential laminar flow bioreactor filled with porous media
Weyand, Birgit
The volumetric modelling of heterogeneous material parameters distribution of human bone
John, Antoni; Duda, Matthew
The metabolic regulation of angiogenesis: a computational approach
Cruys, Bert; Bentley, Katie; Gerhardt, Holger; Carmeliet, Peter
The importance of biological variation: a meta-analysis of biomechanics modeling practices
Cook, Douglas
Stiffness changes in adipocytes during their differentiation process
Shoham, Naama; Girshovitz, Pinhas; Tzvi Shaked, Natan; Benayahu, Dafna; Gefen, Amit
SPECT-like representation of analytical simulation of inhaled aerosol deposition within the lungs
Pichelin, Marine; Dubau, Cécile; Montesantos, Spyridon; Majoral, Caroline; Katz, Ira; Conway, Joy; Fleming, John; Caillibotte,
Georges
Progress towards an in silico framework for vascular mechanobiology research
Bernabeu, Miguel Oscar; Osborne, James Mark
PhysioDesigner and Flint: a platform for multilevel modeling of physiological systems and simulation
Asai, Yoshiyuki; Abe, Takeshi; Oka, Hideki; Okita, Masao; Okuyama, Tomohiro; Hagihara, Ken-ichi; Kurachi, Yoshihisa; Kitano,
Hiroaki
OFF influences microtubules and primary cilia mechanics
Correia Espinha, Lina; A. Hoey, David; R. Fernandes, Paulo; C. Rodrigues, Helder; R. Jacobs, Christopher
Numerical acceleration techniques for a multiscale model of tumor growth
Lejon, Annelies; Samaey, Giovanni; Roose, Dirk
Mathematical modelling and simulations of thrombus evolution using a simplified model
Pavlova, Jevgenija; Fasano, Antonio; Janela, João; Sequeira, Adélia
Insulin sensitivity during hypothermia in critically ill patients
Sah Pri, Azurahisham Bin; Chase, J. Geoffrey; J. LeCompte, Aaron; M.Shaw, Geoffrey; Presier, Jean-Charles; Taccone, Fabio;
Penning, Sophie; Desaive, Thomas
Implant osseointegration: poromechanics, morphogene, animal model and clinical considerations
Swider, Pascal; Khalil, Georges; Bechtold, Joan Elisa beth; Søballe, Kjeld
Identification of the anisotropic stress-strain relationship of human aortic walls in vivo
Wittek, Andreas; Konstaninos, Karatolios; Peter, Bihari; Thomas, Schmitz-Rixen; Sebastian, Vogt; Rainer, Moosdorf; Christopher,
Blase

Evaluation of particle deposition efficiency in human oral passage: a CFD study
Zhu, Jian Hua; How, Hong Siang; Wang, De Yun; Lee, Shu Jin; Lee, Heow Pueh
Computational model of passive diffusion across the retinal pigment epithelium
Tervonen, Aapo; Vainio, Iina; Nymark, Soile; Hyttinen, Jari
Comparison of muscle force estimation methods to predict humeral head translation after total shoulder arthroplasty
Engelhardt, Christoph; Malfroy Camine, Valérie; Ingram, David; Müllhaupt, Philippe; Farron, Alain; Pioletti, Dominique; Terrier,
Alexandre
Change in mechanical properties of the rod reduces the loosening risk of the screw in spinal fusion
Tawara, Daisuke; Noro, Kenta; Tsujikami, Tetsuya; Okamoto, Yoshiyuki; Murakami, Hideki
Characterization of human ex-vivo abdominal wall material properties by reverse engineering
Nováček, Vít; Turquier, Frédéric
Cellular automata model to simulate osteogenesis and bone fracture healing
Arias Moreno, Andrés Julián; Tovar Pérez, Andrés; Garzón-Alvarado, Diego Alexander
Bilevel structured dynamic simulator for predicting E. coli adaptation for mercury uptake in a bioreactor
Maria, Gheorghe; Luta, Ionela
ANIMO: a tool for modelling biological pathway dynamics
Schivo, Stefano; Scholma, Jetse; Wanders, Brend; Urquidi Camacho, Ricardo A.; van der Vet, Paul E.; Karperien, Marcel;
Langerak, Rom; van de Pol, Jaco; Post, Janine N.
ALCIMI: a 3D integrative tool to visualize and correlate experimental and simulation data
Dubau, Cécile; Pichelin, Marine; Montesantos, Spyridon; Majoral, Caroline; Katz, Ira; Conway, Joy; Fleming, John; Caillibotte,
Georges