姓名：李尚熾, Shan-Chih Lee
學歷：國立清華大學生命科學院 博士
經歷：中山醫學大學 助理教授
中山醫學大學 副教授
授課：普通生物學(General Biology)、放射生物學(Radiobiology)、放射腫瘤學
(Radiation Oncology)、解剖學(Human Anatomy)、生物化學(Biochemistry)
專長：放射生物、細胞生物
期刊論文：
1. Sheu JJC, Lee CC, Hua CH, Li CI, Lai MT, Lee SC, Cheng J, Chen CM, Chan C,
Chao SCC, Chen JY, Chang JY, Lee CH (2014) LRIG1 modulates aggressiveness
of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and
extracellular matrix remodeling. Oncogene. 33, 1375-1384. (SCI, Impact Factor:
8.559)
2. Cherry Y-Y Chang, Y Chen, M-T Lai, H-W Chang, Jack Cheng, Carmen Chan,
C-M Chen, S-C Lee, Y-J Lin, L Wan, P-W Tsai, S-H Yang, C Chung, Jim J-C
Sheu , F-J Tsai (2013) BMPR1B Up-Regulation via a miRNA Binding Site
Variation Defines Endometriosis Susceptibility and CA125 Levels . PLOS one. 8,
1-10. (SCI, Impact Factor: 3.73)
3. Chia-Wei Weng , Shan-Chih Lee, Yu-Liang Lee, Ka-Lok Ng (2013) Analysis of
the NCI-60 dataset for cancer-related microRNA and mRNA using expression
profiles. Computational Biology and Chemistry. 44, 15-21. (SCI, Impact Factor:
1.551)
4. Cherry Yin-Yi Chang, Yi Chen, Wu-Chou Lin, Chih-Mei Chen, Chih-Ping Chen,
Shan-Chih Lee, Jim Jinn-Chyuan Sheu and Fuu-Jen Tsai (2012) MUC2
polymorphisms are associated with endometriosis development and infertility: a
case-control study. BMC Medical Genetics, 13:15. (SCI, Impact Factor: 2.44)
5. Ying-Lan Liao, Yu-Sheng Tyan, Shan-Chih Lee, Hui-Yu Tsai (2011)
Optimization of Pediatric Protocol for Multislice CT. Chinese Journal of
Radiologic Technology. 35, 83-90.
6. Ka-Lok Ng, Hsueh-Chuan Liu and Shan-Chih Lee (2009) ncRNAppi--a tool for
identifying disease-related miRNA and siRNA targeting pathways.
Bioinformatics 25, 3199–3201. (SCI, Impact Factor: 4.926)
7. Tien-Fu Chuang, Shan-Chih Lee, Kuang-Wen Liao, Ya-Wen Hsiao, Chia-Hui Lo,
Bor-Luen Chiang, Xi-Zhang Lin, Mi-Hua Tao, Rea-Min Chu (2009)
Electroporation-mediated IL-12 gene therapy in a canine cancer model.
International Journal of Cancer. 125, 698–707 (SCI, Impact Factor: 4.555)
8. Kwo-Ping Chang, Ching-Han Cheng, Ying-Chi Chiang, Shan-Chih Lee,
Chih-Yuan Lin, Bor-Tsung Hsieh, Ching-Chio Ko, Ya-Ling Huang (2008)
Irradiation of Synthesized Magnetic Nanoparticles and its Application for
Hyperthermia.Advanced Materials Research. 47-50, 1298-1301. (EI)
9. Chang-Jer Wu, Shan-Chih Lee, Hui-Wen Huang, Mi-Hua Tao (2004) In vivo
electroporation of skeletal muscles increases the efficacy of Japanese encephalitis
virus DNA vaccine. Vaccine, 22, 1457-1464. (SCI, veterinary science: 1/129,
Impact Factor：3.04)
10. Chia-Hui Lo, Shan-Chih Lee, Pin-Yi Wu, Wen-Yu Pan, Jui Su, Chao-Wen
Cheng, Steve R. Roffler, Bor-Luen Chiang, Chun-Nan Lee, Cheng-Wen Wu, and
Mi-Hua Tao (2003) Antitumor and Antimetastatic Activity of IL-23. The Journal
of Immunology, 171: 600–607. (SCI, Impact Factor：7.014)
11. Shan-Chih Lee, Chang-Jer Wu, Pin-Yi Wu, Yi-Ling Huang, Chen-Wen Wu, and
Mi-Hua Tao (2003) Inhibition of established subcutaneous and mestastatic
murine tumors by instramuscular electroporation of the interleukin 12 gene. J.
Biomed. Sci.10, 73-86. (SCI, Impact Factor：2.322)
12. Shan-Chih Lee, Chu-Yun Kuan, Chuan-Ching Yang, and Shiaw-Der Yang (1998)
Bioflavonoids commonly and potently induce tyrosine
dephosphorylation/inactivation of oncogenic proline-directed protein kinase FA
in human prostate carcinoma cells. Anticancer Res. 18, 1117-1121. (SCI, Impact
Factor：1.375)
13. Shan-Chih Lee, Chu-Yun Kuan, Zen-Der Wen, and Shiaw-Der Yang (1998) The
naturally-occurring PKC inhibitor sphingosine and tumor promoter phorbol ester
potentially induce tyrosine phosphorylation/activation of oncogenic
proline-directed protein kinase FA/GSK-3α in a common signaling pathway. J.
Protein Chem. 17, 15-27. (SCI, Impact Factor：1.255)
14. Shiaw-Der Yang, Shan-Chih Lee, and Hsiou-Chen Chang (1997) Heat stress
induces tyrosine phsphorylation/activation of protein kinase FA/GSK-3α (a
carcinoma differentiation modulator) in A431 cells. J. Cell. Biochem. 66, 16-26.
(SCI, Impact Factor：2.817)
15. Shiaw-Der Yang, Jau-Song Yu, Chuan-Ching Yang, Shan-Chih Lee, Tsong-Tze
Lee, Mei-Hui Ni, Chu-Yun Kuan, and Hsiang-Chin Chen (1996) Overexpression
of protein kinase FA/GSK-3α (a proline-directed protein kinase) correlates with
human hepatoma dedifferentiation/progression. J. Cell. Biochem. 61, 238-245.
(SCI, Impact Factor：2.817)
16. Shiaw-Der Yang, Hsiou-Chen Chang, and Shan-Chih Lee (1996) Okadaic acid,
sphingosine, and phorbol ester reversibly modulate heat induction of protein
kinase FA/GSK-3α in A431 cells. J. Cell. Biochem. 60, 218-225. (SCI, Impact
Factor：2.817)
17. Shan-Chih Lee and Shiaw-Der Yang (1996) Calphostin C induces tyrosine
dephosphorylation/inactivation of protein kinase FA/GSK-3α in a pathway
independent of tumor promoter phorbol ester-mediated down-regulation of
protein kinase C. J. Cell. Biochem. 60,121-129. (SCI, Impact Factor：2.817)
18. Jau-Song Yu, Shan-Chih Lee, and Shiaw-Der Yang (1995) Effect of Mg+2
concentrations on phosphorylation/activation of phosphorylase b kinase by
cAMP/Ca+2-dependent, autophosphorylation-dependent protein kinase. J.
Protein Chem. 14, 747-752. (SCI, Impact Factor：1.255)