Online Appendix
This appendix has been provided by the authors to give readers additional information
about their work.
Contents
I.
Page
Online Tables
A. Online Table 1. Indications for surgery and operative results of excluded patients 2
B. Online Table 2. Baseline characteristics of excluded patients 3
1
I.
Online Tables
Online Table 1. Indications for surgery and operative results of excluded symptomatic
patients and excluded asymptomatic patients who met exclusion criteria.
Indications for surgery
Symptoms
Symptomatic patients
(n=601)
Asymptomatic patients
(n=201)
601 (100%)
185 (92%)
601
EF ≤ 0.60
55
ESD ≥ 40 mm
97
PAP > 50 mm Hg
9
Atrial fibrillation
24
Refusal to surgery
87 (14%)
50 (27%)
Mild or no symptoms
31
44
Old age
34
2
High operative risk
8
1
Malignancy
7
3
EF < 0.30
7
Surgery done
514 (86%)
135 (73%)
MV repair
382 (74%)
121 (90%)
MV replacement
132 (26%)
14 (10%)
8 (1.6%)
1 (0.7%)
Operative mortality
EF = ejection fraction; ESD = end-systolic dimension; MV = mitral valve; PAP =
pulmonary artery pressure.
2
Online Table 2. Baseline clinical and echocardiographic characteristics of excluded
symptomatic patients and excluded asymptomatic patients who met exclusion criteria.
Age, years
Gender, male
Symptomatic patients
(n=601)
Asymptomatic patients
(n=201)
58  15
51  16
328 (55%)
155 (77%)
NYHA functional class
1
201 (100%)
2
274 (46%)
3
253 (42%)
4
74 (12%)
EuroSCORE
2.8  2.3
1.6  2.1
Charlson comorbidity index
1.4  1.5
0.9  1.5
End-systolic dimension
39.6  8.2 mm
41.4  6.3 mm
End-diastolic dimension
61.7  8.4 mm
63.1  7.6 mm
60.2  9.4%
60.7  6.4%
0.91  0.52 cm2
0.93  0.50 cm2
Ejection fraction
ERO
ERO = effective regurgitant orifice area; EuroSCORE = European System for Cardiac
Operative Risk Evaluation score; NYHA = New York Heart Association.
3