Kidney Transplantation
Standard Operating Procedure Manual
Policies and Procedures
Paired Kidney Exchange:
Criteria to Include or to Offer Participation in
The Paired Kidney Exchange List for Compatible Donors
Content Applies To
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Purpose
The 3 Site Kidney Transplant Convergence Group has developed written guidelines
for criteria to be considered for including compatible pairs in the Paired Kidney
Exchange list. All Protocols have been reviewed by the Convergence Group and
approved by the individual sites
Policy Statements
The following principles are to be used when considering when to ask compatible
pairs to participate in Paired Kidney Exchange
1. Principles:
a. Assure recipients’ benefit/non inferior graft
b. Assure timely transplant
2. Criteria to include in PKE:
a. Presence of a positive crossmatch
b. ABO incompatibility
c. EBV mismatched pairs
d. Negative crossmatch with high level DSA
i. Current Class I with MFI >2000
ii. Current Class II with MFI >1000
1
Content Information:
Content ID: KID-POL: 200200a.005E
Release Date: 03/01/2013
Next Review Date: 03/01/2015
Last Review Date: 04/29/2012
Revision Dates:
Approval: Kidney/Pancreas 3-Site Transplant Practice Specialty Council
Site(s): Enterprise
Comments: [Original Implementation Date: 04/29/2012 E]
Kidney Transplantation
Standard Operating Procedure Manual
Policies and Procedures
3. Criteria to offer to participate in PKE:
a. CMV mismatched airs
b. Pairs who are less favorable immunologically
i. Low level or historical DSA
a) Current or historical Class II DSA at any MFI
b) Current Class I DSA with MFI <2000
ii. Positive crossmatch and no identified DSA by Luminex
c. Donor age >10 yrs older than recipient, provided recipient age<50 yrs
d. Size/GFR mismatch
Transplanted graft GFR<50 ml/min/1.73 m²
Transplanted graft GFR= [donor unadjusted iothalamate clearance
(ml/min) /2] * 1.73/recipient BSA
e. Other criteria as determined at selection conference such as
surgical/anatomical suitability
f. Altruistic compatible pairs
Applicable Standards:
Medicare Conditions for Participation
§482.92 Patient and Living Donor Selection
2
Content Information:
Content ID: KID-POL: 200200a.005E
Release Date: 03/01/2013
Next Review Date: 03/01/2015
Last Review Date: 04/29/2012
Revision Dates:
Approval: Kidney/Pancreas 3-Site Transplant Practice Specialty Council
Site(s): Enterprise
Comments: [Original Implementation Date: 04/29/2012 E]