V-FARM DNA - SCIENTIFIC PROGRAM
At the Brasiliana Library (Mindlin), University of Sao Paulo, Sao Paulo, SP
Oct 31st
2:00-2:20
Welcome remarks: Organizing Committee and Authorities
2:20-3:10
Philip Hanawalt, Stanford University, CA, USA
50 years of cutting edges in excision repair
Symposium 1: Biological effects of DNA damage
Chair: Carlos FM Menck
3:10-3:30
3:30-3:50
3:50-4:10
4:10-4:20
Mats Ljungman, University of Michigan, USA
Transcriptional Effects of DNA Damage
Wim Vermeulen, Erasmus Medical Center, The Netherlands
Regulation of transcription-coupled DNA repair
Vanessa Gottifredi, Fundación Instituto Leloir, Argentina
Timely degradation of p21 is required to facilitate damaged-DNA replication and
to preserve genomic stability after UV irradiation
Andre Schuch, Federal University of Sta. Maria, RS, Brazil
DNA damage as a biological sensor for environmental sunlight and sunscreen
photoprotection
4:20-4:50
Coffee Break
Symposium 2: Human Syndromes and DNA repair defects
Chair: Rodrigo Galhardo
4:50-5:10
5:10-5:30
5:30-5:50
5:50-6:10
6:10-6:30
6:30-6:40
7:00-10:00
Alan Lehmann: University of Sussex, UK
The xeroderma pigmentosum population in the UK: unexpected phenotypes and
relationships to molecular defects
Priscilla Cooper, Lawrence Berkley National Laboratory, USA.
XPG partners with BRCA1/2 in homologous recombination to maintain genome
stability
Graciela Spivak, Stanford University, CA, USA
Cockayne and UV-sensitive syndrome cells are defective in transcription-coupled
repair of 8-oxoguanine
Alan Sarasin, University Paris-Sud and Institut Gustave Roussy, France
Correlation of phenotype/genotype in a cohort of 23 xeroderma pigmentosumvariant patients reveals 13 new disease-causing POLH mutations
Lisiane Meira, University of Surrey, UK
When good things go bad: DNA repair driving cell death
Jenifer Saffi, Federal University of Health Sciences, RS, Brazil
DNA damage response and cytotoxicity of topoisomerase II inhibitors
Welcome cocktail
Nov 1st
Symposium 3: New roles for old repair proteins
Chair: João A. P. Henriques
8:30-8:50
8:50-9:10
Annette Larsen, Saint-Antoine Research Center, Paris, France
BRCA2 is needed for both homologous recombination repair and cell cycle arrest
in mammalian cells exposed to S23906, an anticancer monofunctional minor
groove binder
Pete McKinnon, St. Jude Children's Research Hospital, USA
ATM, DNA Damage Signaling and Neurogenesis
9:10-9:30
9:30-9:50
Jean Sebastian Hoffmann, University of Toulouse, France
Novel functions of the alternative DNA Polymerases during S-phase for the
maintenance of genetic stability in human cells
Tinna Stevnsner, Aarhus University, Denmark
Protein interactions for Cockayne Syndrome group B (CSB) protein in Base
Excision Repair (BER)
9:50-10:00
Lucymara F. Agnes-Lima, Federal University of Rio Grande do Norte,Brazil
APE1 as a target for anti-inflammatory therapy
10:00-10:30
Coffee-break
Symposium 4: Oxidative damage to nucleic acids
Chair: Fabio L. Forti
10:30-10:50
10:50-11:10
11:10-11:30
11:30-11:50
11:50-12:10
12:10-2:00
Akihiko Nunomura, University of Yamanashi, Japan
Oxidative RNA Damage and Repair
Roger Woodgate, National Institutes of Health, USA
Mechanisms of ribonucleotide repair in E. coli
Evelyne Sage, Institut Curie, Paris, France
Processing of clustered DNA lesions
Rex Tyrrel, University of Bath, UK
UVA as an oxidative stress : the disruption of iron and heme homeostasis versus
restoration and repair
Jean Cadet, CEA, Grenoble, France
Radical and enzymatic oxidation of 5-methycytosine in cellular DNA
Lunch & Poster Session I
Symposium 5: Interplay between DNA repair and other DNA metabolic processes
Chair: Elza T. S. Hojo
2:00-2:20
2:20-2:40
2:40-3:00
3:00-3:20
Curtis Harris, National Institutes of Health, USA
p53 regulation of cellular senescence and asymmetric division in cancer and
aging
Bernd Kaina, University of Mainz, Germany
DNA Repair and Misrepair in Human Monocytes, DCs and Macrophages
Wilner Martinez-Lopes, Instituto Clemente Estable, Uruguay
Changes in global histone acetylation patterns affect the removal of CPDs in
proficient and deficient TCR cell lines
Gaston Soria, National University of Córdoba, Argentina
Heterochromatin proteins: much more than barrier to DNA repair
Symposium 6: DNA repair and mutagenesis in mitochondria
Chair: Carlos Renato Machado
3:20-3:40
3:40-4:00
4:00-4:20
4:20-4:40
4:40-5:10
Ben Van Houten, University of Pittsburgh, USA
Communication between mitochondria and the nucleus – a novel approach to
cancer chemotherapy
Jason Bielas, School of Medicine, Seattle WA, USA
Fundamental Mechanisms and Clinical Utility of Nuclear and Mitochondrial DNA
Mutagenesis in Cancer
Laurie Kaguni, Michigan State University, MI, USA
Comparative biochemical genetics and evolution of the mitochondrial replisome
Janine Santos, NIEHS, USA
Intrinsic mtDNA repair defect in Ataxia telangectasia
Coffee-break
Symposium 7: DNA repair in differentiation and neurogenesis
Chair: Lucymara F. Agnez
5:10-5:30
5:30-5:50
5:50-6:10
6:10-6:20
6:20-6:30
7:00-10:00
Bevin Engleward, MIT, USA
Cell proliferation potentiates inflammation and alkylation-induced homologous
recombination in vivo
Eugenia Dogliotti, Instituto Superiore di Sanità, Rome, Italy
The response to DNA damage during differentiation: pathways and
consequences
Miria Ricchetti, Institut Pasteur, Paris, France
Double-strand break repair in skeletal muscle adult stem cells and in their
committed progeny
Diego Bonatto, Federal University of Rio Grande do Sul, RS, Brazil
In silico analyses of a new group of fungal and plant RecQ4-homologous proteins
Silvia RB Medeiros, Federal University of Rio Grande do Norte, RN, Brazil
Genetic Instability in Human Senescent Mesenchymal Stem Cells
Speakers' dinner – Clube dos Professores, USP
Nov 2nd
Symposium 8: DNA damage, repair and aging
Chair: Nadja C. de Souza Pinto
8:30-8:50
8:50-9:10
9:10-9:30
9:30-9:50
9:50-10:10
David M Wilson III, NIH, USA
Repair of Endogenous DNA Damage in Premature Aging and Disease
Jan Hoeijmakers, Erasmus Medical Center, The Netherlands
The keyrole of DNA damage in cancer and aging
Laura Niedernhofer, Scripps Research Institute, Jupiter, FL, USA
Endogenous DNA damage as a driver of aging
Patricia Opresko, University of Pittsburgh, USA
Mechanisms of Telomeric DNA Loss and Repair
Vilhelm A Bohr, NIA, NIH, USA
Human premature aging proteins participate in nuclear and mitochondrial DNA
repair
10:10-10:40
Coffee-break
Symposium 9: DNA replication and mutagenesis
Chair: Januario Cabral Neto
10:40-11:00
Thomas Kunkel, NIH/NIEHS, USA
Studying Nuclear DNA Replication Fidelity in Budding Yeast
11:00-11:20 Christophe Cazaux, University of Toulouse, France
DNA polymerase η - dependent DNA synthesis regulates fragile site stability by
preventing under-replicated DNA in mitosis
11:20-11:40 Ivan Matic, Université Paris Descartes, France
Visualization of the mismatch repair in living Escherichia coli cells
11:40-12:00 Katherine Donigan, National Institutes of Health/NICHD, USA
Human DNA pol iota residue Y39 functions as a critical steric gate for DNA sugar
selection
12:00-1:40
Lunch & Poster Session II
Symposium 10: Regulation of DNA repair
Chair: Lucas Argueso
1:40-2:00
2:00-2:20
2:20-2:40
2:40-3:00
3:00-3:20
Manoor P Hande, YLL School of Medicine, NUHS, Singapore
Mechanism-based combination therapy: Telomerase and DNA repair inhibition in
cancer cells
Robert W Sobol, University of Pittsburgh, School of Medicine, USA
Proteosome-mediated regulation of base excision repair
Peter Karran, Clare Hall Laboratories, South Mimms, UK
Sulfur-containing DNA bases as potential therapeutic agents
Leona Samson, MIT, USA
Multiplexed DNA repair assays for multiple lesions and multiple doses via
transcription inhibition and transcriptional mutagenesis
Patricia L Kannouche, Institut Gustave Roussy, Villejuif, France
New Aspects on the Regulation of The Specialized DNA polymerase eta in human
cells
3:20-3:50
Coffee-break
Symposium 11: DNA repair and mutagenesis in procaryotes and lower eukaryotes
Chair: Renata Costa
3:50-4:10
4:10-4:30
4:30-4:50
Richard McCulloch, University of Glasgow, UK
Nucleotide excision repair in Trypanosoma brucei: specialization of transcriptioncoupled repair due to multigenic transcription
Robert Fuchs, Centre de Recherche en Cancérologie de Marseille, France
An integrated view of Translesion Synthesis processes in E. coli
Susan Rosenberg, Baylor College of Medicine, TX, USA
Mutagenic Repair of DNA Breaks, Network and Evolvability
Symposium 12: Genomic instability and mutagenesis
Chair: Jenifer Saffi
4:50-5:10
5:10-5:30
5:30-5:50
5:50-6:10
6:10-6:20
Gloria M Calaf, Columbia University Medical Center, NY, USA
Genomic instability induced by environmental substances and estrogen
Thomas Rosenquist, Stony Brook University, New York, USA
Mutational signature of the environmental carcinogen Aristolochic Acid
Filippo Rosselli, Institut Gustave Roussy, Villejuif, France
ERCC1 and MUS81 process late replication intermediates at fragile sites and
promote sister chromatid separation during mitosis
Jean-Baptiste Charbonnier, Univ Paris Sud, iBiTec-S, Gif-s-Yvette, France
Control of the DNA Mismatch Repair and the Meiosis Recombination by
Eukaryotic MutL Homologues
Awards and Closing ceremony - Organizing Committee