BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Jennifer M. Gillette
Assistant Professor of Pathology (Tenure Track)
eRA COMMONS USER NAME (credential, e.g., agency login)
JGillette
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Gettysburg College
B.S.
05/1999
Ph.D.
05/2004
Post-Doc
2004-2010
University of Colorado Health Sciences Center
National Institutes of Health
Biology
Cell & Developmental
Biology
Cell Biology &
Metabolism
A. Personal Statement
The overall theme of my research is to evaluate the molecular mechanisms of cell-cell and cell-matrix
communication within the bone marrow microenvironment. My lab uses a combinatorial experimental approach
that involves imaging and biochemical techniques as well as mouse models to study the molecular and cellular
interactions between hematopoietic stem cells/leukemic stem cells and the bone marrow microenvironment.
We are currently evaluating the role of the tetraspanin protein family as regulators of adhesion and signaling
within the bone marrow microenvironment. Our imaging modalities include standard live cell imaging
techniques (FRAP, FLIP, FRET) as well as super-resolution imaging techniques (PALM, dSTORM). I am a
member of University of New Mexico Cancer Center and New Mexico Center for the Spatiotemporal Modeling
of Cell Signaling (STMC).
B. Positions and Honors
Professional Appointments
1999-2004
University of Colorado Health Sciences Center Graduate Student
2004-2010
NIH Post Doctoral Intramural Research Training Fellowship
2006-2008
Teaching Assistant, Marine Biological Laboratories, Physiology Course, Woods Hole, MA
2010
Tara Oceans Expedition Research Scientist: Optical Engineer (Abu Dhabi – Mumbai)
2010-present Assistant Professor, University of New Mexico School of Medicine, Department of Pathology
Honors and Awards
2001
University of Colorado Retired Faculty Association Outstanding Graduate Research Award
2002
Gettysburg College Women of Distinction Award
2002
University of Colorado Health Sciences Center Outstanding Student Research Award
2002-2003
National Osteoporosis Foundation's Mazees Student Fellowship
2002-2004
NASA Graduate Student Research Fellowship
2006
American Society for Cell Biology Novel and Newsworthy Research Award
2007
National Institutes of Health Fellows Award for Research Excellence
2008
National Institutes of Health Fellows Award for Research Excellence
2009
National Institutes of Health Fellows Award for Research Excellence
Memberships
American Society for Cell Biology (2001-present); AAAS (2011-present); American Heart Association (2011present).
Ad-hoc Reviewer for Peer Reviewed Journals
Blood, Journal of Cell Science, Biomed Central
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
C. Selected Peer-Reviewed Publications
1. Nielsen-Preiss, S.M., S.R. Silva, J.M. Gillette. Role of PTEN and Akt in the regulation of growth and
apoptosis. J. Cell. Biochem. 90 (5): 964-975. 2003.
2. Gillette, J.M. and S.M. Nielsen-Preiss. The Role of Annexin 2 in Osteoblastic Mineralization. J. Cell Sci.
117 (3): 441-449. 2004.
3. Gillette, J.M. and S.M. Nielsen-Preiss. Annexin 2 expression is reduced in human osteosarcoma
metastases. J. Cell. Biochem. 92 (4). 820-832. 2004.
4. Shroff, H., Galbraith, C.G., Galbraith, J.A., White, H., Gillette, J., Olenych, S., Davidson, M.K., and E.
Betzig. Dual-color superresolution imaging of genetically expressed probes within individual adhesion
complexes. Proc Natl Acad Sci. 104 (51): 20308-13. 2007.
5. Manley, S., J.M. Gillette, G.H.Patterson, H. Shroff, H. Hess, E. Betzig, and J. Lippincott-Schwartz. Highdensity mapping of single-molecule trajectories with photoactivated localization microscopy. Nat. Methods.
5(2): 155-7. 2008.
6. Gillette, J.M., C.P. Gibbs, S.M. Nielsen-Preiss. Establishment and characterization of OS 99-1, a cell line
derived from a highly aggressive primary human osteosarcoma. In Vitro Cell Dev Biol Anim. 44(3-4): 8795. 2008.
7. Subach, F.V., Patterson, G.H., Manley, S., Gillette, J.M., Lippincott-Schwartz, J., and Verkhusha, V.V.
Photoactivatable mCherry for high-resolution two-color fluorescence microscopy. Nat. Methods. 6(2): 153159. 2009. PMC2901231
8. Gillette, J.M., Larochelle, A., Dunbar, C.E., and J. Lippincott-Schwartz. Intercellular transfer to signaling
endosomes for targeted regulation within a bone marrow niche. Nat. Cell Biol. 11(3): 303-11. 2009.
PMC2748410
9. Shtengel. G., Galbraith, J., Galbraith, C., Lippincott-Schwartz, J., Gillette J.M., Manley, S., Sougrat, R.,
Waterman-Storer, C., Pakorn, K., Davidson, M., Fetter, R., Hess, H. Single Photon Fluorescence
Interferometry and 3D Microscopy. Proc Natl Acad Sci. 106(9): 3125-30. 2009. PMC2637278
10. Gillette, J.M. and Nielsen-Preiss, S.M. Cancer Stem Cells: The Seeds of Growth in Osteosarcoma.
Cancer Biol Ther. 8(6): 553-554. 2009.
11. Gillette, J.M. and Lippincott-Schwarz, J. Hematopoeitic progenitor cells regulate their niche
microenvironment through a novel mechanism of cell communication. Commun. Integr. Biol.
2(4):July/August. 2009. PMC2734029
12. Manely, S, Gillette, J.M. and J. Lippincott-Schwartz. Single particle tracking photoactivated localization
microscopy (sptPALM) for mapping single molecule dynamics. Methods Enzymol. 475C:109-120. 2010
13. Larochelle, A*, Gillette, J.M.*, Desmond, R., Ichwan, B., Cantilena, A., Cerf, A., Barrett, A.J., Wayne, A.S.
Lippincott-Schwartz, J., and C.E. Dunbar. Bone marrow homing and engraftment of hematopoietic stem
and progenitor cells is mediated by CD82 polarity.*Equal contribution. Blood. 119(8): 1848-55. 2012.
D. Research Support
Ongoing Research Support
13SDG14630080 (Gillette)
1/1/2013-12/31/2016
4.0 CM
American Heart Association
$308,000
Improving Stem Cell Transplantation by Manipulating Hematopoietic Stem cell / Niche Interactions
The major goal of this project is to determine how the scaffold protein, CD82, can be manipulated to enhance
endothelial niche adhesion, homing and angiogenesis.
Role: PI
Foucar Endowed Training Fund (Q. Zhang)
2/15/13 – 8/15/13
Foucar Fund
$4,000
CLL cell regulation by the cellular microenvironment
This internal pilot award is to evaluate how CLL cell adhesion, proliferation and metabolic activity are affected
by specific stromal cells and matrix.
Role: Co-PI
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
Sub-award: ACS-IRG (M. Ozbun)
10/1/2012-9/30/2013
American Cancer Society
$30,000
CD82 regulation of hematopoietic stem and progenitor cell adhesion to the bone marrow microenvironment.
This internal grant provides pilot funding for the development of the CD82KO mouse model.
Role: PI
UNM CVMD Pilot Grant
7/1/2012-6/30/2013
CVMD Signature Program
$9,875
Hematopoietic stem and Progenitor cell Interactions with the Endothelial cells Stimulates Angiogenesis
This internal pilot award is to eluciate the ability of HSPCs to modify and signal to the vascular endothelium.
Role: PI
UNM Cancer Center FIG (C. Willman)
3/1/2012-2/28/2013
Postdoctoral Fellow Match
$22,848
Microvesicles modify the bone marrow microenvironment into a pre-metastatic niche
The objective of this internal pilot award is to evaulate the stimulatory roles of tumore-derived microvesciles in
priming the bone marrow microenvironment for tumore metastasis.
Role: PI
Research Support Completed During the Last Three Years
UNM Research Allocation Committee Grant
11/1/2011-10/31/2012
Hematopoietic stem cell communication with niche cells.
This internal pilot grant evaluated the regulatory role of CD82 in hematopoietic stem cell adhesion.
Role: PI
UNM Cancer Center FIG (C. Willman)
6/1/2011-7/31/2012
Improving transplantation therapies through the identification of small molecules to induce CD34+ cell
membrane polarity.
This internal pilot award focused on identifing compounds (through collaboration with the UNM Molecular
Discovery Center) that enhance the homing and engraftment of CD34+ cells, thereby improving stem cell
transplantation therapies.
Role: PI
Sub-award: ACS-IRG-92-024 (J. Oliver)
1/3/2011-12/31/2011
CD82 membrane polarity mediates engraftment interactions of hematopoietic stem cells.
This grant evaluates the role of CD82 plasma membrane polarity in hematopoietic stem cell homing and
engraftment.
Role: PI
PHS 398/2590 (Rev. 06/09)
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