贾宗超教授
贾宗超，教授。1961 年出生，1987 年出国留学，1992 年在加拿大获博士学位，
1993 年至 1994 年在牛津大学做博士后，1995 年任加拿大皇后大学助理教授，2000
年副教授，2004 年教授。曾获得多项科研大奖及荣誉，包括 Queen’s National
Scholar (1995-2000), Medical Research Council of Canada Scholar, (1996-2001),
Ontario Premier Research Excellence Award (2000), Basmajian Award for Excellence in
Medical Research (2000), Chancellor’s Research Award (2001), Canada Institutes of
Health Research Investigator (2001), Natural Science and Engineering Research Council
of Canada Steacie Fellow (2004-2006)，Killam Research Fellow (2011-2013) and
Canada Research Chair (2001-至今). 共发表 218 篇高水平文章 (包括 8 篇 Nature,
Science and Cell)。贾宗超是最早获得加拿大国家首席科学家 (Canada Research Chair)
荣誉的科学家之一。在各种国际学术大会上多次作学术报告。
贾宗超教授于 2010 年夏入选国家 “千人计划”。三年多的时间里，从无到有，在
北京师范大学建立了具有先进水平实验条件的结构生物学实验室。在此前， 他还
获得过“长江学者”和“杰青”等荣誉。
PUBLICATION (H 指数 42，引用数 6788）
218) L.M. van Staalduinen, F.R. McSorley, K. Schiessl, J. Séguin, P.B. Wyatt, F.
Hammerschmidt, D.L. Zechel and Z. Jia. (2014) The crystal structure of PhnZ in
complex with substrate reveals a new di-iron oxygenase mechanism for catabolism of
organophosphonates. Proc. Natl. Acad. Sci. 111, 5171-5176.
217) M.J.Y. Lee, D. Schep, B. McLaughlin, M. Kaufmann and Z. Jia. (2014) Structural
analysis and identification of PhuS as a heme-degrading enzyme from Pseudomonas
aeruginosa. J. Mol. Biol. 426, 1936-1946.
216) L.M. van Staalduinen, S.K. Novakowski and Z. Jia. (2014) Structure and functional
analysis of YcfD, a novel 2-oxogluterate/ Fe2+-dependent oxygenase involved in
translational regulation in E. coli. J. Mol. Biol. 426, 1896-1910.
215) N. Wang, R. Wu, X. Cheng, Z. Jia and J. Zheng. (2014) New insights into mTOR
structure and regulation. Chin. Sci. Bull. in press.
214) Z. Jia. (2014) Protein superglue that holds VWF together. Blood, 123, 1771-1772.
213) D. Vukomanovic, M.N. Rahman, Y. Bilokin, A.G. Golub, J.F. Brien, W.A. Szarek,
Z. Jia and K. Nakatsu. (2014) In vitro activation of heme oxygenase-2 by menadione and
its analogs. Med. Gas Res. 4:4.
212) C. Prince and Z. Jia. (2013) Detergent quantification in membrane protein samples
and its application to crystallization experiments. Amino Acids, 45, 1293-1302.
211) Q. Ye, Y. Feng, Y. Yin, F. Faucher, M.A. Currie, M.N. Rahman, J. Jin, S. Li, Q.
Wei and Z. Jia. (2013) Structural basis of calcineurin activation by calmodulin. Cell
Signal. 25, 2661-2667.
210) J. Zheng and Z. Jia. (2013) Tiny enzyme uses context to succeed. Nature, 497, 445446.
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209) Q. Li, J. Zheng, H. Tan, X. Li, G. Chen and Z. Jia. (2013) Unique kinase catalytic
mechanism of AceK with a single magnesium ion. PloS ONE, 8, e72048.
208) M.A. Currie, K. Cameron, F.M.V. Dias, H.L. Spencer, E.A. Bayer, C. M.G.A.
Fontes, S.P. Smith and Z. Jia. (2013) Small angle X-ray scattering analysis of
Clostridium thermocellum cellulosome N-terminal complexes reveals a highly dynamic
structure. J. Biol. Chem. 288, 7978-7985.
207) B. Wahten and Z. Jia. (2013) A hierarchical order within protein structures
underlies large separations between strands in β-sheets. Proteins, 81, 163-175.
206) M.N. Rahman, D. Vukomanovic, J.Z. Vlahakis, W.A. Szarek, K. Nakatsu and Z.
Jia. (2013). Structural insights into human heme oxygenase-1 inhibition by potent and
selective azole-based compounds. J. R. Soc. Interface, 10, 20120697.
205) C. Prince and Z. Jia. (2012) Measurement of detergent concentration using 2,6dimethylphenol in membrane-protein crystallization. Acta Cryst. D68, 1694-1696.
204) F. Faucher and Z. Jia. (2012) High-resolution structure of AKR1a4 in apo form and
its interaction with ligands. Acta Cryst. F68, 1271-1274.
203) V.K. Singh, Kim Munro and Z. Jia. (2012) A novel calmodulin – -PIX interaction
and its implication in receptor tyrosine kinase regulation. Cell Signal. 24, 1790-1796.
202) M.A. Currie, J.J. Adams, F. Faucher, E.A. Bayer, Z. Jia and S.P. Smith. (2012)
Scaffoldin conformation and dynamics revealed by a ternary complex from the
Clostridium thermocellum cellulosome. J. Biol. Chem. 287, 26953-26961.
201) F. Faucher, S. Doublié and Z. Jia. (2012) 8-Oxoguanine DNA glycosylases: one
lesion, three subfamilies. Int. J. Mol. Sci. 13, 6711-6729.
200) V.K. Singh, M.N. Rahman, K. Munro, V.N. Uversky, S.P. Smith and Z. Jia. (2012)
Free cysteine modulates the conformation of human C/EBP homologous protein. PLoS
ONE, 7, e34680.
199) J. Zheng, S. Yates and Z. Jia. (2012) Structural and mechanistic insights into the
bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK. Philos. Trans. R.
Soc. Lond. B Biol. Sci. 367, 2656-2668.
198) M.N. Rahman, J.Z. Vlahakis, D. Vukomanovic, W. Lee, W.A. Szarek, K. Nakatsu
and Z. Jia. (2012) A novel, “double-clamp” binding mode for human heme oxygenase-1
inhibition. PLoS ONE, 7, e29514.
197) S.P. Yates, T.E. Edwards, C.M. Bryan, A.J. Stein, W.C. Van Voorhis, P.J. Myler,
L.J. Stewart, J. Zheng and Z. Jia. (2011) Structural basis of substrate specificity of
bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry, 50, 8103-8106.
196) D. Vukomanovic, B.E. McLaughlin, M.N. Rahman, W.A. Szarek, J.F. Brien, Z. Jia
and K. Nakatsu. (2011) Selective activation of heme oxygenase-2 by menadione. Can. J.
Physiol. Pharmacol. 89, 861-864.
195) S. He, M. Wathier, K. Podzelinska, M. Wong, F. McSorely, A. Asfaw, B. HoveJensen, Z. Jia and D. L. Zechel (2011). Structure and mechanism of PhnP, a
phosphodiesterase from the carbon-phosphorus lyase pathway. Biochemistry, 50, 86038615.
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194) B. Wathen, D.A. Pratt and Z. Jia. (2011) Hyperconjugation contributes to the
bimodal distribution of glycine conformations observed in protein three-dimensional
structures. ChemBioChem, 12, 1674-1677.
193) S.W. Crawley, M. Samimi, Q. Ye, Y. Yang, B. Raveh, O. Schueler-Furman, Z. Jia
and G.P. Côté. (2011) Autophosphorylation activates Dictyostelium myosin II heavy
chain kinase A by providing a ligand for an allosteric binding site in the kinase domain. J. Biol. Chem. 286, 2607-2616.
192) J.Z. Vlahakis, M.N. Rahman, G. Roman, Z. Jia, K. Nakatsu and W.A. Szarek.
(2011) Rapid, convenient method for screening imidazole-containing compounds for
heme oxygenase inhibition. J. Pharmacol. Toxicol. Methods, 63, 79-88.
191) J. Zheng and Z. Jia. (2010) Structure of the bifunctional isocitrate dehydrogenase
kinase/phosphatase. Nature, 465, 961-965.
190) J. Hong, Y. Hu, C. Li, Z. Jia, B. Xia and C. Jin. (2010) NMR characterizations of
the ice binding surface of an antifreeze protein. PLoS ONE, 5, e15682.
189) L.M. van Staalduinen, C.S. Park, S.J. Yeom, M.A. Adams-Cioaba, D.K. Oh and Z.
Jia. (2010) Structure based annotation of a novel sugar isomerase from the pathogenic E.
coli O157:H7. J. Mol. Biol. 401, 866-881.
188) B. Wathen and Z. Jia. (2010) Protein -sheet nucleation is driven by local modular
formation. J. Biol. Chem. 285, 18376-18384.
187) Y.-M. She, X. Xu, A.F. Yakunin, S. Dhe-Paganon, L.J. Donald, K.G. Standing, D.
C. Lee, Z. Jia and T.D. Cyr. (2010) Mass spectrometry following mild enzymatic
digestion reveals phosphorylation of recombinant proteins in Escherichia coli through
mechanisms involving direct nucleotide binding. J. Proteome Res. 9, 3311-3318.
186) K. Podzelinska, R. Latimer, A. Bhattacharya, L.C. Vining, D.L. Zechel and Z. Jia.
(2010) Chloramphenicol biosynthesis: The structure of CmlS, a flavin-dependent
halogenase with a covalently bound flavin. J. Mol. Biol. 397, 316-331.
185) Q. Ye, S.W. Crawley, Y. Yang, G.P. Côté and Z. Jia. (2010) Crystal structure of the
-kinase domain of Dictyostelium myosin heavy chain kinase A. Sci. Signal. 3, ra17.
(cover picture)
184) J.J. Adams, M.A. Currie, E.A. Bayer, Z. Jia and S.P. Smith. (2010) Insights into
higher order organization of the cellulosome revealed by a dissect-and-build approach:
Crystal structure of interacting Clostridium thermocellum multimodular components. J.
Mol. Biol. 396, 833-839. (cover picture)
183) M.A Currie, J.J Adams, S. Ali, S.P Smith and Z. Jia. (2010) Purification and
crystallization of a multimodular heterotrimeric complex containing both type-I and typeII cohesin-dockerin interactions from the cellulosome of Clostridium thermocellum. Acta
Cryst. F66, 327-329.
182) R. Gordienko, H. Ohno, V.K. Singh, Z. Jia, J.A. Ripmeester and V.K. Walker.
(2010) Towards a green hydrate inhibitor: Imaging antifreeze proteins on clathrates.
PLoS ONE 5, e8953.
181) M.N. Rahman, J.Z. Vlahakis, G. Roman, D. Vukomanovic, W.A. Szarek, K.
Nakatsu and Z. Jia. (2010) Structural characterization of human heme oxygenase-1 in
complex with azole-based inhibitors. J. Inorg. Biochem. 104, 324-330.
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180) Y. Zhang, H. Tan, G. Chen and Z. Jia. (2010) Investigating the disorder-order
transition of calmodulin binding domain upon binding calmodulin using molecular
dynamics simulation. J. Mol. Recognit. 23, 360-368.
179) B. Wathen and Z. Jia. (2010) Residue patterning in helix interiors. Biochem. Cell
Biol. 88, 325-337.
178) B. Wathen, P. Kwan, Z. Jia and V.K. Walker. (2010) Modeling the interactions
between poly(N-vinylpyrrolidone) and gas hydrates: Factors involved in suppressing and
accelerating hydrate growth. Lect. Notes Comput. Sci. 5976, 117-133.
177) D. Vukomanovic, B. McLaughlin, M.N. Rahman, J.Z. Vlahakis, G. Roman, R.A.
Dercho, R.T. Kinobe, J.F. Brien, Z. Jia, W.A. Szarek and K. Nakatsu. (2010)
Recombinant truncated and microsomal heme oxygenase-1 and -2: Differential
sensitivity to inhibitors. Can. J. Physiol. Pharmacol. 88, 480-486.
176) G. Roman, M.N. Rahman, D. Vukomanovic, Z. Jia, K. Nakatsu and W.A. Szarek.
(2010) Heme oxygenase inhibition by 2-oxy-substituted 1-azolyl-4-phenylbutanes: Effect
of variation of the azole moiety. X-ray crystal structure of human heme oxygenase-1 in
complex with 4-phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone. Chem. Biol. Drug Des. 75,
68-90.
175) D. Lee and Z. Jia. (2009) Emerging structural insights into bacterial tyrosine
kinases. Trends Biochem. Sci. 34, 351-357.
174) M.A. Currie, F. Merino, T. Skarina, A.H.Y. Wong, A. Singer, G. Brown, A.
Savchenko, A. Caniuguir, V. Guixé, A.F. Yakunin and Z. Jia. (2009) ADP-dependent 6phosphofructokinase from Pyrococcus horikoshii OT3: Structure determination and
biochemical characterization of Ph1645. J. Biol. Chem. 284, 22664-22671.
173) J. Zheng, A.X. Ji and Z. Jia. (2009) Purification, crystallization and preliminary Xray analysis of bifunctional isocitrate dehydrogenase kinase/phosphatase in complex with
its substrate isocitrate dehydrogenase in Escherichia coli. Acta Cryst. F65, 1153-1156.
172) A. Matte, G. Kozlov, J.-F. Trempe, M.A. Currie, D. Burk, Z. Jia, K. Gehring, I.
Ekiel, A.M. Berghuis and M. Cygler. (2009) Preparation and characterization of bacterial
protein complexes for structural analysis. Adv. Protein Chem. Struct. Biol. 76, 1-42.
171) T. Lu, H. Tan, D. Lee, G. Chen and Z. Jia. (2009) New insights into the activation
of Escherichia coli tyrosine kinase revealed by molecular dynamics simulation and
biochemical analysis. Biochemistry 48, 7986-7995.
170) M.N. Rahman, J.Z. Vlahakis, D. Vukomanovic, W.A. Szarek, K. Nakatsu and Z. Jia.
(2009) X-ray crystal structure of human heme oxygenase-1 with (2R, 4S)-2-[2-(4chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[{(5-trifluoromethyl-pyridin-2yl)thio}methyl]-1,3-dioxolane: A novel, inducible binding mode. J. Med. Chem. 52,
4949-4950.
169) J. Guo, H. Massaeli, J. Xu, Z. Jia, J.T. Wigle, N. Mesaeli and S. Zhang. (2009)
Extracellular potassium concentration controls cell surface hERG channel density. J.
Clin. Invest. 119, 2745-2757.
168) B. Wathen and Z. Jia. (2009) Folding by numbers: The statistics of primary
sequences and their use in studying protein folding. Int. J. Mol. Sci. 10, 1567-1589.
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167) K. Podzelinska, S.-M. He, M. Wathier, A. Yakunin, M. Proudfoot, B. Hove-Jensen,
D.L. Zechel and Z. Jia. (2009) Structure of PhnP: A phosphodiesterase of the carbonphosphorous lyase pathway for phosphonate degradation. J. Biol. Chem. 284, 1721617226.
166) J. Zheng, D. Lee and Z. Jia. (2009) Purification, crystallization and preliminary Xray analysis of isocitrate dehydrogenase kinase/phosphatase in Escherichia coli. Acta
Cryst. F65, 536-539.
165) M.D.L. Suits, J. Lang, G.P. Pal, M. Couture and Z. Jia. (2009) Structure and heme
binding properties of Escherichia coli O157:H7 ChuX. Protein Sci.18, 825-838.
164) J.Z. Vlahakis, M. Hum, M.N. Rahman, Z. Jia, K. Nakatsu and W.A. Szarek. (2009)
Synthesis and evaluation of imidazole–dioxolane compounds as selective heme
oxygenase inhibitors: Effect of substituents at the 4-position of the dioxolane ring.
Bioorg. Med. Chem, 17, 2461-2475.
163) T.G Wright, V. Singh, J.J. Li, J. Foley, F.R. Miller, Z. Jia and B.E. Elliott. (2009)
Increased production and secretion of HGF alpha-chain and an antagonistic HGF
fragment in a human breast cancer progression model. Int. J. Cancer 125, 1004-1015.
162) R. Latimer, K. Podzelinska A. Soares, A. Bhattacharya, L.C. Vining, Z. Jia and
D.L. Zechel. (2009) Expression, purification and preliminary diffraction studies of CmlS.
Acta Cryst. F65, 260-263.
161) A. Matte, I. Ekiel, Z. Jia, K. Gehring and M. Cygler. (2009) A medium-throughput
structural proteomics approach applied to the genome of E. coli. In Systems Biology and
Biotechnology of Escherichia coli (Ed. S. Y. Lee). pp. 59-86, Springer.
160) V.A. McPherson, S. Everingham, R. Karisch, J.A. Smith, C.M. Udell, J. Zheng, Z.
Jia and A.W.B. Craig. (2009) Contributions of F-BAR and SH2 domains of Fes protein
tyrosine kinase for coupling to the FcεRI pathway in mast cells. Mol. Cell. Biol. 29, 389401.
159) L. Qin, J. Zheng, C.E. Grant, Z. Jia, S. P. C. Cole and R.G. Deeley. (2008) Residues
responsible for the asymmetric function of the nucleotide binding domains of Multidrug
Resistance Protein (MRP) 1. Biochemistry, 47, 13952-13965.
158) M.N. Rahman, J.Z. Vlahakis, W.A. Szarek, K. Nakatsu and Z. Jia. (2008) X-ray
crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1himidazol-1-yl)ethanone: A common binding mode for imidazole-based heme oxygenase1 inhibitors. J. Med. Chem. 51, 5943-5952.
157) D. Lee, J. Zheng, Y.-M. She and Z. Jia. (2008) Structure of Escherichia coli
tyrosine kinase Etk reveals novel activation mechanism. EMBO J. 27, 1758-1766.
(featured in Science)
156) Z. Jia. (2008) TAFI: Structured for self-destruction. Blood, 112, 2597-2598.
155) V.K. Singh, I. Pacheco, V.N. Uversky, S.P. Smith, R.J. MacLeod and Z. Jia. (2008)
Intrinsically disordered human C/EBP homologous protein regulates biological activity
of colon cancer cells during calcium stress. J. Mol. Biol. 380, 313-326.
154) M.D.L. Suits, P. Sperandeo, G. Dehò, A. Polissi and Z. Jia. (2008) Novel structure
of the conserved Gram-negative lipopolysaccharide transport protein LptA and
mutagenesis analysis. J. Mol. Biol. 380, 476-488.
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153) Q. Ye, H. Wang, J. Zheng, Q. Wei and Z. Jia. (2008) The complex structure of
calmodulin bound to a calcineurin peptide. Proteins, 73, 19-27.
152) K. Podzelinska, S.-M. He, D. Zechel, B. Hove-Jensen and Z. Jia. (2008)
Expression, purification and preliminary diffraction studies of PhnP. Acta Cryst. F64,
554-557.
151) Y. Zhang, H. Tan, Z. Jia and G. Chen. (2008) Ligand-induced dimer formation of
calmodulin. J. Mol. Recognit. 21, 267-274.
150) Y. Zhang, H. Tan, Y. Lu, Z. Jia and G. Chen. (2008) Ca2+ dissociation from the Cterminal EF-hand pair in calmodulin: A steered molecular dynamics study. FEBS Letters,
582, 1355-1361.
149) B. Wathen and Z. Jia. (2008) local and non-local environments around cis peptides.
J. Proteome Res. 7, 145-153.
148) V.K. Singh and Z. Jia. (2008) Targeting -synuclein to counteract drug resistance in
cancer. Expert Opin. Ther. Targets, 12, 59-68.
147) M.A. Adams, Y. Luo, B. Hove-Jensen, S.-M. He, L.M. van Staalduinen, D.L.
Zechel and Z. Jia. (2008) Crystal Structure of PhnH: An essential component of carbonphosphorus lyase in Escherichia coli. J. Bacteriol. 190, 1072-1083.
146) H. Xu, S. Perumal, J. Zhao, N. Du, Z. Jia, X.-Y. Liu and J.R. Lu. (2008) Interfacial
adsorption of antifreeze proteins: A neutron reflection study. Biophys. J. 94, 4405-4413.
145) M.D.L. Suits, A. Matte, Z. Jia and M. Cygler. (2008) The contribution of structural
proteomics to understanding the function of hypothetical proteins. In Structural
Proteomics and Its Impact on the Life Sciences (J. Sussman and I. Silman, Eds.). pp. 135152. World Scientific Publishing, Singapore.
144) L.M. van Staalduinen, A. Bhattacharya, K. Groom, D.L. Zechel and Z. Jia.(2007)
Expression, purification, and preliminary X-ray diffraction studies of RebC. Acta Cryst.
F63, 980-982.
143) M.A. Adams, M.D.L. Suits, J. Zheng and Z. Jia. (2007) Piecing together the
structure-function puzzle: Experiences in structure-based functional annotation of
hypothetical proteins. Proteomics 7, 2920-2932.
142) Q. Ye, H. Wang, A. Wong, X. Li, Q. Wei and Z. Jia. (2007) Crystallization
characteristics of calmodulin in complex and fused with calcineurin peptide. Cryst.
Growth Des. 7, 2198-2201.
141) J. Zheng, C. He, V. K. Singh, N.L. Martin and Z. Jia. (2007) Crystal structure of a
novel prokaryotic Ser/Thr kinase and its implication in the Cpx stress response pathway.
Mol. Mircobiol. 63, 1360-1371.
140) V.K. Singh, Y. Zhou, J.A. Marsh, V.N. Uversky, J.D. Forman-Kay, J. Liu and Z.
Jia. (2007) Synuclein-gamma targeting peptide inhibitor that enhances sensitivity of
breast cancer cells to anti-microtubule drugs. Cancer Res. 67, 626-633.
139) A. Matte, Z. Jia, J. Sivaraman and M. Cygler. (2007) Insights into the biology of
Escherichia coli through structural proteomics. J. Struct. Funct. Genomics, 8, 45-55.
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138) V.K. Singh, S. Nurmohamed, S.K. Davey and Z. Jia. (2007) Tri-cistronic cloning,
overexpression and purification of human Rad9, Rad1, Hus1 protein complex. Protein
Expr. Purif. 54, 204-211.
137) Y. Zhou, Y. Zhang, H. Tang, Z. Jia and G. Chen. (2007) Role of threonine on
antifreeze activity of insect antifreeze protein. Chem. J. Chinese Universities 28, 526-529.
136) M.D.L. Suits, N. Jaffer and Z. Jia. (2006) Structure of the Escherichia coli O157:
H7 heme oxygenase ChuS in complex with heme and enzymatic inactivation by mutation
of the heme coordinating residue His193. J. Biol. Chem. 281, 36776-36782.
135) T.S. Gujral, V.K. Singh, Z. Jia and L.M. Mulligan. (2006) Molecular mechanisms
of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B. Cancer Res.
66, 10741-10749.
134) J.A. Marsh, V.K. Singh, Z. Jia and J.D. Forman-Kay. (2006) Sensitivity of
secondary structure propensities to sequence differences between alpha- and gammasynuclein: Implications for fibrillation. Protein Sci. 15, 2795-2804.
133) M.A. Adams, V.K. Singh, B.O. Kelly and Z. Jia. (2006) Structural and biochemical
characterization of gentisate 1,2-dioxygenase from Escherichia coli O157:H7. Mol.
Microbiol. 61, 1469-1484.
132) M.A. Adams and Z. Jia. (2006) Modulator of Drug Activity B from Escherichia
coli: Crystal structure of a prokaryotic homologue of DT-diaphorase. J. Mol. Biol. 359,
455-465.
131) Q. Ye, X. Li, A. Wong, Q. Wei and Z. Jia. (2006) Structure of calmodulin bound to
calcineurin peptide: A new way of making an old binding mode. Biochemistry, 45, 738745.
130) J. Adams, G.P. Pal, Z. Jia and S. Smith. (2006) Mechanism of bacterial cell surface
attachment revealed by the structure of cellulosomal type II cohesin-dockerin complex.
Proc. Natl. Acad. Sci. 103, 305-310.
129) D.E. Prosser, Y. Ding, Z. Jia and G. Jones. (2006) Structural motif-based homology
modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D
hydroxylation. Biophys. J. 90, 3389-3409.
128) C.S. Strom, X.Y. Liu and Z. Jia. (2006) Structural basis of antifreeze action.
Biophys. Rev. Lett. 1, 259-270.
127) Y. Zhou, H. Tang, Z. Jia, R. Liu and G. Chen. (2006) Molecular basis for antifreeze
activity difference of two insect antifreeze protein isoforms. Sci. China. B50, 266-271.
126) M.D.L. Suits, G.P. Pal, K. Nakatsu, A. Matte, M. Cygler and Z. Jia. (2005)
Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional
repeats. Proc. Natl. Acad. Sci. 102, 16955-16960.
125) J. Zheng, V.K. Singh and Z. Jia. (2005) Identification of an ITPase/XTPase in E.
coli by structural and biochemical analysis. Structure 13, 1511-1520.
124) M.A. Adams and Z. Jia. (2005) Structural and biochemical analysis reveal pirins to
possess quercetinase activity. J. Biol. Chem. 280, 28675-28682.
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123) M.A. Adams and Z. Jia. (2005) Structural and biochemical evidence for an
enzymatic quinone redox cycle in Escherichia coli: Identification of a novel quinol
monooxygenase. J. Biol. Chem. 280, 8358-8363.
122) C.S. Strom, X.-Y. Liu and Z. Jia. (2005) Ice surface reconstruction as AFP-induced
morphological modification mechanism. J. Am. Chem. Soc. 127, 428-440.
121) W. Wu, Z. Jia, P. Liu, Z. Xie and Q. Wei. (2005) A novel PCR strategy for highefficiency, automated site-directed mutagenesis. Nucleic Acids Res. 33, e110.
120) J.-S. Shen, V. Geoffroy, S. Neshat, Z. Jia, A. Meldrum, J.-M. Meyer and K. Poole.
(2005) FpvA-mediated ferric pyoverdine uptake in Pseudomonas aeruginosa:
Identification of aromatic residues in FpvA implicated in ferric pyoverdine binding and
transport. J. Bacteriol. 187, 8511-8515.
119) C.S. Strom, X.-Y. Liu and Z. Jia. (2005) Why does insect AFP from Tenebrio
molitor (TmAFP) produce pyramidal ice crystallites? Biophys. J. 89, 2618-2627.
118) Q. Ye, I. Imriskova-Sosova B.C. Hill and Z. Jia. (2005) Identification of a disulfide
switch in BsSco, a member of the Sco family of cytochrome c oxidase assembly proteins.
Biochemistry, 44, 2934-2942.
117) W. Sangrar, R. Zirngibl, Y. Gao, W. Muller, Z. Jia and P. Greer. (2005) An identity
crisis for fps/fes: Oncogene or tumor-suppressor? Cancer Res. 65, 3518-3522.
116) V. Singh and Z. Jia. (2005) Refolding and one-step purification of recombinant
human ARA70 over-expressed in Escherichia coli. Protein Expr. Purif. 39, 283-287.
115) M.A. Adams, C.M. Udell, G.P. Pal and Z. Jia. (2005) MraZ from Escherichia coli:
Cloning, purification, crystallization and preliminary X-ray analysis. Acta Cryst. F61,
378-380.
114) K. Liu, Z. Jia, G. Chen, C. Tung and R. Liu. (2005) Systematic size study of an
insect antifreeze protein and its interaction with ice. Biophys. J. 88, 953-958.
113) M.A. Adams, P. Iannuzzi and Z. Jia. (2005) MdaB from Escherichia coli: cloning,
purification, crystallization and preliminary X-ray analysis. Acta Cryst. F61, 235-238.
112) C. Li, C. Guo, Z. Jia, B. Xia and C. Jin. (2005) Solution structure of an antifreeze
protein CfAFP-501 from Choristoneura fumiferana. J. Biomol. NMR 32, 251-256.
111) A.R. Belczewski, J. Ho, F.B. Taylor Jr., M.B. Boffa, Z. Jia and M.L. Koschinsky.
(2005) Baboon lipoprotein(a) does not bind to lysine or fibrin despite the presence of a
strong lysine-binding site in apolipoprotein(a) kringle IV type 10. Biochemistry, 44, 555564.
110) Q. Ye, V. Singh, J. Blonde and Z. Jia. (2005) Crystallization and preliminary X-ray
analysis of the GST fused human Bri3 N-terminal domain. Acta Cryst. F61, 62-64.
109) P. Liu, C, Huang, Z. Jia, F. Yi, D-Y. Yu and Q. Wei. (2005) Non-catalytic domains
of subunit A negatively regulate the activity of calcineurin. Biochimie. 87, 215-221.
108) J.J. Adams, G. Pal, K. Yam, H.L. Spencer, Z. Jia and S.P. Smith. (2005)
Purification and crystallization of a tri-modular complex of the type II cohesin-dockerin
interaction from the cellulosome of Clostridium thermocellum. Acta Cryst. F61, 46-48.
8
107) B. Wathen and Z. Jia. (2005) Controlling the freezing process with antifreeze
proteins. In Emerging Technologies for Food Processing (D. Sun, Ed.), pp. 653-672,
Elsevier Science, Amsterdam.
106) X.-J. Xie, Z. Jia and Q. Wei. (2005) Antifreeze protein structure and antifreeze
mechanism. Chin. J. Cell Biology, 27, 5-8.
105) C.M. Hosfield, J.S. Elce and Z. Jia. (2004) Activation of calpain by Ca2+: Roles of
the large subunit N-terminal and domain III-IV linker peptides. J. Mol. Biol. 343, 10491053.
104) C.S. Strom, X.-Y. Liu and Z. Jia. (2004) AFP-induced morphological modification
mechanisms linked to ice binding surface and crystal facets in periodic bond chain theory.
J. Biol. Chem. 279, 32407-32417.
103) T.G. Wright, J. Tsai, Z. Jia and B.E. Elliott. (2004) Inhibition by copper(II) binding
of hepatocyte growth factor interaction with its receptor Met and blockade of HGF/Met
function. J. Biol. Chem. 279, 32499-32506.
102) B. Wathen, M. Kuiper, V. Walker and Z. Jia. (2004) New simulation model of
multi-component crystal growth and inhibition. Chemistry 10, 1598-1605.
101) T. Moldoveanu, Z. Jia and P.L. Davies. (2004) Calpain activation by cooperative
Ca2+ binding at two non-EF-hand sites. J. Biol. Chem. 279, 5088-5099.
100) A.K. Larsen, T. De Veyra, Z. Jia, A. Wells, P. Dutt and J.S. Elce. (2004)
Expression of human, mouse, and rat m-calpains in E. coli and in murine fibroblasts.
Protein Expr. Purif. 33, 246-255.
99) Z. Yang, Z. Jia, R. Liu and G. Chen. (2004) Molecular and quantum mechanical
studies on the monomer recognition of a highly regular -helical antifreeze protein. Sci.
China B47, 34-40.
98) G.P. Pal, T. De Veyra, J.S. Elce and Z. Jia. (2003) Crystal structure of a µ-like
calpain reveals a partially activated conformation with low Ca2+ requirement. Structure,
11, 1521-1526.
97) D. Lee, M. Cortrill, C. Forsberg and Z. Jia. (2003) Functional insights revealed by
the crystal structures of Escherichia coli glucose-1-phosphatase. J. Biol. Chem. 33,
31412–31418.
96) Z. Yang, Y. Zhou, K. Liu, Y. Cheng, R. Liu, G. Chen and Z. Jia. (2003)
Computational study on the function of water within a -helix antifreeze protein dimer
and in the process of ice-protein binding. Biophys. J. 85, 2599-2605.
95) B.Q. Xiang, Z. Jia, F.X. Xiao, K. Zhou, P. Liu and Q. Wei. (2003) The role of loop 7
in mediating calcineurin regulation. Protein Eng. 16, 795-798.
94) I. Sosova, Q. Ye, B.C. Hill and Z. Jia. (2003) Purification, crystallization and
preliminary X-ray analysis of a Sco1-like protein from Bacillus subtilis, a copper binding
protein involved in the assembly of cytochrome c oxidase. Acta Cryst. D59, 1299-1301.
93) T. Moldoveanu, C.M. Hosfield, D. Lim, Z. Jia and P.L. Davies. (2003) Calpain
silencing by a reversible intrinsic mechanism. Nat. Struct. Biol. 10, 371-378.
9
92) A. Matte, J. Sivaraman, I. Ekiel, K. Gehring, Z. Jia and M. Cygler. (2003) The
contribution of structural genomics to understanding the biology of Escherichia coli. J.
Bacteriol. 185, 3994-4002.
91) S.D. Smith, Z. Jia, K.K. Huynh, A. Wells and J.S. Elce. (2003) Glutamate
substitutions at a PKA consensus site are consistent with inactivation of calpain by
phosphorylation. FEBS Letter, 542, 115-118.
90) B. Wathen, M. Kuiper, V. Walker and Z. Jia. (2003) A new model for simulating 3D
crystal growth and its application to the study of antifreeze proteins. J. Am. Chem. Soc.
125, 729-737.
89) E. K. Leinala, J.S.C. Arthur, P. Grochulski, P.L. Davies, J.S. Elce and Z. Jia. (2003)
A second binding site revealed by C-terminal truncation of calpain small subunit, a pentaEF-hand protein. Proteins, 53, 649-655.
88) S.P. Graether, S.M. Gagné, L. Spyracopoulos, Z. Jia, P.L. Davies and B.D. Sykes.
(2003) Spruce budworm antifreeze protein: Changes in structure and dynamics at low
temperature. J. Mol. Biol. 327, 1155-1168.
87) B.C. Hill, L. Becker, V. Anand, A. Kusmierczyk, S. M. Marcovina, M.N. Rahman,
B.R. Gabel, Z. Jia, M.B. Boffa and M.L. Koschinsky. (2003) A role for apolipoprotein(a)
in protection of the low-density lipoprotein component of lipoprotein(a) from coppermediated oxidation. Arch. Biochem. Biophys. 412, 186-195.
86) G.P. Pal, T. DeVeyra, J.S. Elce and Z. Jia. (2003) Purification, crystallization and
preliminary X-ray analysis of a μ-like calpain. Acta Cryst. D59, 369-371.
85) D. Lee and Z. Jia. (2003) Structure and function of Escherichia coli glucose-1phosphatase. Recent Res. Devel. Mol. Biol. 1, 251-261.
84) B. Wathen, M. Kuiper, V. Walker and Z. Jia. (2003) Three-dimensional simulation
of ice growth in the presence of antifreeze proteins. Can. J. Phys. 81, 39-45.
83) E.K. Leinala, P.L. Davies, D. Doucet, M.G. Tyshenko, V. Walker and Z. Jia. (2002)
A -helical antifreeze protein isoform with increased activity: Structural and functional
insights. J. Biol. Chem. 277, 33349-33352.
82) E.K. Leinala, P.L. Davies and Z. Jia. (2002) Crystal structure of -helical spruce
budworm antifreeze protein shows intimate surface complementarity to ice. Structure, 10,
619-627.
81) Z. Jia and P.L. Davies. (2002) Antifreeze proteins: An unusual receptor-ligand
interaction. Trends Biochem. Sci. 27, 101-106.
80) D. Lim and Z. Jia. (2002) Heavy metal-mediated crystallization of Escherichia coli
phytase and analysis of bridging interactions. Protein Pept. Lett. 4, 359-365.
79) Y. Cheng, Z. Yang, H. Tan, R. Liu G. Chen and Z. Jia. (2002) Analysis of icebinding sites in fish type II antifreeze protein by quantum mechanics. Biophys. J. 83,
2202-2210.
78) P. Dutt, C.N. Spriggs, P.L. Davies, Z. Jia and J.S. Elce. (2002) Origins of the
difference in Ca2+ requirement for activation of µ- and m-calpain. Biochem. J. 367, 263269.
10
77) T. Moldoveanu, C.M. Hosfield, D. Lim, J.S. Elce, Z. Jia and P.L. Davies. (2002) A
Ca2+ switch aligns the active site of calpain. Cell, 108, 649-660.
76) Y. Liu, X. Zhang, W. Zhang, Z, Chen, T, Chan, K, Ali, Z. Jia and J. Xiang. (2002)
Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced
CD8(+) cytotoxic T-cell activation and antitumor immunity. Cancer Gene Ther. 9, 202208.
75) M.E. Daley, L. Spyracopoulos, Z. Jia, P.L. Davies and B.D. Sykes. (2002) Structure
and dynamics of a -helical antifreeze protein. Biochemistry, 41, 5515-5525.
74) H. Shiraha, A. Glading, Z. Jia and A. Wells. (2002) Activation of m-calpain (calpain
II) by epidermal growth factor is limited by PKA phosphorylation of m-calpain. Mol.
Cell. Biol. 22, 2716-2727.
73) E.K. Leinala, P.L. Davies and Z. Jia. (2002) Elevated temperature and tyrosine
iodination aid in the crystallization and structure determination of an antifreeze protein.
Acta Cryst. D58, 1081-1083.
72) M.N. Rahman, L. Becker, V. Petrounevitch, B.C. Hill, Z. Jia and M.L. Koschinsky.
(2002) Comparative analyses of the lysine binding site properties of apolipoprotein(a)
kringle IV types 7 and 10. Biochemistry, 41, 1149-1155.
71) Z. Jia, C.M. Hosfield, P.L. Davies and J.S. Elce. (2002) Crystal structure of calpain
and insights into Ca2+-dependent activation. Methods Mol. Biol. 172, 51-67.
70) Z. Jia. (2002) Computational studies of ice-binding sites of fish type II and III
antifreeze proteins. Recent Res. Devel. Biophys. 1, 15-30.
69) Z. Jia, Q. Ye, A.N. Dinaut, Q. Wang, D. Waddleton, P. Payette, C. Ramachandran,
G. Hum and S.D. Taylor. (2001) Structure of protein tyrosine phosphatase 1B in complex
with inhibitors bearing two phosphotyrosine mimetics. J. Med. Chem. 44, 4584-4594.
68) G.P. Pal, J.S. Elce and Z. Jia. (2001) Dissociation and aggregation of calpain in the
presence of calcium. J. Biol. Chem. 276, 47233-47238.
67) Q. Ye, M.N. Rahman, M.L. Koschinsky and Z. Jia. (2001) High-resolution crystal
structure of apolipoprotein (a) kringle IV type 7: Insights into ligand binding. Protein Sci.
10, 1124-1129.
66) Q. Ye, D. Hyndman, N. Green, X. Li, B. Korithoski, Z. Jia and T.G. Flynn. (2001)
Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its
implications for substrate binding. Proteins, 44, 12-19.
65) C.M. Hosfield, T. Moldoveanu, P.L. Davies, J.S. Elce and Z. Jia. (2001) Calpain
mutants with increased Ca2+-sensitivity and implications for the role of the C2-like
domain III. J. Biol. Chem. 276, 7404-7407.
64) Z. Jia, V. Petrounevitch, A. Wong, T. Moldoveanu, P.L. Davies, J.S. Elce and J.S.
Beckmann. (2001) Mutations in calpain 3 associated with limb girdle muscular
dystrophy: Analysis by molecular modelling and by mutation in m-calpain. Biophys. J.
80, 2590-2596.
11
63) M.N. Rahman, V. Petrounevitch, Z. Jia and M.L. Koschinsky. (2001)
Antifibrinolytic effect of single apo(a) kringle domains: Relationship to fibrinogen
binding. Protein Eng. 14, 427-438.
62) S.P. Graether and Z. Jia. (2001) Modeling Pseudomonas syringe ice-nucleation
protein as a -helical protein. Biophys. J. 80, 1169-1173.
61) Q. Ye, D. Hyndman, N. Green, X. Li, Z. Jia and T.G. Flynn. (2001) The crystal
structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for
substrate binding. Chem. Biol. Interact. 130-132, 651-658.
60) T. Moldoveanu, C.M. Hosfield, Z. Jia, J.S. Elce and P.L. Davies. (2001) Ca2+induced structural changes in rat m-calpain revealed by partial proteolysis. Biochim.
Biophys. Acta 1545, 245-254.
59) Z. Chen, T. Moyana, A. Saxena, R. Warrington, Z. Jia and J. Xiang. (2001) Efficient
antitumor immunity derived from maturation of dendritic cells that had phagocytosed
apoptotic/necrotic tumor cells. Int. J. Cancer 93, 539-548.
58) V.K. Walker, M.J. Kuiper, M.G. Tyshenko, D. Doucet, S.P. Graether, Y.-C. Liou,
B.D. Sykes, Z. Jia, P.L. Davies and L.A. Graham. (2001) Surviving winter with
antifreeze proteins: Studies on budworm and beetles. In Insect Timing: Circadian
Rhythmicity and Seasonality (Denlinger, Giebultowicz and Saunders, Eds.), pp. 199-211,
Elsevier Science, Amsterdam.
57) Z. Jia, M. Cottrill, G.P. Pal, D. Lee, M. Sung, C.W. Forsberg and J.P. Phillips
(2001). Purification, crystallization and preliminary X-ray analysis of the Escherichia coli
glucose-1-phosphatase. Acta Cryst. D57, 314-316.
56) Z. Jia. (2001) Structural studies of E. coli phytase and its complex with phytate.
Recent Res. Devel. Protein Eng. 1, 291-301.
55) Y.-C. Liou, A. Tocilj, P.L. Davies and Z. Jia. (2000) Mimicry of ice structure by
surface hydroxyls and water of a -helix antifreeze protein. Nature, 406, 322-324.
54) S.P. Graether, M.J. Kuiper, S.M. Gagne, V.K. Walker, Z. Jia, B.D. Sykes and P.L.
Davies. (2000) -Helix structure and ice-binding properties of a hyperactive insect
antifreeze protein. Nature, 406, 325-328.
53) R. Bell, W.K. Stevens, Z. Jia, J. Samis, H.C.F. Côté, R.T.A. MacGillivray and M.E.
Nesheim. (2000) Fluorescence properties and functional roles of tryptophan residues 60d,
96, 148, 207, and 215 of thrombin. J. Biol. Chem. 275, 29513-29520.
52) D. Lim, S. Golovan, C.W. Forsberg and Z. Jia. (2000) Crystal structures of
Escherichia coli phytase and its complex with phytate. Nat. Struct. Biol. 7, 108-113.
51) J. Xiang, M. Srivamadevan, J. Yang and Z. Jia. (2000) Study of B72.3 combiningsites by molecular modelling and site-directed mutagenesis. Protein Eng. 13, 339-344.
50) Y.-C. Liou, P.L. Davies and Z. Jia. (2000) Crystallization and preliminary X-ray
analysis of insect antifreeze protein from the beetle, Tenebrio molitor. Acta Cryst. D56,
354-356.
49) P.S. David, P.S. Dutt, C.B. Wathen, Z. Jia and B.C. Hill. (2000) Characterization of
a structural model of membrane bound cytochrome c-550 from Bacillus subtilis. Arch.
Biochem. Biophys. 377, 22-30.
12
48) Q. Ye, X. Li, D. Hyndman, T.G. Flynn and Z. Jia. (2000) Crystal structure of CHO
reductase, a member of the aldo-keto reductase superfamily. Proteins, 38, 41-48.
47) C.M. Hosfield, J.S. Elce, P.L. Davies and Z. Jia. (1999) Crystal structure of calpain
reveals the structural basis for Ca2+-dependent protease activity and a novel mode of
enzyme activation. EMBO J. 18, 6880-6889.
46) S.P. Graether, C.I. DeLuca, J. Baardsnes, G.A. Hill, P.L. Davies and Z. Jia. (1999)
Quantitative and Qqualitative analysis of type III antifreeze protein structure and
function. J. Biol. Chem. 274, 11842-11847.
45) M.L. Tejada, Z. Jia and R.G. Deeley. (1999) Determinants of DNA-binding
specificity in the avian homeodomain protein, AKR. DNA Cell Biol. 18, 791-804.
44) G. Chen and Z. Jia. (1999) Ice-binding surface of fish type III antifreeze. Biophys. J.
77, 1602-1608.
43) C.M. Hosfield, Q. Ye, J.S.C. Arthur, C. Hegadorn, D.E. Croall, J.S. Elce and Z. Jia.
(1999) Crystallization and X-ray crystallographic analysis of m-calpain: A Ca2+dependent protease. Acta Cryst. D55, 1484-1486.
42) J. Xiang, L. Prasad, L.T.J. Delbaere and Z. Jia. (1999) Light-chain FR residue Tyr71
of chimeric B72.3 antibody plays an important role in influencing TAG72 antigen
binding. Protein Eng. 12, 417-421.
41) J. Yang, Z. Jia and J. Xiang. (1999) Substitution of surface-exposed framework
residues alters secretion of recombinant fusion protein FV/TNF in Escherichia coli.
IUBMB Life, 48, 327-332.
40) A. Cole, R. Zirngibl, A. Craig, Z. Jia and P. Greer. (1999) Mutation of a highly
conserved aspartate residue in subdomain IX abolishes Fer protein-tyrosine kinase
activity. Protein Eng. 12, 155-162.
39) D. Lim, Q. Ye and Z. Jia (1999) Condensation-free X-ray diffraction data collection
with capillaries at 277 K. J. Appl. Crystallogr. 32, 134-135.
38) S.P. Graether, Q. Ye, P.L. Davies and Z. Jia. (1999) Crystallization and preliminary
X-ray crystallographic analysis of spruce budworm antifreeze protein. J. Struct. Biol.
126, 72-75.
37) Q. Ye, E. Leinala and Z. Jia. (1998) Crystal structure of type III antifreeze protein at
4°C. Acta Cryst. D54, 700-702.
36) M. Rahman, Z. Jia, B.R. Gabel, S.M. Marcovina and M.L. Koschinsky. (1998)
Expression of apo(a) kringle IV type 9 in E. coli: Determination of a specific interaction
between kringle IV type 9 and apoB-100. Protein Eng. 12, 1249-1256.
35) K.J. Rees-Milton, Z. Jia, N.C. Green, M. Bhatia, O.El-Kabbani and T.G. Flynn.
(1998) Aldehyde Reductase: The Role of the C-terminal Residues in Defining Substrate
and Cofactor Specificities. Arch. Biochem. Biophys. 355, 137-144.
34) R.J. Hodgson, Z. Jia and W.C. Plaxton. (1998) A fluorescence study of ligand-induced
conformational change in cytosolic fructose-1,6-bisphophatase from germinating castor oil
seeds. Biochim. Biophys. Acta.1388, 285-294.
13
33) G. Huyer, J. Kelly, J. Moffat, R. Zamboni, Z. Jia, M.J. Gresser and C.
Ramachandran. (1998) Affinity selection from peptide libraries to determine substrate
specificity of protein tyrosine phosphatases. Anal. Biochem. 258, 19-30.
32) S. Desmarias, Z. Jia and C. Ramachandran. (1998) Inhibition of protein tyrosine
phosphatases PTP1B and CD45 by sulfotyrosyl peptides. Arch. Biochem. Biophys. 354,
225-231.
31) J.W. Quail, J. Yang, P. Schneider and Z. Jia. (1998) Crystal structure of the
Rhizomucor miehei aspartic proteinase. Adv. Exp. Med. Biol. 436, 283-292.
30) C.I. DeLuca, P.L. Davies, Q. Ye and Z. Jia. (1998) The effects of steric mutations on
the structure of type III antifreeze protein and its interaction with ice. J. Mol. Biol. 275,
515-525.
29) Z. Jia, S. Golovan, Q. Ye and C.W. Forsberg. (1998) Purification, crystallization and
preliminary X-ray analysis of the Escherichia coli phytase. Acta Cryst. D54, 647-649.
28) Z. Jia. (1997) Protein phosphatases: structures and implications. Biochem. Cell Biol.
75, 17-26.
27) J. Yang, J.W. Quail and Z. Jia. (1997) Succinyl oleanolic acid. Acta Cryst. C53, 349351.
26) Z. Jia, C.L. DeLuca, H. Chao and P.L. Davies. (1996) Structural basis for the binding
of a globular antifreeze protein to ice. Nature, 384, 285-288.
25) T.R. Burke, Jr., B. Ye, X. Yan, S. Wang, Z. Jia, L. Chen, Z.-Y. Zhang and D. Barford.
(1996) Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use
in inhibitor design. Biochemistry, 35, 15989-15996.
24) J. Xiang, Y. Sha, Z. Jia, L. Prasad and L.T.J. Delbaere. (1995) Framework residues 71
and 93 of the chimeric B72.3 antibody are major determinants of the conformation of
heavy-chain hypervariable loops. J. Mol. Biol. 253, 385-390.
23) D. Barford, Z. Jia and N.K. Tonks. (1995) Protein tyrosine phosphatases take off. Nat.
Struct. Biol. 2, 1043-1053.
22) Z. Jia, D. Barford, A.J. Flint and N.K. Tonks. (1995) Structural basis for
phosphotyrosine peptide recognition by human protein phosphatase 1B. Science, 268,
1754-1758.
21) Z. Jia. C.I. DeLuca and P.L. Davies. (1995) Crystallization and preliminary X-ray
crystallographic studies on type III antifreeze protein. Protein Sci. 4, 1236-1238.
20) Z. Jia, S. Hasnain, T. Hirama, X. Lee, R. To and C.P. Huber. (1995) Crystal structures
of recombinant rat cathepsin B and a cathepsin B-inhibitor complex: Implication for
structure-based inhibitor design. J. Biol. Chem. 270, 5527-5533.
19) Z. Jia, L.N. Johnson (1995) Learning modern protein crystallography. Structure, 3,
125.
18) Z. Jia, M. Vandonselaar, P. Schneider and J.W. Quail. (1995??) Crystallization and
preliminary X-ray structure solution of Rhizomucor miehei aspartic proteinase. Acta Cryst.
D51, 243-244.
14
17) T.V. Brennan, J.W. Anderson, Z. Jia, E.B. Waygood and S. Clarke. (1994) Repair of
spontaneously deamidated HPr phosphocarrier protein catalyzed by the L-isoaspartate-(Daspartate) O-methyltransferase. J. Biol. Chem. 269, 24586-24595.
16) Z. Jia, J.W. Quail, L.T.J. Delbaere and E.B. Waygood. (1994) Structural comparison
of histidine-containing phosphocarrier protein HPr. Biochem. Cell Biol. 72, 202-217.
15) Z. Jia, M. Vandonselaar, W. Hengstenberg, J.W. Quail and L.T.J. Delbaere. (1994)
The 1.6 Å resolution structure of histidine-containing phosphocarrier protein HPr from
Streptococcus faecalis. J. Mol. Biol. 236, 1341-1355.
14) Z. Jia, E.B. Waygood, J.W. Quail and L.T.J. Delbaere. (1993) The 2.0 Å resolution
structure of Escherichia coli histidine-containing phosphocarrier protein HPr. J. Biol.
Chem. 268, 22490-22501.
13) Z. Jia, M. Vandonselaar, J.W. Quail and L.T.J. Delbaere. (1993) Active-centre
torsion-angle strain revealed in 1.6 Å resolution structure of the histidine-containing
phosphocarrier protein. Nature, 361, 94-97.
12) J.R. Dimmock, K.M. Advikolanu, H.E. Scott, M.J. Duffy, R.S. Reid, J.W. Quail, Z.
Jia, R.A. Hickie, T.M. Allen, J.M. Rutledge, M.L. Tempest and A.B. Oreski. (1992)
Cytotoxicity evaluation of some mannich bases of various aryl and arylidene ketones and
their corresponding arylhydrazones. J. Pharm. Sci., 81, 1147-1152.
11) J.R. Dimmock, K.K. Sidhu, J.W. Quail, Z. Jia, M.J. Duffy, R.S. Reid, D.L.
Kirkpatrick, L. Zhu and S.M. Fletcher. (1992) Synthesis and cytotoxic evaluation of
some 6-arylidene-2-(-hydroxyamino--aryl-methyl)cyclohexanone oximes and related
compounds. J. Pharm. Sci, 81, 1059-1064.
10) S. Gupta, P.J. Aduma, Z. Jia, A.L. Stuart, S.A. Kumar, G. Tourigny, and L.T.J.
Delbaere. (1992) Relationship between conformation and antiviral activity - II. 5methoxymethyl-2'-deoxycytidine and 5-methoxymethyl-N4-methyl-2'-deoxycytidine.
Antivir. Chem. Chemoth. 3, 15-22.
9) Z. Jia, J.W. Quail and J.R. Dimmock. (1990) Structure of 2-(4dimethylaminobenzylidene)-cyclohexanone. Acta Cryst. C46, 2467-2468.
8) Z. Jia, G. Tourigny, A.L. Stuart, L.T.J. Delbaere and V.S. Gupta. (1990) Structure and
conformation of 5-methoxymethyl-N4-methyl-2'-deoxycytidine. Acta Cryst. C45, 21822185.
7) Z. Jia, G. Tourigny, A.L. Stuart, L.T.J. Delbaere and S.V. Gupta. (1990) Structure and
conformation of 5-methoxymethyl-2'-deoxycytidine. Can. J. Chem. 68, 836-841.
6) J. R. Dimmock, V.K. Arora, S.L. Wonko, N.W. Hamon, J.W. Quail, Z. Jia, R.C.
Warrington, W.D. Fang and J.S. Lee. (1990) 3,5-bis-benzylidene-4-piperidones and
related compounds with high activity towards P388 leukemia cells. Drug Des. Deliv. 6,
183-194.
5) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock. (1989) Structure of 3,5bis(benzylidene)-1-methyl-4-piperidone methobromide hemiethanol solvate. Acta Cryst.
C45, 1117-1118.
15
4) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock. (1989) Structure of 3,5-bis(4dimethyl-aminobenzylidene)-1-methyl-4-piperidone methoiodide. Acta Cryst. C45, 11191120.
3) M.S.C. Pedras, S.R. Abrams, G. Seguin-Swartz, J.W. Quail and Z. Jia. (1989)
Phomalirazine, a novel toxin from the phytopathogenic fungus Phoma lingam. J. Am.
Chem. Soc. 111, 1904-1905.
2) Z. Jia, J.W. Quail, V.K. Arora and J.R. Dimmock. (1989) Structures of 2,6bis(benzylidene)-cyclohexanone (III) and 3,5-(4-dimethylaminobenzylidene)-1-methyl-4piperidone (IV). Acta Cryst. C45, 285-289.
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C44, 2114-2117.
PATENT
P. Davies, J. Elce, C. Hosfield, Z. Jia and T. Modoveanu. Methods of determining
polypeptide structure and function. U.S. Patent No. 7236891, issued June 26, 2007.
R. Kisilevsky, S.-P. Tam, J. Ancsin and Z. Jia. Composition and methods for treating
atherosclerosis. U.S. Patent No. 7291590, issued Nov. 6, 2007.
R. Kisilevsky, S.-P. Tam, J. Ancsin and Z. Jia. Composition and methods for treating
atherosclerosis. U.S. Patent No. 7700544, issued April 20, 2010.
V. Singh and Z. Jia. Compositions for treatment of cancer. U.S. Patent No. 7897568,
issued March 1, 2011.
R. Kisilevsky, S.-P. Tam, J. Ancsin and Z. Jia. Peptides enhancing CEH activity or
inhibiting ACAT activity, pharmaceutical compositions comprising these peptides and
their use in the treatment of atherosclerosis. Australian Patent No. 2004247286, issued
May 19, 2011.
R. Kisilevsky, S.-P. Tam, J. Ancsin and Z. Jia. Peptides enhancing CEH activity or
inhibiting ACAT activity, pharmaceutical compositions comprising these peptides and
their use in the treatment of atherosclerosis. International Patent Application No.
PCT/CA2004/000846, published on Dec. 23, 2004.
V. Singh and Z. Jia. Ankyrin-like motif-based peptides for treatment of cancer. Canadian
patent application filed March 5, 2007 (Canadian patent application No. 2,650,113).
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