Wednesday August 28th 8.00-8.45: Registration 8.45- 9.00: Welcome remarks 9.00 -10.30: Symposium: Molecular architecture of synapses (Chair August Smit) Jean-Philippe Pin (Montpellier) - Sensing mGlu receptor activation and modulation Jean-Louis Bessereau (Lyon) - Extracellular scaffolds: an alternative perspective for post-synaptic organization Vladan Lucic (Martinsried) - Imaging neuronal synapses at molecular resolution by cryo-electron tomography 10.30-11.00: Coffee break 11.00-12.30: Symposium: Molecular architecture of synapses (Chair August Smit) Radu Aricescu (Oxford) - Mind the gap: trans-synaptic protein networks to learn and remember Stephen Smith (Stanford) - From brain maps to brain mechanisms: synapse molecular diversity Short talks Fekrje Selimi (Paris) - Two afferents, one target: what are the molecular pathways controlling their specific connectivity? Lydia Danglot (Paris) - Role of the vesicular SNARE TI-VAMP in post-synaptic receptors distribution and traficking at hippocampal synapses. 12.30-13.30: Lunch 13.30-15.00: Posters session #1 15.00-16.30: Symposium: Presynaptic mechanisms and neurotransmitter release (chair: Michela Matteoli) Timothy Ryan (New York) - Interplay of Ca and K channels in controlling presynaptic waveforms, calcium influx and exocytosis Matthjis Verhage (Amsterdam) - Docking, priming and fusion of dense core vesicles in mammalian CNS neurons Short talks Elisabetta Menna (Milan) - The role of the actin capping protein Eps8 in synapse formation and function Mario Carta (Bordeaux) - Membrane lipids tune synaptic transmission by direct modulation of potassium channels 16.30-16.45: short break 16.45-17.45: Symposium: Presynaptic mechanisms and neurotransmitter release Mike Cousin (Edinburgh) - Control of synaptobrevin retrieval by synaptophysin in health and disease Zoltan Nusser (Budapest) - Quantitative molecular differences in presynaptic active zones Thursday August 29th 9.00 -10.30: Symposium: Synaptic plasticity and networks (chair: Christophe Mulle) Christoph Schmidt-Hieber (London) - Probing synaptic mechanisms of grid cell formation Thomas Oertner (Hamburg) - Form follows function: reverse engineering of spine synapses Short talks Zafar Bashir (Bristol) - NMDA Receptor-mediated metaplasticity at schaffer collateral-CA1 synapses. Kathalin Toth (Quebec) - Distinct pool of vesicles contributing to asynchronous release are generated via bulk endocytosis 10.30-11.00: Coffee break 11.00-12.30: Symposium: Synaptic plasticity and networks (chair: Christophe Mulle) Laure Rondi-Reig (Paris) - Interaction between cerebellum and hippocampus in sequence learning: anatomo-functional studies in human and mice Christian Lüscher (Geneva) - Drug-evoked synaptic plasticity: from molecular mechanism to behavioural correlates and back Short talks Jakob Von Engelhardt (Heidelberg) - CKAMP44 and TARP-γ8 modulate gating and promote surface expression of AMPA receptors in dentate gyrus granule cells Helmut Kessels (Amsterdam) - NMDA Receptor dependent long-term synaptic depression is independent of ion flow through NMDA receptors 12.30-13.30: Lunch 13.30-15.00: Posters session #2 15.00-16.00: Symposium: Synaptic plasticity and networks (chair: Christophe Mulle) Jeff Magee (Ashburn) - The high spine neck resistance in CA1 pyramids increases nonlinear input interactions Seth Grant (Edinburgh) - Deconstructing synapse complexity 16.00: Free time 20.00: Gala dinner for everyone at the restaurant “H 36”, 1 rue de la Gironde, Bordeaux (Tram line B, stop “Bassins à flot”) Friday August 30th 9.00 -10.30: Symposium: Trafficking and synaptogenesis (chair: Monica Di Luca) Nathalie Sans (Bordeaux) - Regulation of glutamate receptor trafficking by scaffolding proteins of the planar cell polarity signaling pathway Peter Scheiffele (Basel) - Deconvolving molecular diversity of synaptic adhesion molecules Short talks Thomas Biederer (Yale) - Activity-driven changes in the synaptogenic potential of neurons modulate memory processing Fabrizio Gardoni (Milan) - A novel partner for GluN2A-containing NMDA receptors, RNF10: a synapse-to-nucleus signal 10.30-11.00: Coffee break 11.00-12.30: Symposium: Trafficking and synaptogenesis (chair: Monica Di Luca) Eric Wanker (Berlin) - First interactome maps for synaptic proteins Nicola Allen (San Diego) - Astrocyte regulation of neuronal glutamate receptors Arnivan Gosh (Basel) - title missing 12.30-12.45: Concluding remarks and prospects for the ESM 2015 12.45-14.00: Farewell buffet lunch