Supplemental table S1. Baseline demographics, clinical characteristics and outcomes among study
patients
RECIPIENT
n=97(%)
Age at transplant, mean±SD, y
30.3±10.5 [16 to 58]
Male sex
65 (67)
Recipient BMI, mean±SD, kg/m²
21.4±4.2 [14.6 to 34.4]
Type of hospital
Hospital 1 non-specialized in ACHD care
28 (28.9)
Hospital 2 specialized in ACHD care
36 (37.1)
Hospital 3 specialized in ACHD care
33 (34)
Medical history
Previous surgery
87 (90.6)
More than 3 previous surgeries
44 (45.4)
Previous sternotomies, mean±SD
1.8±1.3 [0 to 6]
Previous thoracotomies, mean±SD
0.6 ±0.8 [0 to 3]
History of supraventricular arrhythmias
55 (56.7)
ICD before listing
9 (9.3)
CRT before listing
11 (11.3)
Clinical status and laboratory values at transplant
Clinical signs of right heart failure
52 (53.6)
Protein losing enteropathy
4 (4.2)
Fistulae or collateral vessels*
10 (10.3)
Saturation before HT, mean±SD, %
90.9 ±9.5 [60 to 100]
Saturation< 90%
27 (27.8)
Waiting time, mean±SD, d
197±247 [0 to 1192]
Priority HT listing
20 (20.6)
At home before HT
69 (71.1)
ECMO/VAD dependent before HT
13 (13.4)
Inotrope dependent before HT
20 (20.6)
UNOS status 1
22 (22.7)
Hematocrit before HT, mean±SD, %
45.1±9.6 [28 to 71]
Hemoglobin before HT, mean±SD, g/dL
14.8 ±3.1 [9.1 to 23]
Creatinine clearance < 60mL/min
16 (16.5)
PER-OPERATIVE DATA
Ischemic time, mean±SD, min
203±66 [74 to 355]
Bypass time, mean±SD, min
198±102 [67 to 780]
Prior femoral cannulation
19 (20.6)
Additional surgical procedure
21 (21.6)
Per HT circulatory assistance
18 (18.6)
Post HT circulatory assistance
23 (23.7)
Reoperation for haemostasis, mean±SD, n
0.3±0.6 [0 to 3]
LONG TERM OUTCOMES
Dialysis dependent
2 (2.1)
Creatinine clearance at1 year after HT, mean±SD, mL/min
73±30 [14.7 to 181]
Cardiac allograft vasculopathy
6 (6.2)
Cancer
8 (11.1)
Treated for cellular rejection
33 (56.9)
Cellular rejections 1st year, n/per patient
0.9±1.6 [0 to 7]
Humoral rejection
2 (3.2)
Infection occurred during the 1st year
9 (11.7)
Retransplantation
3 (3.1)
Death (all)
44 (45.4)
Early death (in-hospital mortality)
33 (34)
One year death
35 (36.1)
CAUSE OF DEATH (n=44)
Graft dysfunction
11 (25)
Haemorrhage
11 (25)
Sepsis
11 (25)
Rejection
2 (4.6)
Stroke
2 (4.6)
Others
7 (15.9)
Note: Numbers in brackets indicate ranges.
SD indicates standard deviation; BMI, body mass index; ICD, implantable cardioverter defibrillator;
CRT, cardiac resynchronization therapy; ECMO, extracorporeal membrane oxygenation and VAD;
ventricular Assist Device
* Fistulae or collateral vessels: Pulmonary arteriovenous fistulae or systemic-to-pulmonary artery
collateral vessels
Supplemental table S2. Comparison of donors' characteristics and between the 2 eras
All donors
Era 1
(1988-2005)
n=48
Era 2
(2006-2012)
n=49
P value
38.1±14.8 [9 to 65]
34.9±15.8
41.2±13.1
0.03
Male sex
55 (58.5)
28 (59.6)
27 (55.1)
0.7
Sex mismatch
34 (36.2)
20/41.7%
14/28.6%
0.4
BMI, mean±SD, kg/m²
23.9±4.4 [15.6 to 44.2]
23.6±4.6
24.2±4.3
0.6
Need for inotropic agent
66 (89.2)
27 (87.1)
39(90.7)
0.6
Previous external massage
14 (19.2)
4 (13.3)
10 (23.3)
0.3
Age, mean±SD, y
Note: Values in brackets are percentages. Numbers in brackets indicate ranges.
SD indicates standard deviation; BMI, body mass index;
Supplemental table S3. Pre-transplant diagnoses by era of transplant
Variable
Era 1
Era 2
(1988-2005)
(2006-2012)
n=48 (%)
n=49 (%)
Primary diagnosis
P
0.06
D-TGA (Senning or Mustard’s procedure)
4 (8.3)
15 (30.6)
0.009
Single ventricle
10 (20.8)
5 (10.2)
0.17
Tricuspid atresia
8 (16.7)
5 (10.2)
0.39
TOF
8 (16.7)
4 (8.2)
0.23
Double outlet left ventricle
4 (8.3)
7 (14.3)
0.52
Congenital valvular disease
7 (14.6)
4 (8.2)
0.32
Congenitally Corrected TGA
5 (10.4)
2 (4.1)
0.27
Ventricular septal defect
1 (2.1)
2 (4.1)
1
Pulmonary atresia with intact ventricular septum
0
2 (4.1)
0.5
TOF with pulmonary atresia
0
1 (2.0)
1
Others (miscellaneous)
1 (2.1)
2 (4.1)
1
24 (50)
19 (38.8)
0.27
Univentricular anatomy (versus biventricular)
Complexity of CHD
Note: Values in brackets are percentages.
TGA, transposition of the great arteries; TOF, tetralogy of Fallot
0.05
Supplemental table S4. Multivariable factors associated with 1-year mortality after HT in era 1
and era 2
Variable
OR (95% CI)
p value
Age at listing for HT
1.096 (1.007-1.193)
0.033
Male sex
0.179 (0.038-0.853)
0.031
Biventricular anatomy
0.102 (0.015-0.712)
0.021
Reoperation for hemostasis
8.559 (1.422-51.523)
0.019
8.171 (2.125-31.422)
0.002
HT in era 1 (1988-2005)
HT in era 2 (2006-2012)
Post HT circulatory assistance
OR, odds ratio; CI confidence interval