Center for Advanced Orthopaedic Studies
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline Avenue, RN 119
Boston, MA 02215
Education
Phone: 617-667-8440
Fax: 617-667-7175
LKarim@bidmc.harvard.edu
Lamya.Karim@gmail.com
2011 Ph.D. in Biomedical Engineering
Dissertation title: The Biomolecular Basis of Bone Fracture
Rensselaer Polytechnic Institute, Troy, NY
2007
Appointments
B.E. in Biomedical Engineering, cum laude
Degree concentration: Biomechanics
Stony Brook University (Honors College), Stony Brook, NY
2015-present Instructor, Department of Orthopedic Surgery, Harvard Medical School
Staff Scientist, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess
Medical Center
2012-2015 Post-doctoral Research Fellow, Department of Orthopedic Surgery, Harvard
Medical School
Post-doctoral Research Fellow, Center for Advanced Orthopaedic Studies, Beth
Israel Deaconess Medical Center
2007-2011 Graduate Research Assistant, Center for Biotechnology and Interdisciplinary
Studies, Rensselaer Polytechnic Institute
2003-2007 Undergraduate Research Assistant, Integrative Skeletal Adaptation and Genetics
Laboratory, Stony Brook University
Research Fellowships and Grants
2015-2016
“Bone Quality Deficits in Type 2 Diabetes Mellitus”
Harvard Catalyst Early Clinical Data Support for Grant Submissions
NIH-NCRR and NIH-NCATS Award UL1TR001102
Role: PI ($13,167 direct costs)
Mentor: Dr. Mary L. Bouxsein
2012-2014 “Effect of Bone Quality on Bone Mechanical Properties as Determined by a
Novel Microindentation Approach”
Translational Research in Aging Program
NIH-NIA NRSA Award T32AG023480
Role: Post-doctoral trainee
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Mentor: Dr. Mary L. Bouxsein
2009-2011
“The Biomolecular Basis of Bone Toughness”
Biomolecular Science and Engineering Training Program
NIH-NIGMS NRSA Award T32GM067545
Role: Pre-doctoral trainee
Mentor: Dr. Deepak Vashishth
Journal Articles
1.
Karim L , Bouxsein ML. Effect of Type 2 Diabetes-Related Non-Enzymatic Glycation on
Bone Biomechanical Properties. Bone, 2015 (in press).
2.
Karim L , Van Vliet M, Bouxsein ML. Comparison of Cyclic and Impact-Based Reference
Point Indentation Measurements in Human Cadaveric Tibia. Bone, 2015 (in press).
3.
Ural A, Janeiro C, Karim L , Diab T, Vashishth D. Association between Non-Enzymatic
Glycation, Resorption, and Microdamage in Human Tibial Cortices. Osteoporos Int,
26(3):865-73, 2015.
4.
Devlin MJ, Van Vliet M, Motyl K, Karim L , Brooks DJ, Louis L, Conlon C, Rosen C,
Bouxsein ML. Early Onset Type 2 Diabetes Impairs Skeletal Acquisition in the Male
TALLYHO/JngJ Mouse. Endocrinology, 155(10):3806-16, 2014.
5.
Fajardo RJ, Karim L , Calley VI, Bouxsein ML. A Review of Rodent Models of Type 2
Diabetic Skeletal Fragility. J Bone Miner Res, 29(5):1025-40, 2014.
6.
Karim L , Judex S. Low Level Irradiation in Mice can Lead to Enhanced Trabecular Bone
Morphology. J Bone and Miner Metab, 32(5):476-483, 2013.
7.
Faje AT, Karim L , Taylor A, Miller KK, Mendes N, Meenaghan E, Bouxsein ML, Misra M,
Klibanski A. Adolescent Girls with Anorexia Nervosa have Impaired Cortical and Trabecular
Microarchitecture and Lower Estimated Bone Strength at the Distal Radius. J Clin
Endocrinol Metab, 98(5):1923-1929, 2013.
8.
Karim L , Tang SY, Sroga GE, Vashishth D. Differences in Non-Enzymatic Glycation and
Collagen Crosslinks between Human Cortical and Cancellous Bone. Osteoporos Int,
24(9):2441-2447, 2013.
9.
Karim L , Bouxsein ML. The Relative Influence of Damage versus Density on Trabecular
Bone Mechanical Behavior. IBMS BoneKEy 9, article 161, 2012.
10.
Karim L , Vashishth D. Heterogeneous Glycation of Cancellous Bone and its Association with Bone Quality and Fragility. PLoS ONE 7(4):e35047, 2012.
11.
Sroga GE, Karim L , Colon W, Vashishth D. Biochemical Characterization of Major Bone-
Matrix Proteins Using Nanoscale-Size Bone Samples and Proteomics Methodology. Mol
Cell Proteomics 10(9):M110.006718, 2011.
12.
Karim L , Vashishth D. The Role of Trabecular Microarchitecture in the Formation,
Accumulation, and Morphology of Microdamage in Human Cancellous Bone. J Orthop Res
29(11):1739-1744, 2011.
Book Chapters
1.
Karim L , Bouxsein ML. Bone Biomechanics and the Determinants of Skeletal Fragility.
Holick MF, Nieves J (Eds.) Nutrition and Bone Health, 2nd edition, ISBN 978-1-4939-2000-
6, Springer 2015.
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2.
Karim L , Hussein AI, Morgan EF, Bouxsein ML. The Mechanical Behavior of Bone.
Marcus R, Feldman D, Dempster DW, Luckey M, Cauley JA (Eds.) Osteoporosis, 4th edition, ISBN: 978-0-12- 415853-5, Boston: Elsevier 2013.
3.
Karim L , Vashishth D. Bone Microdamage and its Contributions to Fracture. Silva MJ and
Guo XE (Eds.) Skeletal Aging and Osteoporosis: Biomechanics and Mechanobiology, ISBN-
13: 978- 3642180521, New York: Springer 2013.
Conference Proceedings
1.
Karim L , Velie K, Van Vliet M, Abdeen A, Ayres D, Bouxsein ML. Cortical Bone Tissue
Properties are Deteriorated in Adults with Type 2 Diabetes Mellitus. Transactions of the 62 nd
Annual Meeting of the Orthopaedic Research Society, Orlando, FL, 2016.
2.
Karim L , Brooks DJ, Adams R, Dadourian G, Easson G, Bouxsein ML. Association between Reference Point Indentation Measures, Bone Composition, and Mechanical
Properties in Human Cortical Bone.
Transactions of the 61st Annual Meeting of the
Orthopaedic Research Society, Las Vegas, NV, 2015.
3.
Karim L , Portero-Muzy NR, Brooks DJ, Gineyts E, Chavassieux PM, Chapurlat RD,
Bouxsein ML. Association Between Reference Point Indentation Measures and Cortical
Bone Composition, Bending Properties, and Fracture Toughness. Abstracts of the 36 th
Annual Meeting for the American Society for Bone and Mineral Research, Houston, TX,
2014.
4.
Karim L , Van Vliet M, Bouxsein ML. Cyclic- and Impact-Based Reference Point
Indentation Measurements Are Moderately Correlated with Each Other in Human Cadaveric
Tibia.
Abstracts of the 7 th
World Congress of Biomechanics, Boston, MA, 2014.
5.
Karim L , Diallo M, Bouxsein ML. Reference Point Indentation Detects Changes in Rat
Bone Induced by In Vitro Sodium Fluoride Incubation. Abstracts of the 35th Annual Meeting for the American Society for Bone and Mineral Research, Baltimore, MD, 2013.
6.
Devlin M, Conlon C, Van Vliet M, Louis L, Karim L , Rosen C, Bouxsein ML. Leptin
Blunts the Starvation-Induced Increase in Bone Marrow Adiposity. Abstracts of the 35th
Annual Meeting for the American Society for Bone and Mineral Research, Baltimore, MD,
2013.
7.
Karim L
, Serell S, Louis L, Bouxsein ML. Reference Point Indentation Reflects In Vitro
Alterations of Bone Matrix in Murine Bone. Transactions of the 59th Annual Meeting of the
Orthopaedic Research Society, San Antonio, TX, 2013.
8.
Devlin M, Van Vliet M, Conlon C, Louis L, Karim L , Bouxsein ML. Early Onset Type 2
Diabetes Impairs Skeletal Acquisition in the Tallyho Mouse. Abstracts of the 34th Annual
Meeting of the American Society for Bone and Mineral Research, Minneapolis, MN, 2012.
9.
Faje A, Karim L , Taylor A, Miller K, Mendes N, Meenaghan E, Bouxsein ML, Misra M,
Klibanski A. Cortical and Trabecular Microarchitecture and Finite Element Analysis
Strength Estimates at the Ultradistal Radius Reflect Skeletal Fragility in Adolescent Girls with Anorexia Nervosa. Abstracts of the 34th Annual Meeting of the American Society for
Bone and Mineral Research, Minneapolis, MN, 2012.
10.
Karim L , Louis L, Conlon C, Bouxsein ML. Reference Point Indentation Measures are
Associated with Whole Bone Mechanical Properties Independent of Geometry. Abstracts of the 34th Annual Meeting of the American Society for Bone and Mineral Research,
Minneapolis, MN, 2012.
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11.
Karim L , Poundarik A, Vashishth D. Non-Collagenous Matrix Proteins and Post-
Translational Modifications Explain Bone Toughness Loss in an Aging Mouse Model.
Transactions of the 58th Annual Meeting of the Orthopaedic Research Society, San
Francisco, CA, 2012.
12.
Karim L , Vashishth D. Non-Enzymatic Glycation is Associated with Markers of Bone
Quality in Human Cortical and Cancellous Bone. Transactions of the 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 2012.
13.
Karim L , Campbell J, Tommasini S, Judex S, Vashishth D. Effects of Parathyroid Hormone
Treatment in Ovariectomized Rats. Transactions of the 58th Annual Meeting of the
Orthopaedic Research Society, San Francisco, CA, 2012.
14.
Karim L , Vashishth D. Effects of Trabecular Level Glycation on Bone Fragility. Abstracts of the 22nd Annual Meeting of the Biomedical Engineering Society, Hartford, CT, 2011.
15.
Karim L , Vashishth D. Role of Glycation in Microdamage Morphology in Cancellous and
Cortical Bone. Abstracts of the 33nd Annual Meeting of the American Society for Bone and
Mineral Research, San Diego, CA, 2011.
16.
Karim L , Vashishth D. Trabecular Rods Have Higher Levels of Non-Enzymatic Glycation than Plates. Abstracts of the 37th Annual Meeting of the Northeast Bioengineering
Conference, Troy, NY, 2011.
17.
Karim L , Poundarik A, Vashishth D. Acquisition and Loss of Bone Matrix Quality in Mice.
Trans- actions of the 57th Annual Meeting of the Orthopaedic Research Society, Long
Beach, CA, 2011.
18.
Karim L , Vashishth D. Effects of Non-Enzymatic Glycation on Trabecular Bone Fragility
May be Mediated Through Changes in Bone Matrix Quality and Microarchitecture. Abstracts of the 32nd Annual Meeting of the American Society for Bone and Mineral Research,
Toronto, ON, 2010.
19.
Karim L , Sroga GE, Tang SY, Vashishth D. The Accumulation of Advanced Glycation End
Products and Pentosidine in Human Cancellous and Cortical Bone. Abstracts of the 32nd
Annual Meeting of the American Society for Bone and Mineral Research, Toronto, ON,
2010.
20.
Karim L , Sroga GE, Vashishth D. Measurement of Osteopontin and Osteocalcin from Laser
Microdissected Microdamaged Regions in Bone. Abstracts of the 21st Annual Meeting of the
Biomedical Engineering Society, Austin, TX, 2010.
21.
Karim L , Vashishth D. Non-Enzymatic Glycation Weakens Trabecular Bone and May
Influence Changes in Bone Quality. Abstracts of the 36th Annual Meeting of the Northeast
Bioengineering Conference, New York, NY, 2010.
22.
Ani Ural, Karim L , Vashishth D. Cohesive Finite Element Modeling of Mouse Bone
Fracture. Transactions of the 56th Annual Meeting of the Orthopaedic Research Society,
New Orleans, LA, 2010.
23.
Karim L , Tommasini S, Judex S, Vashishth D. Creep Characteristics of the Extracellular
Bone Matrix Modulate Whole Bone Toughness. Transactions of the 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, 2010.
24.
Karim L
, Vashishth D. Microarchitecture Paired With Bone Volume Fraction Influences
Microdamage Formation. Abstracts of the 31st Annual Meeting of the American Society for
Bone and Mineral Research, Denver, CO, 2009.
25.
Mulligan M, Bellapianta J, Roberts J, Karim L , Uhl R, Vashishth D. The Effects of Non-
Enzymatic Glycation: A Comparison Between Hip Osteoarthritis and Hip Fractures.
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Abstracts of the 76th Annual Meeting of the American Academy of Orthopaedic Surgeons,
Las Vegas, NV, 2009.
26.
Karim L , Vashishth D. Effects of Microarchitecture on Trabecular Microdamage.
Transactions of the 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas,
NV, 2009.
27.
Sroga GE, Karim L , Vashishth D. Increased Levels of Osteocalcin and Osteopontin
Correlate With Bone Microdamage. Transactions of the 55th Annual Meeting of the
Orthopaedic Research Society, Las Vegas, NV, 2009.
28.
Poundarik A, Karim L , Gundberg C, Vashishth D. The Role of Osteocalcin in Bone
Fracture. Transactions of the 55th Annual Meeting of the Orthopaedic Research Society, Las
Vegas, NV, 2009.
29.
Karim L , Xu S, Ozcivici E, Grossman S, Judex S. Skeletal Effects of Low-Level Radiation on Adult C57BL/6J Strain Mice. Abstracts of the 17th Annual Meeting of the Biomedical
Engineering Society, Chicago, IL, 2006.
30.
Karim L , Xu S, Garman R, Judex S. Exposure of the Adult C57BL/6J Strain Mice Skeleton to Long- Term Low-Level Radiation. Abstracts of the 16th Annual Meeting of the
Biomedical Engineering Society, Baltimore, MD, 2005.
31.
Karim L , Schirmer A, Judex S. Effects of Diet and Radiation on Rat Bone Growth and
Morphology. Abstracts of the 15th Annual Meeting of the Biomedical Engineering Society,
Philadelphia, PA, 2004
32.
Judex S, Karim L , Garman R, Donahue LR, Rubin C. Stimulation of Cortical Bone
Formation Using Extremely Low-Level, High-Frequency Mechanical Signals. Abstracts of the 26th Annual Meeting of the American Society for Bone and Mineral Research, Seattle,
WA, 2004.
Honors and Awards
2016 John Haddad Young Investigator Award from the American Society for Bone and
Mineral Research
2015
2015 Travel Award from the Department of Orthopedic Surgery at Beth Israel
Deaconess Medical Center
2012-2014 Post-doctoral T32 fellowship, Translational Research in Aging Training Program,
Harvard Medical School (T32 director: Dr. Lewis Lipsitz)
2011
Innovation Travel Award from the Center for Skeletal Research (NIH P30 Core) at Massachusetts General Hospital
2010
Rensselaer Founders Award of Excellence, the highest honor of the convocation ceremony
Young Investigator Travel Award from the American Society for Bone and
Mineral Research
2009/10/11 Paul B. Daitch Travel Award from Rensselaer Polytechnic Institute
2009-2011 Pre-doctoral T32 Fellowship, Biomolecular Science and Engineering Training
Program, Rensselaer Polytechnic Institute (T32 director: Dr. Jonathan Dordick)
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2007-2008 Departmental Fellowship from the Department of Biomedical Engineering at
Rensselaer Polytechnic Institute
2007 Inducted into Tau Beta Pi, the Engineering Honor Society
2005/06
2005
Undergraduate Research and Creative Activities Summer Research Fellowship
Mentor: Dr. Stefan Judex
Stony Brook University Undergraduate Recognition Award
2004/05/06 Undergraduate Research and Creative Activities Travel Award
2004 Interdisciplinary Biomedical Research Program Fellowship
Mentor: Dr. Stefan Judex
2003-2007 Stony Brook University Honors College Scholarship
2003 Howard Hughes Medical Institute Summer Fellowship
Mentor: Dr. Stefan Judex
Invited Talks and Symposia Oral Presentations
2016
2016
2016
2015
2014
2012
2011
2011
2010
Title TBA, Bone and Mineral Seminar Series, Indiana University School of
Medicine, Indianapolis, IN
“Mechanisms of Diabetic Skeletal Fragility,” Advances in Mineral Metabolism
Meeting, Snowmass, CO
“Cortical Bone Tissue Properties are Deteriorated in Adults with Type 2 Diabetes
Mellitus,” Orthopaedic Research Society Meeting, Orlando, FL
“The Effect of Type 2 Diabetes on Skeletal Fragility,” Research Assistant
Learning Initiative Seminar Series, Beth Israel Deaconess Medical Center,
Boston, MA
“In Vivo Assessment of Cortical Bone Properties Using Reference Point
Indentation,” World Congress for Biomechanics, Boston, MA
“Non-Collagenous Matrix Proteins and Post-Translational Modifications Explain
Bone Toughness Loss in an Aging Mouse Model,” Orthopaedic Research Society
Meeting, San Francisco, CA
“Effects of Trabecular Level Glycation on Bone Fragility,” Biomedical
Engineering Society Meeting, Hartford, CT
“Acquisition and Loss of Bone Matrix Quality in Mice,” Orthopaedic Research
Society Meeting, Long Beach, CA
“Effects of Non-Enzymatic Glycation on Trabecular Bone Fragility May be
Mediated Through Changes in Bone Matrix Quality and Microarchitecture,”
American Society for Bone and Mineral Research Meeting, Toronto, ON
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2010
2009
2009
“Measurement of Osteopontin and Osteocalcin from Laser Microdissected
Microdamaged Regions in Bone,” Biomedical Engineering Society Meeting,
Austin, TX
“Effects of Microarchitecture on Trabecular Microdamage,” Orthopaedic
Research Society Meeting, Las Vegas, NV
“Increased Levels of Osteocalcin and Osteopontin Correlate With Bone
Microdamage,” Orthopaedic Research Society Meeting, Las Vegas, NV
2006
“Skeletal Effects of Low-Level Radiation on Adult C57BL/6J Strain Mice,”
Biomedical Engineering Society Meeting, Chicago, IL
Teaching and Mentorship Experience
2016 Guest lecturer, Mineralized Tissue Biology and Diseases (OB 614), Harvard
School of Dental Medicine
2014/15/16 Guest lecturer, Musculoskeletal Biomechanics (ME 5665), Northeastern
University
2013 Guest lecturer, Skeletal Tissue Mechanics (ME/BE/MS 524), Boston University
2013-2014 Career mentor, Science Club for Girls
2013-present Research supervisor for undergraduate students and research assistants, Center for
Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center
2011-2013 Math and science tutor for high school students
2009-2011 Research supervisor for high school and undergraduate students, Rensselaer
Polytechnic Institute
2008 Teaching assistant, Biomechanics (BMED 4540), Rensselaer Polytechnic Institute
2007 Teaching assistant, Laboratory Methods in Biomedical Engineering (BME 212),
Stony Brook University
2007 Physics tutor, Stony Brook University
Service and Outreach Experience
Journal peer reviewer: Journal of Applied Biomaterials, Journal of Biomechanics, Journal of
Bone and Mineral Research, Osteoporosis International
2015
2014
Volunteer, Cambridge Science Festival
Panelist, “Explore Careers in Life Sciences,” Harvard University
2009-2010 Chair, Biomedical Engineering Graduate Council, Rensselaer Polytechnic
Institute
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2008-2009 Vice Chair, Biomedical Engineering Graduate Council, Rensselaer Polytechnic
Institute
2004-2007 Secretary, Biomedical Engineering Society, Stony Brook University Chapter
Training Activities and Coursework
2015
2015
Clinical Research Orientation Program for Ph.D.s, The Harvard Clinical and
Translational Science Center (9-week course)
Conquering the K: Applying for an NIH Career Development Award,
Massachusetts General Hospital’s Clinical Research Program (7-week course)
2014-2015 Certificate in Applied Biostatistics, The Harvard Clinical and Translational
Science Center (10-month course)
2014 Grant Writing Workshop, Orthopaedic Research Society and the Orthopaedic
Research and Education Foundation (1-day course)
2014 Issues in Frailty, Health Sciences and Technology division at Massachusetts
Institute of Technology and Harvard Medical School (7-week course)
2012, 2013 Endocrine Fellows Forum, Endocrine Fellows Foundation and American Society for Bone and Mineral Research (2-day forum)
2012-2014 Advanced Aging Research Training Seminar Series, Hebrew SeniorLife Institute for Aging Research (monthly seminar program for T32 fellows)
2012 Responsible Conduct of Research, The Harvard Clinical and Translational
Science Center (8-week course)
2012 Musculoskeletal Pathophysiology, Health Sciences and Technology division at
Massachusetts Institute of Technology and Harvard Medical School (4-week course)
Technical Skills and Expertise
Laboratory: microcomputed tomography, high-resolution peripheral quantitative computed tomography, dual energy x-ray absorptiometry, testing methods using servo-hydraulic and micromechanical systems, microindentation, reference point indentation, microdamage characterization via lead-uranyl acetate staining, high performance liquid chromatography, enzyme-linked immuno-sorbent assays, hydrolysis and preparation of bone tissue for protein analyses, laser microdissection of bone tissue
Software: MicroCT software suite (Scanco Medical), ImageJ, WinTest (EnduraTEC),
WaveMatrix (Instron), TestStar II (MTS), Biodent Hfc (Active Life Scientific), Empower
(Waters), SigmaStat (SPSS), JMP, STATA
Professional Affiliations
2014-2015 National Postdoctoral Association
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2013-present Orthopaedic Research Society
2008-present American Society for Bone and Mineral Research
2007-present Tau Beta Pi, the Engineering Honor Society
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