Additional files:
List S1- Read codes for type 2 diabetes
Table S1 - Sensitivity analysis censoring observation periods at time of stopping or changing
therapy.
Table S2 - Baseline characteristics (%) of hypertensive and CVD patients, according to exposure
status
Table S3 - Incident rates of T2DM at different follow-up times, according to hypertension and
CVD diagnosis, for individuals with BMI≤25Kg/m2
1
Read codes for type 2 diabetes - list S1
9OL..00
66A..00
66AS.00
C10..00
9N1Q.00
C10F.00
9OL4.00
66A2.00
9NND.00
66AP.00
9OL1.00
66A4.00
68A7.00
66AZ.00
66AJ.00
C100112
66Ac.00
9OL5.00
66A3.00
66Aq.00
C109.00
F420.00
13B1.00
9OLA.00
7L19800
66AR.00
9h42.00
2G5E.00
66A5.00
2G5I.00
9h41.00
F420000
9N4I.00
66AI.00
C109.12
66AQ.00
66AD.00
8BL2.00
1434.00
9OL6.00
66Ai.00
9N1v.00
8CA4100
2BBP.00
2BBQ.00
Diabetes monitoring admin.
Diabetic monitoring
Diabetic annual review
Diabetes mellitus
Seen in diabetic clinic
Type 2 diabetes mellitus
Diabetes monitoring 1st letter
Follow-up diabetic assessment
Under care of diabetic foot screener
Diabetes: practice programme
Attends diabetes monitoring
Diabetic on oral treatment
Diabetic retinopathy screening
Diabetic monitoring NOS
Diabetic - poor control
Non-insulin dependent diabetes mellitus
Diabetic peripheral neuropathy screening
Diabetes monitoring 2nd letter
Diabetic on diet only
Diabetic foot screen
Non-insulin dependent diabetes mellitus
Diabetic retinopathy
Diabetic diet
Diabetes monitor. check done
Subcutaneous injection of insulin
Diabetes management plan given
Excepted from diabetes quality indicators: Informed dissent
O/E - Right diabetic foot at low risk
Diabetic on insulin
O/E - Left diabetic foot at low risk
Excepted from diabetes qual indicators: Patient unsuitable
Background diabetic retinopathy
DNA - Did not attend diabetic clinic
Diabetic - good control
Type 2 diabetes mellitus
Diabetes: shared care programme
Fundoscopy - diabetic check
Patient on maximal tolerated therapy for diabetes
H/O: diabetes mellitus
Diabetes monitoring 3rd letter
Diabetic 6 month review
Seen in diabetic eye clinic
Pt advised re diabetic diet
O/E - right eye background diabetic retinopathy
O/E - left eye background diabetic retinopathy
2
8B3l.00
66A9.00
66Ab.00
42W..00
66AU.00
9NM0.00
8H7r.00
8I3X.00
2G5F.00
2G5J.00
66A1.00
F420400
66AW.00
9OLA.11
13AB.00
2BBM.00
ZC2C800
C100100
66Ao.00
9OL8.00
9N4p.00
9N1i.00
14P3.00
C101.00
66A8.00
66AT.00
C10FJ00
9OL3.00
66AV.00
66A7.00
9OL..11
66AA.11
66AH000
8CS0.00
2G5G.00
66AH.00
2G5K.00
9OLD.00
F372.12
F420600
C106.12
9OL7.00
C106.00
8H4F.00
8I3W.00
68A9.00
Diabetes medication review
Understands diet - diabetes
Diabetic foot examination
Hb. A1C - diabetic control
Diabetes care by hospital only
Attending diabetes clinic
Refer to diabetic foot screener
Diabetic retinopathy screening refused
O/E - Right diabetic foot at moderate risk
O/E - Left diabetic foot at moderate risk
Initial diabetic assessment
Diabetic maculopathy
Diabetic foot risk assessment
Diabetes monitored
Diabetic lipid lowering diet
O/E - diabetic maculopathy absent both eyes
Dietary advice for diabetes mellitus
Diabetes mellitus, adult onset, no mention of complication
Diabetes type 2 review
Diabetes monitor.phone invite
Did not attend diabetic retinopathy clinic
Seen in diabetic foot clinic
H/O: insulin therapy
Diabetes mellitus with ketoacidosis
Has seen dietician - diabetes
Annual diabetic blood test
Insulin treated Type 2 diabetes mellitus
Diabetes monitoring default
Diabetic on insulin and oral treatment
Frequency of hypo. attacks
Diabetes clinic administration
Injection sites - diabetic
Conversion to insulin
Diabetes care plan agreed
O/E - Right diabetic foot at high risk
Diabetic treatment changed
O/E - Left diabetic foot at high risk
Diabetic patient unsuitable for digital retinal photography
Diabetic neuropathy
Non proliferative diabetic retinopathy
Diabetes mellitus with neuropathy
Diabetes monitor.verbal invite
Diabetes mellitus with neurological manifestation
Referral to diabetologist
Diabetic foot examination declined
Diabetic retinopathy screening offered
3
13AC.00
F420100
66AY.00
C10FM00
C109.13
C109.11
9OLZ.00
2G5A.00
2BBW.00
2BBX.00
2G5B.00
8HBG.00
8H7C.00
C109J00
66Af.00
66A6.00
ZLA2500
8Hj0.00
7276.00
C10FL00
8Hl1.00
68AB.00
8Hj4.00
F420200
C104.11
8HTk.00
9h4..00
C100.00
2BBL.00
66AM.00
9N2i.00
C10F.11
M271200
2BBR.00
66Ae.00
2BBS.00
8H7f.00
42c..00
M271000
679R.00
F171100
66Am.00
ZL62500
C109700
F464000
F420z00
Diabetic weight reducing diet
Proliferative diabetic retinopathy
Diabetic diet - good compliance
Type 2 diabetes mellitus with persistent microalbuminuria
Type II diabetes mellitus
NIDDM - Non-insulin dependent diabetes mellitus
Diabetes monitoring admin.NOS
O/E - Right diabetic foot at risk
O/E - right eye diabetic maculopathy
O/E - left eye diabetic maculopathy
O/E - Left diabetic foot at risk
Diabetic retinopathy 12 month review
Refer, diabetic liaison nurse
Insulin treated Type 2 diabetes mellitus
Patient diabetes education review
Last hypo. attack
Seen by diabetic liaison nurse
Referral to diabetes structured education programme
Pan retinal photocoagulation for diabetes
Type 2 diabetes mellitus with persistent proteinuria
Referral for diabetic retinopathy screening
Diabetic digital retinopathy screening offered
Referral to DESMOND diabetes structured education programme
Preproliferative diabetic retinopathy
Diabetic nephropathy
Referral to diabetic eye clinic
Exception reporting: diabetes quality indicators
Diabetes mellitus with no mention of complication
O/E - diabetic maculopathy present both eyes
Diabetic - follow-up default
Seen by diabetic liaison nurse
Type II diabetes mellitus
Mixed diabetic ulcer - foot
O/E - right eye preproliferative diabetic retinopathy
HbA1c target
O/E - left eye preproliferative diabetic retinopathy
Referral to diabetes nurse
HbA1 - diabetic control
Ischaemic ulcer diabetic foot
Patient offered diabetes structured education programme
Autonomic neuropathy due to diabetes
Insulin dose changed
Referral to diabetes nurse
Non-insulin dependent diabetes mellitus - poor control
Diabetic cataract
Diabetic retinopathy NOS
4
C10FC00
C105.00
8Hj5.00
2BBT.00
C10F600
M271100
8Hl4.00
2BBV.00
C104.00
9N0m.00
9OLB.00
9NN9.00
66Aa.00
C107.00
F372.00
66AJz00
9N2d.00
8H2J.00
2BBF.00
9OL2.00
66Ad.00
8A13.00
C10F700
9N0n.00
93C4.00
66AJ.11
9M00.00
F420300
C10F900
66AJ000
66AK.00
2G5C.00
66Ap.00
9N0o.00
9NN8.00
ZL62600
C100z00
N030100
F381311
TJ23A00
M037200
C10FN00
66AN.00
8HHy.00
2G5H.00
2G51000
Type 2 diabetes mellitus with nephropathy
Diabetes mellitus with ophthalmic manifestation
Referral to XPERT diabetes structured education programme
O/E - right eye proliferative diabetic retinopathy
Type 2 diabetes mellitus with retinopathy
Neuropathic diabetic ulcer - foot
Referral to community diabetes specialist nurse
O/E - left eye proliferative diabetic retinopathy
Diabetes mellitus with renal manifestation
Seen in diabetic nurse consultant clinic
Attended diabetes structured education programme
Under care of diabetes specialist nurse
Diabetic diet - poor compliance
Diabetes mellitus with peripheral circulatory disorder
Polyneuropathy in diabetes
Diabetic - poor control NOS
Seen by diabetologist
Admit diabetic emergency
Retinal abnormality - diabetes related
Refuses diabetes monitoring
Hypoglycaemic attack requiring 3rd party assistance
Diabetic stabilisation
Type 2 diabetes mellitus - poor control
Seen in community diabetes specialist clinic
Patient consent given for addition to diabetic register
Unstable diabetes
Informed consent for diabetes national audit
Advanced diabetic maculopathy
Type 2 diabetes mellitus without complication
Chronic hyperglycaemia
Diabetic - cooperative patient
Foot abnormality - diabetes related
Insulin treatment initiated
Seen in community diabetic specialist nurse clinic
Under care of diabetologist
Referral to diabetic liaison nurse
Diabetes mellitus NOS with no mention of complication
Diabetic Charcot arthropathy
Diabetic amyotrophy
Adverse reaction to metformin hydrochloride
Cellulitis in diabetic foot
Type 2 diabetes mellitus with ketoacidosis
Date diabetic treatment start
Referral to diabetic register
O/E - Right diabetic foot - ulcerated
Foot abnormality - diabetes related
5
2G5L.00
66Ak.00
9OLM.00
8CR2.00
C10FK00
66A7100
ZV65312
C103.00
ZRB6.00
66AJ200
9OLK.00
C104z00
F372100
F3y0.00
C107.11
F372.11
66AL.00
9kL..00
9OLL.00
C109400
C10D.00
M21yC00
L180500
C109900
66A7000
8H4e.00
C106z00
C102.00
K01x100
66AJ300
C101z00
G73y000
66Al.00
ZRbH.00
N030000
8A12.00
C105z00
9OLN.00
8HBH.00
ZL22500
9OLF.00
F35z000
8H3O.00
C10FQ00
C10G.00
C10F000
O/E - Left diabetic foot - ulcerated
Diabetic monitoring - lower risk albumin excretion
Diabetes structured education programme declined
Diabetes clinical management plan
Hyperosmolar non-ketotic state in type 2 diabetes mellitus
Frequency of GP or paramedic treated hypoglycaemia
[V]Dietary counselling in diabetes mellitus
Diabetes mellitus with ketoacidotic coma
Diabetes wellbeing questionnaire
Loss of hypoglycaemic warning
DESMOND diabetes structured education programme completed
Diabetes mellitus with nephropathy NOS
Chronic painful diabetic neuropathy
Diabetic mononeuropathy
Diabetes mellitus with gangrene
Diabetic polyneuropathy
Diabetic-uncooperative patient
Insulin initiation - enhanced services administration
XPERT diabetes structured education programme completed
Non-insulin dependent diabetes mellitus with ulcer
Diabetes mellitus autosomal dominant type 2
Insulin lipohypertrophy
Pre-existing diabetes mellitus, insulin-dependent
Non-insulin-dependent diabetes mellitus without complication
Frequency of hospital treated hypoglycaemia
Referral to diabetes special interest general practitioner
Diabetes mellitus NOS with neurological manifestation
Diabetes mellitus with hyperosmolar coma
Nephrotic syndrome in diabetes mellitus
Recurrent severe hypos
Diabetes mellitus NOS with ketoacidosis
Diabetic peripheral angiopathy
Diabetic monitoring - higher risk albumin excretion
Perceived control of insulin-dependent diabetes
Diabetic cheiroarthropathy
Diabetic crisis monitoring
Diabetes mellitus NOS with ophthalmic manifestation
Diabetes monitor invitation by SMS (short message service)
Diabetic retinopathy 6 month review
Under care of diabetic liaison nurse
Diabetes structured education programme completed
Diabetic mononeuritis NOS
Non-urgent diabetic admission
Type 2 diabetes mellitus with exudative maculopathy
Secondary pancreatic diabetes mellitus
Type 2 diabetes mellitus with renal complications
6
C10F911
C106100
C10FB00
C10F200
7L10000
66AG.00
8HLE.00
C10FH00
F372200
9OLG.00
C109600
U60231C
8Hg4.00
F420500
9OL9.00
M21yC11
C10FE00
2BBk.00
F372000
66AO.00
TJ23400
8I3k.00
C105100
Cyu2.00
9OLJ.00
C107.12
C10zz00
44V3.00
C10F400
C10FJ11
42WZ.00
ZLD7500
C107z00
C10K.00
C10A100
ZV6DA00
C101000
2BBl.00
9OLH.00
C106.13
R054200
C10y.00
C10F711
C10FL11
U602300
C10z.00
Type II diabetes mellitus without complication
Diabetes mellitus, adult onset, + neurological manifestation
Type 2 diabetes mellitus with polyneuropathy
Type 2 diabetes mellitus with neurological complications
Continuous subcutaneous infusion of insulin
Diabetic drug side effects
Diabetology D.V. done
Type 2 diabetes mellitus with neuropathic arthropathy
Asymptomatic diabetic neuropathy
Attended XPERT diabetes structured education programme
Non-insulin-dependent diabetes mellitus with retinopathy
[X] Adverse reaction to metformin hydrochloride
Discharged from care of diabetes specialist nurse
Advanced diabetic retinal disease
Diabetes monitoring deleted
Insulin site lipohypertrophy
Type 2 diabetes mellitus with diabetic cataract
O/E - right eye stable treated prolif diabetic retinopathy
Acute painful diabetic neuropathy
Date diabetic treatment stopp.
Adverse reaction to gliclazide
Insulin therapy declined
Diabetes mellitus, adult onset, + ophthalmic manifestation
[X]Diabetes mellitus
DAFNE diabetes structured education programme completed
Diabetes with gangrene
Diabetes mellitus NOS with unspecified complication
Glucose tol. test diabetic
Type 2 diabetes mellitus with ulcer
Insulin treated Type II diabetes mellitus
Hb. A1C - diabetic control NOS
Discharge by diabetic liaison nurse
Diabetes mellitus NOS with peripheral circulatory disorder
Type A insulin resistance
Malnutrition-related diabetes mellitus with ketoacidosis
[V]Admitted for commencement of insulin
Diabetes mellitus, juvenile type, with ketoacidosis
O/E - left eye stable treated prolif diabetic retinopathy
Attended DAFNE diabetes structured education programme
Diabetes mellitus with polyneuropathy
[D]Gangrene of toe in diabetic
Diabetes mellitus with other specified manifestation
Type II diabetes mellitus - poor control
Type II diabetes mellitus with persistent proteinuria
[X]Insul/oral hypoglyc drugs caus adverse eff therapeut use
Diabetes mellitus with unspecified complication
7
C109C00
C10F100
679L000
C10z100
C10FR00
8Hj3.00
C10FA00
C10FD00
2G5W.00
F440700
ZC2CA00
C10A.00
C10N.00
R054300
C104100
C10N100
F345000
C109711
C107200
C10F500
2BBo.00
C101100
C109712
C107100
8HVU.00
C109J12
F381300
ZV6DB00
8HTi.00
66Ae000
TJ23000
F420700
C10F611
2G5V.00
C109K00
C102100
C10FF00
F420800
C107400
C10F300
8CP2.00
N030011
66At.00
C10M.00
9M10.00
C10FP00
Non-insulin dependent diabetes mellitus with nephropathy
Type 2 diabetes mellitus with ophthalmic complications
Education in self management of diabetes
Diabetes mellitus, adult onset, + unspecified complication
Type 2 diabetes mellitus with gastroparesis
Referral to DAFNE diabetes structured education programme
Type 2 diabetes mellitus with mononeuropathy
Type 2 diabetes mellitus with hypoglycaemic coma
O/E - left chronic diabetic foot ulcer
Diabetic iritis
Dietary advice for type II diabetes
Malnutrition-related diabetes mellitus
Secondary diabetes mellitus
[D]Widespread diabetic foot gangrene
Diabetes mellitus, adult onset, with renal manifestation
Cystic fibrosis related diabetes mellitus
Diabetic mononeuritis multiplex
Type II diabetes mellitus - poor control
Diabetes mellitus, adult with gangrene
Type 2 diabetes mellitus with gangrene
O/E - sight threatening diabetic retinopathy
Diabetes mellitus, adult onset, with ketoacidosis
Type 2 diabetes mellitus - poor control
Diabetes mellitus, adult, + peripheral circulatory disorder
Private referral to diabetologist
Insulin treated Type II diabetes mellitus
Myasthenic syndrome due to diabetic amyotrophy
[V]Admitted for conversion to insulin
Referral to multidisciplinary diabetic clinic
HbA1c target level - IFCC standardised
Adverse reaction to insulins
High risk proliferative diabetic retinopathy
Type II diabetes mellitus with retinopathy
O/E - right chronic diabetic foot ulcer
Hyperosmolar non-ketotic state in type 2 diabetes mellitus
Diabetes mellitus, adult onset, with hyperosmolar coma
Type 2 diabetes mellitus with peripheral angiopathy
High risk non proliferative diabetic retinopathy
NIDDM with peripheral circulatory disorder
Type 2 diabetes mellitus with multiple complications
Transition of diabetes care options discussed
Diabetic cheiropathy
Diabetic dietary review
Lipoatrophic diabetes mellitus
Informed dissent for diabetes national audit
Type 2 diabetes mellitus with ketoacidotic coma
8
C109611
C10FG00
C109J11
C101y00
C109411
8I2S.00
C109000
C109100
C106y00
TJ23.00
9h43.00
C106.11
TJ23z00
C104y00
C109612
C109212
C109200
C106000
ZRB4.00
C109412
ZRB5.11
C109E00
8I2P.00
C109B00
C109E11
8HKE.00
C10yz00
C109C12
C109500
C109H00
C109D00
C109011
C109300
U602312
C10zy00
U602311
TJ23500
66Ar.00
C109H11
889A.00
C109H12
9NiC.00
66AQ100
C10yy00
C10F311
C109E12
Type II diabetes mellitus with retinopathy
Type 2 diabetes mellitus with arthropathy
Insulin treated non-insulin dependent diabetes mellitus
Other specified diabetes mellitus with ketoacidosis
Type II diabetes mellitus with ulcer
Glitazones contraindicated
Non-insulin-dependent diabetes mellitus with renal comps
Non-insulin-dependent diabetes mellitus with ophthalm comps
Other specified diabetes mellitus with neurological comps
Adverse reaction to insulins and antidiabetic agents
Excepted from diabetes qual indicators: service unavailable
Diabetic amyotrophy
Adverse reaction to insulins and antidiabetic agents NOS
Other specified diabetes mellitus with renal complications
Type 2 diabetes mellitus with retinopathy
Type 2 diabetes mellitus with neurological complications
Non-insulin-dependent diabetes mellitus with neuro comps
Diabetes mellitus, juvenile, + neurological manifestation
Diabetes clinic satisfaction questionnaire
Type 2 diabetes mellitus with ulcer
DTSQ - Diabetes treatment satisfaction questionnaire
Non-insulin depend diabetes mellitus with diabetic cataract
Sulphonylureas contraindicated
Non-insulin dependent diabetes mellitus with polyneuropathy
Type II diabetes mellitus with diabetic cataract
Diabetology D.V. requested
Diabetes mellitus NOS with other specified manifestation
Type 2 diabetes mellitus with nephropathy
Non-insulin dependent diabetes mellitus with gangrene
Non-insulin dependent d m with neuropathic arthropathy
Non-insulin dependent diabetes mellitus with hypoglyca coma
Type II diabetes mellitus with renal complications
Non-insulin-dependent diabetes mellitus with multiple comps
[X] Adverse reaction to insulins
Other specified diabetes mellitus with unspecified comps
[X] Adverse reaction to insulins and antidiabetic agents
Adverse reaction to glipizide
Insulin treatment stopped
Type II diabetes mellitus with neuropathic arthropathy
Diab mellit insulin-glucose infus acute myocardial infarct
Type 2 diabetes mellitus with neuropathic arthropathy
Did not attend DAFNE diabetes structured education programme
Declined consent for diabetes year of care programme
Other specified diabetes mellitus with other spec comps
Type II diabetes mellitus with multiple complications
Type 2 diabetes mellitus with diabetic cataract
9
C108y00
TJ23300
C109511
C10y100
C10N000
66As.00
66At100
C109012
C109D12
U602316
C102z00
C109512
C109F00
C109C11
C103z00
9N1o.00
C109G00
C105y00
C109F11
C10FM11
C10F411
66Au.00
66Av.00
Cyu2000
C109B11
C10F011
C103y00
C109211
ZRB4.11
3883.00
8IAs.00
2BBr.00
TJ23900
C10FB11
C109D11
C109111
C109F12
C10A000
C103100
C109A00
8HME.00
C10FA11
U60231B
U60231E
Cyu2300
8HgC.00
Other specified diabetes mellitus with multiple comps
Adverse reaction to glibenclamide
Type II diabetes mellitus with gangrene
Diabetes mellitus, adult, + other specified manifestation
Secondary diabetes mellitus without complication
Diabetic on subcutaneous treatment
Type II diabetic dietary review
Type 2 diabetes mellitus with renal complications
Type 2 diabetes mellitus with hypoglycaemic coma
[X] Adverse reaction to gliclazide
Diabetes mellitus NOS with hyperosmolar coma
Type 2 diabetes mellitus with gangrene
Non-insulin-dependent d m with peripheral angiopath
Type II diabetes mellitus with nephropathy
Diabetes mellitus NOS with ketoacidotic coma
Seen in multidisciplinary diabetic clinic
Non-insulin dependent diabetes mellitus with arthropathy
Other specified diabetes mellitus with ophthalmic complicatn
Type II diabetes mellitus with peripheral angiopathy
Type II diabetes mellitus with persistent microalbuminuria
Type II diabetes mellitus with ulcer
Diabetic erectile dysfunction review
Diabetic assessment of erectile dysfunction
[X]Other specified diabetes mellitus
Type II diabetes mellitus with polyneuropathy
Type II diabetes mellitus with renal complications
Other specified diabetes mellitus with coma
Type II diabetes mellitus with neurological complications
CSQ - Diabetes clinic satisfaction questionnaire
Diabetes treatment satisfaction questionnaire
Diabetic dietary review declined
Impaired vision due to diabetic retinopathy
Adverse reaction to tolbutamide
Type II diabetes mellitus with polyneuropathy
Type II diabetes mellitus with hypoglycaemic coma
Type II diabetes mellitus with ophthalmic complications
Type 2 diabetes mellitus with peripheral angiopathy
Malnutrition-related diabetes mellitus with coma
Diabetes mellitus, adult onset, with ketoacidotic coma
Non-insulin dependent diabetes mellitus with mononeuropathy
Listed for Diabetology admissn
Type II diabetes mellitus with mononeuropathy
[X] Adverse reaction to tolbutamide
[X] Adverse reaction to insulins and antidiabetic agents NOS
[X]Unspecified diabetes mellitus with renal complications
Discharged from diabetes shared care programme
10
66AQ000
C10F111
TJ23B00
C109G11
U602315
C109G12
C109A11
C10K000
U60231A
C108z00
C109112
U602318
TJ23200
C10FE11
U602317
C10G000
ZRB6.11
C10F211
C10E512
C10FD11
SL23100
Kyu0300
C10A500
C10FC11
66Aw.00
TJ23800
Unsuitable for diabetes year of care programme
Type II diabetes mellitus with ophthalmic complications
Adverse reaction to glucagon
Type II diabetes mellitus with arthropathy
[X] Adverse reaction to glibenclamide
Type 2 diabetes mellitus with arthropathy
Type II diabetes mellitus with mononeuropathy
Type A insulin resistance without complication
[X] Adverse reaction to tolazamide
Unspecified diabetes mellitus with multiple complications
Type 2 diabetes mellitus with ophthalmic complications
[X] Adverse reaction to gliquidone
Adverse reaction to chlorpropamide
Type II diabetes mellitus with diabetic cataract
[X] Adverse reaction to glipzide
Secondary pancreatic diabetes mellitus without complication
DWBQ - Diabetes wellbeing questionnaire
Type II diabetes mellitus with neurological complications
Insulin dependent diabetes mellitus with ulcer
Type II diabetes mellitus with hypoglycaemic coma
Biguanide poisoning
[X]Glomerular disorders in diabetes mellitus
Malnutritn-relat diabetes melitus wth periph circul complctn
Type II diabetes mellitus with nephropathy
Insulin dose
Adverse reaction to tolazamide
11
Table S1 - Sensitivity analysis censoring observation periods at time of stopping or changing therapy
Follow up time
(years) Ps [595%]
(N=1,448,993)
Hazard ratio (95% CI)*
STOP
Incident T2DM per 1000 person-years
STOP
CHANGE
Exposed
CHANGE
Unexposed
Exposed
Unexposed
No Hypertension
0-1 yr
2.35 (2.25-2.46)
2.97 (2.86-3.09)
22.07 (21.46-22.70)
8.65 (8.44-8.85)
29.71 (28.99-30.44)
8.91 (8.70-9.11)
1-3 yr
1.62 (1.57-1.68)
1.89 (1.83-1.95)
20.07 (19.63-20.53)
10.60 (10.42-10.77)
23.83 (23.33-24.33)
10.68 (10.49-10.86)
3-5 yr
2.14 (2.06-2.24)
2.33 (2.23-2.43)
23.55 (22.98-24.14)
9.56 (9.33-9.80)
26.31 (25.66-26.98)
9.64 (9.41-9.88)
5-10 yr
10-15 yr
15-20 yr
2.66 (2.55-2.79)
3.31 (2.90-3.78)
4.37 (2.86-6.67)
2.78 (2.65-2.92)
3.09 (2.66-3.59)
4.20 (2.57-6.86)
29.32 (28.70-29.96)
34.17 (32.48-35.96)
44.52 (38.06-52.09)
9.32 (9.06-9.59)
9.31 (8.48-10.21)
11.55 (8.41-15.88)
30.84 (30.10-31.59)
34.59 (32.37-36.96)
45.38 (36.14-56.99)
9.37 (9.11-9.65)
9.34 (8.50-10.26)
11.72 (8.49-16.17)
0-1 yr
1-3 yr
3-5 yr
5-10 yr
10-15 yr
15-20 yr
No CVD
1.08 (1.02-1.14)
0.90 (0.86-0.94)
1.29 (1.22-1.37)
1.64 (1.53-1.75)
2.26 (1.73-2.95)
2.66 (0.89-7.97)
1.31 (1.25-1.38)
1.01 (0.97-1.05)
1.39 (1.31-1.47)
1.62 (1.51-1.75)
2.19 (1.64-2.93)
1.09 (0.22-5.51)
23.11 (19.86-20.96)
23.67 (23.09-24.72)
29.80 (29.01-30.61)
35.80 (34.90-36.73)
41.68 (38.76-44.83)
47.97 (36.25-63.47)
20.40 (19.86-20.96)
24.20 (23.68-24.72)
20.51 (19.82-21.23)
19.25 (18.38-20.17)
18.33 (15.02-22.37)
22.38 (9.31-53.77)
31.15 (30.26-32.07)
27.86 (27.21-28.54)
32.72 (31.83-33.63)
37.02 (35.97-38.10)
42.79 (38.98-46.97)
26.73 (16.12-44.35)
21.28 (20.72-21.85)
24.76 (24.23-25.30)
20.96 (20.24-21.70)
19.70 (18.79-20.65)
19.15 (15.64-23.44)
19.21 (7.21-51.17)
0-1 yr
1-3 yr
3-5 yr
5-10 yr
10-15 yr
15-20 yr
1.99 (1.92-2.06)
1.42 (1.38-1.46)
1.98 (1.91-2.05)
2.49 (2.39-2.59)
3.14 (2.77-3.55)
4.28 (2.83-6.46)
2.49 (2.41-2.58)
1.63 (1.58-1.67)
2.12 (2.04-2.20)
2.53 (2.42-2.64)
2.85 (2.47-3.29)
3.80 (2.31-6.25)
23.47 (22.92-24.03)
21.90 (21.50-22.32)
26.58 (26.04-27.14)
32.31 (31.69-32.94)
35.31 (33.47-37.27)
46.07 (39.13-54.25)
10.74 (10.54-10.95)
12.93 (12.75-13.11)
11.18 (10.95-11.42)
10.56 (10.30-10.83)
10.08 (9.26-10.99)
11.81 (8.70-16.04)
31.35 (30.71-32.00)
25.44 (24.99-25.90)
28.83 (28.23-29.45)
32.99 (32.27-33.72)
33.97 (31.64-36.47)
41.48 (32.47-52.99)
11.04 (10.83-11.25)
13.05 (12.87-13.24)
11.29 (11.06-11.53)
10.62 (10.35-10.89)
10.21 (9.37-11.13)
11.71 (8.55-16.03)
0-1 yr
1-3 yr
3-5 yr
0.83 (0.77-0.91)
0.79 (0.74-0.85)
1.02 (0.92-1.12)
1.01 (0.94-1.09)
0.95 (0.88-1.01)
1.18 (1.07-1.30)
18.85 (17.91-19.83)
20.11 (19.38-20.88)
24.24 (23.31-25.21)
21.05 (20.08-22.07)
23.77 (22.79-24.79)
21.30 (19.83-22.88)
26.31 (25.19-27.48)
25.44 (24.58-26.32)
28.96 (27.86-30.10)
22.84 (21.81-23.91)
24.54 (23.52-25.60)
21.79 (20.25-23.45)
5-10 yr
10-15 yr
15-20 yr
1.40 (1.25-1.57)
2.26 (1.42-3.58)
1.62 (0.35-7.51)
1.51 (1.34-1.71)
2.96 (1.73-5.05)
1.29 (0.24-6.88)
30.22 (29.29-31.17)
37.96 (35.54-40.55)
43.57 (33.90-56.01)
18.73 (16.98-20.66)
14.70 (9.49-22.79)
48.47 (12.12-193.81)
33.45 (32.31-34.63)
42.06 (38.70-45.71)
38.54 (26.04-57.03)
19.71 (17.82-21.81)
13.05 (7.87-21.65)
57.40 (14.35-22.95)
Hypertension
CVD
PS – propensity score; *Final model: adjusted for age and propensity score; CVD – cardiovascular disease; STOP – observation
periods censored at time of statin withdrawn; CHANGE – observation periods censored at time exposure status changed.
12
Table S2 - Baseline characteristics (%) of hypertensive and CVD patients, according to exposure status
Baseline Characteristics
Pscore [5-95%]
BMI>25Kg/m2
Hyperlipidaemia
Abnormal glucose
CVD
Hypertension
Hypertension
Exposed
Unexposed
110,781 (71.73%)
175,663 (67.04%)
9,782 (6.33%)
11,771 (4.49%)
2,779 (1.80%)
4,488 (1.71%)
27,542 (17.83%)
41,622 (15.88%)
-
CVD
Exposed
51,438 (63.46%)
4,134 (5.10%)
751 (0.93%)
27,542 (33.98%)
Unexposed
46,852 (56.94%)
4,108 (4.99%)
1,020 (1.24%)
41,622 (50.58%)
13
Table S3 - Incident rates of T2DM at different follow-up times, according to hypertension and CVD
diagnosis, for individuals with BMI≤25Kg/m2
Statin use
Follow up time (years)
PS [5-95%]
No Hypertension
0-1 yr
1-3 yr
3-5 yr
5-10 yr
10-15 yr
15-20 yr
20-25 yr
Hypertension
0-1 yr
1-3 yr
3-5 yr
5-10 yr
10-15 yr
15-20 yr
20-25 yr
No CVD
0-1 yr
1-3 yr
3-5 yr
5-10 yr
10-15 yr
15-20 yr
20-25 yr
CVD
0-1 yr
1-3 yr
3-5 yr
5-10 yr
10-15 yr
15-20 yr
20-25 yr
Yes
No
Hazard ratio
(95% CI)*
Incident T2DM per 1000
person-years (95% CI)
Incident T2DM per 1000
person-years (95% CI)
1.81 (1.64-2.01)
11.39 (10.62-12.22)
5.20 (4.95-5.47)
1.39 (1.28-1.50)
1.62 (1.47-1.79)
2.12 (1.91-2.35)
2.59 (1.94-3.45)
2.10 (1.00-4.43)
n.e.
11.00 (10.43-11.60)
11.74 (11.04-12.47)
15.06 (14.30-15.87)
17.30 (15.35-19.50)
26.86 (19.78-36.48)
0
6.05 (5.83-6.27)
5.42 (5.14-5.71)
5.15 (4.85-5.48)
5.38 (4.47-6.48)
10.92 (6.69-17.82)
0
1.11 (0.97-1.28)
0.85 (0.76-0.95)
1.11 (0.95-1.29)
1.51 (1.27-1.81)
4.29 (2.11-8.70)
n.e.
n.e.
12.58 (11.49-13.78)
11.99 (11.19-12.85)
14.86 (13.81-16.00)
17.24 (16.07-18.50)
21.19 (17.58-25.54)
21.13 (10.57-42.25)
0
11.05 (10.31-11.85)
12.81 (12.11-13.54)
11.47 (10.52-12.49)
10.47 (9.33-11.75)
7.48 (4.24-13.16)
0
0
1.75 (1.59-1.91)
1.27 (1.18-1.36)
1.55 (1.42-1.70)
2.05 (1.87-2.26)
2.77 (2.10-3.66)
2.53 (1.20-5.34)
n.e.
11.72 (10.99-12.50)
11.21 (10.67-11.76)
12.64 (11.97-13.35)
15.66 (14.89-16.47)
17.82 (15.67-20.27)
26.70 (19.26-37.02)
0
5.79 (5.54-6.05)
6.74 (6.52-6.97)
6.04 (5.76-6.33)
5.63 (5.32-5.95)
5.44 (4.54-6.52)
9.75 (5.88-16.17)
0
0.89 (0.75-1.07)
0.85 (0.73-0.98)
0.99 (0.80-1.22)
1.44 (1.11-1.86)
2.10 (0.83-5.35)
0.37 (0.33-4.04)
n.e.
12.09 (10.81-13.53)
11.80 (10.84-12.85)
13.39 (12.22-14.68)
16.01 (14.85-17.27)
19.04 (16.19-22.38)
23.35 (13.56-40.21)
0
12.86 (11.60-14.26)
14.80 (13.53-16.18)
12.53 (10.75-14.61)
10.40 (8.39-12.90)
9.33 (3.89-22.41)
6.74 (9.49-47.85)
0
14