Additional file 2

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Additional file 2 Outcomes reflecting care processes
Outcome
Definition
Feeding
=
Head of bed elevated at 30°
Adequate prevention of venous
thromboembolism
Rate of antibiotic use
When we assessed
How we assessed
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘Ÿπ‘’π‘π‘’π‘–π‘£π‘–π‘›π‘” π‘’π‘›π‘‘π‘’π‘Ÿπ‘Žπ‘™ π‘œπ‘Ÿ π‘π‘Žπ‘Ÿπ‘’π‘›π‘‘π‘’π‘Ÿπ‘Žπ‘™ 𝑓𝑒𝑒𝑑𝑖𝑛𝑔
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Every 3 three days from ICU
day 2 to 17.
Checked prescription
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘€π‘–π‘‘β„Ž β„Žπ‘’π‘Žπ‘‘ π‘œπ‘“ 𝑏𝑒𝑑 π‘’π‘™π‘’π‘£π‘Žπ‘‘π‘’π‘‘ π‘Žπ‘‘ ≥ 30°
𝑒𝑙𝑖𝑔𝑖𝑏𝑙𝑒 π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Every 3 three days from ICU
day 2 to 17.
Bed observation We considered
only patients with indication of
head of the bed at 30° (MV, enteral
feeding or altered level of
consciousness)
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘€π‘–π‘‘β„Ž π‘Žπ‘‘π‘’π‘žπ‘’π‘Žπ‘‘π‘’ 𝐷𝑉𝑇 π‘π‘Ÿπ‘’π‘£π‘’π‘›π‘‘π‘–π‘œπ‘›
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Every 3 three days from ICU
day 2 to 17.
Checked prescription
Every 3 three days from ICU
day 2 to 17.
Checked prescription
Adequate prevention of VTE is defined as: Dalteparin 5.000U 1x a day SC, enoxaparin
40mg 1x a day SC or heparin 5.000U 12/12hs SC or fondaparinux 2.5 mg 1x a day SC. A
higher dose can be used if the patient has indication of anticoagulation therapy. If
heparin is contraindicated: compression stockings ± pneumatic compression
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘€π‘–π‘‘β„Ž π‘Žπ‘›π‘‘π‘–π‘π‘–π‘œπ‘‘π‘–π‘ π‘π‘Ÿπ‘’π‘ π‘π‘Ÿπ‘–π‘π‘‘π‘–π‘œπ‘›
=
X 100
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘’π‘›π‘‘π‘’π‘Ÿ π‘Žπ‘‘π‘’π‘žπ‘’π‘Žπ‘‘π‘’ π‘ π‘’π‘‘π‘Žπ‘‘π‘–π‘œπ‘›
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘œπ‘› 𝑀𝑉
Every 3 three days from ICU
day 2 to 17.
We assessed RASS of patients on
invasive mechanical ventilation
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘€π‘–π‘‘β„Ž π‘Žπ‘›π‘Žπ‘™π‘”π‘’π‘ π‘–π‘ π‘π‘Ÿπ‘’π‘ π‘π‘Ÿπ‘–π‘π‘‘π‘–π‘œπ‘›
X 100
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Every 3 three days from ICU
day 2 to 17.
Checked prescription
Tidal volume ≤ 8mL/kg of predicted
weight
=
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  𝑇𝑉 ≤ 8π‘šπΏ π‘π‘’π‘Ÿ 𝐾𝑔 π‘π‘Ÿπ‘’π‘‘π‘–π‘π‘‘π‘’π‘‘ π‘€π‘’π‘–π‘”β„Žπ‘‘
× 1000
π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘œπ‘› 𝑀𝑉
Every 3 three days from ICU
day 2 to 17.
Checked mechanical ventilator
data
Central line-associated bloodstream
infection (CLABSI) rate
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ 𝐢𝐿𝐴𝐡𝑆𝐼
× 1000
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘€π‘–π‘‘β„Ž π‘π‘’π‘›π‘‘π‘Ÿπ‘Žπ‘™ 𝑙𝑖𝑛𝑒
Daily from ICU day 2 to 17.
Blood cultures and clinical data
Patients under adequate sedation
Patient-days under moderate, mild
sedation, or alert and calm (RASS -3 to 0)
Rate of analgesic use
Bloodstream infection defined according to the CDC criteria
Rate of ventilator-associated
pneumonia (VAP)
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ 𝑃𝐴𝑉𝑠
× 1000
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘œπ‘› 𝑀𝑉
Daily from ICU day 2 to 17.
Laboratory and clinical data
Rate of urinary tract infection
associated with catheter (UTI)
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘ˆπ‘‡πΌπ‘ 
× 1000
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘€π‘–π‘‘β„Ž 𝑖𝑛𝑑𝑀𝑒𝑙𝑙𝑖𝑛𝑔 π‘’π‘Ÿπ‘–π‘›π‘Žπ‘Ÿπ‘¦ π‘π‘Žπ‘‘β„Žπ‘’π‘‘π‘’π‘Ÿ
Daily from ICU day 2 to 17.
Urine culture and clinical data
Rate of mechanical ventilation
Rate of use of central line catheter
Rate of use of indwelling urinary
catheter
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘  π‘œπ‘› 𝑀𝑉
× 100
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Daily from ICU day 2 to 17.
Patients’ inspection
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ 𝐢𝑉𝐢 − π‘‘π‘Žπ‘¦
× 100
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Daily from ICU day 2 to 17.
Patients’ inspection
=
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ πΌπ‘ˆπΆ − π‘‘π‘Žπ‘¦
π‘₯ 100
π‘›π‘’π‘šπ‘π‘’π‘Ÿ π‘œπ‘“ π‘π‘Žπ‘‘π‘–π‘’π‘›π‘‘ − π‘‘π‘Žπ‘¦π‘ 
Daily from ICU day 2 to 17.
Patients’ inspection
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