WG1+WG5 JOINT MEETING
“From biomolecular recognition processes to design of innovative metallo-drugs”
MEETING PROGRAME
VENUE
University of Belgrade
Faculty of Chemistry,
Studentski trg 12-16
Lecture room- first floor, room 455
September 11th 2015
8:30 – 9.00
9:00 – 9:10
9:10 – 9:40
Registration
Welcome by Organizers
G.L. # 1 – Dr Siniša Radulović (Institute for Oncology and Radiology of Serbia, Belgrade,
Serbia, “Anticancer Activity Of Ru(II)-p-cymene Complexes With Pyridine Derivatives”)
The latest developments in researching of metal-based anti-tumor agents
Chairs:
Gilles Gasser and Adoracion Quiroga
9:40 – 10:10
O.P. # 1 – Gianni Sava, “Metal anticancer drugs: targeting tumour cells replicative
machinery or their adaptative processes?”
1st Oral session “New synthesis and studies on emerging metallo-drugs”
10:10 – 10:30 O.P. # 2 – George Psomas, “Recent results on the interaction of Copper(II) and Cobalt(II)
with Quinolones”
10:30 – 10:50 O.P. # 3 – Iztok Turel, “Ruthenium Complexes with O,O Ligands. Structure-Related
Mode-of-Action Differences of Organoruthenium Complexes with β-Diketonates”
10:50 – 11:00 O.P. # 4 – Stefano Tinello, “One-pot synthesis of a new unsymmetrical cisplatin-based
Pt(IV) complex using peroxyacetimidic acid as oxidizing agent”
11:00 – 11:10 O.P. # 5 – Nilab Feizy, “iClick reactions of platinum group metal azide complexes with
electron-deficient alkynes”
11:10 – 11:30 Coffee Break
2nd Oral session “Various analytical techniques in investigations of drugs interactions with
biomolecules”
Chairs:
Petra Heffeter and Mauro Ravera
11:30 – 11:50 O.P. # 6 – Wolfgang Weigand, “Reactivity of Pt(II) Complexes with (O,S) Bidentate
Ligands Towards Biomolecules: Protein and DNA Binding Probed by Various Analytical
Techniques”
11:50 – 12:10 O.P. # 7 – Turgay Tekinay, “Comparative Human Serum Albumin Binding and Anticancer
Activities of Au(III) and Ga(III) Ions”
12:10 – 12:30 O.P. # 8 – Carlos Romao, “Structural characterization of the interaction of Ru, Ir and Pt
carbonyls with lysozyme and blood proteins: the Ru-Hb case”
12:30 – 12:40 O.P. # 9 – Tiziano Marzo, “New Interest for Old Iodide Analogues of Cisplatin: the Case
of cis-PtI2(NH3)2”
12:40 – 12:50 O.P. # 10 – Aleksandar Savić, “Reactions of Cytotoxic Metallodrugs With Lysozyme in
Pure DMSO Explored Through ESI MS”
12:50 – 13:20 General discussion
13:20 – 14:40 Lunch
3rd Oral session “Different methods for drug delivery – improved efficiency of medical treatment”
Chairs:
Alberta Bergamo and Ulrich Schatzschneider
14:40 – 15:00 O.P. # 11 – Mauro Ravera, “Amino-decorated nonporous silica nanoparticles as carriers
for Pt(IV) anticancer prodrugs”
15:00 – 15:10 O.P. # 12 – Jiaying Han, “Application of self-assembled Pd2L4 coordination cages in
protein imaging and drug delivery”
15:10 – 15:20 O.P. # 13 – Francisco J Carmona, “Improving the Loading of ALF794 in CYCU-3: Influence
of MOF particle size/morphology”
4th Oral session “Photodiagnostic, photodynamic therapy and photoactivation of metallodrugs”
Chairs:
Anne Vessieres and Sylvestre Bonnet
15:20 – 15:40 O.P. # 14 – Adoracion Quiroga, “DNA interaction and “in vitro” photoactivation studies
of trans diiodidoPt(II) complexes with different aliphatic amines”
15:40 – 15:50 O.P. # 15 – Vincent van Rixel, “New trans-tetrapyridyl ruthenium complexes as lightactivatable metallodrugs”
15:50 – 16:10 O.P. # 16 – Leticia Cubo, “Analysis of the light irradiation effects onto the cytotoxicity of
different series of iodidoplatinum(II)complexes”
16:10 – 16:30 Coffee Break
16:30 – 16:50 O.P. # 17 – Gilles Gasser, “Evaluation of novel Ru(II) Polypyridyl Complexes as
Photosensitizers in Photodynamic Therapy”
16:50 – 17:10 O.P. # 18 – Sylvestre Bonnet, “Upconverting lipid vesicles for the red light activation of
anticancer metallodrugs”
17:10 – 17:20 O.P. # 19 – Silvia Alonso-de Castro, “Hybrid Upconverting Nanosystems for NIR
Photoactivation and Theranostics”
17:20 – 18:00 General discussion
20:00
SOCIAL DINNER
September 12th 2015
The latest developments in researching of metal-based anti-tumor agents
Chairs:
Turgay Tekinay and Wolfgang Weigand
9:30 – 9:50
O.P. # 20 – Luigi Messori, “Gold Compounds as Prospective Anticancer Agents: an
Exploration of Inherent Molecular Mechanisms?”
5th Oral session “Biomolecules – targets for metal-based drugs”
9:50 – 10:10
O.P. # 21 – Alberta Bergamo, “NAMI-A controls the HCT-116 Colorectal Cancer Cells
Invasion Processes through the Modulation of 51 Integrin Expression and Activation”
10:10 – 10:30 O.P. # 22 – Christian Gaiddon, “Differential mode of action between a ruthenium-based
compound and cisplatin revealed by transcriptomic analyses: the example of histone-deacetylases”
10:30 – 10:50 O.P. # 23 – Petra Heffeter, “In vivo evaluation of serum binding, tissue distribution and
anticancer activity of bismaleimide-containing oxaliplatin prodrugs after short- and long-time
treatment”
10:50 – 11:00 O.P. # 24 – Julius Grosche, “RAPTA-T changes the structure of integrins and likely affects
thiol-based redox regulation of integrins”
11:00 – 11:20 Coffee Break
6th Oral session “Biomolecules – targets for metal-based drugs”
Chairs:
George Psomas and Iztok Turel
11:20 – 11:40 O.P. # 25 –Jaroslav Malina, “Sequence Specific Recognition of DNA Abasic Site by
Metallohelices. Inhibition of Human AP Endonuclease 1”
11:40 – 12:00 O.P. # 26 – Anne Vessieres, “Evidence for Targeting Thioredoxin Reductase with
Ferrocenyl Quinone Methides”
12:00 – 12:20 O.P. # 27 – Ulrich Schatzschneider, “Antimicrobial activity of organometallic complexes”
12:20 – 13:00 General discussion
Concluding remarks and future perspectives of the WGs
13:00 – 14:30 Lunch & departure