Table 1. Data elements present in the real data set. Data Element

Table 1. Data elements present in the real data set. Data Element % of visits in model data Chief Complaint or Reason for Visit 85.16 Sub-syndrome 83.52 Syndrome 54.41 Final diagnosis ICD-9 code 99.72 Table 2. Possible ICD-9 codes associated with the chief complaint “sore throat.” This does not include misspellings or abbreviations. ICD-9 Code Description 034.0 034.0 STREP SORE THROAT 079.99 079.99 VIRAL INFECTION NOS 382.9 382.9 OTITIS MEDIA NOS 462 462 ACUTE PHARYNGITIS 463 463 ACUTE TONSILLITIS 465.9 465.9 ACUTE URI NOS 466.0 466.0 ACUTE BRONCHITIS 473.9 473.9 CHRONIC SINUSITIS NOS 486 486 PNEUMONIA, ORGANISM NOS 528.0 528.0 STOMATITIS 786.07 786.07 WHEEZING Table 3. Example Analysis Visit Descriptor (for Visit 2307262). Patient Id Visit Id Visit Date Patient Class Age Range Gender Race Ethnic Group Deceased Flag Deceased Date Syndrome 1 Syndrome 2 … Subsyndrome 1 Subsyndrome 2 … Working Diagnosis 1 Working Diagnosis 2 … Final Diagnosis 1 Final Diagnosis 2 … Number Laboratory Orders Number Laboratory Results Number Radiology Orders Number Radiology Results Number Rx Orders Botulism Like Fever … Respiratory … Abdominal pain … Otitis media … Blood Culture MRSA Culture … Strep Group A Culture Urine Culture DX Chest DX Sinus Paranasal … 127151 2307262 12AUG2006:20:15:00.000 E 4-11 Years F White Not Hispanic or Latino Respiratory … Otitis media … 388.7 382.7 1 1 Table 4. Example Analysis Visit Descriptor (for Visit 3102841). Patient Id Visit Id Visit Date Patient Class Age Range Gender Race Ethnic Group Deceased Flag Deceased Date Syndrome 1 Syndrome 2 … Subsyndrome 1 Subsyndrome 2 … Working Diagnosis 1 Working Diagnosis 2 … Final Diagnosis 1 Final Diagnosis 2 … Number Laboratory Orders Number Laboratory Results Number Radiology Orders Number Radiology Results Number Rx Orders Botulism Like Fever … Respiratory … Abdominal pain Abdominal cramps … Headache … Blood Culture MRSA Culture … Strep Group A Culture Urine Culture DX Chest DX Sinus Paranasal … 127151 3102841 10JAN2007:08:41:07.000 E 4-11 Years F White Not Hispanic or Latino Fever Respiratory … Fever Headache … 462 462 465.9 1 1 1 1 1 1 1 2 Table 5. Patient Care Descriptor for Patient 127151. Patient Id Age Range Gender Race Ethnic Group Deceased Flag Number AVisits Number Laboratory Orders Number Laboratory Results Number Radiology Orders Number Radiology Results Number Rx Orders Botulism Like Fever GI Hemorrhagic Illness Localized Cutaneous Lesion Neurological Rash Respiratory Severe Illness or Death Specific Infection Other Abdominal pain Abdominal cramps … Headache … Otitis media … Blood Culture MRSA Culture … Strep Group A Culture Urine Culture DX Ankle DX Chest … DX Sinus Paranasal … 127151 4-11 Years F White Not Hispanic or Latino 2 1 1 1 1 1 1 1 1 2 Table 6. Syndromes assigned to synthetic tularemia injects. Syndrome % of 221 visits with listed syndrome Fever 92.76 Gastrointestinal 12.22 Hemorrhagic Illness 10.86 Localized Cutaneous Lesion .45 Lymphadenitis 1.81 Neurological 12.67 Rash 4.52 Respiratory 79.64 Severe Illness or Death 11.76 Specific Infection 7.24 Table 7. Sub-syndromes assigned to synthetic tularemia injects. Sub-Syndrome Abdominal Pain % of 221 visits with listed SubSyndrome 8.14 Sub-Syndrome Heart disease, ischemic % of 221 visits with listed SubSyndrome 2.26 Alteration of Consciousness 12.67 Hempotysis 7.24 Anemia 10.86 Hypotension 1.81 Asthma 3.62 Influenza-like Illness 8.14 Bronchitis and Bronchiolitis 11.31 Intestinal infections, ill-defined .45 Cardiac dysrythmias 14.48 Lymphadenopathy 1.81 Chest pain 9.95 Malaise and fatigue .45 Coagulation defects .45 Mental disorders Coma 8.14 Migraine .45 COPD 1.36 Nausea and vomiting 9.95 Cough 44.34 Pleurisy .45 Cyanosis and hypoxemia 2.71 Pneumonia and lung abscess 19.00 Death .45 Pupurae and petechiae 1.36 Dehydration 1.81 Rash 10.41 Diabetes mellitus 1.81 Respiratory failure 12.67 Diarrhea 8.60 Septicemia and bacteremia 4.52 Dizziness .45 Shock 9.95 Dyspnea 39.82 Skin infection .45 Edema 2.71 Syncope and collapse .45 Fever 47.51 Upper respiratory infections 2.26 Gastrointestinal hemorrhage 2.71 Urinary tract infections 1.81 Headache .90 Viral infection, unspecified 11.31 10.86 Table 8. Laboratory Tests for Synthetic Tularemia Injects. There were 609 tests ordered. Ordered Test Name Local (Laboratory Test) ASO Titer(ASO) Aerobic Blood Culture (BLC) Blood Culture Isolator(BLDC) Percent of Tests Ordered .66 .16 39.90 .66 Ordered Test Name Local (Laboratory Test) Influenza Antigen(FLUAG) Percent of Tests Ordered 3.45 Legionella Ag Urine Culture (LEGEIA) Lyme IgG .82 Mono Test (MONO) .16 .66 C Difficile Toxin A 11.33 Ova and Parasite Exam (OVAP) 2.46 C Reactive Protein (CRP) 3.28 Prealbumin (PAB) 1.64 CMV AB IgG (CMVGAB) .66 Reproductive Culture .66 CMV AB IgM(CMVMAB) .66 12.97 Chlamydia/GC by Amplified Probe(CGPT) Enteric Pathogen Culture(ENPC) .66 .16 Epstein Barr Virus Antibody Screen (EBVSRN) Gram Smear (GRAS) .66 Respiratory Culture and Smear (RTCS) Respiratory Viral Panel Acute (RVPA) Strep Group A Screen Rapid (RSTREP) Urine Culture (URC) .16 Urine Culture and Smear (URCS) Haptoglobin (HAPT) 1.15 Herpes Virus Six Culture(HHV6Q) .66 2.46 .66 2.63 10.67 Table 9. Radiology Orders for synthetic tularemia injects. Ordered Test Name Local (Radiology Order) DX Abdomen 2 View DX Abdomen AP Percent of Tests Ordered .64 13.74 DX Abdomen Acute .64 DX Chest 1 View AP 34.50 DX Chest 1 View NR 1.60 DX Chest 2 View 23.64 DX Chest Special Vi 32 DX Small Bowel Series .64 PX Abdomen Portable 2.88 PX Chest 1 V Portable 20.77 PX Cholangiogram In .64 Table 10. Electronic medical records for two synthetic tularemia inject patients. Some fields have been omitted for clarity; most of the omitted fields are blank. Table 11. Electronic medical records for two synthetic background patients. Some fields have been omitted for clarity; most of the omitted fields are blank. Table 12. Validation of Synthetic background electronic medical records. There were 3272 visit records. Error Number of Errors found Percent of total Records Care Model did not match ICD-9 codes completely. 80 2.4% ICD-9 Codes contradictory 8 .24% Gender or Age ICD-9 mismatch 6 .18% Sub-syndrome or syndrome assignment inconsistent with ICD-9 or chief complaint 4 .12% Typographical or formatting error 4 .12% Total 91 2.8%

Table 1. Data elements present in the real data set. Data Element

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