Simplicef is Used to Treat Animals with Skin Infections
PRODUCT INFO
Simplicef tablets are a semi-synthetic cephalosporin antibiotic cefpodoxime proxetil used to
cure infections caused by the susceptible strains of bacteria in dogs.
WHAT THIS PRODUCT CURES
Simplicef is
as wounds
susceptible
intermedius,
Escherichia
mirabilis).
used to treat animals with skin infections, such
and abscesses caused by the of bacteria
to β-lactam antibiotics (Staphylococus
Staphylococcus aureus, Streptococcus canis,
coli, Pasteurella multocida and Proteus
PET SYMPTOMS
The skin is the protective barrier of the body, but its
protective function depends on its integrity. Once the surface of the skin is damaged due to
some kind of injury, it becomes more susceptible to various bacterial infections. Dogs are
dynamic pets prone to injuries during their everyday activities whether they are playing or
fighting. Wounds and cuts on the skin can easily become infected. Such wound is inflamed,
red and swollen, often with purulent discharge. In some cases, animals can even get feverish
and lethargic. Dogs can often develop a bacterial infection of the skin caused by some other
pre-existing condition or predisposing factor. The affected areas of the skin are itchy, swollen
and crusted, filled with small raised, pus-filled lesions. Partial loss of hair is quite common in
such cases.
PET AILMENTS
Skin infections in dogs are often associated with the secondary superficial pyoderma, one of
the most common dermatologic conditions in household pets. In dogs, pyoderma is often
caused by the Staphylococcus intermedius or Streptoccocus canis.
Wounds or abscesses can often lead to skin infections. The damaged surface of the skin
provides an entering point for bacteria.
Dogs suffering from fungal infections or endocrine diseases (hyperthyroidism) are at higher
risk of developing skin infections. Flea bite, food allergies and infestations with external
parasites (e.g. Demodex) are also predisposing factors for skin infections.
RELATIVE INFO ON BREEDS MOST ASSOCIATED WITH THIS AILMENT
All dogs are susceptible to skin infections, but certain types of dogs are predisposed to
developing pyoderma. Breeds with a short coat, skin folds (such as bulldogs, sharpie, sphinx
cats) and pressure calluses are likely to suffer from skin infections. Higher incidence of
pyoderma has been noted in the population of German shepherd dogs.
QUESTIONS FOR MY VET
1. What is Simplicef?
a) Simplicef is a cephalosporin antibiotic used mostly for treatment of bacterial skin infections
in dogs.
2. Is Simplicef safe for my pet?
a) Simplicef is generally safe for dogs and rarely causes adverse reactions. However, the safe
use of Simplicef tablets in pregnant or lactating bitches and dogs used for breeding has not
been determined.
3. My pet is allergic to penicillin. Is it safe to administer Simplicef?
a) Do not administer Simplicef do dogs with known allergy to penicillin, Simplicef or any of
the other β-lactam antibiotics.
4. What are the signs of an allergic reaction to Simplicef?
a) If your dog has difficulties breathing, with hives, rash, diarrhea or vomiting, its face, lips or
tongue are swollen; stop giving Simplicef and seek veterinary help immediately.
5. I am allergic to penicillin. Am I allowed to handle Simplicef?
a) Yes, but handle Simplicef tablets with extra caution, and avoid direct contact of the product
with your skin or mucous membranes. In case of exposure, contact your physician
immediately.
6. What side effects are connected with Simplicef administration?
a) Simplicef rarely causes side effects, but they are still possible. Stop administering
Simplicef tablets and seek veterinary help if our dog has an allergic reaction with hives,
difficult breathing, rash, vomiting, diarrhea, blood in stool, unexplained bruising, swollen lips,
face or tongue. Less serious side effects include yeast infections, mild diarrhea and nausea.
Inform your vet if you notice any of the listed symptoms in your dog.
7. What if my dog suffers an accidental overdose?
a) In case of overdose, seek veterinary help as soon as possible. Symptoms of overdose
include abdominal cramps, nausea, diarrhea and vomiting.
8. What drugs can interact with Simplicef?
a) Provide your veterinarian with a list of all prescription or over the counter drugs your dog
is taking as well as nutritional supplements and herbal products before starting treatment with
Simplicef. Other antibiotics, warfarin, furosemide and probenecid will interact with
Simplicef.
HOW IT WORKS
Active ingredient of Simplicef is cefpodoxime proxetil, a prod rug that gets activated into
cefpodoxime in the gastrointestinal tract. Cefpodoxime is a cephalosporin antibiotic from the
group of β-lactam antimicrobials. It interferes with the synthesis of the bacterial cell wall,
subsequently killing the bacteria. Cefpodoxime if very effective against both Gram positive
and Gram negative bacterial, especially E. coli, Staphylococci, Streptococci, Proteus and
Pasteurella infections in dogs.
DIRECTIONS FOR USE
Simplicef tablets are prescribed by a licensed veterinarian and must be used strictly according
to veterinary instructions.To ensure better absorption, Simplicef tablets should be
administered with food. The product label contains detailed instructions for use; if you do not
understand them, consult with your veterinarian or pharmacist.
DOSAGE AND ADMINISTRATION
The usual dose range of Simplicef is between 5 and 10 mg/kg of body weight or 2.3-4.5 mg/lb
of body weight. The tablets are administered by mouth once a day. Although the tablets can
be given without food, it is advisable to administer them with a meal to help the absorption of
the drug in the body. The treatment with Simplicef tablets usually lasts for 5-7 days or at least
2-3 days beyond the cessation of symptoms, depending on the nature and severity of
infection. Simplicef tablets should not be administered longer than 28 days in a row.
INGREDIENTS
Simplicef tablets are available in two strengths: 100 mg tablets contain 100 mg of
cefpodoxime equivalent and 200 mg tablets contain 200 mg of cefpodoxime equivalent.
PRODUCT CAUTIONS
This product is for animal use only. Keep away from children and pets.
For oral administration in dogs; do not administer to cats.
Do not administer to dogs with known allergy to β-lactam group of antibiotics or
cefpodoxime.
Individuals with known allergy to penicillin and cephalosporin antibiotics should avoid direct
contact of Simplicef with skin and mucous membranes while handling the product.
The safe use of Simplicef in pregnant, breeding or lactating animals has not been determined.
STORAGE AND DISPOSAL
Simplicef tablets should be stored at room temperature between 20°C and 25°C. Securely
close the cap after each opening.
BRAND VS. GENERIC COMPARISON
Simplicef is manufactured as the name brand, but it can also be sold as the generic product.
The generic form, called Cefpodoxime proxetil, can be used in dogs. These products contain
the same active ingredient but cost less and can contain more tablets per container. However,
the generic forms are not issued by the licensed veterinarian and storage regulations are
variable. Name brand has a higher reliance rate and is veterinarian recommended.