Genetics
Objectives Chapters 9 and 10, plus Mutations
1. Identify these mutations: missense, nonsense, frameshift, deletion, insertion, duplication,
inversion, entire chromosome mutation, translocation, and point mutation.
2. Describe the roles of Watson, Crick, Wilkins, and Franklin in the discovery of the DNA double
helix.
3. Define antiparallelism, nucleotide, purine, pyrimidine, complementary base pairs,
semiconservative, replication fork, DNA polymerase, RNA polymerase, template strand, and
codon.
4. Describe the structure of DNA sugar-phosphate backbone using its 4 base pairs and the 5’-3’
sequence.
5. Describe the structure of RNA sugar-phosphate backbone using its 4 base pairs and the 5’-3’
sequence.
6. List the 3 main differences between DNA and RNA.
7. Describe replication of DNA. When and where in the cell cycle is it occurring?
8. Describe transcription and translation of RNA. When and where in the cell cycle is it occurring?
9. Complete a DNA replication sequence using base pairs.
10. Complete a transcription using base pairs, and translation (using base pairsamino
acidsprotein).
11. List the 3 types of RNA and their function.
12. Describe the 4 types of folding of a protein, why folding is important for a protein, and what
diseases are caused by misfolded proteins.
Reading
Chapter 9, all
Chapter 10, all
Chapter 12, pg. 222-223 (mutations)
Labs
KNEX Modeling Labs Lessons #1,3,4,5