Supplemental Fig. 1: Health questionnaire - completed by patients at study enrollment
Health Questionnaire
At Start of Administration
This questionnaire contains questions on the degree of severity of your chest and stomach conditions
and your life-style activities. Your cooperation will be highly appreciated.
You will later receive another questionnaire on your conditions after taking the drug.
1. Tick (☑) the most appropriate box for each of Questions #1 to 9 below.
(1) Did you experience any sensation of heartburn, chest pain, or chest heaviness
in the previous week? (heartburn)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(2) Did you feel a regurgitation of stomach contents into the mouth, leaving an acid
or bitter taste in the previous week? (regurgitation)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(3) Did you feel your stomach was upset, heavy, or containing food for a long time
in the previous week? (postprandial fullness)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(4) Did you feel too full to eat any more after small amounts of food in the previous
week? (early satiation)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(5) Did you feel pain in the stomach or epigastrium in the previous week?
(epigastric pain)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(6) Did you feel burning sensation in the stomach or epigastrium in the previous
week? (epigastric burning)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(7) Did you feel your stomach was distended in the previous week? (upper
abdominal bloating)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(8) Did you have nausea or churning feeling in the stomach in the previous week? (nausea/vomiting)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(9) Did you belch in the previous week? (belching)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
2. Tick (☑) all relevant boxes concerning your daily life style.
□ You keep on eating until you feel full.
□ You eat greasy food (e.g., fries, high-fat meat, potato chips) at least once in 2 to 3 days.
□ You eat sweets (e.g., manju cakes, sweet bean-jam cakes, cream cakes) at least once in 2 to 3 days.
□ You eat hot and spicy food (e.g., curry rice, chili pepper food) at least once in 2 to 3 days.
□ You drink alcoholic drink almost daily.
□ You drink coffee almost daily.
□ You smoke 10 or more cigarettes a day.
□ You usually wear girdles or corsets.
□ You often have a bent-forward posture during work and other activities.
□ You frequently lie down after eating.
□ You are feeling continued stress.
Supplemental Fig. 2: Health questionnaire - completed by patients 2 weeks after the start of lansoprazole
administration
Health Questionnaire
At Week 2
This questionnaire contains questions on the degree of severity of your chest and stomach conditions.
Your cooperation will be highly appreciated.
Two weeks later, you will receive another questionnaire on your conditions after taking the drug.
Tick (☑) the most appropriate box for each of Questions #1 to 10 below.
(1) Did you experience any sensation of heartburn, chest pain, or chest heaviness
in the previous week? (heartburn)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(2) Did you feel a regurgitation of stomach contents into the mouth, leaving an acid
or bitter taste in the previous week? (regurgitation)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(3) Did you feel your stomach was upset, heavy, or containing food for a long time
after meal in the previous week? (postprandial fullness)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(4) Did you feel too full to eat any more after taking small amounts of food in the
previous week? (early satiation)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(5) Did you feel pain in the stomach or epigastrium in the previous week?
(epigastric pain)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(6) Did you feel burning sensation in the stomach or epigastrium in the previous
week? (epigastric burning)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(7) Did you feel your stomach was distended in the previous week? (upper
abdominal bloating)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(8) Did you have nausea or churning feeling in the stomach in the previous week? (nausea/vomiting)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(9) Did you belch in the previous week? (belching)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(10) How often did you take the medicine to relieve your chest and stomach symptoms? (compliance)
□Took
every day
□Missed
1-2 days/week
□Missed
3-4 days/week
□Missed
almost every day
Supplemental Fig. 3: Health questionnaire - completed by patients 4 weeks after the start of lansoprazole
administration
Health Questionnaire
At Week 4
This questionnaire contains questions on the degree of severity of your chest and stomach conditions.
Your cooperation will be highly appreciated.
Tick (☑) the most appropriate box for each of Questions #1 to 12 below.
(1) Did you experience any sensation of heartburn, chest pain, or chest heaviness
in the previous week? (heartburn)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(2) Did you feel a regurgitation of stomach contents into the mouth, leaving an acid
or bitter taste in the previous week? (regurgitation)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(3) Did you feel your stomach was upset, heavy, or containing food for a long time
after meal in the previous week? (postprandial fullness)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(4) Did you feel too full to eat any more after taking small amounts of food in the
previous week? (early satiation)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(5) Did you feel pain in the stomach or epigastrium in the previous week?
(epigastric pain)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(6) Did you feel burning sensation in the stomach or epigastrium in the previous
week? (epigastric burning)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(7) Did you feel your stomach was distended in the previous week? (upper
abdominal bloating)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(8) Did you have nausea or churning feeling in the stomach in the previous week? (nausea/vomiting)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(9) Did you belch in the previous week? (belching)
□Never
□Sometimes/mild
□Often/moderate
□Frequent/severe
(10) How often did you take the medicine to relieve your chest and stomach symptoms? (compliance)
□Took
every day
□Missed
1-2 days/week
□Missed
3-4 days/week
□Missed
almost every day
(11) Are you satisfied with the medicine to relieve your chest and stomach symptoms? (Treatment
satisfaction)
□Very satisfied
□Satisfied
□Neutral
□Dissatisfied
□Very dissatisfied
(12) Are you willing to continue use of the medicine to relieve your chest and stomach symptoms?
(Willingness to continue)
□Willing to continue to use
□Willing to use if symptoms relapse
□Unwilling to use
Supplemental Table 1. Classification of treatment response
After two and four weeks of LPZ treatment
At the start of
LPZ treatment
Never
Sometimes/Mild Often/Moderate Frequent/Severe
Never
None before or
become worse
become worse
become worse
after treatment
Sometimes/Mild Disappearance
no change
become worse
become worse
of symptoms
Often/Moderate Disappearance
Improvement
no change
become worse
of symptoms
Frequent/Severe Disappearance
Improvement
no change
no change
of symptoms
Unclear
Unclear
Unclear
Unclear
Unclear
LPZ: Lansoprazole
Unclear
Unclear
Unclear
Unclear
Unclear
Unclear