WINONA STATE UNIVERSITY
PROPOSAL FOR GENERAL EDUCATION PROGRAM COURSES
Department
HERS
368
Course No.
Date September, 2012
Pathophysiology for the Health Professions
Course Name
3
Credits
Prerequisites BIO 211 & Grade of “C” or better in BIO 212
GEP Goal Area(s):*
CORE GOAL AREAS
_____Goal 1: Communication
_____Goal 3: Natural Science
_____Goal 4: Mathematics/Logical Reasoning
_____Goal 5: History and the Social and Behavioral
Sciences
_____Goal 6: The Humanities and Fine Arts
THEME GOAL AREAS
_____Goal 7: Human Diversity
_____Goal 8: Global Perspective
_____Goal 9: Ethical and Civic Responsibility
_____Goal 10: People and the Environment
* Courses may be submitted for up to two Goal Areas.
Additional Requirement Categories:
X
Intensive:
_____ 1. Writing
_____ 2. Oral Communication
_____ 3. a. Mathematics/Statistics
X
b. Critical Analysis
_____ Physical Development and Wellness
Provide information as specified in the previous directions.
Attach a General Education Program Approval Form.
Department Contact Person for this Proposal:
Gary Kastello, PhD
Name (please print)
x5219
Phone
gkastello@winona.edu
e-mail address
[Revised 9-6-11]
Catalog description
This course is designed to examine alterations in functions affecting individuals across
the lifespan. The student will explore pathophysiological concepts utilizing biology,
microbiology, and physiological sciences as a basis for the student approach. The scientific
approach will provide a further understanding of the mechanisms of disease, and students will
incorporate critical thinking skills with practical application. The course provides a
comprehensive rehabilitation approach to common alterations in body systems. It is assumed
that students will have a good knowledge of anatomy and physiology to enroll into this course.
Prerequisites include receiving a letter grade of “C” or better in BIO 211 & BIO 212.
The major emphasis of this course will be on the physiological factors that underlie
diseases states. This is a rigorous course containing an enormous amount of information that is
covered during a semester. It will require a great deal of time and effort on the part of the
student. In order to understand the dysfunctions of a system it is essential to understand the
normal structure and function of that system. Hence, only students who completed a course in
human physiology should enroll. Class notes will contain an overview of normal structure and
function to aid in self-directed review. The class notes will also cover the pathophysiology
material.
Assessment of Outcomes
Student outcome success will be determined via performance on 3 quizzes and 3 exams
covering PowerPoint lecture, textbook readings, class discussion, in class student to student
(small fingers talk) short discussions, case studies, and chapter review/critical analysis of
Worried Sick by Norton Hadler.
Course Outline of the Major Topics and Subtopics
1. Foundations of pathophysiology, Cell injury, death and adaptation.
a) Causes of cell injury.
b) Forms and morphology of cell injury.
c) Cellular adaptations of growth and differentiation
d) Cellular aging.
2. Acute and Chronic Inflammation.
a) Acute inflammation: vascular changes, leukocyte cellular events, chemical mediators of
inflammation, outcomes of acute inflammation.
b) Chronic inflammation.
c) Role of lymphatics and lymph nodes in inflammation.
d) Morphologic patterns in acute and chronic inflammation.
e) Systemic effects of inflammation.
3. Repair: Cell regeneration, fibrosis, and wound healing.
a) Regeneration.
b) Control of cell growth and differentiation at sites of injury.
c) Intracellular matrix and cell-matrix.
d) Repair by connective tissue. Pathologic aspects of repair.
e) Wound healing,
f) Overview of the inflammatory-reparative response.
4. Disorders of Immune System.
a) Cells of the immune system.
b) Cytokines.
c) Histocompatibility genes.
d) Immune mechanisms of tissue injury.
e) Autoimmune diseassess.
f) Immunodeficiency diseases.
g) Amyloidosis
5. Neoplasia.
a) Characteristics of benign and malignant neoplasms.
b) Epidemiology of neoplasia.
c) Carcinogenesis-the molecular basis of cancer.
d) Biology of tumor growth.
e) Etiology of cancer-carcinogenic agents.
f) Host defense against tumors-tumor immunity.
g) Clinical features of neoplasia
6. Hemodynamic disorders, thrombosis and shock.
a) Edema, hyperemia and congestion.
b) Hemorrhage.
c) Hemostasis and thrombosis.
d) Embolism, infarction, shock.
7. Fluid, Electrolyte, Acid-base.
a) Fluid and electrolyte homeostasis aqnd imbalances.
b) Acid-base homeostasis and imbalances.
8. Pathophysiology of integumentary system.
a) Alterations in the integumentary system.
b) Burn injuries.
9. General pathophysiology of infectious diseases.
a) Categories of infectious agents.
b) Host barriers to infectious agents and how they break down.
c) How infectious agents cause disease (mechanisms of virus-induced injury, mechanisms
of bacteria-induced injury).
d) Immune evasion by microbes.
e) Special techniques for diagnosis of infectious agents.
f) Inflammatory response to infectious agents.
g) HIV and AIDS.
10. Arterial disorders: Arteriosclerosis, Hypertension and hypertensive vascular disease.
a) Vasculitis, Aneurysm.
b) Venous disorders.
c) Lymphatic disorders.
d) Congestive heart failure.
e) Ischemic heart disease.
f) Hypertensive heart disease.
g) Cor pulmonare.
h) Valvular heart diseases.
i) Primary myocardial diseases.
j) Congenital heart disease (left-to-right shunts, right-to-left shunts).
k) Pericardial diseases.
11. Pathophysiology of hematopoietic and lymphoid systems.
a) Hemorrhage: Blood loss anemia, Increased rate of red cell destruction-the hemolytic
anemia.
b) Anemias of diminished erythropoiesis.
c) Polycythemia.
d) Non-neoplastic disorders of white cells. Neoplastic proliferations of white cells,
Thrombocytopenia. Coagulation disorders.
12. Pathophysiology of respiratory system.
a) Atelectasis.
b) Obstructive and restrictive lung diseases (Asthma, Chronic obstructive pulmonary
diseases, Acute restrictive lung diseases, Chronic restrictive lung diseases).
c) Vascular lung diseases.
d) Pulmonary infections.
e) Lesions of the upper respiratory tract.
f) Alterations in gas exchange.
13. Pathophysiology of renal system.
a) Glomerular diseases: Pathogenesis of glomerular diseases, Glomerular syndromes and
disorders, Chronic glomerulonephritis.
b) Diseases affecting tubules and interstitium.
c) Diseases involving blood vessels.
d) Cystic diseases of the kidney.
14. Pathophysiology of gastrointestinal system.
a) Motor disorders of esophagus.
b) Acute and chronic gastritis.
c) Gastric ulceration.
d) Vascular disorders of small and large intestines.
e) Diarrheal diseases.
f) Jaundice and cholestasis.
g) Hepatic failure.
h) Cirrhosis.
i) Inflammatory disorders of liver (hepatitis).
j) Drug- and toxin-induced liver disease.
k) Inborn errors of metabolism and pediatric liver disease.
l) Intrahepatic biliary tract disease
m) Disorders of the gallbladder.
n) Disorders of extrahepatic bile ducts.
o) Pancreatitis.
p) Diabetes mellitus.
q) Hyperinsulinism.
r) Zollinger-Ellison Syndrome.
15. Pathophysiology of endocrine system.
a) Hyperpituarism. Hypopituarism.
b) Posterior pituitary syndromes.
c) Hyperthyroidism, Hypothyroidism.
d) Graves’s disease.
e) Diffuse nontoxic goiter and multinodular goiter.
f) Thyroiditis.
g) Hyperparathyroidism, Hypoparathyroidism.
h) Adrenocortical hyperfunction, Adrenal insufficiency.
i) Multiple endocrine neoplasia syndromes.
j) Alterations in metabolism and nutrition.
16. Pathophysiology of musculoskeletal system.
a) Osteoporosis and acquired metabolic diseases (rickets and osteomalacia, bone diseases
associated with hyperparathyroidism).
b) Osteomyelitis.
c) Osteoarthritis.
d) Gout.
e) Infectious arthritis.
f) Neurogenic muscle athrophy, Type II myofiber atrophy.
g) Myasthenia gravis.
h) Inflammatory myopathies.
i) Muscular dystrophies.
17. Pathophysiology of nervous system.
a) Cells of the nervous system.
b) Edema and hydrocephalus.
c) Vascular diseases.
d) Central nervous system trauma.
e) Infections of the nervous system.
f) Primary diseases of myelin.
g) Acquired metabolic and toxic disturbances.
h) Degenerative disorders (Alzheimer’s disease, Parkinsonism, Huntington disease,
Diseases of motor neurons).
i) Peripheral neuropathies.
j) Pain.
Students will be able to
 Recognize and evaluate appropriate evidence to advance a claim;
 Apply critical analytical skills in making decisions or in advancing a theoretical position; and
 Evaluate alternative arguments, decision strategies, or theories within a systematic
framework.
Critical Analysis ability
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368 Learning Outcome
Recognize and evaluate
appropriate evidence to
advance a claim;
Apply critical analytical
skills in making decisions or
in advancing a theoretical
position; and
Evaluate alternative
arguments, decision
strategies, or theories within
a systematic framework.

Apply critical analytical
skills in making decisions or
in advancing a theoretical
position; and
Evaluate alternative
arguments, decision
strategies, or theories within
a systematic framework.





Assignment/activity
Demonstrate an
understanding of current
scientific evidence related to
physiological processes and
phenomena that form the
basis for understanding
pathophysiology
Applies current scientific
principles to the
understanding the
interrelationships between
pathophysiology,
pharmacology, diagnostic
testing, and management.
Case Studies non-graded for class
discussion
Apply previous knowledge
from sciences to
understanding the concepts
of health and disease.
Utilize evidence-based
practices to guide
understanding of
pathophysiology in disease
prevention, diagnosis, and
management.
Applies current scientific
principles to the
understanding the
interrelationships between
pathophysiology,
pharmacology, diagnostic
testing, and management.
Articulate an understanding
In class, small fingers talk….
Case Studies graded (10 pts each)
Worried Sick Chapter Reviews (10
pts each)
Exams
1 Comprehensive final exam (80100 points)
Quizzes (50 pts)
Case Studies non-graded for class
discussion
Case Studies graded (10 pts each)
Worried Sick Chapter Reviews (10
pts each)
of laboratory and diagnostic
tests used in the ongoing
diagnosis, treatment, and
management of selected
health conditions.
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


Recognize and evaluate
appropriate evidence to
advance a claim;
Apply critical analytical
skills in making decisions or
in advancing a theoretical
position; and
Evaluate alternative
arguments, decision
strategies, or theories within
a systematic framework.
Recognize and evaluate
appropriate evidence to
advance a claim;




Explain the physiologic
changes and human
responses to
pathophysiologic responses
that produce signs and
symptoms of health
conditions and their impact
on functional health status.
Identify the impact of
specific diseases upon the
U.S. and global population.
Using current evidence,
delineate the risk factors
highly correlated with
specific health conditions.
In class, dark eyes talk
Using current evidence,
delineate the risk factors
highly correlated with
specific health conditions.
Case Studies non-graded for class
discussion
Case Studies graded (10 pts each)
Worried Sick Chapter Reviews (10
pts each)
Exam I
Exam II
Final Exam
Lecture Points
100
100
100
Sub-Total
300 (50% critical analysis related questions)
Quiz 1
Quiz 2
Quiz 3
Lecture Points
50
50
50
Subtotal
150 (50% critical analysis related questions)
Exams
1 Comprehensive final exam (80100 points)
Quizzes (50 pts)
Case Studies non-graded for class
discussion
Case Studies graded (10 pts each)
Worried Sick Chapter Reviews
Worried Sick Chapter Reviews & Critical Analysis
10 chapters x 10 pts= 100 pts (100% of points are critical analysis related)
Case Studies
4 case studies x 10 pts = 40 pts (100% of points are critical analysis related)
Total course points = 590
Intensive Critical Analysis point estimate = 365 points or 62% of the total course points
WINONA STATE UNIVERSITY
GENERAL EDUCATION PROGRAM APPROVAL FORM
Routing form for General Education Program Course approval.
Course______________________
Department Approval
_________________________________
Department Chair
________________
Date
Dean’s Recommendation _____ Yes
_____ No*
_________________________________
Dean of College
________________
Date
____________________________________________
e-mail address
*If the dean does not approve the proposal, a written rationale shall be provided to the General Education Program Subcommittee.
GEPS Recommendation
_____ Approved
_________________________________
General Education Program Director
A2C2 Recommendation
_____ Disapproved
________________
Date
_____ Approved
_________________________________
Chair of A2C2
Faculty Senate Recommendation
_____ Disapproved
________________
Date
_____ Approved
_________________________________
President of Faculty Senate
_____ Disapproved
________________
Date
Academic Vice President Recommendation _____ Approved
_________________________________
Academic Vice President
Decision of President
_____ Approved
_________________________________
President
_____ Disapproved
________________
Date
_____ Disapproved
________________
Date
Please forward to Registrar.
Registrar
_________________
Date entered
Please notify department chair via e-mail that curricular change has been recorded.
[Revised 7-13-11]