Foundations of Clinical Neurophysiology
Neuroscience 1046
Jeffrey R. Balzer, Ph.D.: Course Director
balzerjr@upmc.edu
412-648-9779
Tuesday and Thursday, 3:30-5:00 pm
Tuesdays: Room 230, Victoria Bldg.
Thursdays: Room 129, Victoria Bldg.
Lecture
Topic
Lecturer
1
Course Overview
o What is Clinical Neurophysiology?
Dr. Crammond
(08/30/11)
2
Functional Neuroanatomy
o Brain
o Brainstem
o Spinal Cord
o Cerebrovasculature
o Cranial Nerves
o Brachial Plexus/Peripheral Nerves
Dr. Thirumala
(09/01/11)
3
Neuropathophysiology
o Injury and Neuronal Responses
o Cellular Homeostasis
o Ischemia
o Excitatory Amino Acids
Dr. Haybech
(09/06/11)
4
Functional Neurophysiology
o Cerebral Metabolism
o Cerebral Blood Flow
o AVD02
o Autoregulation
o CSF Dynamics
o Blood-Brain Barrier
Dr. Balzer
(09/08/11)
5
Cerebrovascular Anatomy and Physiology
o Circle of Willis
o Anterior Circulation
o Posterior Circulation
o Stroke
o Relationship to Evoked Potentials
Dr. Balzer
(09/13/11)
6
Techniques for Electroencephalographic Recording
o Electrodes
o International “Ten-Twenty” System
o Equipment
Dr. Crammond
(09/15/11)
7
Basic Scalp Electroencephalography
o Origin of EEG
o Technical Considerations
o EEG and Anesthesia
o EEG and Surgical Procedures
o Computer Processed EEG
Dr. Thirumala
(09/20/11)
8
Electrocorticography
o Use in Epilepsy Surgery
o Technical Aspects of ECoG and Stimulation
o Awake Craniotomy
o Anesthetic Considerations
Dr. Thirumala
(09/22/11)
9
Intraoperative Evoked Potentials
o Neurophysiologic Basis
o Instrumentation
o Technical Standards
Dr. Balzer
(09/27/11)
10
Somatosensory Evoked Potentials
o Placement of Electrodes
o Sensory Tracts
o Stimulating Electrodes
o Phase Reversal
o Clinical Indications for SSEP Recording
Dr. Crammond
(09/29/11)
11
Brainstem Auditory Evoked Potentials
o Placement of Electrodes
o Recording Parameters
o Auditory Pathways/Obligate Waves
o Clinical Indications for BAEP Recording
Dr. Crammond
(10/04/11)
12
Visual Evoked Potentials
o Stimulating and Recording
o Visual Pathways
o Clinical Indications for VEP Recording
o Electroretinogram (ERG)
Dr. Crammond
(10/06/11)
October 11, 2011: NO CLASS
13
Motor Evoked Potentials
o Stimulating and Recording
o Neurogenic vs. Myogenic
o Transcranial Electrical Stimulation
o Motor Pathways
o Clinical Indications for MEP Recording
o Anesthetic Considerations
Dr. Balzer
(10/13/11)
MIDTERM EXAMINATION 10/18/11
15
Intraoperative Electromyography (EMG)
o Basic Principles of EMG
o Recording EMG
o Free-Running EMG
o Stimulus-Evoked EMG
o Alarm Criteria
Dr. Balzer
(10/20/11)
16
Intraoperative Facial Nerve Monitoring
o Monitoring Methods
o Electrode Placement
o Discharge Patterns
o Hemifacial Spasm
o Clinical Indications
Dr. Habeych
(10/25/11)
17
Other Cranial Nerve EMG
o Extra-ocular Muscle EMG
o Trigeminal Nerve EMG
o Lower Cranial Nerve EMG
Dr. Habeych
(10/27/11)
18
Nerve Root Monitoring in the Spine
o Free-Run vs. Stimulus-Evoked EMG
o Pedicle Screw EMG
o Cervical EMG
o Thoracic EMG
o Lumbosacral EMG
Dr. Balzer
(11/01/11)
19
Deep Brain Stimulation
o Anatomy
o Physiology
o Micro-Electrode Recording
o Guiding the Surgical Placement
Dr. Crammond
(11/03/11)
20
Traumatic Brain Injury
o Principles
o Pathophysiology
o ICP
o Evoked Potentials and Prediction of Outcome
Dr. Okonkwo
(11/08/11)
21
Anesthesia and Evoked Potentials
o Halogenated Anesthesia
o Intravenous Anesthetics
o Effects on Evoked Potentials
o Effects on EMG
Dr. Balzer
(11/10/11)
22
Surgical Treatment of Epilepsy
o Epilepsy
o Conventional Treatment
o Surgery
o ECOG and Mapping
Dr. Richardson
(11/15/11)
23
Interventional Radiology, Aneurysms and Stroke
o Endovascular Treatments
o Angiography
o Aneurysms
o Stroke
Dr. Jankowitz
(11/17/11)
24
Cerebral Oximetry
o Principles
o Techniques and Examination
o Clinical Application
Dr. Balzer
(11/22/11)
Thanksgiving Break: NO CLASS 11/24/11
25
Brain Mapping Techniques
o Phase Reversal
o Direct Cortical Stimulation
o Awake Craniotomy
o Fourth Ventricle Mapping
Dr. Balzer
(11/29/11)
26
Transcranial Doppler
o Cerebrovascular Anatomy
o Anatomical Anomalies
o Techniques and Examination
o Clinical Application
Dr. Balzer
(12/01/11)
27
Intraoperative Monitoring: Case Reviews
All Faculty
o Spine
(12/06/11)
o Vascular
o Cranial/Tumor
o Awake Craniotomy
o Cranial/Microvascular Decompression
o Brachial Plexus/Peripheral Nerve
o Deep Brain Stimulation/Microelectrode Recording
28
Paper Review
Dr. Balzer
(12/08/11)
December 16, 2011: FINAL PAPER DUE
If you have a disability for which you are or may be requesting an accommodation, you are encouraged to
contact both your instructor and Disability Resources and Services, 216 William Pitt Union, 412-648-7890
(412-383-7355 (TTY)), as early as possible in the term. DRS will verify your disability and determine
reasonable accommodations for this course.